Survey
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
Download PTEN
Document related concepts
no text concepts found
Transcript
PTEN Multifunctional Tumor Suppressor PTEN crystal structure contains a phosphatase and C2 domain Lumb, C. N., & Sansom, M. S. (2013). Defining the Membrane-Associated State of the PTEN Tumor Suppressor Protein. Biophysical Journal, 104(3), 613-621. PTEN binds PIP3, a phospholipid substrate Lumb, C. N., & Sansom, M. S. (2013). Defining the Membrane-Associated State of the PTEN Tumor Suppressor Protein. Biophysical Journal, 104(3), 613-621. PTEN opposes PI3 Kinase to keep PIP3 levels low J. Clin Oncol. July 15, 2004 vol. 22 no. 14 2954-2963. DOI: 10.1200/JCO.2004.02.141 PTEN regulates the AKT pathway which has multiple biological roles Backman, S., Stambolic, V., & Mak, T. (2002). PTEN function in mammalian cell size regulation. Current opinion in neurobiology, 12(5), 516. Mice PTEN null ES cells grow excessively with disorganized patterning Cristofano, A. D., Pesce, B., Cordon-Cardo, C., & Pandolfi, P. P. (1998). Pten is essential for embryonic development and tumour suppression. Nature genetics, 19(4), 348-355. Cancers with PTEN mutations occur in a dosage dependent manner Cristofano, A. D., Pesce, B., Cordon-Cardo, C., & Pandolfi, P. P. (1998). Pten is essential for embryonic development and tumour suppression. Nature genetics, 19(4), 348-355. http://www.nature.com/ng/journal/v42/n5/images_article/ng.556-F3.jpg PTEN is one of the most frequently mutated genes in human cancers Eng, C. (2003). PTEN: one gene, many syndromes. Human mutation, 22(3), 183-198. Cowden Syndrome : hamartomas, benign tumors due to germline mutations often in PTEN phosphatase catalytic site http://www.hinsdale86.org/staff/kgabric/Disease10/Cowden%20Syndrome/Index1.htm Cowden Syndrome patients display an increased predisposition for cancer
Related documents