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Table S2 – Enriched KEGG pathways and GO Terms for biological process for the genes targeted by the regulated miRNA during
aging in Normal mice.
Pathways and GO Terms
KEGG pathways
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton
Axon guidance
AMPK signaling pathway
Pathways in cancer
HTLV-I infection
Focal adhesion
Endocytosis
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
MAPK signaling pathway
Proteoglycans in cancer
Cytokine-cytokine receptor interaction
Wnt signaling pathway
FoxO signaling pathway
Oxytocin signaling pathway
Insulin signaling pathway
Choline metabolism in cancer
Rap1 signaling pathway
Transcriptional misregulation in cancer
Thyroid hormone signaling pathway
TGF-beta signaling pathway
ErbB signaling pathway
Ras signaling pathway
Neurotrophin signaling pathway
Fc gamma R-mediated phagocytosis
P value
Genes
miRNAs
4.30E-09
0.002
2.39E-06
0.004
1.71E-07
0.002
1.15E-05
0.009
0.001
2.36E-06
0.008
6.64E-07
0.024
4.20E-06
4.10E-05
0.025
0.030
0.001
0.002
4.10E-05
2.09E-06
3.99E-07
0.006
0.001
0.015
0.015
104
58
46
34
104
70
63
49
46
44
62
62
51
47
42
39
36
32
55
50
41
32
25
57
32
25
18
18
18
18
17
17
17
17
17
17
16
16
16
16
16
16
16
16
15
15
15
15
15
14
14
14
mTOR signaling pathway
Phosphatidylinositol signaling system
T cell receptor signaling pathway
Prostate cancer
Protein digestion and absorption
Renal cell carcinoma
ECM-receptor interaction
Amoebiasis
Adherens junction
Glioma
Small cell lung cancer
Melanoma
Inositol phosphate metabolism
Basal cell carcinoma
Non-small cell lung cancer
Thyroid hormone synthesis
Lysine degradation
Other types of O-glycan biosynthesis
Prion diseases
Hedgehog signaling pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
0.030
5.18E-06
0.027
0.011
0.016
0.001
3.87E-28
0.001
2.69E-04
0.002
0.009
0.017
0.004
0.048
0.045
0.004
0.025
0.035
2.21E-15
0.030
0.002
19
30
28
27
26
21
29
28
24
19
25
20
19
17
15
14
12
10
7
16
5
14
13
13
13
13
13
12
12
12
12
11
11
11
11
11
11
11
9
9
7
5
GO Term Biological Processes
Anatomical structure development
Biosynthetic process
Cellular nitrogen compound metabolic process
Cell differentiation
Embryo development
Anatomical structure formation involved in morphogenesis
Cell morphogenesis
Homeostatic process
4.84E-169
1.39E-13
5.39E-18
6.24E-93
1.09E-71
1.65E-37
1.00E-28
2.54E-08
901
702
815
668
291
221
186
179
22
22
21
21
20
20
20
20
Cell death
Cellular protein modification process
Cellular component assembly
Cell cycle
Chromosome organization
Cell motility
Cell division
In utero embryonic development
Circulatory system process
Cytoskeleton organization
Cell-cell signaling
Growth
Developmental maturation
Odontogenesis of dentin-containing tooth
0.015
8.14E-20
0.002
4.70E-05
1.05E-22
2.69E-12
1.49E-08
0.006
0.001
0.001
0.013
2.32E-09
9.77E-15
0.016
158
464
221
199
148
145
116
81
39
136
118
105
55
27
20
19
19
19
19
19
19
19
19
18
18
18
18
16