Download Slide Show: AACR Annual Meeting 2014

Slide Show: AACR Annual Meeting 2014
Published on Physicians Practice (http://www.physicianspractice.com)
Slide Show: AACR Annual Meeting 2014
Conference Report [1] | April 22, 2014
By Anna Azvolinsky [2]
This slide show features some of the highlights from the 105th Annual Meeting of the American
Association for Cancer Research (AACR).
Slide 1: Subpopulation of Breast Cancer Patients Most Likely to Respond to Palbociclib. Image source:
Richard S. Finn, MD, Associate Professor of Medicine, University of California, Los Angeles.
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Slide Show: AACR Annual Meeting 2014
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Slide 2: Novel Immunotherapy Shows Activity in Advanced Melanoma. Image source: Mark Middleton,
MD, PhD, Professor, Experimental Cancer Medicine, University of Oxford, United Kingdom;
Immunocore Limited, Oxfordshire.
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Slide Show: AACR Annual Meeting 2014
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Slide 3: Antibody-Drug Conjugate Active in Three Types of Melanoma. Image source: Jeffrey Infante,
MD, Director, Drug Development Program, Sarah Cannon Research Institute, Nashville, Tennessee.
Slide 4: Blocker of Epigenetic Activity Exhibits Efficacy in AML and Other Hematologic Malignancies.
Image source: Esteban Cvitkovic, MD, Professor of Oncology; Founder and CEO, OncoEthix.
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Slide Show: AACR Annual Meeting 2014
Published on Physicians Practice (http://www.physicianspractice.com)
Slide 5: FGFR Inhibitor Demonstrates Activity Against Solid Tumors. Image source: Lecia V. Sequist,
MD, MPH, Associate Professor of Medicine, Harvard Medical School, Massachusetts General Hospital,
Boston.
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Slide Show: AACR Annual Meeting 2014
Published on Physicians Practice (http://www.physicianspractice.com)
Slide 6: Liver Cancer Risk Reduced With Greater Coffee Consumption. Image source: V. Wendy
Setiawan, PhD, Assistant Professor, Department of Preventive Medicine, USC Norris Comprehensive
Cancer Center, Los Angeles.
Slide 1: Subpopulation of Breast Cancer Patients Most Likely to Respond
to Palbociclib
Palbociclib in combination with letrozole nearly doubled progression-free survival compared with
letrozole alone in first-line metastatic hormone receptor–positive, HER2-negative postmenopausal
breast cancer patients. Progression-free survival was 20.2 months in the palbociclib arm compared
with 10.2 months in the letrozole alone arm. The PALOMA-2 phase II trial randomized 165 patients
1:1 to two treatment arms. Progression-free survival was the primary endpoint of the study. Patients
in the combination treatment arm had a 51% reduction in the risk of disease progression compared
to patients treated with letrozole alone. Preliminary median overall survival was 37.5 months in the
combination arm compared with 33 months in the control arm, not a statistically significant
difference.[1]
Slide 2: Novel Immunotherapy Shows Activity in Advanced Melanoma
A novel two-component immunotherapy was shown to have efficacy and to be tolerable in a phase I
trial of 31 advanced melanoma patients. Thus far, four patients had confirmed partial responses and
multiple other patients had lesser responses that have not met the RECIST criteria for a partial
response. Two of the partial responses have stayed on the therapies for more than 9 months, and
one patient has had stable disease for more than 10 months. Dose-limiting toxicities included
high-grade hypotension, rash, fever, and edema.[2]
Slide 3: Antibody-Drug Conjugate Active in Three Types of Melanoma
The antibody-drug conjugate, DEDN6526A was shown to be safe and resulted in encouraging
responses in cutaneous, mucosal, and ocular melanoma. Twelve of the nineteen patients in the
phase I trial benefited from treatment, including four partial responses. Eight patients had stable
disease. The agent consists of a cytotoxic chemotherapy molecule linked to an antibody against the
endothelin B receptor (ETBR). Elevated levels of ETBR are present on the surface of about half of
melanoma tumors.[3]
Slide 4: Blocker of Epigenetic Activity Exhibits Efficacy in AML and Other
Hematologic Malignancies
In a phase I dose escalation trial, 7 of 38 patients with hematologic malignancies responded to
treatment with OTX015, a small-molecule inhibitor of the BET-bromodomain proteins BRD2, 3, and 4.
BET-bromodomain proteins create epigenetic modifications on genes that can turn gene expression
on or off. Responses were seen in four acute myeloid leukemia (AML) patients, a patient with
lymphoplasmacytic lymphoma, one patient with follicular lymphoma, and a patient with diffuse large
B-cell lymphoma. Two of the AML patients had complete responses. Three of the seven patients are
continuing to receive treatment.[4]
Slide 5: FGFR Inhibitor Demonstrates Activity Against Solid Tumors
In a first-in-human trial, previously treated patients whose tumors harbored FGFR genetic alterations
had tumor regressions upon treatment with BGJ398, an oral pan-FGFR inhibitor. Four patients with
urothelial cell carcinoma had tumor reductions from 27% to 48%. A patient with FGFR1-amplified
squamous cell carcinoma lung cancer had a complete response and another lung cancer patient had
a partial response. A patient with cholangiocarcinoma and FGFR1-amplified breast cancer also had
tumor regression. BGJ398 was shown to have a tolerable safety profile.[5]
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Slide Show: AACR Annual Meeting 2014
Published on Physicians Practice (http://www.physicianspractice.com)
Slide 6: Liver Cancer Risk Reduced With Greater Coffee Consumption
Greater coffee consumption results in lower risk of developing hepatocellular carcinoma, the most
common type of liver cancer. Compared to those who consumed fewer than six cups of coffee per
week, those who drank one to three cups per day had a 29% lower risk of developing hepatocellular
carcinoma. Those who drank four or more cups of coffee per day had their risk reduced by 42%
compared with those who drank six or fewer cups per week. The prospective study included almost
180,000 men and women of different ethnic backgrounds. The coffee consumption and liver cancer
link was independent of age, gender, ethnicity, body mass index, smoking or alcohol consumption,
diabetes, as well as hepatitis infection.[6]
References:
1. Finn RS, Crown JP, Lang I, et al. Final results of a randomized phase II study of PD 0332991, a
cyclin-dependent kinase (CDK)-4/6 inhibitor, in combination with letrozole vs letrozole alone for
first-line treatment of ER+/HER2-advanced breast cancer (PALOMA-1; TRIO-18). American
Association for Cancer Research Annual Meeting 2014; April 5–9, 2014; San Diego. Abstr CT101.
2. Middleton M, Evans J, Steven N, et al. A Phase I study of IMCgp100: durable responses with a
novel first-in-class immunotherapy for advanced melanoma. American Association for Cancer
Research Annual Meeting 2014; April 5–9, 2014; San Diego. Abstr CT329.
3. Infante JR, Sandhu SK, McNeil CM, et al. A first-in-human phase I study of the safety and
pharmacokinetic (PK) activity of DEDN6526A, an anti-endothelin B receptor (ETBR) antibody-drug
conjugate (ADC), in patients with metastatic or unresectable melanoma. American Association for
Cancer Research Annual Meeting 2014; April 5–9, 2014; San Diego. Abstr CT233.
4. Herait PE, Berthon C, Thieblemont C, et al. BET-bromodomain inhibitor OTX015 shows clinically
meaningful activity at nontoxic doses: interim results of an ongoing phase I trial in hematologic
malignancies. American Association for Cancer Research Annual Meeting 2014; April 5–9, 2014; San
Diego. Abstr CT231.
5. Sequist LV, Cassier P, Varga A, et al. Phase I study of BGJ398, a selective pan-FGFR inhibitor in
genetically preselected advanced solid tumors. American Association for Cancer Research Annual
Meeting 2014; April 5–9, 2014; San Diego. Abstr CT326.
6. Setiawan VW, Wilkens LR, Hernandez BY, et al. Coffee intake reduces hepatocellular carcinoma
risk: The Multiethnic Cohort. American Association for Cancer Research Annual Meeting 2014; April
5–9, 2014; San Diego. Abstr LB-281.
Source URL:
http://www.physicianspractice.com/conference-report/slide-show-aacr-annual-meeting-2014
Links:
[1] http://www.physicianspractice.com/conference-report
[2] http://www.physicianspractice.com/authors/anna-azvolinsky
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