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CURRICULUM VITAE NAME Stephen F. Vatner, M.D. HOME ADDRESS 15 West 72nd Street, Apt. 34C New York, NY 10023 (212) 874-3045 PRESENT POSITION University Professor Director, Cardiovascular Research Institute New Jersey Medical School University of Medicine and Dentistry of New Jersey PO Box 1709 185 South Orange Avenue Medical Science Building, G-609 Newark, NJ 07101-1709 973-972-8920 EDUCATION Grinnell College Grinnell, IA B.A. Chemistry, 1961 New York University New York, NY M.D., 1965 POST-GRADUATE TRAINING Intern, Medicine University of Virginia Charlottesville, VA Supervisor: William Parsons, M.D. 1965 – 1966 Senior Medical Resident Medicine University of Virginia Charlotteville, VA Supervisor: Byrd Leavell, M.D. 1966 – 1967 Post Doctoral Fellow Physiology & Biophysics University of Washington Seattle, WA Mentor: Robert L. VanCitters, M.D. 1967 – 1969 1 PROFESSIONAL APPOINTMENTS Academic Appointments: University Professor Director, Cardiovascular Research Institute Chair, Department of Cell Biology and Molecular Medicine (2002 – 2011) New Jersey Medical School University of Medicine and Dentistry of New Jersey PO Box 1709 185 South Orange Avenue Medical Science Building, G-609 Newark, NJ 07101-1709 2000 Director, Weis Center for Research Henry Hood Research Program Charles B. Degenstein Professor Penn State College of Medicine Danville, PA 1999 – 2000 George J. Magovern Professor and Director Cardiovascular and Pulmonary Research Institute Allegheny University of the Health Sciences Pittsburgh, PA 1997 – 1999 Professor of Medicine Harvard Medical School Boston, MA 1990-1997 Associate Professor of Medicine Harvard Medical School Boston, MA 1974 – 1990 Assistant Professor of Medicine Harvard Medical School Boston, MA 1972 – 1974 Assistant Professor of Medicine University of California, San Diego La Jolla, CA 2 1971 – 1972 Assistant Research Physiologist Department of Medicine University of California, San Diego La Jolla, CA 1969 – 1970 Hospital Appointments: Senior Physiologist Department of Medicine Brigham and Women's Hospital Boston, MA 1992 – 1997 Physiologist Department of Medicine Brigham and Women's Hospital Boston, MA 1982 – 1991 Associate in Cardiology Brigham and Women's Hospital Children's Hospital Medical Center Boston, MA 1972 – 1997 OTHER PROFESSIONAL POSITIONS Chairman, President and Chief Executive Officer Vasade Biosciences, Inc. 16 East 27th Street Barnegat Light, NJ 08006 Chairman, President and Chief Executive Officer CV Dynamics, Inc. 16 East 27th Street P.O. Box 339 Barnegat Light, NJ 08006 HONORS Established Investigator, American Heart Association, 1974 – 1979 NIH MERIT Award, 1974 - 1983 3 George E. Brown Lecture, American Heart Association, 1986 Hawthorne Lecture, Howard University, 1990 Honorary Doctor of Medicine Degree, Kagawa Medical School, Kagawa, Japan, 1992 Welcome Visiting Professor, University of Nebraska, 1993 Wiggers Awardee, Cardiovascular Section of the American Physiological Society, 1995 Foaud A. Bashour Distinguished Physiologist lecturer, the University of Texas, Dallas, Southwestern Medical Center, 1996 Konrad Witzig Memorial Lecturer, The Cardiovascular System Dynamics Society, Danville, PA, 1996 J. R. Neely Lecturer, Geisinger Clinic, Danville, PA, 1997 Thomas L. O’Donohue Memorial Lecture in Neuropharmacology, Howard University, Washington, DC, 1997 Invited Lecture in Honor of Emeritus Professor Andre Charlier, the Unit of Cardiovascular Physiology, Universite Catholique de Louvain, Brussels, Belgium, 1997 Honorary Professor, The Fourth Military Medical University, Xian China, 1998 Scientific Councils Distinguished Achievement Award, American Heart Association, 1998 Research Achievement Award, American Heart Association, 2000 Fellowship of the International Society for Heart Research (ISHR) Fellowship of the International Academy of Cardiovascular Sciences (IACS), 2002 Robert Beamish Award, Institute of Cardiovascular Sciences, 2004 Included in Who’s Who in America 58th Edition, 2004 59th Edition, 2005 Distinguished Scientist of the American Heart Association Award, 2005 4 Honorary Doctor "Honoris Causa" Degree, University of Buenos Aires, Buenos Aires, Argentina, 2008 Robert M. Berne Distinguished Lectureship Award, 2011 International Academy of Cardiovascular Sciences (IACS) Lifetime Achievement Award, 2011 PROFESSIONAL SOCIETIES Member, American Heart Association, 1968 Member, American Federation for Clinical Research, 1970 Member, American Physiological Society, 1972 Member, American Society for Clinical Investigation, 1974 Member, American Society for Pharmacology and Experimental Therapeutics, 1974 Member, American Association of Physicians, 1987 Vice President, American Heart Association, Massachusetts Affiliate, 1990 – 1992 Vice President, International Academy of Cardiovascular Sciences, 1997 – 2005 Member, Biophysical Society, 1998 President, International Academy of Cardiovascular Sciences, 2005 – 2009 EXTRAMURAL PROFESSIONAL ACTIVITIES Major Committees American Heart Association - Council on Circulation (Executive, Credentials, Program, and Nominating Committees) 1968 – Present Chairman, Program Committee, Council on Circulation, American Heart Association 1982 – 1985 5 Co-Director, Scientific Sessions of Councils on Basic Science and Circulation, Keystone, CO, American Heart Association 1986 Vice Chairman, Council on Circulation, American Heart Association Chairman, Council on Circulation, American Heart Association 1988 – 1990 Chairman, Council on Circulation, American Heart Association 1990 – 1992 American Association for Accreditation of Laboratory and Animal Care (AAALAC) Board of Trustees 1992 Chairman, Nominating Committee, Council on Circulation 1997 – 1999 American Heart Association, Board of Directors, Allegheny County 1997 – 2000 American Heart Association Research Committee 2000 – 2005 American Heart Association, Distinguished Scientists Selection Committee 2009 - present Review Committees and Study Sections American Heart Association - Cardiovascular A Study Section 1979 – 1982 American Heart Association, Massachusetts Affiliate, Research Study Section 1982 – 1984 AHA Chairman, Research Study Section, Massachusetts Affiliate 1986 – 1988 AHA Chairman, Research Committee, Massachusetts Affiliate 1988 – 1990 NIH - CVB (Cardiovascular and Renal), Study Section 1985 – 1989 6 NASA - Large Primate Facility Advisory Committee 1985 Chairman, American Heart Association Cardiovascular (Patho) Physiology I Study Section 2000 – 2003 UMDNJ – New Jersey Medical School, Dean Search Committee 2008 – 2009 NHLBI – SMARTT (Science Moving toward Research Translation and Therapy) 2011 – present Editorial Boards American Journal of Physiology 1979 – 1981 & 1985 Board of Medical Editors, American Journal of Physiology- Heart and Circulatory Physiology 1998 – 2007 Circulation Research 1981 – 1987 Editor in Chief 1991 – 1999 Consulting Editor 1999 – present Proceedings of the Society for Experimental Biology and Medicine 1981 – 1987 Hypertension 1983 – 1989 Circulation 2000 – present Journal of Molecular and Cellular Cardiology Consulting Editor 2000 – 2008 7 Basic Research in Cardiology 2006 – present INSTITUTIONAL SERVICE Allegheny University of the Health Sciences (AUHS), 1997 – 1999 AUHS Ad Hoc Committee on Goals, Objectives and Incentive Planning 1997 – 1998 AUHS Bailey Chair Search Committee, 1997 – 1998 AUHS Basic Science Chairs and Centers, 1997 AUHS Department Chairs, Institute Directors and Center Directors, 1997 AUHS University Leadership Committee, 1997 AUHS University Research Committee, 1997 AUHS Western Regional Steering Committee, 1997 – 1998 AUHS Corporate Management Committee, 1998 Pennsylvania State University College of Medicine Executive Committee, 1999 UMDNJ, New Jersey Medical School, Intellectual Property Committee, 2001 – 2003 UMDNJ, New Jersey Medical School Faculty Council, 2001 – present UMDNJ, New Jersey Medical School Faculty Organization Committee, 2001 – present UMDNJ, NHLBI Student Research Advisory Committee, 2002 UMDNJ, President’s Strategic Council on Research Advancement, 2005 UMDNJ, Dean’s Executive Group, 2004 - present UMDNJ, Liaison Committee for Medical Education, 2005 8 TEACHING Classroom Instruction University of Virginia Teaching Award as Intern and Resident, 1965 – 1967 University of Washington Medical Student Teaching, 1962 – 1969 University of California, San Diego Medical Student Teaching, 1969 – 1972 Harvard Medical School Tutor in Medicine, 1973 – 1975 University of Medicine and Dentistry of New Jersey Human Anatomy and Development Intergrative Structure and Function 2002 - Present Postdoctoral Research Trainees (1972 – Present) 1. Ronald W. Millard, Ph.D., Professor of Pharmacology, University of Cincinnati College of Medicine, Cincinnati, Ohio 2. Robert J. McRitchie, M.D., Professor of Medicine, University of South Australia, Adelaide, Australia 3. Julie A. Swain, M.D., Professor of Surgery, Louisiana State University, Shreveport, LA 4. Guy Heyndrickx, M.D., Ph.D., Professor, 5. Dedo H. Boettcher, M.D., Deutsche Klinic für Diagnostik, Hannover, Germany 6. Massimo Pagani, M.D., Professor of Medicine, Milan, Italy 7. John D. Rutherford, M.D., Professor of Cardiology, University of Texas, Southwestern, Dallas, Texas 8. Hermann R. Ochs, M.D., Professor of Medicine, Bonn, Germany 9. Paul A. Murray, Ph.D., Professor and Chairman of Anesthesia Research, Cleveland, Ohio 10. Peter Kerkhof, M.D., Professor, Leiden, Netherlands 11. Pilar Macho, M.D., Associate Professor of Physiology, Santiago, Chile 9 12. Ares D. Pasipoularides, M.D., Ph.D., Professor of Bioengineering, Duke University, Durham, NC 13. Michael Zimpfer, M.D., Professor and Chairman of Anesthesia, University of Vienna, Vienna, Austria 14. Siu Po Sit, Ph.D., Senior Pharmacologist, Ciba-Geigy, NJ 15. Kenneth L. Baughman, M.D., Chief of Cardiology, The Johns Hopkins University, Baltimore, MD 16. Thomas H. Hintze, Ph.D., Professor of Physiology, New York Medical College, Valhalla, NY 17. Michel Lavallee, Ph.D., Professor of Physiology, University of Montreal, Montreal, Quebec, Canada 18. Delvin R. Knight, Ph.D., Pharmacologist, Pfizer, Groton, CT 19. Mark A. Young, Ph.D., Pharmacologist, San Diego, CA 20. Alan M. Fuji, M.D., Pediatric Cardiologist, Children’s Hospital, Boston, MA 21. Hironobu Morita, Ph.D., Professor and Chairman of Physiology, Gifu University, Japan 22. Jun Amano, M.D., Professor of Surgery, Tokyo Women’s College, Tokyo, Japan 23. Owen L. Woodman, Ph.D., Associate Professor of Pharmacology, University of Melbourne, Australia 24. Jacqueline Ohanian, Ph.D., Lecturer, University of Manchester, England 25. You-Tang Shen, M.D., Professor (appointment pending), University of Pennsylvania, Philadelphia, PA 26. Ricardo J. Gelpi, M.D., Professor of Physiology, University of Buenos Aires, Buenos Aires, Argentina 27. Jun Nejima, M.D., Assistant Professor of Cardiology, Tokyo, Japan 28. Richard P. Shannon, M.D., Chairman, Department of Medicine, Allegheny General Hospital, Pittsburgh, PA 29. Suzanne Kohin, Ph.D., Post Doctoral Resident, Scripps Institute of Oceanography, LaJolla, CA 30. Luc Hittinger, M.D., Ph.D., Professor of Cardiology, Hospital Leon Bernard, Paris, France 31. Nobuhisa Uemura, M.D., Ph.D., Assistant Professor of Physiology, Kagawa Medical School, Japan 10 32. Kazuo Komamura, M.D., Ph.D., Assistant Professor, Osaka University School of Medicine, Osaka, Japan 33. Kaname Kiuchi, M.D., Ph.D., Assistant Professor of Cardiology, Tokyo, Japan 34. Naoyuki Hasebe, M.D., Associate Professor of Medicine, Hokkaido, Japan 35. Naoki Sato, Ph.D., Professor, Dept Molecular Biology, Saitama Univ., Saitama, Japan 36. Bernd Kalthof, Ph.D., Pharmacologist, Bayer Pharmaceuticals, Germany 37. Mitsunori Iwase, M.D., Ph.D., Chief, Div of Integrated Medicine, Toyota Memorial Hospital, Nagoya, Japan 38. Bijan Ghaleh, Ph.D., Assistant Professor of Pharmacology, Faculte de Medicine Parie-Sud, Le Kremlin – Bicetre Cedex, France 39. Masami Uechi, DVM, Ph.D., Assistant Professor, School of Veterinary Medicine and Animal Sciences, Animal Teaching Hospital, Towada, Japan 40. Cheng-Hsiung Huang, M.D., Assistant Professor of CV Surgery, Veterans General Hospital, Taipei, Taiwan 41. Song-Jung Kim, Ph.D., Assistant Professor, Dept of Cell Biology & Molecular Medicine, University of Medicine and Dentistry of New Jersey – New Jersey Medical School, Newark, NJ 42. Raymond K. Kudej, DVM, Ph.D., Associate Professor, Tufts University School of Veterinary Medicine, McGrafton, MA 43. Weiqun Shen, M.D., Ph.D., Lilly Research Laboratories, Indianapolis, IN 44. Guiping Yang, M.D., Dept of Cell Biology & Molecular Medicine, University of Medicine and Dentistry of New Jersey – New Jersey Medical School, Newark, NJ 45. Gen Takagi, Assistant Professor, Nippon Medical School, Tokyo, Japan 46. Kuniya Asai, M.D., Assistant Professor, Nippon Medical School, Tama-Nagayama Hospital, Tokyo, Japan 47. Tomomi Meguro, M.D., Ph.D., Department of Cardiovascular Medicine & Therapeutics, Inagi Municipal Hospital, Tokyo, Japan 48. Carmine Morisco, M.D., Ph.D., Assistant Professor in Internal Medicine at Department of Clinical Medicine, Cardiovascular Sciences and Immunology, FEDERICO II University, Naples, Italy 11 49. Pallavi Peter, M.D., Assistant Professor, Division of Cardiology, Ohio State University School of Medicine 50. Samuel Lieber, Ph.D., Senior Engineer, Stryker Orthopaedics, Mahwah, NJ 51. David Ho, M.D., Assistant Professor, Cell Biology and Molecular Medicine, UMDNJ, Newark, NJ CURRENT RESEARCH GRANT SUPPORT NIH/NIA Grant 1P01 AG027211, “Longevity and Stress Resistance” (Program Project), Stephen F. Vatner, P.I. $10,165,654 total cost over 5 years $1,431,783 current year direct cost 06/01/2007 - 04/30/2012 NIH/NHLBI Grant 5R01 HL033107, “Cardiovascular Control in Normal and Disease States”, Stephen F. Vatner, P.I. $3,650,000 total cost over 5 years $482,227 current year direct cost 1/01/1984 – 12/31/2011 This grant is in the 24th year. NIH/NHLBI Grant 5P01 HL069020, “Mechanisms of Myocardial Ischemia and Reperfusion”, Dorothy E. Vatner, PI Project 2 “Molecular Mechanisms in Chronically Stunned Myocardium” Stephen F. Vatner, Project Leader $1,623,205 total cost over 5 years $206,427 current year direct cost 09/30/01 – 08/31/11 This grant is in the 7th year and supersedes the former NIH/NHLBI Grant 7R01 HL33065, “Myocardial Ischemia and Coronary Artery Reperfusion”, Stephen F. Vatner, P.I., which was in its 27th year of funding. NIH/NHLBI Grant 1R01 HL093481-01 “Adenylyl cyclase isoforms in hypertrophy and heart failure” Stephen F. Vatner, P.I. $2,491,325 total cost over 5 years $299,602 current year direct cost 8/15/09 – 6/30/14 NIH 1P20 HL101420-01 “AC5 inhibitor for heart failure” Stephen F. Vatner, P.I. $1,558,222 total cost over 2 years $499,430 current year direct cost 4/1/10 – 3/31/12 12 Note: Applications for clinical trials of this drug for treatment of heart failure, obesity and diabetes were submitted to the FDA (investigational new drug) and NIH (P50 translational research grant) valued at $12 million total cost over 5 years. NIH/NHLBI Grant 1R01 HL102472-01 “Intrinsic vascular smooth muscle cell stiffness” Stephen F. Vatner, P.I. $2,585,753 total cost over 5 years $494,095 current year direct cost 4/1/10 – 3/31/15 NIH/NHLBI Grant 2T32 HL069752-06A1 “Integrative Mechanisms in Cardiovascular Disease” Stephen F. Vatner, P.I. $1,344,545 total cost over 5 years $249,390 current year direct cost 07/01/2002 - 08/31/2014 NIH/NHLBI Grant 1 R01 HL106511-01A1 “Skeletal Muscle Basis for Improved Exercise Endurance in AC5 KO,” Impact/Priority Score: 10; Percentile: 3 Stephen F. Vatner, P.I. $2,446,481 total cost over 5 years $314,800 current year direct cost PATENTS Transgenic model of heart failure USPTO#: 6,333,447 12/25/01 pDJA1, a cardiac specific gene, corresponding proteins, and uses thereof USPTO#: 7,009,038 3/7/2006 PATENT APPLICATIONS A method for identifying agents which modulate cell growth or survival PCT/US2005/034228 Filed on: 9/24/2005 Adenylyl cyclase and isoforms thereof, and uses thereof 10/429,214 Filed on: 05/02/2003 Adenylyl cyclase type 5 monoclonal antibody 5/26/2005 Filed on: 10/10/2003 Prevention of Heart Cell death by longevity factors 60/726,259 13 Filed on: 10/13/2005 INVITED SEMINARS 2003 – Present 2003: Grand Rounds – St. Michael’s Medical Center – Newark, New Jersey • “The Role of the Sympathetic Nervous System in Congestive Heart Failure” February 27, 2003 Surgical Grand Rounds – New York Medical College – Valhalla, New York • “New Concepts of Mechanisms of Hibernating and Stunned Myocardium” March 11, 2003 UMDNJ – New Jersey Medical School National Heart, Lung & Blood Institute – Introductory Session of Summer Research Program – Newark, New Jersey • “Developing a Research Proposal and Communicating the Results” June 11, 2003 XXV Annual Meeting of the International Society for Heart Research (ISHR) North American Section – Mystic, Connecticut • “New Insights into Stunning and Hibernation” June 29, 2003 European Society of Cardiology and the Basic Cardiovascular Sciences Council of the American Heart Association – Myocardial Ischemia: From Molecular Adaptation to Cellular Repair – Capri, Italy Stephen F. Vatner – Organization Committee Member and Speaker October 18-20, 2003 American Heart Association 2003 Scientific Sessions – Orlando, Florida • “Myocardial Ischemia and Reperfusion: Basic Science and Translational Applications” November 10, 2003 2004: Surgical Grand Rounds – New York Medical College, Valhalla, New York • “Beta-Adrenergic Signaling in Heart Failure and Longevity: Changing Roles of Sympathetic Stimulation and Inhibition” February 6, 2004 UMDNJ – New Jersey Medical School Sigma Phi XI Distinguished Lecture Series, Newark, New Jersey • “Integrative Cardiovascular Physiology: From Mice to Men and Vice Versa” March 2, 2004 14 American College of Cardiology: How to Become a Cardiovascular Investigator Program – Bethesda, Maryland • “Careers in Basic Cardiovascular Research” May 14, 2004 UMDNJ – New Jersey Medical School National Heart, Lung & Blood Institute – Introductory Session of Summer Research Program, Newark, NJ • “Research Funding” June 9, 2004 Institute of Cardiovascular Sciences 6th Annual Cardiovascular Awards Symposium – Winnipeg, Manitoba, Canada Stephen F. Vatner – Recipient of Robert Beamish Award • “Physiological and Molecular Mechanisms Mediating Hibernating Myocardium” June 11, 2004 International Society for Heart Research (ISHR) – Latin American Section – Iguazu Falls, Argentina • “Mechanisms of Hibernating Myocardium” August 3, 2004 European Society of Cardiology (ESC) Congress 2004 – Munich, Germany • Jury Member – Young Investigators’ Award Session – Basic Sciences Session August 29, 2004 • Chair of Session – Altered Calcium Handling in Heart Failure: New Concepts, New Targets August 30, 2004 • Speaker – “The Benefits and Pitfalls of Treating Hypertrophy” August 30, 2004 International Workshop “A Focus on Heart Failure: From the Molecular Mechanisms to the Rationale of New Strategies of Clinical Approach” – Sorrento, Italy • “From the Identification of Hibernating Myocardium to the Recovery of LV Contractility” October, 2004 Cytokinetics Scientific Advisory Board Meeting – San Francisco, CA • “Heart Failure: Rationale for Inhibiting Beta-Adrenergic-G Protein-Adenylyl Cyclase Signaling” December, 2004 2005: University of Illinois at Chicago, Department of Physiology & Biophysics – Chicago, IL • “Heart Failure: Rationale for Inhibiting β-Adrenergic G Protein-Adenylyl Cyclase Signaling” February, 2005 University of Connecticut Health Center – Cardiovascular Grand Rounds – Farmington, CT • “Myocardial Stunning & Hibernation” 15 May, 2005 28th Annual Meeting of the Japanese Society of Hypertension (JSH) - Asahikawa, Japan • "Role of Adenylyl Cyclase in Longevity and Stress Resistance" September, 2005 Symposium: Life and Death of the Vascular Tree – Paris, France • “Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress” October, 2005 David Geffen School of Medicine at the University of California, Los Angeles – Los Angeles, CA • “Cell Survival Mechanisms in Myocardial Stunning & Hybernation“ October, 2005 XXXII Argentine Congress of Cardiology – Buenos Aires, Argentina • “Mechanisms Mediating the Transition from Hypertrophy to Heart Failure” October 7, 2005 • “Mechanisms Mediating Myocardial Survival in Patients and Experimental Animals with Hibernating Myocardium” October 8, 2005 • “Cardioprotective Mechanisms in Heart Failure” October 9, 2005 2006: International Society of Heart Research (ISHR) Indian Section/International Academy of Cardiovascular Sciences (IACS) Indian Chapter – Chennai, India • “Hibernating Myocardium” January, 2006 Memorial Lecture, Nagoya University – Nagoya, Japan • “Your Manuscript and High-Impact Journals” March 23, 2006 Japanese Circulation Society – Nagoya, Japan • Takeda Satellite Symposium, “Genomics/Proteomics” March 25, 2006 • Special Congress Lecture, “Integrative Cardiovascular Pathophysiology” March 26, 2006 Keio Medical Association Meeting – Tokyo, Japan • “The Role of Transgenic Animal Models in Providing Rationale for Beta-Adrenergic receptor Blockade Therapy in Heart Failure” March 27, 2006 Nippon Medical School – Tokyo, Japan 16 • “Mechanisms of Cardioprotection in Hibernating Myocardium” July 14, 2006 International Academy of Cardiovascular Sciences, 2nd World Congress – Sapporo, Japan • “Novel Mechanisms of Cell Survival in Ischemic Preconditioning and Hibernating Myocardium” • “The Role of AC5 in Longevity and Stress Resistance” July 15, 2006 XXXIII Argentine Congress of Cardiology/International Academy of Cardiovascular Sciences, Buenos Aires, Argentina • “Left Ventricular Hypertrophy – Adaptive or Maladaptive” • “Mechanisms of Cell Survival - Hibernating and Preconditioned Myocardium” October 7, 2006 67th Annual Congress of the Italian Society of Cardiology – Rome, Italy • “Novel Mechanisms in the Second and Third Windows of Ischemic Protection: • “Cardioprotective Mechanisms in Hibernating Myocardium” December 17, 2006 2007 Distinguished Scientists Seminar - University of South Alabama – Mobile, AL • “Cardiovascular Dysfunction with Age and Myocardial Ishemia in Non-human Primate” April 19, 2007 XXXIV Argentine Congress of Cardiology/International Academy of Cardiovascular Sciences, Buenos Aires, Argentina • “An Inotropic Agent that Activates Cardiac Myosin as a Novel Treatment or Heart Failure” August 18, 2007 2008 72nd Annual Scientific Meeting of the Japanese Circulation Society • “Adenylyl Cyclase Type 5 Disruption Prolongs Longevity and Protects the Heart Against Stress” • “Molecular Mechanism and Novel Therapeutic Target in Heart Failure” March 28, 2008 University of Missouri-Columbia, Dalton Cardiovascular Research Center, Columbia, Missouri • Inaugural Franklin Lecture – “Adrenergic Regulation in Heart Failure – Last Half Century” September 12, 2008 Harvard Medical School, Bringham and Women’s Hospital, Boston, Massachuesettes • “Myocardial Metabolism and Energ etics” October 4, 2008 17 University of Buenos Aires, Buenos Aires, Argentina • “Stress Resistance and Longevity: Implication for Heart Failure Therapy” October 31, 2008 12th Annual Scientific Meeting of the Japanese Heart Failure Society • “Cardioprotective mechanisms in the third window of ischemic protection” October 17, 2008 • “Adenylyl Cyclase Type 5 Disruption Prolongs Longevity and Protects the Heart against Stress” October 18, 2008 • “Inhibition of Adenylyl Cyclase Type 5 as a Novel Target for Heart Failure Therapy” October 18, 2008 2009 American Society for Pharmacology & Experimental Therapeutics, Inc. (ASPET) • "Role of AC Type 5 in longevity and Stress Resistance" April 18, 2009 Medical Grand Rounds, Robert Wood Johnson, UMDNJ • "Cardioprotective Effects of Adenylyl Cyclase Type 5 Inhibition” May 6, 2009 International Society for Heart Failure • “Adenylyl cyclase disruption, and resistance to stress” May 29, 2009 XXXV Argentine Congress of Cardiology ● “Novel Cardioprotective Mechanisms in the Third Window of Preconditioning” October 2, 2009 ● “Type 5 Inhibition and Stress Resistance and Longevity” October 3, 2009 2010 Indiana University • “Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress” March 10, 2010 Victor Chang Cardiac Research Institute, Australia • "Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress" March 22, 2010 Hackensack University Medical Center • “Stress Resistance and Longevity: Adenylyl Cyclase Type 5 Inhibition” May 11, 2010 18 University of Washington • “Adenylyl cyclase type 5 (AC5), cardiac stress and longevity” June 8, 2010 XXXVI Argentine Congress of Cardiology • “Adenylyl Cyclase Type 5 Inhibitor: A Novel Therapeutic Approach for Remodeling Post Myocardial Infarction” October 8, 2010 The Cardiovascular Center, OLV Hospital AALST • "The Birth of Myocardial Stunning, Circa Christmas 1973" November 20, 2010 2011 Robert M. Berne Distinguished Lectureship, Washington, DC • “A Physiologist’s Evolution: From Coronary Circulation to Adenylyl Cyclase Type 5 Inhibition” April 11, 2011 XXXVII Argentine Congress of Cardiology • “Adenylyl Cyclase Type 5 and Protection from Heart Failure" October 6, 2010 2012 New York Medical College Graduate Student Research Forum Keynote Address • "From Free Ranging Giraffes in Africa to To Disruption of Adenylyl Cyclase Type 5 Mice" April 18, 2012 International Society of Heart Research (ISHR)-North American Section (NAS) Pathology and Treatment of Heart Failure, Banff, Alberta, Canada • “Myosin Activators and Inhibitors as Novel Therapies for Heart Failure” May 31, 2012 International Hypertension Research Meeting, Sydney, Australia • “Myosin Activators and Inhibitors: Novel Therapy for Heart Failure and Hypertension” October 1, 2012 BOOKS AND MONOGRAPHS 1. Vanhoutte PM and Vatner SF (Eds). Vasodilator Mechanisms. S. Karger, Basel, Switzerland, Bibliotheca Cardiologica 1984; 38. 19 2. Strauss HC and Vatner SF (Eds). Mechanisms of Autonomic Cardiovascular Control, Parts I and II. Circ Res 1987; 61(4,5). 3. Shepherd JT and Vatner SF (Eds). The Nervous Control of the Heart (The Autonomic Nervous System Vol. 9) Harwood Academic Publishers, 1996. 4. Heyndrickx GR, Vatner SF and Wijns WC (Eds). Sympathetic signal transduction in myocardial ischemia. In: Stunning, Hibernation and Preconditioning: Clinical Pathophysiology of myocardial ischemia. Lippincott-Raven, Philadelphia, PA; New York, NY. 1997. 5. Vatner, SF (Section Ed of Contractile Depression) in Molecular Mechanisms for Cardiac Hypertrophy and Failure. Ed: RA Walsh; The Parthenon Publishing Group, Lancaster, UK 2004. 6. Shen YT, Rossi F, Vatner SF. Nonhuman Primate Models for Cardiovascular Research. In: Cardiovascular Toxicology, Fourth Edition (Target Organ Toxicology series). Ed: Daniel Acosta Jr; Informa Healthcare USA, Inc. NY, 2008: pages 133-152. 7. Depre C, Vatner SF, Gross G. Coronary Blood Flow and Myocardial Ischemia. In: Hurst’s the Heart 13th Edition. Ed: Valentine Fuster, Richard Walsh, and Robert Harrington. McGrawHill, Burr Ridge, IL, USA, 2010. 8. Qiu H, Depre C, Vatner DE, Vatner SF. Cardiovascular Effects of Aging in Primates - Gender Differences In: Handbook of the Biology of Aging 7th Edition. Ed: Masoro EJ and Austad SN. 2010. PUBLICATIONS 1. Van Citters RL, Franklin DL, Vatner SF, Patrick T and Warren JV: Cerebral hemodynamics in the giraffe. Trans Assoc Am Physicians 1969; 82:293-303. 2. Vatner SF, Franklin D and Van Citters RL: Mesenteric vasoactivity associated with eating and digestion in the conscious dog. Am J Physiol 1970; 219:170-174. 3. Vatner SF, Franklin D, Van Citters RL and Braunwald E: Effects of carotid sinus nerve stimulation on the coronary circulation of the conscious dog. Circ Res 1970; 27:11-21. 4. Vatner SF, Franklin D and Van Citters RL: Coronary and visceral vasoactivity associated with eating and digestion in the conscious dog. Am J Physiol 1970; 219:1380-1385. 5. Vatner SF, Franklin D, Van Citters RL and Braunwald E: Effects of carotid sinus nerve stimulation on blood flow distribution in conscious dogs at rest and during exercise. Circ Res 1970; 27:495-503. 6. Vatner SF, Franklin D and Van Citters RL: Simultaneous comparison and calibration of the Doppler and electromagnetic flowmeters. J Appl Physiol 1970; 29:907-910. 20 7. Braunwald E, Vatner SF, Braunwald NS and Sobel BE: Carotid sinus nerve stimulation in the treatment of angina pectoris and supraventricular tachycardia. Cal Med 1970; 112: 41-50. 8. Vatner SF, Franklin D and Braunwald E: Effects of anesthesia and sleep on circulatory response to carotid sinus nerve stimulation. Am J Physiol 1971; 220:1249-1255. 9. Vatner SF, Higgins CB, Franklin D and Braunwald E: Effects of a digitalis glycoside on coronary and systemic dynamics in conscious dogs. Circ Res 1971; 28:470-479. 10. Higgins CB, Vatner SF, Franklin D, Patrick T and Braunwald E: Effects of prostaglandin A1 on the systemic and coronary circulations in the conscious dog. Circ Res 1971; 28:638-648. 11. Vatner SF, Higgins CB, White S, Patrick T and Franklin D: The peripheral vascular response to severe exercise in untethered dogs before and after complete heart block. J Clin Invest 1971; 50:1950-1960. 12. Franklin D, Patrick T, Kemper S and Vatner SF: A system for radiotelemetry of blood pressure, blood flow and ventricular dimensions from animals: A summary report. Proceedings of International Telemetry Conference, Washington, D.C., September, 1971, pp. 224-250. 13. Vatner SF and Braunwald E: The physiologic effects of carotid sinus nerve stimulation. In: Clinical Application of Carotid Sinus Nerve Stimulation in Hypertension. Amsterdam, The Netherlands, September 2 & 3, 1971, pp. 29-37. 14. Vatner SF, Franklin D, Higgins CB, Patrick T, White S and Van Citters RL: Coronary dynamics in unrestrained conscious baboons. Am J Physiol 1971; 221:1396-1401. 15. Vatner SF, Higgins CB, Patrick T, Franklin D and Braunwald E: Effects of cardiac depression and of anesthesia on the myocardial action of a cardiac glycoside. J Clin Invest 1971; 50:2585-2595. 16. White SW, Patrick T, Higgins CB, Vatner SF, Franklin D and Braunwald E: Effects of altering ventricular rate on blood flow distribution in conscious dogs. Am J Physiol 1971; 221:1402-1407. 17. Franklin D, Vatner SF and Van Citters RL: Studies on peripheral vascular dynamics using animal models. Animal Models for Biomedical Research IV, National Academy of Sciences, Washington, D.C., 1971, pp. 74-84. 18. Vatner SF and Van Citters RL: Effects of acute pulmonary embolism on coronary dynamics in the conscious dog. Am Heart J 1972; 83:50-60. 19. Vatner SF and Braunwald E: Cardiac frequency: Control and adjustments to alterations. Prog Cardiovasc Dis 1972; 14:431-445. 20. Vatner SF, Higgins CB, Franklin D and Braunwald E: Role of tachycardia in mediating the coronary hemodynamic response to severe exercise. J Appl Physiol 1972; 32:380-385. 21 21. Higgins CB, Vatner SF, Eckberg DL and Braunwald E: Alterations in the baroreceptor reflex in conscious dogs with heart failure. J Clin Invest 1972; 51:715-724. 22. Vatner SF, Higgins CB, Franklin D and Braunwald E: Extent of carotid sinus regulation of the myocardial contractile state in conscious dogs. J Clin Invest 1972; 51:995-1008. 23. Higgins CB, Vatner SF and Braunwald E: Regional hemodynamic effects of a digitalis glycoside in the conscious dog with and without experimental heart failure. Circ Res 1972; 30:406-417. 24. Higgins CB, Vatner SF, Franklin D and Braunwald E: Effects of prostaglandin A1 on left ventricular dynamics in the conscious dog. Am J Physiol 1971; 222:1534-1538. 25. Higgins CB, Vatner SF, Franklin D and Braunwald E: Effects of experimentally produced heart failure on the peripheral vascular response to severe exercise in conscious dogs. Circ Res 1972; 31:186-194. 26. Vatner SF, Higgins CB and Franklin D: Regional circulatory adjustments to moderate and severe chronic anemia in conscious dogs at rest and during exercise. Circ Res 1972; 30:731-740. 27. Vatner SF, Franklin D, Higgins CB, White S and Van Citters RL: Calibration of the ultrasonic Doppler flowmeter in situ. In: Chronically Implanted Cardiovascular Instrumentation. Ed. EP McCutcheon, Academic Press, New York, 1973, pp. 63-70. 28. Vatner SF, Franklin D, Higgins CB and Van Citters RL: Backpack telemetry. Chronically Implanted Cardiovascular Instrumentation. Ed. EP McCutcheon, Academic Press, New York, 1973, pp. 357-364. 29. Franklin D, Vatner SF, Higgins CB, Patrick T, Kemper WS and Van Citters RL: Measurement and radiotelemetry of cardiovascular variables in conscious animals: Techniques and applications. In: Research Animals in Medicine, 1973, pp. 1119-1133. 30. Vatner SF, Higgins CB, Millard RW and Franklin D: Direct and reflex effects of nitroglycerin on coronary and left ventricular dynamics in conscious dogs. J Clin Invest 1972; 51:2872-2882. 31. Vatner SF, Franklin D, Higgins CB, Patrick T and Braunwald E: Left ventricular response to severe exertion in untethered dogs. J Clin Invest 1972; 51:3052-3060. 32. Higgins CB, Vatner SF and Braunwald E: Regional hemodynamic effects of prostaglandin A1 in the conscious dog. Am Heart J 1973; 85:349-357. 33. Higgins CB, Vatner SF, Franklin D and Braunwald E: Depression of left ventricular contractility by anesthesia and the protective effects of digitalis. Surgical Forum 1972; 23:160-162. 22 34. Higgins CB, Vatner SF, Millard RW, Franklin D and Braunwald E: Alterations in regional hemodynamics in experimental heart failure in conscious dogs. Trans Assoc Am Physicians 1972; 85:267-278. 35. Millard, RW, Higgins CB, Franklin D and Vatner SF: Regulation of the renal circulation during severe exercise in normal dogs and dogs with experimental heart failure. Circ Res 31:881-888, 1972. 36. Higgins CB, Vatner SF and Braunwald E: Parasympathetic control of the heart. Pharmacol Rev 1973; 25:119-155. 37. Vatner SF: Clinical applications of the carotid sinus reflex. Clinical Cardiology. West Virginia Medical Journal 1973; 69:5-6. 38. Higgins CB, Vatner SF, Franklin D and Braunwald E: Extent of regulation of the heart’s contractile state in the conscious dog by alteration in the frequency of contraction. J Clin Invest 1973; 52:1187-1194. 39. Higgins CB, Pavelec R and Vatner SF: Modified technique for production of experimental right-sided congestive heart failure. Cardiovasc Res 1973; 7:870-874. 40. Vatner SF, Millard RW and Higgins CB: Coronary and myocardial effects of dopamine in the conscious dog: Parasympatholytic augmentation of pressor and inotropic actions. Cardiovasc Res 1973; 187:280-295. 41. Higgins CB, Millard RW, Braunwald E and Vatner SF: Effects and mechanisms of action of dopamine on regional hemodynamics in the conscious dog. Am J Physiol 1973; 225:432-437. 42. Vatner SF, Higgins CB, Millard RW and Franklin D: Role of the spleen in the peripheral vascular response to severe exercise in untethered dogs. Cardiovasc Res 1974; 8:276-282. 43. Higgins CB, Vatner SF, Franklin D and Braunwald E: Pattern of differential vasoconstriction in response to acute and chronic low output states in the conscious dog. Cardiovasc Res 1974; 8:92-98. 44. Monroe RG, Gamble WJ, LaFarge CG and Vatner SF: Homeometric autoregulation, Ciba Foundation Symposium 24 (new series), The Physiological Basis of Starling’s Law of the Heart, 1974, pp. 257-271. 45. Vatner SF and Smith NT: Effects of halothane on left ventricular function and distribution of regional blood flow in dogs and primates. Circ Res 1974; 34:155-167. 46. Vatner SF, Patrick TA, Higgins CB and Franklin D: Regional circulatory adjustments to eating and digestion in conscious unrestrained primates. J Appl Physiol 1974; 36:524-529. 47. Vatner SF, Higgins CB and Braunwald E: Sympathetic and parasympathetic components of reflex tachycardia induced by hypotension in conscious dogs with and without heart failure. Cardiovasc Res 1974; 8:153-161. 23 48. Vatner SF, Higgins CB and Braunwald E: Effects of norepinephrine on coronary Circulation and left ventricular dynamics in the conscious dog. Circ Res 1974; 34:812-823. 49. Vatner SF and Patrick TA: Radio telemetry of blood flow and pressure measurements in untethered conscious animals. Bibl Cardiol 1974; 34:1-11. 50. Patrick TA, Vatner SF, Kemper WS and Franklin D: Telemetry of left ventricular diameter and pressure measurements from unrestrained animals. J Appl Physiol 1974; 37:276-281. 51. Vatner SF, McRitchie RJ, Maroko PR, Patrick TA and Braunwald E: Paradoxical effects of isoproterenol, nitroglycerin and exercise in conscious dogs with myocardial ischemia. Trans Assoc Am Physicians 1973; 86:201-213. 52. Vatner SF: Effects of hemorrhage on regional blood flow distribution in dogs and primates. J Clin Invest 1974; 54:225-235. 53. Vatner SF, McRitchie RJ and Braunwald E: Effects of dobutamine on left ventricular performance, coronary dynamics, and distribution of cardiac output in conscious dogs. J Clin Invest 1974; 53:1265-1273. 54. Vatner SF and Patrick TA: Instrumented primates as cardiovascular models. Symposium of the Comparative Pathology of the Heart. Adv Cardiol 1974; 13:302-314. 55. Vatner SF, Monroe RG and McRitchie RJ: Effects of anesthesia, tachycardia, and autonomic blockade on the Anrep effect in intact dogs. Am J Physiol 1974; 226:1450-1456. 56. Higgins CB, Vatner SF and Braunwald E: Postprandial redistribution of regional blood flow at rest and during exercise in conscious dogs with experimental heart failure. Amer J Cardiol 1974; 34:318-324. 57. Vatner SF, McRitchie RJ, Maroko PR, Patrick TA and Braunwald E: Effects of catecholamines, exercise and nitroglycerin on the normal and ischemic myocardium in conscious dogs. J Clin Invest 1974; 54:563-575. 58. Vatner SF: Effects of exercise on distribution of regional blood flows and resistances. In: The Peripheral Circulations, Ed. R Zelis, Grune & Stratton, New York, 1975, pp 211-233. 59. Vatner SF, Marsh JD and Swain JA: Effects of morphine on coronary and left ventricular dynamics in conscious dogs. J Clin Invest 1975; 55:207-217. 60. Vatner SF and Braunwald E: Effects of chronic heart failure on the inotropic response of the right ventricle of the conscious dog to a cardiac glycoside and to tachycardia. Circulation 1974; 50:728-734. 61. Vatner SF and Heyndrickx GR: Mechanism of action of nitroglycerin: Coronary, cardiac and systemic effects. Ed. P Needleman, Handbook of Experimental Pharmacology 1975; 40:131-161. 24 62. Swain JA, Heyndrickx GR, Boettcher DH and Vatner SF: Prostaglandin control of renal circulation in the unanesthetized dog and baboon. Am J Physiol 1975; 229:826-830. 63. Vatner SF, Boettcher DH, Heyndrickx GR and McRitchie RJ: Reduced baroreflex sensitivity with volume loading in conscious dogs. Circ Res 1975; 37:236-242. 64. Vatner SF and Braunwald E: Cardiovascular control mechanisms in the conscious state. New Engl J Med 1975; 293:970-976. 65. Heyndrickx GR, Millard RW, McRitchie RJ, Maroko PR and Vatner SF: Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs. J Clin Invest 1975; 56:978-985. 66. Vatner SF and McRitchie RJ: Interaction of the chemoreflex and the pulmonary inflation reflex in the regulation of coronary circulation in conscious dogs. Circ Res 1975; 37:664-673. 67. McRitchie RJ, Vatner SF, Boettcher DH, Heyndrickx GR, Patrick TA and Braunwald E: Role of arterial baroreceptors in mediating cardiovascular response to exercise. Am J Physiol 1976; 230:85-89. 68. McRitchie RJ and Vatner SF: The role of arterial baroreceptors in mediating the cardiovascular response to a cardiac glycoside in conscious dogs. Circ Res 1976; 38:321-326. 69. Vatner SF and McRitchie RJ: Reflex limb dilatation following norepinephrine and angiotensin II in conscious dogs. Am J Physiol 1976; 230:557-563. 70. Heyndrickx GR, Boettcher DH and Vatner SF: Effects of angiotensin, vasopressin, and methoxamine on cardiac function and blood flow distribution in conscious dogs. Am J Physiol 1976; 231:1587. 71. Vatner SF, Millard RW, Patrick TA and Heyndrickx GR: Effects of isoproterenol on regional myocardial function, electrogram, and blood flow in conscious dogs with myocardial ischemia. J Clin Invest 1976; 57:1261-1271. 72. Vatner SF: Effects of severe exercise on distribution of cardiac output in conscious dogs. Cardiovascular System Dynamics. Eds. J Baan, A Noordergraaf and J Raines. The MIT Press, Cambridge, Massachusetts, 1978, pp 449-457. 73. McRitchie RJ, Vatner SF, Heyndrickx GR and Braunwald E: The role of arterial baroreceptors in the regulation of arterial pressure in conscious dogs. Circ Res 1976; 39:666-670. 74. Vatner SF and Pagani M: Cardiovascular adjustments to exercise: Hemodynamics and mechanisms. Prog Cardiovasc Dis 1976; 19:91-108. 75. Vatner SF, Pagani M, Rutherford JD, Millard RW and Manders WT: Effects of nitroglycerin on cardiac function and regional blood flow distribution in conscious dogs. Am J Physiol 1978; 3:H244-H252. 25 76. Manders WT and Vatner SF: Effects of sodium pentobarbital anesthesia on left ventricular function and distribution of cardiac output in dogs, with particular reference to the mechanism for tachycardia. Circ Res 1976; 39:512-517. 77. Baig H, Patrick TA and Vatner SF: Implantable pressure gauges for use in chronic animals. In: Indwelling and Implantable Pressure Transducers. Eds. DG Fleming, WH Ko and MR Neuman. CRC Press, Inc., Cleveland, Ohio, 1977, pp 35-43. 78. Vatner SF and Boettcher, DH: Regulation of cardiac output by stroke volume and heart rate in conscious dogs. Circ Res 1978; 42:557-561. 79. Vatner SF, Baig H, Manders WT and Maroko PR: Effects of coronary artery reperfusion on myocardial infarct size calculated from creatine kinase. J Clin Invest 1978; 61:1048-1056. 80. Boettcher DH, Vatner SF, Heyndrickx GR and Braunwald E: Extent of utilization of the Frank Starling mechanism in conscious dogs. Am J Physiol 1978; 3:H338-H345. 81. Millard RW, Baig H and Vatner SF: Cardiovascular effects of radioactive microsphere suspensions and Tween 80 solutions. Am J Physiol 1977; 1:H331-H334. 82. Vatner SF, Baig H, Manders WT, Ochs H and Pagani M: Effects of propranolol on regional myocardial function, electrograms, and blood flow in conscious dogs with myocardial ischemia. J Clin Invest 1977; 60:353-360. 83. Manders WT, Pagani M and Vatner SF: Depressed responsiveness to vasoconstrictor and dilator agents and baroreflex sensitivity in conscious, newborn lambs. Circulation 1979; 60:945-955. 84. Pagani M, Vatner SF, Baig H and Braunwald E: Initial myocardial adjustments to brief periods of ischemia and reperfusion in the conscious dog. Circ Res 1978; 43:83-92. 85. Vatner SF: Effects of exercise and excitement on mesenteric and renal dynamics in conscious, unrestrained baboons. Am J Physiol 1978; 234(2):H210-H214. 86. Pagani M, Vatner SF and Braunwald E: Hemodynamic effects of intravenous sodium nitroprusside in the conscious dog. Circulation 1978; 57:144-151. 87. Ochs HR, Vatner SF and Smith TW: Reversal of inotropic effects of digoxin by specific antibodies and their Fab fragments in the conscious dog. Cardiovasc Res 1978; 207:64-71. 88. Vatner SF, Baig H, Manders WT and Murray PA: Effects of a cardiac glycoside on regional function, blood flow, and electrograms in conscious dogs with myocardial ischemia. Circ Res 1978; 43:413-423. 89. Vatner SF: Effects of arrhythmias on regional myocardial function in conscious dogs with myocardial ischemia. In: Neural Mechanisms in Cardiac Arrhythmias, Raven Press, New York, 1978, pp. 289-292. 26 90. Heyndrickx GR, Baig H, Nellens P, Leusen I, Fishbein M and Vatner SF: Depression of regional blood flow and wall thickening after brief coronary occlusions. Am J Physiol 1978; 3:H653-H659. 91. Maroko PR and Vatner SF: Altered relationship between creatine phosphokinase and infarct size with reperfusion in conscious dogs. J Mol Med 1977; 2:309-315. 92. Vatner SF, Baig H, Manders WT and Murray PA: Effects of a cardiac glycoside in combination with propranolol on the ischemic heart of conscious dogs. Circulation 1978; 57:568-575. 93. Rutherford JD and Vatner SF: Integrated carotid chemoreceptor and pulmonary inflation reflex control of peripheral vasoactivity in conscious dogs. Circ Res 1978; 43:200-208. 94. Vatner SF and Rutherford JD: Control of the myocardial contractile state by carotid chemo- and baroreceptor and pulmonary inflation reflexes in conscious dogs. J Clin Invest 1978; 61:1593-1601. 95. Pagani M, Baig H, Sherman A, Manders WT, Quinn P, Patrick TA, Franklin DL and Vatner SF: Measurement of multiple simultaneous small dimensions and study of arterial pressure-dimension relations in conscious animals. Am J Physiol 1978; 235:H610-H617. 96. Pagani M, Mirsky I, Baig H, Manders WT, Kerkhof P and Vatner SF: Effects of age on aortic pressure-diameter and elastic stiffness-stress relationships in the unanesthetized sheep. Circ Res 1979; 44:420-429. 97. Vatner SF and Baig H: Comparison of the effects of ouabain and isoproterenol on ischemic myocardium of conscious dogs. Circulation 1978; 58:654-662. 98. Vatner SF: Effects of anesthesia on cardiovascular control mechanisms. Environmental Health Perspectives 1978; 26:193-206. 99. Murray PA, Baig H, Fishbein MC and Vatner SF: Effects of experimental right ventricular hypertrophy on myocardial blood flow in conscious dogs. J Clin Invest 1979; 64:421-427. 100. Vatner SF, Rutherford JD and Ochs HR: Baroreflex and vagal mechanisms modulating left ventricular contractile responses to sympathomimetic amines in conscious dogs. Circ Res 1979; 44:195-207. 101. Vatner SF, Baig H (Introduced by L. Dexter): The effects of inotropic stimulation on ischemic myocardium in conscious dogs. Trans Assoc Am Physicians 1979; 91:282-293. 102. Macho P, Vatner SF: Differences in structure and function of fetal and neonatal circulation. JAMA 1979; 34:147-154. 103. Millard RW, Baig H and Vatner SF: Prostaglandin control of the renal circulation in response to hypoxemia in the fetal lamb in utero. Circ Res 1979; 45:172-179. 27 104. Vatner SF and Manders WT: Depressed responsiveness of the carotid sinus reflex in conscious, newborn animals. Am J Physiol 1979; 237:H40-H43. 105. Vatner SF and Baig H: Importance of heart rate in determining the effects of sympathomimetic amines on regional myocardial function and blood flow in conscious dogs with acute myocardial ischemia. Circ Res 1979; 45:793-803. 106. Rutherford JD, Vatner SF and Braunwald E: Adrenergic control of myocardial contractility in conscious hyperthyroid dogs. Am J Physiol 1979; 237:H590-H596. 107. Vatner SF, Priano LL, Rutherford JD and Manders WT: Sympathetic regulation of the cerebral circulation by the carotid chemoreceptor reflex. Am J Physiol 1980; 238:H594-H598. 108. Vatner SF and Rutherford JD: Autonomic control of myocardial contractility in conscious dogs. Proceedings of the Fifth European Congress of Anesthesiology, Paris, France, September 4-9, l978. In: Hemodynamic Changes in Anesthesia, pp. 95-119. 109. Vatner SF, Pagani M, Manders WT and Pasipoularides AD: Alpha adrenergic vasoconstriction and nitroglycerin vasodilation of large coronary arteries in the conscious dog. J Clin Invest 1980; 65:5-14. 110. Murray PA and Vatner SF: α-adrenoceptor attenuation of coronary vascular response to severe exercise in the conscious dog. Circ Res 1979; 45:654-660. 111. Vatner SF, Pagani M and Manders WT: Alpha adrenergic constriction of coronary arteries in conscious dogs. Trans Assoc Am Physicians 1979; 92:229-238. 112. Murray PA and Vatner SF: Fractional contributions of the right and left coronary arteries to perfusion of normal and hypertrophied right ventricles of conscious dogs. Circ Res 1980; 47:190-200. 113. Vatner SF and Zimpfer M: Bainbridge reflex in conscious, unrestrained, and tranquilized baboons. Am J Physiol 1981; 240:H164-H167. 114. Rutherford JD, Vatner SF and Braunwald E: Effects and mechanism of action of aminophylline on cardiac function and regional blood flow distribution in conscious dogs. Circulation 1981; 63:378-387. 115. Vatner SF: Correlation between acute reductions in myocardial blood flow and function in conscious dogs. Circ Res 1980; 47:201-207. 116. Pagani M, Mirsky I, Manders WT and Vatner SF: Age related changes in the elastic properties of the thoracic aorta of conscious sheep. Proceedings of the International Symposium on “Juvenile Hypertension,” Parma, Italy, 1980. 117. Rockson SG, Homcy CJ, Quinn P, Manders WT, Haber E and Vatner SF: Cellular mechanisms of impaired adrenergic responsiveness in neonatal dogs. J Clin Invest 1981; 67:319-327. 28 118. Vatner SF and Rutherford JD: Interaction of carotid chemoreceptor and pulmonary inflation reflexes in circulatory regulation in conscious dogs. Fed Proceedings 1981; 40:2188-2193. 119. Zimpfer M, Sit SP and Vatner SF: Effects of anesthesia on the canine carotid chemoreceptor reflex. Circ Res 1981; 48:400-406. 120. Manders WT, Vatner SF and Braunwald E: Cardio-selective beta adrenergic stimulation with prenalterol in the conscious dog. J Pharmacol Exp Ther 1980; 215:266-270. 121. Baughman KL, Maroko PR and Vatner SF: Effects of coronary artery reperfusion on myocardial infarct size and survival in conscious dogs. Circulation 1981; 63:317-323. 122. Murray PA and Vatner SF: Abnormal coronary vascular response to exercise in dogs with severe right ventricular hypertrophy. J Clin Invest 1981; 67:1314-1323. 123. Vatner SF and Murray PA: Changes in autonomic control of peripheral vascular resistance in dogs with severe right ventricular hypertrophy and failure. In: Disturbances of Neurogenic Control of the Circulation. Am Physiol Society, Bethesda, M.D., 1981, pp. 51-64. 124. Murray PA and Vatner SF: Reduction of maximal coronary vasodilator capacity in conscious dogs with severe right ventricular hypertrophy. Circ Res 1981; 48:25-33. 125. Murray PA and Vatner SF: Coronary vascular alpha adrenergic receptor activation during severe exercise. In: Les Alpha Bloquants. Proceedings of the Symposium International, Paris, France, September 20-22, 1979. Masson, Paris, 1981, pp. 186-192. 126. Vatner SF, Pagani M, Manders WT and Pasipoularides AD: Alpha adrenergic control of large coronary arterial resistance and elastic stiffness in the conscious dog. In: Les Alpha Bloquants. Proceedings of the Symposium International, Paris, France, September 20-22, 1979. Masson, Paris, 1981, pp. 169-178. 127. Zimpfer M and Vatner SF: Effects of acute increases in left ventricular preload on indices of myocardial function in conscious, unrestrained and intact, tranquilized baboons. J Clin Invest 1981; 67:430-438. 128. Macho P, Hintze TH and Vatner SF: Regulation of large coronary arteries by increases in myocardial metabolic demands in conscious dogs. Circ Res 1981; 49:594-599. 129. Macho P and Vatner SF: Effects and mechanism of action of trimazosin on coronary and left ventricular dynamics in conscious dogs. J Pharmacol Exp Ther 1981; 217:333-339. 130. Pagani M, Pasipoularides A and Vatner SF: Elastic properties of coronary arteries in conscious dogs. Adv Physiol Sci 1980; 8:263-270. 131. Vatner SF and Murray PA: Cardio-circulatory adaptations to severe exercise in conscious dogs. In: Exercise Bioenergetics and Gas Exchange. Proceedings of the Symposium on Exercise Bioenergetics and Gas Exchange, Milan, Italy, July 7-9, 1980, Elsevier/North Holland Biomedical Press, Amsterdam, 1980, pp. 253-265. 29 132. Vatner SF and Macho P: Regulation of large coronary vessels by adrenergic mechanisms in conscious dogs. In: Basic Research in Cardiology 1981; 76:508-517. 133. Hintze TH and Vatner SF: Cardiac dynamics during hemorrhage: Relative unimportance of adrenergic inotropic responses. Circ Res 1982; 50:705-713. 134. Murray PA and Vatner SF: Carotid sinus baroreceptor control of right coronary circulation in normal, hypertrophied, and failing right ventricles of conscious dogs. Circ Res 1981; 49:1339-1349. 135. Macho P and Vatner SF: Effects of nitroglycerin and nitroprusside on large and small coronary vessels in conscious dogs. Circulation 1981; 64:1101-1107. 136. Vatner SF: Alpha-adrenergic control of the coronary circulation in conscious dogs. In: Myocardial Revascularization. Proceedings of the Symposium on “Myocardial Revascularization,” Bahamas, October 11-14, 1980, pp. 85-94. 137. Boettcher D, Zimpfer M and Vatner SF: Phylogenesis of the Bainbridge reflex. Am J Physiol 1982; 242:244-246. 138. Rutherford JD, Vatner SF and Braunwald E: Effects of aminophylline in the conscious dog following coronary occlusion. Am J Cardiol 1981; 48:1071-1077. 139. Vatner SF and Murray PA: Reflex control of coronary arteries. In: The Coronary Artery. Ed. S Kalsner, Croom Helm Ltd., London, 1982; pp. 216-238. 140. Vatner SF and Hintze TH: Effects of a calcium channel antagonist on large and small coronary vessels in conscious dogs. Circulation 1982; 66:579-588. 141. Vatner SF, Patrick TA and Murray PA: Monitoring of cardiovascular dynamics in conscious animals. In: Cardiovascular Toxicology. Ed. EW Van Stee, Raven Press, NY, 1982; pp. 35-55. 142. Zimpfer M, Manders WT, Barger AC and Vatner SF: Pentobarbital alters compensatory neural and humoral mechanisms in response to hemorrhage. Am J Physiol 1982; 243:H713-H721. 143. Macho P and Vatner SF: Effects of prazosin on coronary and left ventricular dynamics in conscious dogs. Circulation 1982; 64:1186-1192. 144. Cox DA, Patrick TA and Vatner SF: Myocardium salvaged by coronary artery reperfusion responds appropriately to cardiovascular stress. Trans Assoc Am Physicians 1981; 44:333-340. 145. Vatner SF, Hintze TH and Macho P: Regulation of large coronary arteries by β-adrenergic mechanisms in the conscious dog. Circ Res 1982; 51:56-66. 30 146. Cox DA and Vatner SF: Myocardial function in areas of heterogeneous perfusion following coronary artery occlusion in conscious dogs. Circulation 1982; 66:1154-1158. 147. Hintze TH and Vatner SF: Comparison of effects of nifedipine and nitroglycerin on large and small coronary arteries and cardiac function in conscious dogs. Symposium on Calcium Channel Blocking Agents. Circ Res 1983; 52 (Suppl. 1):139-146. 148. Sit SP and Vatner SF: Integrated circulatory response to volume expansion. In: International Review of Physiology. Ed. AC Guyton, University Park Press, Baltimore, M.D., 1982, pp. 323-354. 149. Cox DA, Hintze TH and Vatner SF: Effects of acetylcholine on large and small coronary arteries in conscious dogs. Cardiovasc Res 1983; 225:764-769. 150. Macho P, Hintze TH and Vatner SF: Effects of α-adrenergic receptor blockade on coronary circulation in conscious dogs. Am J Physiol 1982; 243:H94-H98. 151. Vatner SF, Manders WT, Bronson R and Priano LL: Carotid chemoreceptor reflex induced sympathetic vasoconstriction of the cerebral circulation. In: Cerebral Blood Flow: Effects of Nerves and Neurotransmitters. Eds. DD Heistad and ML Marcus. Elsevier North Holland, NY, 1982, pp. 327-334. 152. Murray PA, Lavallee M and Vatner SF: α-adrenergic mediated reduction in coronary blood flow secondary to carotid chemoreceptor reflex activation in conscious dogs. Circ Res 1984;54:96-106. 153. Vatner SF, Hintze TH and Macho P: Coronary effects of nifedipine with and without alpha-adrenergic stimulation. In: Ca2+ Entry Blockers, Adenosine, and Neurohumors. Eds. GF Merrill and HR Weiss. Urban and Schwarzenberg, Baltimore, M.D., 1983, pp. 307-322. 154. Vatner SF: Alpha-adrenergic regulation of the coronary circulation in the conscious dog. Am J Cardiol 1983; 52:15A-21A. 155. Vatner SF: Physiology of the Blood Circulation. In: Blood Vessels and Lymphatics in Organ Systems. Eds. DI Abramson and PB Dobrin. Academic Press, Inc., New York, NY, 1984, pp. 326-334. 156. Vatner SF: Pharmacology of the Blood Circulation. In: Blood Vessels and Lymphatics in Organ Systems. Eds. DI Abramson and PB Dobrin. Academic Press, Inc., New York, NY, 1984, pp. 334-340. 157. Vatner SF and Hintze TH: Mechanism of constriction of large coronary arteries by β-adrenergic receptor blockade. Circ Res 1983; 53:389-400. 158. Murray PA and Vatner SF: Reflex cardiovascular responses to carotid chemoreceptor activation in conscious dogs with right ventricular hypertrophy. Am J Physiol 1983; 245:H871-H879. 31 159. Lavallee M, Cox D, Patrick TA and Vatner SF: Salvage of myocardial function by coronary artery reperfusion 1, 2 and 3 hours after occlusion in conscious dogs. Circ Res 1983; 53:235-247. 160. Sit SP, Morita H and Vatner SF: Responses of renal hemodynamics and function to acute volume expansion in the conscious dog. Circ Res 1984; 54:185-195. 161. Vatner SF: Neural control of the heart and the coronary circulation during exercise. In: Nervous Control of Cardiovascular Function. Ed. W Randall, Oxford University Press, New York, NY, 1984, pp. 414-424. 162. Vatner DE, Homcy CJ, Sit SP and Vatner SF: Effects of pressure overload, left ventricular hypertrophy on β-adrenergic receptors and responsiveness to catecholamines. J Clin Invest 1984; 73:1473-1482. 163. Hintze TH and Vatner SF: Reactive dilation of large coronary arteries in conscious dogs. Circ Res 1984; 54:50-57. 164. Hintze TH and Vatner SF: Dipyridamole dilates large coronary arteries in conscious dogs. Circulation 1983; 68:1321-1327. 165. Lavallee M and Vatner SF: Regional myocardial blood flow and necrosis in conscious primates following coronary occlusion. Am J Physiol 1984; 246:H635-H639. 166. Vatner SF, Pasipoularides AD and Mirsky I: Measurement of arterial pressure-dimension relationships in conscious animals. Annals Biomed Eng 1984; 12:521-531. 167. Hintze TH and Vatner SF: Purinergic control of large coronary arteries in the conscious dog. Bibl Cardiol 1984; 38:189. 168. Vatner SF, Knight D and Hintze TH: β1-adrenergic regulation of large coronary arteries in conscious dogs. Bibl Cardiol 1984, 38:169-177. 169. Vatner SF and Hintze TH: Regulation of large coronary arteries by beta-adrenergic mechanisms. In: The Role of Coronary Vascular Tone in Ischemic Heart Disease. Travemunde, 1985. 170. Vatner SF and Hintze TH: Regulation of large coronary arteries in conscious dogs. In: Proceedings, The Peripheral Circulation Symposium Sydney, Australia. Eds. S Hunyor, J Lundbrook, J Shaw and M McGrath. Elsevier, Amsterdam, 1984, pp. 137-148. 171. Vatner SF: α-adrenergic tone in the coronary circulation of the conscious dog. Fed Proceedings 1984; 43(14):2867-2872. 172. Young MA, Hintze TH and Vatner SF: Correlation between cardiac performance and plasma catecholamine levels in conscious dogs. Am J Physiol 1985; 248:H82-H88. 32 173. Vatner SF, Knight DR and Hintze TH: Norepinephrine induced β1-adrenergic peripheral vasodilation in conscious dogs. Am J Physiol 1985; 249:H49-H56. 174. Fujii AM and Vatner SF: Direct vs. indirect pressor and vasoconstrictor actions of angiotensin in conscious dogs. Hypertension 1985; 7:253-261. 175. Patrick T and Vatner SF: Instrumentation techniques for cardiovascular research in conscious animals. In: Techniques in the Life Sciences, P3/11; Cardiovascular Physiology, P318/1-22; Elsevier Scientific Publishers, Ireland, Ltd., 1984. 176. Morita H and Vatner SF: Effects of volume expansion on renal nerve activity, renal blood flow and sodium and water excretion in conscious dogs. Am J Physiol 1985; 249:F680-F687. 177. Vatner DE, Vatner SF, Fujii AM and Homcy CJ: Loss of high affinity cardiac beta adrenergic receptors in dogs with heart failure. J Clin Invest 1985; 76:2259-2264. 178. Knight DR, Kirby DA and Vatner SF: Effects of a calcium blocker on cardiac output distribution in conscious hypertensive dogs. Hypertension 1985; 7:380-385. 179. Lavallee M, Cox D and Vatner SF: Effects of coronary artery reperfusion on recovery of regional myocardial function in conscious dogs. Eur Heart J 1985; 6, (Suppl. E), 109-116. 180. Heyndrickx GR, Vilaine JP, Knight DR and Vatner SF: Effects of altered site of electrical activation on myocardial performance during inotropic stimulation. Circulation 1985; 71(5):1010-1016. 181. Knight DR and Vatner SF: Calcium channel blockers induce preferential coronary vasodilation by an α1-mechanism. Am J Physiol 1987; 253(3):H604-H613. 182. Knight DR and Vatner SF: Cardiovascular surgery for chronic experimentation in conscious animals. Chapter 2. In: Methods of Animal Experimentation. Ed. WI Gay Orlando: Academic Press, 1986, pp. 31-65. 183. Lavallee M, Amano J, Vatner SF, Manders WT, Randall WC and Thomas JX Jr: Adverse effects of chronic cardiac denervation in conscious dogs with myocardial ischemia. Circ Res 1985; 57:383-392. 184. Vatner DE, Lavallee M, Amano J, Finizola A, Homcy CJ and Vatner SF: Mechanisms of supersensitivity to sympathomimetic amines in the chronically denervated heart of the conscious dog. Circ Res 1985; 57:55-64. 185. Cox DA and Vatner SF: Effects of myocardial ischemia on regional myocardial function in the experimental animal. In: Diagnosis and Therapy of Coronary Artery Disease. Ed. P Cohn, Martinus Nijhoff Publishing, 1985, pp. 3-25. 186. Fujii AM and Vatner SF: Autonomic reflex control of cardiac contractility. In: The Ventricle. Eds. HJ Levine and WH Gaasch. Martinus Nijhoff Publishers, 1985, pp. 105-121. 33 187. Heyndrickx GR, Amano J, Patrick TA, Manders WT, Rogers GG, Rosendorff C and Vatner SF: Effects of coronary artery reperfusion on regional myocardial blood flow and function in conscious baboons. Circulation 1985; 71:1029-1037. 188. Vatner DE, Kirby DA, Homcy CJ and Vatner SF: β-adrenergic and cholinergic receptors in hypertension induced hypertrophy. Hypertension 1985; 7:I 55-I 60. 189. Young MA and Vatner SF: Enhanced adrenergic constriction of iliac artery with removal of endothelium in conscious dogs. Am J Physiol 1986; 250:H892-H897. 190. Vatner DE, Homcy CJ, Kirby DA and Vatner SF: Beta-adrenergic mechanisms in pressure overload left ventricular hypertrophy. In: Proceedings of Symposium on Myocardial Hypertrophy (1984). Eds. EL Ison-Franklin and H Sandler. Howard University Press, Washington, D.C., 1991; pp. 65-84. 191. Heyndrickx GR, Amano J, Kenna T, Fallon JT, Patrick TA, Manders WT, Rogers G, Rosendorff C and Vatner SF: Creatine kinase release not associated with necrosis after short periods of coronary artery occlusion in conscious baboons. J Am Coll Cardiol 1985; 6:1299-1303. 192. Morita H and Vatner SF: Effects of hemorrhage on renal nerve activity in conscious dogs. Circ Res 1985; 57:788-793. 193. Fujii A and Vatner SF: Baroreflex mechanisms buffering α-adrenergic agonists in conscious dogs. Am J Physiol 1987; 253:H728-H736. 194. Vatner SF, Young M and Patrick TA: Measurement of coronary blood flow in conscious animals. In: Cardiovascular Ultrasonic Flowmetry, Eds. SA Altobelli, WF.Voyles, and ER Greene. Elsevier, North Holland, NY, 1985, pp. 81-99. 195. Fujii AM and Vatner SF: Autonomic mechanisms regulating myocardial contractility in conscious animals. International Pharmacology and Therapeutics 1986; 29:221-238. 196. Woodman OL, Amano J, Hintze TH and Vatner SF: Augmented catecholamine uptake by the heart during hemorrhage in the conscious dog. Am J Physiol 1986; 250:H76-H81. 197. Vatner SF, Manders WT and Knight DR: Vagally mediated regulation of renal function in conscious primates. Am J Physiol 1986; 250:H546-H549. 198. Morita H, Manders WT, Skelton MM, Cowley AW and Vatner SF: Vagal regulation of arginine vasopressin in conscious dogs. Am J Physiol 1986; 251(20):H19-H23. 199. Vatner SF: Regulation of coronary resistance vessels and large coronary arteries. Am J Cardiol 1985; 56:16E-22E. 200. Woodman OL and Vatner SF: Coronary vasoconstriction mediated by α1 and α2 adrenoceptors in the conscious dog. Am J Physiol 1987; 253:H388-H393. 34 201. Amano J, Thomas JX Jr, Lavallee M, Mirsky I, Glover D, Manders WT, Randall WC and Vatner SF: Effects of myocardial ischemia on regional function and stiffness in conscious dogs with cardiac denervation. Am J Physiol 1987; 252:21:H110-H117. 202. Woodman OL, Constantine JW and Vatner SF: Nifedipine attenuates both alpha-1 and alpha-2 adrenoceptor mediated pressor and vasoconstrictor responses in conscious dogs and primates. Cardiovasc Res 1986; 239(3):648-653. 203. Woodman OL and Vatner SF: Cardiovascular responses to the stimulation of alpha-1 and alpha-2 adrenoceptors in the conscious dog. Cardiovasc Res 1986; 237(1):86-91. 204. Young MA and Vatner SF: Brief review: Regulation of large coronary arteries. Circ Res 1986; 59:579-595. 205. Vatner SF and Morita H: Dissociation of effects of volume loading in renal nerve activity, renal hemodynamics and renal function in conscious dogs. In: Neural Mechanisms and Cardiovascular Disease. Eds. B Lown, A Malliani and M Prosdocimi. Liviana Press, Padova, 1986, pp. 63-71. 206. Fujii AM, Mirsky I, Serur J, Als A and Vatner SF: Mechanical and inotropic reserve in conscious dogs with severe pressure overload left ventricular hypertrophy. Am J Physiol 1986; 251(20):H815-H823. 207. Vatner SF: Effects of anesthesia and recent surgery on ventricular performance. In: Simulation and Control of the Cardiac System. Eds. S Sideman and R Beyar. CRC Press, Boca Raton, 1987, Chap. 12. 208. Duling BR, Hogan RD, Langille BL, Lelkes P, Segal SS, Vatner SF, Weigelt H and Young MA: Vasomotor control: Beyond functional hyperemia. Fed Proceedings 1987; 46:251-263. 209. Vatner SF, Heyndrickx G and Fallon JT: Effects of brief periods of myocardial ischemia on regional myocardial function and creatine kinase release in conscious dogs and baboons. Can J Cardiol 1986; Supplement A:19A-24A. 210. Knight DR, Thomas JX Jr, Randall WC and Vatner SF: Effects of left circumflex coronary flow transducer implantation on posterior wall innervation, Am J Physiol 1987; 252(3):H536H539. 211. Fujii AM and Vatner SF: Sympathetic mechanisms regulating myocardial contractility in conscious animals. Chapter 52. In: The Heart and Cardiovascular System. Ed. HA Fozzard et al., New York: Raven Press, 1986, pp. 1119-1132. 212. Vatner SF: Utilization of Frank-Starling mechanism in conscious animal. Appl Cardiopulm Pathophysiol 1987; 1:1-10. 213. Vatner DE, Knight DR, Homcy CJ, Vatner SF and Young MA: Subtypes of β adrenergic receptors in bovine coronary arteries. Circ Res 1986; 59:463-473. 35 214. Vatner SF: Modification of the cardiovascular effects of carotid chemoreceptor stimulation by pulmonary inflation reflexes. Appl Cardiopulm Pathophysiol 1987; 1:101-108. 215. Vatner SF and Morita H: Biphasic response of renal nerve activity to hemorrhage in the conscious animal. In: Cardiogenic Reflexes, Eds. R Hainsworth and PN McWilliam. D.A.S.G. Mary, Oxford University Press, 1987, pp. 402-410. 216. Knight DR and Vatner SF: The effects of nitrendipine on the distribution of cardiac output in conscious dogs. J Cardiovasc Pharmacol 1987; 9(4):S25-S30. 217. Lavallee M and Vatner SF: Comparison of the effects of coronary artery occlusion on regional myocardial blood flow distribution and necrosis in conscious primates and dogs. In: Clinics of CSI -Proceedings of the 2nd International Symposium on Myocardial Protection via the Coronary Sinus. Eds. W Mohl, D Faxon and E Wolmer. Springer Verlag, New York, N.Y., 1986, pp.71-80. 218. Kirby DA and Vatner SF: Enhanced responsiveness to carotid baroreceptor unloading in conscious dogs during development of perinephritic hypertension. Circ Res 1987; 61(5):678686. 219. Young MA and Vatner SF: Blood flow and endothelium mediated vasomotion of iliac arteries in conscious dogs. Circ Res 1987; 61(5):II88-II93. 220. Young MA, DR Knight and Vatner SF: Autonomic control of large coronary arteries and resistance vessels. Prog Cardiovasc Dis 1987; 30(3):211-234. 221. Ohanian J, Vatner SF, Nicolosi RJ, Graham RM and Young MA: Altered adrenergic control in hypercholesterolemia. J Cardiovasc Pharmacol 1987; 10(9):S11-S15. 222. Vatner SF, Patrick TA, Knight DR, Manders WT and Fallon JT: Effects of calcium channel blocker on response of blood flow, function, arrhythmias and extent of infarction following reperfusion in conscious baboons. Circ Res 1988; 62:105-115. 223. Fujii AM, Gelpi RJ, Mirsky I and Vatner SF: Systolic and diastolic dysfunction during atrial pacing in conscious dogs with left ventricular hypertrophy. Circ Res 1988; 62: 462-470. 224. Longabaugh JP, Vatner DE, Vatner SF and Homcy CJ: Decreased stimulatory guonosine triphosphate binding protein in dogs with pressure-overload left ventricular failure. J Clin Invest 1988; 81:420-424. 225. Vatner DE, Knight DR, Shen YT, Thomas JX, Homcy CJ and Vatner SF: One hour of myocardial ischemia in conscious dogs increases β-adrenergic receptors, but decreases adenylate cyclase activity. J Mol Cell Cardiol 1988; 20(1):75-82. 226. Young MA, Knight DR and Vatner SF: Parasympathetic coronary vasoconstriction induced by nicotine in conscious calves. Circ Res 1988; 62:891-895. 36 227. Vatner DE, Lee DL, Schwarz KR, Longabaugh JP, Fujii AM, Vatner SF and Homcy CJ: Impaired cardiac muscarinic receptor function in dogs with heart failure. J Clin Invest 1988; 81:1836-1842. 228. Knight DR, Shen Y-T, Thomas JX Jr, Randall WC and Vatner SF: Sympathetic activation induces asynchronous contraction in awake dogs with regional denervation. Am J Physiol 1988; 255:H358-H365. 229. Morita H, Uemura N, Motochigawa H, Hosomi H and Vatner SF: Opiate receptor-mediated decrease in renal nerve activity during hypotensive hemorrhage in conscious rabbits. Circ Res 1988; 63:165-172. 230. Vatner SF: Reduced subendocardial myocardial perfusion as one mechanism for cardiac failure. Am J Cardiol 1988; 62:94E-98E. 231. Shen Y-T, Knight DR, Vatner SF, Randall WC and Thomas JX Jr: Responses to coronary artery occlusion in conscious dogs with selective cardiac denervation. Am J Physiol 1988; 255:H525-H533. 232. Young MA, Knight DR, Homcy CJ, Graham RM, Vatner SF and Vatner DE: α -adrenergic vasoconstriction and receptor subtypes in large coronary arteries of calves. Am J Physiol 1988; 255: H1452-H1459. 233. Gelpi RJ, Hittinger L, Fujii AM, Mirsky I, Crocker VM and Vatner SF: Sympathetic augmentation of cardiac function early in developing hypertension in conscious dogs. Am J Physiol 1988; 255: H1525-H1534. 234. Nejima J, Knight DR, Fallon JT, Uemura N, Manders WT, Canfield D, Cohen M and Vatner SF: Superoxide dismutase reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs. Circulation 1989; 79: 143-153. 235. Shen Y-T, Knight DR, Canfield DR, Vatner SF and Thomas JX Jr: Progressive change in collateral blood flow after coronary occlusion in conscious dogs. Am J Physiol 1989; 256:H478-H485. 236. Young MA and Vatner SF: Endothelium, blood flow, and vascular responses in arteries of conscious dogs. In: Relaxing and Contracting factors, Ed. PM Vanhoutte, Humana Press, 1988; 88:347-360. 237. Vatner SF and Cox DA: Circulatory Function and Control. Textbook of Internal Medicine, 1st Edition, Ed. WM Kelley, J.B. Lippincott Company, 1988, pp. 110-117. 238. Heyndrickx GR and Vatner SF: Effects of acute myocardial ischemia and reperfusion in conscious animals. In: Coronary Angioplasty: A controlled model of ischemia, Eds. PW Surruys and GT Meester. Martinus Nijhoff, pub. 1986. 37 239. Hittinger L, Shannon RP, Kohin S, Lader AS, Manders WT, Patrick TA, Kelly P and Vatner SF: Isoproterenol-induced alterations in myocardial blood flow, systolic and diastolic function in conscious dogs with heart failure. Circulation 1989; 80:658-668. 240. Hittinger L, Shannon RP, Bishop SP, Gelpi R and Vatner SF: Subendomyocardial exhaustion of blood flow reserve and increased fibrosis in conscious dogs with heart failure. Circ Res 1989; 65:971-980. 241. Ohanian J, Young MA, Shen Y-T, Gaivin R, Vatner SF and Graham R: Natriuretic and diuretic effects of infusion of atrial natriuretic factor in conscious dogs. Am J Physiol 1989; 257:F565-F573. 242. Shen Y-T, Vatner DE, Gagnon HE and Vatner SF: Species differences in regulation of α-adrenergic receptor function. Am J Physiol 1989; 257:R1110-R1116. 243. Susanni E, Manders WT, Knight DR, Vatner DE, Vatner SF and Homcy CJ: One hour of myocardial ischemia decreases the activity of the stimulatory guanine nucleotide regulatory protein Gs. Circ Res 1989; 65:1145-1150. 244. Vatner DE, Young MA, Knight DR and Vatner SF: β-receptors and adenylate cyclase: comparison of non-ischemic, ischemic, and postmortem tissue. Am J Physiol 1989; 258 H140H144. 245. Hui KY, Knight DR, Nussberger J, Hartley HL, Vatner SF and Haber E: Effects of renin inhibition in the conscious primate macaca fascicularis. Hypertension 1989; 14:480-487. 246. Vatner SF, Shannon R and Hittinger L: Reduced subendocardial coronary reserve, a potential mechanism for impaired diastolic function in the hypertrophied and failing heart. Circulation 1990; 81(2 Suppl):III8-III14). 247. Vatner DE, Vatner SF, Nejima J, Uemura N, Susanni EE, Hintze T and Homcy CJ: Chronic norepinephrine elicits desensitization by uncoupling the β-receptor. J Clin Invest 1989; 84:1741-1748. 248. Uemura N, Knight DR, Shen Y-T, Nejima J, Cohen MV, Thomas JX Jr and Vatner SF: Increased myocardial infarct size because of reduced coronary collateral blood flow in beagles. Am J Physiol 1989; 257(Heart Circ. Physiol 26):H1798-H1803. 249. Shen YT, Knight DR, Thomas JX Jr and Vatner SF: Relative roles of cardiac receptors and arterial baroreceptors during hemorrhage in conscious dogs. Circ Res 1990; 66:397-405. 250. Hittinger L, Shannon RP, Kohin S, Manders WT, Kelly P and Vatner SF: Exercise induced subendocardial dysfunction in dogs with left ventricular hypertrophy. Circ Res 1990; 66:329343. 251. Shen Y-T, Young MA, Ohanian J, Graham RM and Vatner SF: Atrial natriuretic factorinduced systemic vasoconstriction in conscious dogs, rats, and monkeys. Circ Res 1990; 66:647-661. 38 252. Nejima J, Uemura N, Vatner DE, Homcy CJ, Hintze TH and Vatner SF: Role of intact cardiac nerves and reflex mechanisms in desensitization to catecholamines in conscious dogs. J Clin Invest 1990; 86:2046-2053. 253. Young MA, Vatner DE and Vatner SF: α- and β-adrenergic control of large coronary arteries in conscious calves. Basic Res Cardiol 1990; 85(Suppl 1):97-109. 254. Shen Y-T, Knight DR, Thomas JX Jr and Vatner SF: Effects of selective cardiac denervation on collateral blood flow after coronary artery occlusion in conscious dogs. Basic Res Cardiol 1990; 85:(Suppl 1):229-239. 255. Vatner SF, Stambler BS and Shannon RP: Effects of alpha- and beta-adrenergic stimulation and blockade on the coronary Circulation in conscious dogs. In: Coronary and Cerebrovascular Effects of Antihypertensive Drugs. Eds. J Atkinson, C Capdeville, and F Zannad. TransMedica Europe Limited, United Kingdom, 1990, pp. 39-52. 256. Chen L, Vatner DE, Vatner SF, Hittinger L and Homcy CJ: Decreased Gsα mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses. J Clin Invest 1991; 87:293-298. 257. Shannon RP, Gelpi RJ, Hittinger L, Vatner DE, Homcy CJ, Graham RM and Vatner SF: The inotropic response to norepinephrine is augmented early and maintained late in conscious dogs with perinephritic hypertension. Circ Res 1991; 68:543-554. 258. Gelpi RJ, Pasipoularides A, Lader AS, Patrick TA, Chase N, Shannon RP, Bishop SP and Vatner SF: Changes in diastolic cardiac function in developing and stable perinephritic hypertension in conscious dogs. Circ Res 1991; 68:555-567. 259. Homcy CJ, Vatner SF and Vatner DE: β-adrenergic receptor regulation in the heart in pathophysiologic states: Abnormal adrenergic responsiveness in cardiac disease. Annu Rev Physiol 1991; 53:137-159. 260. Vatner SF, Young MA and Vatner DE: Large coronary artery regulation by α-and βadrenergic receptors in conscious calves. In Coronary Circulation in Physiological and PathoPhysiological States. Eds. M Nakamura and PM Vanhoutte. Springer-Verlag, 1991, pp. 29-41. 261. Shen Y-T, Cowley AW and Vatner SF: Relative roles of cardiac and arterial baroreceptors in vasopressin regulation during hemorrhage in conscious dogs. Circ Res 1991; 68:1422-1436. 262. Shannon RP, Komamura K, Stambler BS, Manders WT and Vatner SF: Alterations in myocardial contractility in conscious dogs with dilated cardiomyopathy. Am J Physiol 1991; 260:H1903-H1911. 263. Shen Y-T, Graham RM and Vatner SF: Effects of atrial natriuretic factor on blood flow distribution and vascular resistance in conscious dogs. Am J Physiol 1991; 260:H1893-H1902. 39 264. Vatner SF and Uemura N: Integrative Cardiovascular Control by Pulmonary Inflation Reflexes, In Reflex Control of the Circulation. Eds. IH Zucker and JP Gilmore. CRC Press, Boca Raton, FL, 1991, pp.609-626. 265. Vatner DE, Homcy CJ and Vatner SF: Beta-adrenergic receptor regulation in cardiac disease. In Reflex Control of the Circulation. Eds. IH Zucker and JP Gilmore. CRC Press, Boca Raton, FL, 1991, pp. 829-848. 266. Bigaud M and Vatner SF: Endothelium and blood flow mediated vasomotion in the conscious dog. In: Endothelial Mechanisms of Vasomotor Control. Eds. H Drexler, AM Zeiher, E Bassenge and H Just. Steinkopff, Verlag, Darmstadt, Germany, 1991, pp. 59-68. 267. Knight DR, Shen Y-T, Young MA and Vatner SF: Acetylcholine-induced coronary vasoconstriction and vasodilation in tranquilized baboons. Circ Res 1991; 69:706-713. 268. Vatner SF and Cox DA: Circulatory Function and Control. In: Textbook of Internal Medicine, 2nd Edition. Ed. WN Kelley. J. B. Lippincott Company, Philadelphia, 1992, pp. 96-104. 269. Vatner SF: Sympathetic mechanisms regulating myocardial contractility in conscious animals in The Heart and Cardiovascular System, 2nd Edition. Eds. HM Fozzard, E Haber, RB Jennings, AM Katz and HE Morgan. Raven Press, New York, 1991, pp. 1709-1728. 270. Perreault CL, Shannon RP, Komamura K, Vatner SF and Morgan JP: Abnormalities in intracellular calcium regulation and contractile function in myocardium from dogs with pacing-induced heart failure. J Clin Invest 1992; 89:932-938. 271. Vatner SF: Pursuing New Frontiers While Preserving Traditions. Circ Res 1991; 69(1):1 (Editorial). 272. Komamura K, Shannon RP, Pasipoularides A, Ihara T, Lader AS, Patrick TA, Bishop SP and Vatner SF: Alterations in left ventricular diastolic function in conscious dogs with pacinginduced heart failure. J Clin Invest 1992; 89:1825-1838. 273. Nadal-Ginard B, Leinwand LA, Libby P, Schwartz K, Strauss HC and Vatner SF: Cellular and molecular biology of the cardiovascular system. Circ Res 1992; 71:1-2 (Editorial). 274. Hittinger L, Shen Y-T, Patrick TA, Hasebe N, Komamura K, Ihara T, Manders WT and Vatner SF: Mechanisms of subendocardial dysfunction in response to exercise in dogs with left ventricular hypertrophy. Circ Res 1992; 71:423-434. 275. Kiuchi K, Vatner DE, Uemura N, Bigaud M, Hasebe N, Hempel DM, Graham RM and Vatner SF: Mechanisms of α1-adrenergic vascular desensitization in conscious dogs. Circ Res 1992; 71:1185-1199. 276. Vatner SF, Patrick TA, Shen Y-T and Murray PA. Monitoring of cardiovascular dynamics in conscious animals. In: Cardiovascular Toxicology, 2nd Edition, Ed. D Acosta, New York: Raven Press, 1992: pp. 45-72. 40 277. Heyndrickx GR and Vatner SF: Stunned Myocardium: Historical perspective. In: Stunned Myocardium: Properties, Mechanisms, and Clinical Manifestations. Eds. RA Kloner and K Przyklenk. New York: Marcel Dekker, Inc., 1993, pp. 3-15. 278. Vatner DE, Kiuchi K, Manders WT and Vatner SF. Effects of coronary arterial reperfusion on β-adrenergic receptor-adenylyl cyclase coupling. Am J Physiol 1993; 264:H196-H204. 279. von Harsdorf R, Schott RJ, Shen T-Y, Vatner SF, Mahdavi V and Nadal-Ginard B. Gene injection into canine myocardium as a useful model for studying gene expression in the heart of large mammals. Circ Res 1993; 72:688-695. 280. Kiuchi K, Shannon RP, Komamura K, Cohen DJ, Bianchi C, Homcy CJ, Vatner SF and Vatner DE. Myocardial β-adrenergic receptor function during the development of pacinginduced heart failure. J Clin Invest 1993; 91:907-914. 281. Shannon RP, Stambler BS, Komamura K, Ihara T and Vatner SF. Cholinergic modulation of the coronary vasoconstriction induced by cocaine in conscious dogs. Circulation 1993; 87:939-949. 282. Uemura N, Vatner DE, Shen Y-T, Wang J and Vatner SF. Increased α1-adrenergic vascular sensitivity during the development of hypertension in conscious dogs. Am J Physiol 1993; 264:H1259-H1268. 283. Shen Y-T and Vatner SF. Effects of a K+ATP channel opener, lemakalim, on systemic, coronary, and regional vascular dynamics in conscious dogs: Comparison with nifedipine, adenosine, nitroglycerin, and acetylcholine. J Pharmacol Exp Ther 1993; 265:1026-1037. 284. Vatner SF, Leinwand LA, Libby P, Nadal-Ginard B, Schwartz K and Strauss HC. All manuscripts are not created equal: The expedited publication. Circ Res 1993; 73:1-2 (Editorial). 285. Vatner SF and Hittinger L. Myocardial perfusion dependent and independent mechanisms of regional myocardial dysfunction in hypertrophy. In: Angiotensin and the Heart. Eds. H Grobecker, G Heusch and BE Strauer. Darmstadt, Steinkopff Verlag, 1993, pp 81-95. 286. Vatner SF and Hittinger L. Coronary vascular mechanisms involved in decompensation from hypertrophy to heart failure. J Am Coll Cardiol 1993; 22(Suppl A): 34A-40A. 287. Shannon RP, Komamura K, Shen Y-T, Bishop SP and Vatner SF. Impaired regional subendocardial coronary flow reserve in conscious dogs with pacing-induced heart failure. Am J Physiol 1993; 265:H801-H809. 288. Komamura K, Shannon RP, Ihara T, Shen Y-T, Mirsky I, Bishop SP and Vatner SF. Exhaustion of Frank-Starling mechanism in conscious dogs with heart failure. Am J Physiol 1993; 265:H1119-H1131. 41 289. Kiuchi K, Sato N, Shannon RP, Vatner DE, Morgan K and Vatner SF. Depressed β-adrenergic receptor- and endothelium-mediated vasodilation in conscious dogs with heart failure. Circ Res 1993; 73:1013-1023. 290. Hasebe N, Shen Y-T and Vatner SF. Inhibition of endothelium-derived relaxing factor enhances myocardial stunning in conscious dogs. Circulation 1993; 88:2862-2871. 291. Shen Y-T, Zhang H and Vatner SF. Peripheral vascular effects of beta-3 adrenergic receptor stimulation in conscious dogs. J Pharmacol Exp Ther 1994; 268:466-473. 292. Hasebe N, Shen Y-T, Kiuchi K, Hittinger L, Bishop SP and Vatner SF. Enhanced postischemic dysfunction selective to the subendocardium in conscious dogs with LV hypertrophy. Am J Physiol 1994; 266:H702-H713. 293. Shannon RP, Komamura K, Gelpi RJ and Vatner SF. Altered load: an important component of impaired diastolic function in hypertension and heart failure. In: Diastolic Relaxation of the Heart. Eds. W Grossman and B Lorrell. Kluwer Academic Publishers, Boston, 1994, pp. 177185. 294. Ihara T, Shannon RP, Komamura K, Pasipoularides A, Patrick TA, Shen Y-T and Vatner SF: Effects of anesthesia and recent surgery on diastolic function. Cardiovasc Res 1994; 28:325336. 295. Ishikawa Y, Sorota S, Kiuchi K, Shannon RP, Komamura K, Katsushika S, Vatner DE, Vatner SF and Homcy CJ: Downregulation of adenylyl cyclase Types V and VI mRNA levels in pacing-induced heart failure in dogs. J Clin Invest 1994; 93:2224-2229. 296. Hittinger L, Patrick T, Ihara T, Hasebe N, Shen Y-T, Kalthof B, Shannon RP and Vatner SF: Exercise induces cardiac dysfunction in both moderate, compensated and severe hypertrophy. Circulation 1994; 89:2219-2231. 297. Perreault CL, Shannon RP, Shen Y-T, Vatner SF and Morgan JP. Excitation-contraction coupling in isolated myocardium from dogs with compensated left ventricular hypertrophy. Am J Physiol 1994; 266:H2436-H2442. 298. Ihara T, Komamura K, Shen Y-T, Patrick TP, Mirsky I, Shannon RP and Vatner SF: Left ventricular systolic dysfunction precedes diastolic dysfunction during myocardial ischemia in conscious dogs. Am J Physiol 1994; 267:H333-H343. 299. Kiuchi K, Shannon RP, Sato N, Bigaud M, Lajoie C, Morgan K and Vatner SF: Factors involved in delaying the rise in peripheral resistance in developing heart failure. Am J Physiol 1994; 267:H211-H216. 300. Vatner DE, Sato N, Kiuchi K, Shannon RP and Vatner SF: Decrease in myocardial ryanodine receptors and altered excitation-contraction coupling early in the development of heart failure. Circulation 1994; 90: 1423-1430. 42 301. Kiuchi K, Shen Y-T, Vatner SF and Vatner DE: Mechanisms mediating responsiveness to βadrenergic stimulation after coronary reperfusion in conscious dogs. Am J Physiol 1994; 267:H1578-H1588. 302. Komamura K, Shannon RP and Vatner SF: Systolic and diastolic dysfunction in heart failure. In: Cardiac Adaptation and Failure, Eds. M Hori, Y Maruyama, and RS Reneman. SpringerVerlag, Publishers, Tokyo 1994, pp. 327-336 303. Hasebe N, Hittinger L, Kohin S, Shen Y-T, Graham RM and Vatner SF: Effects of hypertrophy on left atrial and ventricular compliance and plasma ANF levels in conscious dogs. Am J Physiol 1995; 268:H781-H787. 304. Shen Y-T and Vatner SF: Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs. Hibernation vs. stunning? Circ Res 1995; 76:479-488. 305. Sato N, Kiuchi K, Shen Y-T, Vatner SF and Vatner DE: Adrenergic responsiveness is reduced, while baseline cardiac function is preserved in old adult conscious monkeys. Am J Physiol 1995; 269:H1664-H1671. 306. Hittinger L, Mirsky I, Shen Y-T, Patrick TA, Bishop SP and Vatner SF: Hemodynamic mechanisms responsible for reduced subendocardial coronary reserve in dogs with severe left ventricular hypertrophy. Circulation 1995; 92:978-986. 307. Kalthof B, Sato N, Iwase M, Shen Y-T, Israel M, Patrick T, Vatner SF: Effects of ryanodine on cardiac contraction, excitation contraction coupling and “treppe” in conscious dog. J Mol Cell Cardiol 1995; 27:2111-2121. 308. Sato N, Shen Y-T, Kiuchi K, Shannon RP and Vatner SF: Splenic contraction-induced increases in arterial O2 reduce requirement for CBF in conscious dogs. Am J Physiol 1995; 269:H491-H503. 309. Vatner SF and Heyndrickx GR: Ubiquity of Myocardial Stunning. Basic Res Cardiol. 1995; 90:253-256. 310. Bishop SP, Powell PC, Hasebe N, Shen Y-T, Patrick TA, Hittinger L and Vatner SF: Coronary vascular morphology in pressure-overload left ventricular hypertrophy. J Mol Cell Cardiol 1995;28 (1):141-154. 311. Vatner DE, Kiuchi K, Shannon RP, and Vatner SF: Initial changes in β-adrenergic receptor function during development of rapid ventricular pacing-induced heart failure. In: Pathophysiology of Heart Failure. Eds. NS Dhalla, GN Pierce and V Panagia. Kluwer Academic Publishers, Boston, MA, 1995, pp. 263-275. 312. Shen Y-T and Vatner SF: Differences in myocardial stunning following coronary artery occlusion in conscious dogs, pigs and baboons. Am J Physiol 1996; 270:H1312-H1322. 313. Shen Y-T, Fallon JT, Iwase M and Vatner SF: Innate protection of baboon myocardium: effects of coronary artery occlusion and reperfusion. Am J Physiol 1996; 270:H1812-H1818. 43 314. Iwase M, Bishop SP, Uechi M, Vatner DE, Shannon RP, Kudej R, Wight DC, Wagner TE, Ishikawa Y, Homcy CJ and Vatner SF: Adverse effects of chronic endogenous sympathetic drive induced by cardiac Gsα overexpression. Circ Res 1996; 78:517-524. 315. Cui Y, Shen Y-T, Kalthof B, Iwase M, Sato N, Uechi M, Vatner SF and Vatner DE: Identification and functional role of β-adrenergic receptor subtypes in primate and rodent: in vivo versus isolated myocytes. J Mol Cell Cardiol 1996;28(6): 1307-1317. 316. Vatner DE, Sato N, Galper JB and Vatner SF: Physiological and Biochemical Evidence for coordinate increases in muscarinic receptors and Gi in heart failure. Circulation 1996; 93:102107. 317. Iwase M, Ishikawa Y, Shen Y-T, Shannon RP, Sato N, Ganguly PK, Eki T, Vatner DE and Vatner SF: Neurally mediated cardiac effects of forskolin in conscious dogs. Am J Physiol 1996; 271:H1473-H1482. 318. Ghaleh B, Shen Y-T and Vatner SF: Spatial heterogeneity of myocardial blood flow presages salvage vs. Necrosis with coronary artery reperfusion in conscious baboons. Circulation 1996; 94 (9): 2210-2215. 319. Shen Y-T, Cervoni P, Claus T and Vatner SF: Differences in ß3-adrenergic receptor cardiovascular regulation in conscious primates, rats and dogs. J Pharmacol Exp Ther 1996; 278(3): 1435-1443. 320. Vatner DE, Sato N, Ishikawa Y, Kiuchi K, Shannon RP and Vatner SF: β-adrenoceptor desensitization during development of canine pacing-induced heart failure. J Clin Exp Pharmacol Physiol 1996; 23: 688-692. 321. Shen Y-T, Kudej RK, Bishop SP Vatner SF: Inotropic reserve and histological appearance of hibernating myocardium in conscious pigs with ameroid-induced coronary stenosis. Basic Res Cardiol 1996; 91(6):479-485. 322. Vatner, Stephen F.; Berk, Bradford C.; Leinwand, Leslie A.; Libby, Peter; Schwartz, Ketty; Strauss, Harold C. A Second Term for the Editors: Status and Goals for the Review Process Circ Res 1996;79:1-3 [Editorial] 323. Iwase, M, Uechi M, Vatner DE, Asai K, Shannon RP, Kudej RK, Wagner TE, Wight DC, Patrick TA, Ishikawa Y, Homcy CJ and Vatner SF: Cardiomyopathy induced by cardiac Gsα overexpression. Am J Physiol 1997; 272:H585-H589. 324. Sato N, Uechi M, Asai K, Patrick T, Kudej RK and Vatner SF: Effects of a novel inotropic agent, BAY y 5959, in conscious dogs: Comparison with dobutamine and milrinone. Am J Physiol 1997; 272:H753-H759. 325. Sato N, Vatner SF, Shen Y-T, Kudej RK, Ghaleh-Marzban B, Uechi M, Asai K, Mirsky I, Patrick TA, Shannon RP and Vatner DE: Effects of cardiac denervation on development of heart failure and catecholamine desensitization. Circulation 1997; 95: 2130-2140. 44 326. Sato S, Sato N, Kudej RK, Uechi M, Asai K, Shen Y-T, Ishikawa Y, Vatner SF, Vatner DE: β-adrenergic receptor signalling in stunned myocardium of conscious pigs. J Mol Cell Cardiol 1997; 29:1387-1400. 327. Muntz KH, Ishikawa Y, Wagner TE, Homcy CJ, Vatner SF and Vatner DE: Localization of cardiac Gsα in transgenic mice overexpressing Gsα. J Mol Cell Cardiol 1997; 29:1649-1653. 328. Kim S-J, Ghaleh B, Kudej RK, Huang C-H, Hintze TH and Vatner SF: Delayed, enhanced nitric oxide-mediated coronary vasodilation following brief ischemia and prolonged reperfusion in conscious dogs. Circ Res 1997; 81:53-59. 329. von Harsdorf R, Edwards J, Shen Y-T, Kudej RK, Dietz R, Leinwand LA, Nadal-Ginard B and Vatner SF: Identification of a cis-acting regulatory element conferring inducibility of the atrial natriuretic factor gene in acute pressure overload. J Clin Invest 1997; 100:1294-1304. 330. Kudej RK, Iwase M, Uechi M, Vatner DE, Oka N, Ishikawa Y, Shannon RP, Bishop SP and Vatner SF: Effects of chronic ß-adrenergic receptor stimulation in mice. J Mol Cell Cardiol 1997; 29:2735-2746. 331. Camici PG, Wijns W, Borgers M, De Silva RD, Ferrari R, Heusch G, Knuuti J, Lammertsma AA, Liedtke AJ, Paternostro G and Vatner SF: Pathophysiological mechanisms of chronic reversible left ventricular dysfunction due to coronary artery disease (Hibernating Myocardium). Circulation 1997; 96:3205-3214. 332. Conner DA, Mathier MA, Mortensen RM, Christe M, Vatner SF, Seidman CE and Seidman JG: β-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to β-adrenergic stimulation. Circ Res 1997; 81:1021-1026. 333. Oka N, Asai K, Kudej RK, Edwards JG, Toya Y, Schwencke C, Vatner DE, Vatner SF and Ishikawa Y: Downregulation of caveolin by chronic β-adrenergic receptor stimulation in mice. Am J Physiol 1997; 273:C1957-C1962. 334. Ghaleh B, Hittinger L, Kim S-J, Kudej R, Iwase M, Uechi M, Berdeaux A, Bishop SP and Vatner SF: Selective large coronary endothelial dysfunction in conscious dogs with chronic coronary pressure overload. Am J Physiol 1998; 274:H539-H551. 335. Uechi M, Asai K, Osaka M, Smith A, Sato N, Wagner TE, Ishikawa Y, Vatner DE, Shannon RP, Homcy CJ and Vatner SF: Depressed Heart Rate Variability and Arterial baroreflex in Conscious Transgenic Mice with Overexpression of Cardiac Gsα Circ Res 1998;82 (4):416423. 336. Vatner DE, Asai K, Iwase M, Ishikawa Y, Wagner TE, Shannon RP, Homcy CJ and Vatner SF: Overexpression of Myocardial Gsα Prevents Full Expression of Catecholamine Desensitization Despite Increased β-Adrenergic Receptor Kinase. J Clin Invest 1998;101(9):1916-1922. 45 337. Kloner RA, Bolli R, Marban E, Reinlib L, Braunwald E, and participants: Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning: An NHLBI Workshop. Circulation 1998;97 (18):1848-1867. 338. Wijns W, Vatner SF and Camici PG: Mechanisms of Disease: Hibernating Myocardium. N Engl J Med 1998; 339(3):173-181. 339. Lader AS, Xiao YF, Ishikawa Y, Cui Y, Vatner DE, Vatner SF, Homcy CJ and Cantiello HF: Cardiac Gsα overexpression enhance L-type calcium channels through an adenylyl cyclase independent pathway. Proc Natl Acad Sci 1998; 95(16):9669-9674. 340. Kudej RK, Ghaleh B, Sato N, Shen YT, Bishop SP and Vatner SF. Ineffective PerfusionContraction Matching in Conscious, Chronically Instrumented Pigs with an Extended Period of Coronary Stenosis. Circ Res 1998;82:1199-1205. 341. Asai K, Uechi M, Sato N, Shen W, Meguro T, Mathier M, Shannon RP and Vatner SF: Lack of Desensitization and Enhanced Efficiency of a Calcium Channel Promoter in Conscious Dogs with Heart Failure. Am J Physiol 1998; 275:H2219-H2226. 342. Mathier MA, Asai K, Shannon RP, Vatner SF: Cardiovascular Physiology in Mice: Conscious Measurements and Effects of Anesthesia. In: Cardiovascular Physiology in the Genetically Engineered Mouse. Kluwer Academic Publishers, 1998. 343. Vatner DE and Vatner SF. Physiological and biochemical adrenergic regulation of the stunned myocardium. Mol Cell Biochem 1998; 186:131-137. 344. Uechi M, Asai K, Sato N and Vatner SF: Voltage-Dependent Calcium Channel Promoter Restores Baroreflex Sensitivity in Conscious Dogs with Heart Failure. Circulation 1998; 98:1342-1347. 345. Geng YJ, Ishikawa Y, Vatner DE, Wagner TE, Bishop SP, Vatner SF and Homcy CJ: Apoptosis of Cardiac Myocytes in Gsα Transgenic Mice. Circ Res 1999; 84:34-42. 346. Sato N, Asai K, Okumura S, Takagi G, Shannon RP, Fujita-Yamaguchi Y, Ishikawa Y and Vatner SF, Vatner DE: Mechanisms of desensitization to a PDE Inhibitor (milrinone) in conscious dogs with heart failure. Am J Physiol 1999; 276:H1699-H1705. 347. Huang C-H, Kim S-J, Bhaleh B, Kudej RK, Shen Y-T, Bishop SP and Vatner SF: An adenosine agonist and preconditioning shift the distribution of myocardial blood flow in conscious pigs. Am J Physiol 1999; 276:H368-H375. 348. Kim S-J, Yatani A, Vatner DE, Yamamoto S, Ishikawa Y, Wagner TE, Shannon RP, Kim YK, Takagi G, Asai K, Homcy CJ and Vatner SF: Differential Regulation of Inotropy and Lusitropy in Overexpressed Gsα Myocytes through cAMP and Ca2+ Channel Pathways. J Clin Invest 1999; 103:1089-1097 349. Kim S-J, Iizuka K, Kelly RA, Geng Y-J, Bishop SP, Yang G, Kudej A, McConnell BK, Seidman C, Seidman JG and Vatner SF: An α-cardiac myosin heavy chain gene mutation 46 impairs contraction and relaxation function of cardiac myocytes. Am J Physiol 1999; 276:H1780-H1787. 350. Meguro T, Hong C, Asai K, Takagi G, McKinsey TA, Olson EN and Vatner SF: Cyclosporine Attenuates Pressure-Overload Hypertrophy in Mice While Enhancing Susceptibility to Decompensation and Heart Failure. Circ Res 1999; 84(6):735-740 351. Hittinger L, Ghaleh B, Chen J, Edwards JG, Kudej RK, Iwase M, Kim S-J, Vatner SF and Vatner DE: Reduced Subendocardial Ryanodine Receptors and Consequent Effects on Cardiac Function in Conscious Dogs with Left Ventricular Hypertrophy. Circ Res 1999; 84(9):999-1006. 352. Vatner DE, Asai K, Iwase M, Ishikawa Y, Shannon RP, Homcy CJ and Vatner SF: BetaAdrenergic Receptor-G Protein-Adenylyl Cyclase Signal Transduction in the Failing Heart. Am J Cardiol 1999;83:80H-85H. 353. Asai K, Yang G-P, Geng Y-J, Takagi G, Bishop S, Ishikawa Y, Shannon RP, Wagner TE, Vatner DE, Homcy CJ and Vatner SF: β-Adrenergic Receptor Blockade Arrests Myocyte Damage and Preserves Cardiac Function in the Transgenic Gsα Mouse. J Clin Invest 1999; 104(5):551-558. 354. Vatner SF, Berk BC, Hintze TH, Leinwand LA, Libby P, Marban E, Schwartz K, Strauss HC, Yazaki Y: Eight Years Behind the Masthead. Circ Res 1999; 84(12):1361-4 (Editorial). 355. Shen W, Asai K, Uechi M, Mathier MA, Shannon RP, Vatner SF and Ingwall JS: Progressive Loss of Myocardial ATP Due to a Loss of Total Purines During the Development of Heart Failure in Dogs. Circulation 1999;100:2113-2118. 356. Vatner SF, Vatner DE and Homcy CJ: β-Adrenergic Receptor Signalling: An Acute Compensatory Adjustment; Inappropriate for the Chronic Stress of Heart Failure? Insights from Gsα Overexpression and other Genetically Engineered Animal Models. Circ Res 2000; 86:502-506. 357. Vatner DE, Yang GP, Geng YJ, Asai K, Yun JS, Wagner TE, Ishikawa Y, Bishop SP, Homcy CJ and Vatner SF: Determinants of the Cardiomyopathic Phenotype in Chimeric Mice Overexpressing Cardiac Gsα. Circ Res 2000; 86(7):802-806. 358. Asai K, Kudej RK, Shen Y-T, Yang G-P, Takagi G, Kudej A, Geng Y-J, Sato N, Nazareno JB, Vatner DE, Natividad F, Bishop SP and Vatner SF: Peripheral Vascular Endothelial Dysfunction and Apoptosis in Old Monkeys. Arterioscler Thromb Vasc Biol 2000; 20(6):1493-1499. 359. Morisco C, Zebrowski DC, Vatner DE, Vatner SF and Sadoshima J: The Akt-Glycogen Synthase Kinase 3β Pathway Regulates Transcription of Atrial Natriuretic Factor Induced by β-Adrenergic Receptor Stimulation in Cardiac Myocytes. J Biol Chem 2000; 275(19):1446614475. 47 360. Homcy CJ and Vatner SF. G Proteins in Cardiac Hypertrophy and Heart Failure. McGraw Hill, Harrison Textbook of Medicine, 2000. 361. Kudej RK, Kim SJ, Shen YT, Jackson JB, Kudej AB, Yang GP, Bishop SP, Vatner SF: Nitric Oxide, an Important Regulator of Perfusion-Contraction Matching in Conscious Pigs. Am J Physiol Heart Circ Physiol 2000 Jul;279(1):H451-H456. 362. Kudej RK, Zhang XP, Ghaleh B, Huang CH, Jackson JB, Kudej AB, Sato N, Sato S, Hintze TH, Vatner SF: Enhanced cylic-AMP-Induced Nitric Oxide-Dependent Coronary Dilation During Myocardial Stunning in Conscious Pigs. Am J Physiol Heart Circ Physiol 2000; 279(6):H2967-H2974. 363. Asai K, Kudej RK, Takagi G, Kudej AB, Natividad F, Shen YT, Vatner DE and Vatner SF. Paradoxically Enhanced Endothelin-B Receptor-Mediated Vasoconstriction in Conscious Old Monkeys. Circulation 2001; 103:2382-2386. 364. Morisco C, Zebrowski DC, Vatner DE, Vatner SF and Sadoshima J. β-Adrenergic Cardiac Hypertrophy is Mediated Primarily by the β1-Subtype in the Rat Heart. J Mol Cell Cardiol 2001; 33:561-573 365. Yang GP, Meguro T, Hong C, Asai K, Takagi G, Karoor VL, Sadoshima J, Vatner DE, Bishop SP and Vatner SF. Cyclosporine Reduces Left Ventricular Mass with Chronic Aortic Banding in Mice, Which Could Be Due to Apoptosis and Fibrosis. J Mol Cell Cardiol 2001; 33: 1505-1514. 366. Morisco C, Seta K, Hardt SE, Lee Y, Vatner SF and Sadoshima J. Glycogen Synthase Kinase 3β Regulates GATA4 in Cardiac Myocytes. J Biol Chem. 2001; 276(30):28586-28597. 367. Depre C, Tomlinson JE, Kudej RK, Gaussin V, Thompson E, Kim S-J, Vatner DE, Topper JN and Vatner SF. Gene Program for Cardiac Cell Survival Induced by Transient Ischemia in Conscious Pigs. Proc Natl Acad Sci 2001; 98(16)9336-9341. 368. Vatner SF, Takagi G, Asai K and Shannon RP. Cardiovascular Physiology in Mice: Conscious Measurements and Effects of Anesthesia. In: Cardiovascular Phenotyping in the Genetically Engineered Mouse 2nd Edition. Kluwer Academic Publishers, 2001. 369. Yamamoto S, Seta K, Morisco C., Vatner SF and Sadoshima J. Chelerythrine Rapidly Induces Apoptosis through Generation of Reactive Oxygen Species in Cardiac Myocytes. J Mol Cell Cardiol 2001; 33:1829-1848 370. Kim S-J, Kudej RK, Yatani A, Kim Y-K, Takagi G, Honda R, Colantonio D, VanEyk JE, Vatner DE, Rasmusson RL and Vatner SF. A Novel Mechanism for Myocardial Stunning Involving Impaired Ca2+ Handling. Circulation Research 2001; 89:831-837 371. Kim S-J, Kim YK, Takagi G, Huang CH, Geng YJ and Vatner SF. Enhanced iNOS Function in Myocytes One Day Following a Brief Ischemic Episode. Am J Physiol Heart Circ Physiol 2002; 282:H423-428. 48 372. Lewandowski ED, Kudej RK, White LT, O’Donnell JM and Vatner SF. Mitochondrial Preference for Short Chain Fatty Acid Oxidation during Coronary Artery Constriction. Circulation 2002; 105:367-372. 373. Kim YK, Kim S-J, Kramer CM, Yatani A, Takagi G, Mankad S, Szigeti GP, Singh D, Bishop FP, Shannon RP, Vatner DE and Vatner SF. Altered Excitation-Contraction Coupling in Myocytes from Remodeled Myocardium after Chronic Myocardial Infarction. J Mol Cell Cardiol 2002; 34:63-73. 374. Hardt SE, Geng Y-J, Montagne O, Asai K, Hong C, Yang G-P, Bishop SP, Kim S-J, Vatner DE, Seidman CE, Seidman JG, Homcy CJ and Vatner SF. Accelerated Cardiomyopathy in Mice with Overexpression of Cardiac Gsα and a Missense Mutation in the α-Myosin Heavy Chain. Circulation 2002; 105:614-620. 375. Vatner SF: Heart rate as a risk factor in modifying the effects of myocardial ischemia: experimental and clinical correlations. In: Heart Rate and Coronary Disease. Eds. PM VanHoutte and B Singh. Lippincott Williams & Wilkins, London, England, 2002 376. Kim S-J, Depre C and Vatner SF. Novel Mechanisms Mediating Stunned Myocardium. Heart Failure Reviews 2003; 8(2):143-153. 377. Sadoshima J, Montagne O, Wang Q, Yang G, Warden J, Liu J, Takagi G, Karoor V, Hong C, Johnson GL, Vatner DE and Vatner SF. The MEKK1-JNK Pathway Plays a Protective Role in Pressure Overload but does not Mediate Cardiac Hypertrophy. J Clin Invest 2002; 110:271279. 378. Kudej RK, White LT, Kudej AB, Vatner SF and Lewandowski ED. Brief Increase in Carbohydrate Oxidation Following Reperfusion Reverses Myocardial Stunning in Conscious Pigs. Circulation, 2002; 106(22):2836-2841 379. Depre C, Hase M, Gaussin V, Zajav A, Wang L, Hittinger L, Ghaleh B, Yu X, Kudej RK, Wagner T, Sadoshima J and Vatner SF. H11 Kinase Is a Novel Mediator of Myocardial Hypertrophy In Vivo. Circ Res, 2002; 91:1007-1014. 380. Morisco C, Sadoshima J, Trimarco B, Arora R, Vatner DE and Vatner SF. Is Treating Cardiac Hypertrophy Salutary or Detrimental: The Two Faces of Janus. Am J Physiol Heart Circ Physiol, 2003; 284(4):H1043-H1047 (Editorial). 381. Depre C, Wang L, Tomlinson JE, Gaussin V, Abdellatif M, Topper JN, Vatner SF. Characterization of pDJA1, A Cardiac-Specific Chaperone Found by Genomic Profiling of the Post-Ischemic Swine Heart. Cardiovasc Res, 2003; 58(1):126-135. 382. Iwamoto T, Okumura S, Iwatsubo K, Kawabe J, Ohtsu K, Sakai I, Hashimoto Y, Izumitani A, Sango K, Ajiki K, Toya Y, Umemura S, Goshima Y, Arai N, Vatner S F,and Ishikawa Y. Motor Dysfunction in Type 5 Adenylyl Cyclase-Null Mice. J Biol Chem, 2003; 278(19):16936-16940. 49 383. Takagi G, Asai K, Vatner SF, Kudej RK, Rossi F, Peppas A, Takagi I, Resuello RRG, Natividad F, Shen Y-T and Vatner DE. Gender Differences on the Effects of Aging on Cardiac and Peripheral Adrenergic Stimulation in Old Conscious Monkeys. Am J Physiol Heart Circ Physiol. 2003; 285(2):H527-H534. 384. Kudej RK and Vatner SF. Nitric Oxide-Dependent Vasodilation Maintains Blood Flow in True Hibernating Myocardium. J Mol Cell Cardiol. 2003, 35(8):931-935 385. Kim S-J, Peppas A, Hong S-K, Yang G, Huang Y, Diaz G, Sadoshima J, Vatner DE and Vatner SF. Persistent Stunning Induces Myocardial Hibernation and Protection: Flow/Function and Metabolic Mechanisms. Circ Res. 2003; 92(11):1233-1239. 386. Wang M, Takagi G, Asai K, Resuello RG, Natividad FF, Vatner DE, Vatner SF and Lakatta EG. Aging Increases Aortic MMP-2 Activity and Angiotensin III in Nonhuman Primates. Hypertension. 2003; 41(6):1308-1316. 387. Yamamoto S, Yang G, Zablocki D, Liu J, Hong C, Kim S-J, Soler S, Odashima M, Thaisz J, Tehia G, Molina CA, Yatani A, Vatner DE, Vatner SF and Sadoshima J. Activation of Mst1 Causes Dilated Cardiomyopathy by Stimulating Apoptosis Without Compensatory Ventricular Myocyte Hypertrophy. J Clin Invest. 2003; 111(10):1463-1474. 388. Yatani A, Xu D-Z, Kim S-J, Vatner SF and Deitch EA. Mesenteric lymph from rats with thermal injury prolongs the action potential and increases Ca2+ transient in rat ventricular myocytes. Shock. 2003; 20(5):458-464. 389. Li J, Yatani A, Kim S-J, Takagi G, Irie K, Zhang Q, Karoor V, Hong C, Yang G, Sadoshima J, Depre C, Vatner DE, West MJ, Vatner SF. Neurally-mediated increase in calcineurin activity regulates cardiac contractile function in absence of hypertrophy. Cardiovascular Research. 2003; 59(3):649-657. 390. Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos C, Takagi G, Hein L, Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF, Vatner DE. Common genomic response in different mouse models of β-adrenergic-induced cardiomyopathy. Circulation. 2003; 108(23):2926-2933 391. Liu J, Masurekar, MR, Vatner DE, Jyothirmayi GN, Regan TJ, Vatner SF, Meggs LG, Malhotra A. Glycation end-product cross-link breaker reduces collagen and improves cardiac function in the aging diabetic heart. Am J Physiol Heart Circ Physiol.2003; 285(6):H25872591. 392. Vatner SF. In Memoriam: Arthur C. Guyton, M.D. (1919-2003). Circ Res. 2003; 92(12):12721275. (Editorial) 393. Vatner SF. A Three-Decade Dialectic with Circulation Research. Circ Res. 2003; 92(9):939940 (Editorial) 50 394. Okumura S, Takagi G, Kawabe J, Yang G, Lee MC, Hong C, Liu J, Vatner DE, Sadoshima J, Vatner SF, Ishikawa Y. Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proc Natl Acad Sci. 2003, 100(17):9986-9990. 395. Okumura S, Kawabe J, Yatani A, Takagi G, Lee MC, Hong C, Liu J, Takagi I, Sadoshima J, Vatner DE, Vatner SF, Ishikawa Y. Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation. Circ. Res. 2003, 93(4):364-371. 396. Huang C-H, Vatner SF, Peppas AP, Yang G, Kudej RK. Cardiac nerves affect myocardial stunning through reactive oxygen and nitric oxide mechanisms. Circ. Res. 2003; 93(9):866873. 397. Kim, Y-K, Kim S-J, Yatani A, Huang Y, Castelli G, Vatner DE, Liu J, Zhang Q, Diaz G, Zieba R, Thaisz J, Drusco A, Croce C, Sadoshima J, Condorelli G, Vatner SF. Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt. J Biol Chem, 2003; 278(48):47622-47628. 398. Yamamoto M, Yang G, Hong C, Liu J, Holle E, Yu X, Wagner T, Vatner, SF, Sadoshima J. Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. J Clin Invest. 2003; 112(9):1395-1406. 399. Karoor V, Vatner SF, Takagi G, Yang GP, Thaisz J, Sadoshima J, Vatner DE. Propranolol prevents enhanced stress signaling in Gsα cardiomyopathy: potential mechanism for βblockade in heart failure. J Mol Cell Cardiol. 2004, 36(2):305-312. 400. Yatani A, Kim S-J, Kudej RK, Wang Q, Depre C, Irie K, Kranias EG, Vatner SF and Vatner DE. Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals. Am J Physiol Heart Circ Physiol, 2004, 286(6):H2219-2228 401. Lieber SC, Aubry N, Pain J, Diaz G, Kim, SJ, and Vatner SF. Aging increases stiffness of cardiac myocytes measured by atomic force microscopy nanoindentation. Am J Physiol Heart Circ Physiol, 2004, 287(2):H645-H651. 402. O’Donnell JM, Kudej RK, LaNoue KF, Vatner SF, Lewandowski ED. Limited transfer of cytosolic NADH into mitochondria at high cardiac workload. Am J Physiol Heart Circ Physiol, 2004. 286(6):H2237-H2242. 403. Depre C, Kim S-J, John AS, Huang Y, Rimoldi OE, Pepper JR, Dreyfes GD, Gaussin V, Pennell DJ, Vatner DE, Camici PG, Vatner SF. Program of cell survival underlying human and experimental hibernating myocardium. Circ Res. 2004, 95(4):433-440. 404. Yan L, Ge H, Li H, Lieber SC, Natividad F, Resuello RRG, Kim S-J, Akeju S, Sun A, Loo K, Peppas AP, Rossi F, Lewandowski ED, Thomas AP, Vatner SF and Vatner DE. GenderSpecific Proteomic Alterations in Glycolytic and Mitochondrial Pathways in Aging Monkey Hearts. J Mol Cell Cardiol. 2004; 37(5):921-929. 51 405. Alcendor RR, Kirshenbaum LA, Imai S, Vatner SF, Sadoshima J. Silent Information Regulator 2α, a Longevity Factor and Class III Histone Deacetylase, Is an Essential Endogenous Apoptosis Inhibitor in Cardiac Myocytes. Circ Res. 2004; 95(10):971-980. 406. Vatner S.F. FGF Induces Hypertrophy and Angiogenesis in Hibernating Myocardium. Circ Res. 2005, 96(7)705-707. 407. Hase M, Depre C, Vatner SF, Sadoshima, J. H11 has dose-dependent and dual hypertrophic and proapoptotic functions in cardiac myocytes. Biochem. J. 2005; 388, 475–483 408. Depre C, Vatner S.F. Mechanisms of Cell Survival in Myocardial Hibernation. Trends Cardiovasc Med. 2005; 15(3), 101 409. Song L-S, Pi YQ, Kim S-J, Yatani A, Guatimosim S, Kudej R.K., Zhang Q, Cheng H, Hittinger L, Ghaleh B, Vatner D.E., Lederer W.J., Vatner S.F. Paradoxical Cellular Ca2+ Signaling in Severe, but Compensated Canine Left Ventricular Hypertrophy. Circ Res. 2005; 97:457-464 410. Yatani A, Shen YT, Yan L, Chen W, Kim SJ, Sano K, Irie K, Vatner SF, Vatner DE. Down regulation of the L-type Ca2+ channel, GRK2, and phosphorylated phospholamban: protective mechanisms for the denervated failing heart. J Mol Cell Cardiol. 2006; 40:619-28. 411. Yan L, Vatner D.E., Kim S-J, Ge H, Masurekar M, Massover W.H., Yang G, Matsui Y, Sadoshima J, Vatner S.F. Autophagy in Chronically Ischemic Myocardium. Proc Natl Acad Sci. 2005; 102(39):13807-12 412. Gaussin V, Morley GE, Cox L, Zwijsen A, Vance KM, Emile L, Tian Y, Liu J, Hong C, Myers D, Conway SJ, Depre C, Mishina Y, Behringer RR, Hanks MC, Schneider MD, Huylebroeck D, Fishman GI, Burch JBE, Vatner SF. The Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus. Circ Res. 2005; 97(3): 219-226 413. Yatani A, Xu DZ, Irie K, Sano K, Jidarian A, Vatner SF, Deitch EA. Dual effects of mesenteric lymph isolated from rats with burn injury on contractile function in rat ventricular myocytes. Am J Physiol Heart Circ Physiol. 2006; 290(2):H778-85. 414. Zhai P, Yamamoto M, Galeotti J, Lui J, Masurekar M, Thaisz J, Irie K, Holle E, Yu Xianzhong, Kupershmidt S, Roden DM, Wagner T, Yatani A, Vatner DE, Vatner SF, Sadoshima J. Cardiac-specific Overexpression of AT1 Receptor Mutant Lacking Gαq/Gαi Coupling Causes Hypertrophy and Bradycardia in Transgenic Mice. J Clin Invest. 2005;115(11):3045-3056. 415. Depre C, Wang L, Sui X, Qiu H, Hong C, Hedhli N, Ginion A, Shah A, Pelat M, Bertrand L, Wagner T, Gaussin V, Vatner S.F. H11 Kinase prevents myocardial infarction by pre-emptive preconditioning of the heart. Circ Res. 2006; 98(2):280-8. 416. Yan L, Sadoshima J, Vatner DE, Vatner SF. Autophagy: a novel protective mechanism in chronic ischemia. Cell Cycle 2006; 5(11):1175-7. 52 417. Depre C, Wang Q, Yan L, Hedhli N, Peter P, Chen L, Hong C, Hittinger L, Ghaleh B, Sadoshima J, Vatner D.E., Vatner S.F., Madura K. Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation 2006; 114: 18211828. 418. Liu J, Sadoshima J, Zhai P, Hong C, Yang G, Chen W, Yan L, Wang Y, Vatner SF, Vatner DE. Pressure overload induces greater hypertrophy and mortality in female mice with p38α MAPK inhibition. J Mol Cell Cardiol. 2006; 41:680-8. 419. Nishizawa T, Vatner SF, Hong C, Shen Y-T, Hardt SE, Robbins J, Ishikawa Y, Sadoshima J, Vatner DE. Overexpressed Cardiac Gsα in Rabbits. J Mol Cell Cardiol. 2006; 41:44-50. 420. Kudej R, Shen Y-T, Peppas A, Huang C-H, Chen W, Yan L, Vatner DE, Vatner SF. Obligatory Role of Cardiac Nerves and α1-Adrenergic Receptors for the Second Window of Ischemic Preconditioning in Conscious Pigs. Circ Res. 2006; 99:1270-6. 421. Yan L, Vatner DE, O’Connor JP, Ivessa A, Ge H, Chen W, Hirotani S, Ishikawa Y, Sadoshima J, Vatner SF. Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects against Stress. Cell. 2007; 130: 247–258. 422. Okumura S, Vatner DE, Kurotani R, Bai Y, Gao S, Yuan Z, Iwatsubo K, Ulucan C, Kawabe J, Ghosh K, Vatner SF, Ishikawa Y. Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress. Circulation. 2007; 116(16):1776-83. 423. Kim S-J, Zhang X, Xu X, Chen A, Gonzalez JB, Koul S, Vijayan K, Crystal G, Vatner SF, Hintze TH. Evidence for Enhanced eNOS Function in Coronary Microvessels during the Second Window of Protection. Am J Physiol Heart Circ Physiol. 2007; 292(5):H2152-8. 424. Nishizawa T, Shen YT, Rossi F, Hong C, Robbins J, Ishikawa Y, Sadoshima J, Vatner DE, Vatner SF. Altered Autonomic Control in Conscious Transgenic Rabbits with Overexpressed Cardiac Gsα. Am J Physiol Heart Circ Physiol. 2007; 292:H971-5. 425. Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y, Sadoshima J, Vatner SF, Vatner DE. Inhibition of p38α MAPK Rescues Overexpressed β2-Adrenergic Receptor but not β1Adrenergic Receptor Induced Cardiomyopathy. J Clin Invest. 2007; 117(5):1335-1343. 426. Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF, Sadoshima J. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res. 2007; 100(10):1512-21. 427. Qiu H, Tian B, Resuello R.G., Natividad F.F., Peppas A, Shen Y-T, Vatner D.E., Vatner S.F., Depre C. Sex-specific regulation of gene expression in the aging monkey aorta. Physiol Genomics. 2007; 29(2):169-80. 428. Rottlaender D, Matthes J, Vatner SF, Seifert R, Herzig S. Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2’(3’)-O-(N-methylanthraniloyl)-guanosine 5’-[γthio]triphosphate. J Pharmacol Exp Ther. 2007; 321(2):608-15. 53 429. Qiu H, Depre C, Ghosh K, Resuello RG, Natividad FF, Rossi F, Peppas A, Shen Y-T, Vatner DE, Vatner SF. Mechanism of Gender-Specific Differences in Aortic Stiffness with Aging in Non-Human Primates. Circulation. 2007;116:669-676. 430. Depre C, Vatner SF. Cardioprotection in stunned and hibernating myocardium. Heart Fail Rev. 2007; 2(3-4):307-17. 431. Shen Y-T*, Depre C*, Yan L, Park JY, Tian B, Jain K, Chen L, Kudej R.K., Xi Zhao, Sadoshima J, Vatner D.E., Vatner S.F. Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation. 2008;118(19):1961-9. *equal contribution. 432. Zhang X-P, Vatner SF, Shen Y-T, Rossi F, Tian Y, Peppas A, Resuello RG, Natividad FF, Vatner DE. Increased Apoptosis and Myocyte Enlargement with Decreased Cardiac Mass; Distinctive Features of the Aging Male, but not Female, Monkey Heart. J Mol Cell Cardiol. 2007; 43(4):487-91. 433. Qiu H, Depre C, Vatner SF, Vatner DE. Sex Differences in Myocardial Infarction and Rupture (Editorial). J Mol Cell Cardiol. 2007; 43:532-34. 434. Morisco C, Marrone C, Galeotti J, Shao D, Vatner DE, Vatner SF, Sadoshima J. Endocytosis Machinery Is Required for 1-Adrenergic Receptor-Induced Hypertrophy in Neonatal Rat Cardiac Myocytes. Cardiovasc Res. 2008;78(1):36-44. 435. Qiu H, Dai H, Jain K, Sha R, Hong C, Pain J, Tian B, Vatner DE, Vatner SF, Depre C. Characterization of a novel cardiac isoform of the cell cycle-related kinase that is regulated during heart failure. J Biol Chem. 2008;283(32):22157-65. 436. Lieber S*, Qiu H*, Chen L, Shen Y-T, Hong C, Hunter WC, Aubry A, Vatner SF, Vatner DE. Cardiac Dysfunction in Aging Conscious Rats: Altered Cardiac Cytoskeletal Proteins as a Potential Mechanism. Am J Physiol Heart Circ Physiol. 2008; 295:H860-H866. *equal contribution. 437. Ago T, Liu T, Zhai P, Chen W, Li H, Molkentin JD, Vatner SF, Sadoshima J. A RedoxDependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy. Cell. 2008;133:978-993. 438. Matsui Y, Kyoi S, Takagi H, Hsu CP, Hariharan N, Ago T, Vatner SF, Sadoshima J. Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy. 2008;4:409-415. 439. Hedhli N, Lizano P, Hong C, Fritzky LF, Dhar SK, Liu H, Tian Y, Gao S, Madura K, Vatner SF, Depre C. Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload. Am J Physiol Heart Circ Physiol. 2008; 295(4):H1385-93. 440. Vatner SF, Yan L, Ishikawa Y, Vatner DE, Sadoshima J. Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress. Circ J. 2009 Feb;73(2):195-200. 54 441. Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M. Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes. Circ Res. 2009;104(7):879-86. 442. Yan L, Sadoshima J, Vatner DE, Vatner SF. Autophagy in ischemic preconditioning and hibernating myocardium. Autophagy. 2009; 23:5(5). 443. Hu CL*, Chandra R*, Ge H, Pain J, Yan L, Babu G, Depre C, Iwatsubo K, Ishikawa Y, Sadoshima J, Vatner SF, Vatner DE.. Adenylyl Cyclase Type 5 Protein Expression during Cardiac Development and Stress. Am J Physiol Heart Circ Physiol. 2009;297(5):H1776-82. *Equal contribution 444. Park M, Shen Y-T, Gaussin V, Heyndrickx G.R, Bartunek J, Resuello RG, Natividad FF, Kitsis RN, Vatner DE, Vatner SF. Apoptosis Predominates in Non-Myocytes in Heart Failure. Am J Physiol Heart Circ Physiol. 2009; 297(2):H785-91. 445. Gelpi RJ, Gao S, Zhai P, Yan L, Hong C, Danridge LMA, Maejima Y, Donato M, Nagata K, Yokota M, Molkentin JD, Vatner DE, Vatner SF, Sadoshima J. Genetic Inhibition of Calcineurin Induces Diastolic Dysfunction in Mice with Chronic Pressure Overload. Am J Physiol Heart Circ Physiol. 2009 Nov; 297(5):H1814-9. 446. Wu C, Yan L, Depre C, Dhar SK, Shen Y-T, Sadoshima J, Vatner SF, Vatner DE. Cytochrome c Cxidase III as a Mechanism for Apoptosis in Heart Failure following Myocardial Infarction. Am J Physiol Cell Physiol. 2009; 297(4):C928-34. 447. Lieber SC, Kruithof BP, Aubry N, Vatner SF, Gaussin V. Design of a Miniature Tissue Culture System to culture mouse heart valves. Ann Biomed Eng. 2010 Mar; 38(3):674-82. 448. Shen W, Vatner DE, Vatner SF, Ingwall JS. Progressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha. J Mol Cell Cardiol. 2010; 48(4) 591–99. 449. Rameshwar P, Qiu H, Vatner SF. Stem cells in Cardiac Repair in an Inflammatory Microenvironment. Minerva Cardioangiol. 2010; 58(1):127-46. 450. Mann L, Heldman E, Bersudsky Y, Vatner SF, Ishikawa Y, Almog O, Belmaker RH, Agam G. Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect. Bipolar Disord. 2009; 11(8):885-96. 451. Shen Y-T, Malik F.I., Zhao X, Depre C, Dhar S.K.,Abarzúa P, Morgans D.J., Vatner S.F. Improvement of Cardiac Function by a Cardiac Myosin Activator in Conscious Dogs with Systolic Heart Failure. Circ Heart Fail. 2010; 3(4): 522-27. 452. Guellich A, Gao S, Hong C, Yan L, Wagner TE, Dhar SK, Ghaleh B, Hittinger L, Iwatsubo K, Ishikawa Y, Vatner SF, Vatner DE. Effects of Cardiac Overexpression of Type 6 Adenylyl Cyclase Affects on the Response to Chronic Pressure Overload. Am J Physiol Heart Circ Physiol. 2010; 299:H707-H712. 55 453. Depre C, Park JY, Shen Y-T, Zhao X, Qiu H, Yan L, Tian B, Vatner SF, Vatner DE. Molecular Mechanisms Mediating Preconditioning Following Chronic Ischemia Differ from those in Classical Second Window. Am J Physiol Heart Circ Physiol. 2010; 299: H752–H762. 454. Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF. Modulation of Beta-Adrenergic Signaling in Heart Failure and Longevity: Targeting Adenylyl Cyclase Type 5. Heart Fail Rev. 2010; 15(5):495-512. 455. Qiu H, Zhu Y, Sun Z, Trzeciakowski JP, Ganser M, Depre C, Resuello RG, Natividad FF, Hunter WC, Genin GM, Elson EL, Vatner DE, Meininger GA, Vatner SF. Vascular Smooth Muscle Cell Stiffness as a Mechanism for Increased Aortic Stiffness with Aging. Circ Res. 2010; 107(5):615-9. 456. Ho D, Zhao X, Gao S, Hong C, Vatner DE, Vatner SF. Heart Rate Monitoring in Mice. Current Protocols in Mouse Biology. 2011. 1:123-139. 457. Zhao X, Ho D, Gao S, Hong C, Vatner DE, Vatner SF. Arterial Pressure Monitoring in Mice. Current Protocols in Mouse Biology. 2011. 1:105-122. 458. Gao S, Ho D, Vatner DE, Vatner SF. Echocardiography in Mice. Current Protocols in Mouse Biology. 2011. 1:71-83. 459. Malik FI, Hartman JJ, Elias KA, Morgan BP, Hector R, Brejc K., Anderson RL, Sueoaka, SH, Lee KH, Finer JT, Sakowicz R, Baliga R, Cox DR, Gerard M, Godinez G, Kawas R, Kraynack E, Lenzi D, Lu PP, Muci A, Niu C, Qian X, Pierce DW, Pokrovskii M, Suehiro I, Sylvester S, Tochimoto T, Valdez C, Wang W, Katori T, Kass DA, Shen Y-T, Vatner SF, Morgans DJ. Cardiac Myosin Activation: A Potential Therspeutic Approach for Systolic Heart Failure. Science. 2011;331(6023):1439-43. 460. Gelpi RJ, Park M, Gao S, Dhar S, Vatner DE, Vatner SF. Apoptosis in Severe, Compensated Pressure Overload Predominates in Non-myocytes and is Related to the Hypertrophy but not Function. Am J Physiol Heart Circ Physiol. 2011;300(3):H1062-8. 461. Chen L, Lizano P, Zhao X, Sui X, Dhar SK, Shen Y-T, Vatner DE, Vatner SF and Depre C. Pre-emptive Conditioning of the Swine Heart by H11 Kinase/Hsp22 Provides Nitric OxideDependent Cardiac Protection. Am J Physiol Heart Circ Physiol. 2011;300(4):H1303-10. 462. Qiu H, Lizano P, Laure L, Sui X, Rashed E, Park J, Hong C, Gao S, Holle E, Morin D, Dhar S, Wagner T, Berdeaux A, Tian B, Vatner SF, Depre C. H11 Kinase/Hsp22 Promotes both Nuclear and Mitochondrial Functions of STAT3 in Response to Cardiac Overload. Circ. 2011; 124(4):406-15. 463. De Lorenzo MS, Baljinnyam E, Vatner DE, Abarzúa P, Vatner SF, Rabson AB. Caloric Restriction Reduces Growth of Mammary Tumors and Metastases. Carcinogenesis. 2011; 32(9):1381-7. 56 464. Park JY, Li W, Zheng D, Zhai P, Zhao Y, Matsuda T, Vatner SF, Sadoshima J, Tian B. Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules. PLoS Genetics. 2011; 6(7): e22391 465. Zhao X, Ho D, Abarzúa P, Dhar SK, Morgans D, Malik FI, Vatner SF. Inhibition of Smooth Muscle Myosin as a Novel Therapeutic Target for Hypertension. J Pharmacol Exp Ther. 2011 Oct;339(1):307-12. 466. Kudej RK, Fasano M, Zhao X, Lopaschuk GD, Fischer SK, Vatner DE, Vatner SF, Lewandowski ED. Second Window of Preconditioning Normalizes Palmitate Use for Oxidation and Improves Function during Low Flow Ischemia. Cardiovasc Res. 2011 Dec 1;92(3):394-400. 467. Banke NH, Yan L, Pound KM, Dhar S, Reinhardt H, De Lorenzo MS, Vatner SF, Lewandowski ED. Sexual Dimorphism in Cardiac Triacylglyceride Dynamics in Mice on Long Term Caloric Restriction. J Mol Cell Cardiol. In Press. 468. Xin Zhao, David Ho, Lin Yan, Jiyeon Park, Hui Ge, Siiri Ilsmaa, Bin Tian, Dorothy E. Vatner, Robert Graham, Stephen F. Vatner Cardioprotection in Transgenic Rats with Cardiac Overexpression of α1A Adrenergic Receptors. Am J Physiol Heart Circ Physiol. In Press. 469. David Ho, Li Chen, Xin Zhao, Dorothy E. Vatner, David J. Morgans, Fady I. Malik, Stephen F. Vatner, You-Tang Shen. Smooth Muscle Myosin Inhibition; a Novel Therapeutic Approach for Pulmonary Hypertension. PloS One. In Press. 57
