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Lung Cancer Diagnosis and Treatment Odessa National Medical University Grubnik V.V., Polyak S. D. Lung anatomy Lung anatomy Anatomical differences in the left and right lung Various types of lung cancer • Squamous cell lung cancer: commonest type in males, central origin, manifests early •Adenocarcinoma: commonest type in females, peripheral origin, manifests late •Large cell lung cancer: least common type, peripheral origin •Small cell lung cancer: most aggressive type, central origin, spreads quickly Who is at risk? • Patients that are former (or current) smokers with COPD/Emphysema • Patients with prior lung, esophageal, head/neck cancers • Patients with pulmonary fibrosis • Patients with pulmonary asbestosis The Lung and Thorax Exam Chest X-ray Interpretation 5 Steps to Chest X-ray Interpretation: • Assess lung expansion • Assess the pleura • Look for infiltrates • Look at the mediastinum • Assess the abdomen Chest X-ray Interpretation Details (D) •Patient name, age / DOB, sex •Type of film – PA or AP, erect or supine, correct L/R marker, inspiratory/expiratory series •Date and time of study Chest X-ray Interpretation RIPE (Assessing The Image Quality) (R) •Rotation – medial clavicle ends equidistant from spinous process •Inspiration – 5-6 anterior ribs in MCL or 8-10 posterior ribs above diaphragm, poor inspiration?, hyperexpanded? •Picture – straight vs oblique, entire lung fields, scapulae outside lung fields, angulation (ie ’tilt’ in vertical plane) •Exposure (Penetration) – IV disc spaces, spinous processes to ~T4, L) hemidiaphragm visible through cardiac shadow. Chest X-ray Interpretation Soft Tissues And Bones (S) •Ribs, sternum, spine, clavicles – symmetry, fractures, dislocations, lytic lesions, density •Soft tissues – looking for symmetry, swelling, loss of tissue planes, subcutaneous air, masses •Breast shadows •Calcification – great vessels, carotids Chest X-ray Interpretation Airway & Mediastinum (A) •Trachea – central or slightly to right lung as crosses aortic arch •Paratracheal/mediastinal masses or adenopathy •Carina & RMB/LMB •Mediastinal width <8cm on PA film •Aortic knob •Hilum – T6-7 IV disc level, left hilum is usually higher (2cm) and squarer than the V-shaped right hilum. •Check vessels, calcification. Chest X-ray Interpretation Breathing (B) •Lung fields – Vascularity – to ~2cm of pleural surface (~3cm in apices), vessels in bases > apices – Pneumothorax – don’t forget apices – Lung field outlines – abnormal opacity/lucency, atelectasis, collapse, consolidation, bullae – Horizontal fissure on Right Lung – Pulmonary infiltrates – interstitial vs alveolar pattern – Coin lesions – Cavitary lesions •Pleura – Pleural reflections – Pleural thickening Chest X-ray Interpretation Circulation (C) •Heart position –⅔ to left, ⅓ to right •Heart size – measure cardiothoracic ratio on PA film (normal <0.5) •Heart borders – R) border is R) atrium, L) border is L) ventricle & atrium •Heart shape •Aortic stripe Chest X-ray Interpretation Diaphragm (D) •Hemidiaphragm levels – Right Lung higher than Left Lung (~2.5cm / 1 intercostal space) •Diaphragm shape/contour •Cardiophrenic and costophrenic angles – clear and sharp •Gastric bubble / colonic air •Subdiaphragmatic air (pneumoperitoneum) Chest X-ray Interpretation Extras (E) •ETT, CVP line, NG tube, PA catheters, ECG electrodes, PICC line, chest tube •PPM, AIDC, metalwork CT scan - Lung cancer New methods AutoFluorscence bronchoscopy (lung imaging fluorescence endoscopy LIFE) Flexible video bronchoscopy (FVB) and Lung imaging fluorescence endoscopy (LIFE) a) and d) show normal appearance with flexible video bronchoscopy (FVB) and abnormal lesion with lung imaging fluorescence endoscopy (LIFE), respectively, at the same site. b) and e) show abnormal appearance at FVB and suspicious lesion at LIFE, respectively, at the same site. c) and f) show suspicious lesions at both FVB and LIFE, respectively, at the same site. New methods Transbronchial Needle Biopsy (WANG) Specimen: Transbronchial fine needle aspiration biopsy is performed during the bro nchoscopic procedure to sample endobronchial or peribronchial lesions and peritracheal or peribronchial lymph nodes, usually for evaluation of malignancy: Transbronchial Needle Biopsy (WANG) Wang needle biopsy should be done before other diagnostic procedures, such as performing exfoliative cytologic studies or bronchial biopsy to minimize contamination of the needle aspirate with blood and mechanically exfoliated cells Make direct smears from the WANG needle biopsy at the procedure and fix in 95% alcohol (Pap fixative). At least 2 direct smears are required from each site sampled. The needle itself must never be submitted to the laboratory. Fresh specimen (or the syringe recapped with the needle removed) may be refrigerated and submitted if transport time to the laboratory will be less than 4 hours. If transport to the laboratory will be less than 4 hours a physiologic transport medium may be used. Refrigerate needle rinses in transport medium until sent to the lab. Transbronchial Needle Biopsy (WANG) New methods ELECTROMAGNETIC NAVIGATION BRONCHOSCOPY Description: Electromagnetic Navigation Bronchoscopy® (ENB)™ extends the reach the bronchoscope to regions deep within the lung enabling physicians to locate small lung lesions for diagnostic testing and potential treatment. The system uses natural airway access, and implements proprietary software and electromagnetic technology. Benefits: ENB minimizes the need for more invasive, surgical procedures to access lung lesions in the distant regions of the lung. These procedures may require an inpatient hospital stay or cause complications such as collapsed lung (pneumothorax). ENB also provides the ability to detect lung disease and lung cancer earlier, even before symptoms are evident, enhancing treatment options for patients. ELECTROMAGNETIC NAVIGATION BRONCHOSCOPY Algorithm of management of lung cancer Stage 0 – II Central Tumor doesn't invade lobar bronchus Tumor invades lobar of principle bronchi Lobectomy (pre- or posoperative radiation or chemotherapy is possible) Pulmonectomy (pre- or posoperative radiation or chemotherapy is possible) Algorithm of management of lung cancer Stage 0 – II Peripheral Tumor is limited to One lobe Tumor spreads into adjacent lobe Lobectomy (pre- or posoperative radiation or chemotherapy is possible) Pulmonectomy (pre- or posoperative radiation or chemotherapy is possible) Algorithm of management of lung cancer Stage III a Non-small cell carcinoma Patient fit for common anesthesia Small cell Carcinoma Patient doesn’t fit for common anesthesia Preoperative radiation with further pulmonectomy (including extended /lymphadenectomy/ or combined/ resection of adjacent structures/) Radiation and chemotherapy Algorithm of management of lung cancer Stage III b -IV Uncomplicated Radiation and chemotherapy Complicated by obstruction of major bronch Laser reconalization with further radiation and chemotherapy Treatment Treatment Surgical treatment Thoracoscopic Right Upper Lobectomy Surgical treatment Thoracoscopic Right Lower Lobectomy Surgical treatment Pulmonary Left Upper Lobectomy for Lung Cancer Treatment