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Cairo Dental Journal (24) Number (I), 85:97 January, 2008 Soft Tissue Profile Changes Associated With Treatment of Anterior Open Bite Amany Hassan Abdel Ghany1 1. Assistant Professor, Orthodontic Department, Faculty of Oral and Dental Medicine, Cairo University. .. Abstract I n this study the soft tissue profile changes following treatment of anterior dentoalveolar open bite were evaluated. Fifteen females with age ranging from 17-20 years were selected based on clinical and cephalometric identification of dentoalveolar or mild skeletal anterior open bite. Treatment was accomplished by a fixed appliance using a reverse counter arch wire together with a head gear and a fixed tongue guard. Lateral cehphalograms were taken at the onset of treatment and after an achievement of a positive overbite of 1 to 2 mm. The results of this study demonstrated a significant increase in the soft tissue upper anterior facial height, while the soft tissue lower anterior facial height was controlled leading to an improvement in the soft tissue upper to lower facial height ratio. A significant decrease was evident in the interlabial gap. Moreover, a significant increase was found in upper and lower lip lengths, upper lip thickness and nasolabial angle. .. INTRODUCTION because of interaction of many etiologic factors, both Facial aesthetics are an important social concern in current society.1 Orthodontic patients and their parents believe that well-aligned teeth are important for overall facial appearance.2 They expect that orthodontic treatment will improve their dentofacial, esthetics3 and consequently their social acceptance.4 Therefore, over hereditary and environmental in nature.8-10 When there is only dental and dentoalveolar involvement, there is predominance of environmental causes such as thumb or dummy sucking habits, mouth breathing, and tongue or lip thrusting in addition to some local factors such as tooth ankylosis and eruption disturbances. However, the the last decades orthodontists focus their treatment plans larger the skeletal involvement, the more the aetiology more and more on improvement of facial esthetics. is related to genetic factors, which are restricted to an Facial disharmonies in the vertical plane, including the unfavorable growth tendency. anterior open bite, are great challenges to orthodontists5 To achieve a successful and stable result, however, because of the remarkable difficulties of treatment and it is essential to establish a correct diagnosis, identify the instability of the correction. the cause, locate the deformity and select an appropriate 6,7 Open bite develops (86) C.D.J. Vol. 24. No. (I) Amany Hassan Abdel Ghany method of treatment. Various therapeutic modalities crib associated with high-pull chin cup therapy in children have been proposed for the treatment of anterior open with an Angle Class I anterior open bite malocclusion bite malocclusion. These treatment modalities may start and found that hard tissue changes did not imply any from self-correction, removable, functional and fixed soft tissue changes. Vertical lip changes resulting from appliances to surgical intervention in severe skeletal cases. maxillary incisor retraction by orthodontic treatment were Conventional orthodontic treatment has been directed at evaluated by Jacobs38 who found no correlation between 11 inhibiting the vertical maxillary growth with headgear, the amount of maxillary incisor retraction and the vertical retarding the mandibular growth with chincups,12 or closure of the interlabial gap. Nor did he find a significant extruding anterior teeth with vertical elastics.13-15 correlation between the vertical decrease in the distance Among the methods available for the treatment of open bite also is with fixed appliance using multilooped between labrale superius and labrale inferius and the relative upper-incisor extrusion or intrusion occurring arches16-19 (MEAW therapy) or extrusion arch wires.20,21 during incisor retraction. Abdel Kader39 assessed changes The goals of these techniques include proper vertical in vertical lip height relative to changes in dental height, positioning of maxillary incisors, compatible cant of overjet, and overbite and noted insignificant increase the upper and lower occlusal planes, and uprighting in Vertical lip height, although overjet of posterior teeth. And since oral habits are frequently measurements showed significant reductions during the involved in the development of or the maintenance of treatment. There appear to be conflicting reports on the anterior open bite during growth.20-24 Tongue cribs has response of the soft-tissue to changes in the hard tissues. been advocated to allow normal development of the The issue draws the attention of orthodontists as the anterior dentoalveolar region, since it prevents thumb or effect of orthodontic treatment on the face continues to dummy sucking and avoids tongue thrusting. be debated. Therefore it was the purpose of this study 25-29 When developing an orthodontic treatment plan, both the hard and soft tissues should be considered. Successful treatment means that objective treatment to assess the soft tissue profile changes secondary to treatment of anterior dentoalveolar open bite with a fixed appliance using upper reverse curve of spee arch arch goals and subjective patient desires were met. wire in a group of adult Egyptian females. Therefore, improvement in facial appearance should be .. 30 considered in the treatment plan.31 Soft tissue changes and overbite Subjects and Methods following orthodontic treatment are usually regarded The sample of the present study consisted of 15 as secondary to underlying hard tissues alterations.32-35 Egyptian adult females. With an age range from 18-20 Different opinions exist as to whether there is a definite years. They were selected from the out patient clinic of correlation between hard tissue change and soft tissue change.30,36 Orthodontic Department, Faculty of Oral and Dental Medicine, Cairo University. All of the cases presented Soft tissue changes after treatment of skeletal open with anterior open bite greater than 1.0 mm. Skeletal bite was evaluated by Taher37 using maxillary removable relationship in the sagittal direction was Class I, with posterior bite plane combined with extraoral vertical pull normal or slightly increased anterior vertical facial height. chincup, a significant improvement in soft tissue profile The molar relationship was Angle Class I. All patients was observed, such improvement was demonstrated by were having oral habits before treatment. Extraction the significant change of the soft tissue upper to lower cases were excluded from this study to eliminate any facial height ratio, the soft tissue angle of convexity and effects that may be caused by the extraction treatment. lower lip length. However, Torres et al studied soft tissue No history of other craniofacial anomalies, and had not changes produced by a removable appliance with a palatal undergone prior orthodontic treatment. 8 (87) Soft Tissue Profile Changes Associated Treatment Procedure A preajusted edgewise appliance (0.022 inch slot size) was used with a triple tube bands for the upper molars stabilizing wire of size 0.016 × 0.022 inch stainless steel was placed bilaterally, and the anterior segment was tied by a ligature wire. and with single tube for the lower molars. For every Extrusion of the upper anterior segment proceeded subject a headgear was adjusted and the patients were with ready made reverse counter arch 0.016 × 0.022 inch instructed to wear it at least 14 hours/day. The head gear Nickel Titanium (Fig. 1 B). The legs of the wire was was used to reinforce anchorage of the posterior segment inserted in the auxiliary tubes of the maxillary molar concurrently with a transpalatal bar. A fixed tongue guard bands. The wire bypassed the premolars and was tied in the was fabricated for each subject and soldered to upper anterior bracket slots. After bite closure detailing of tooth first molar band (fig. 1 A). Treatment was initiated with position and the finishing procedures were accomplished. alignment and leveling of the maxillary and mandibular Average treatment time with fixed appliances was 16 teeth. After 3 months of initial alignment, extrusion of months. Each subject was instructed to perform lip seal upper anterior segment was done using a segmented exercises by holding a wooden blade between upper and technique, in the posterior anchorage segment a buccal lower lips during different activities of the day. Fig.1: A. Soldered transpalatal arch with tongue guard. B. Reverse curve of spee arch wire before insertion. Cephalometric analysis Measurements obtained Cephalometric evaluation of the treatment changes Five dentoalveolar and twelve soft tissue angular and was conducted on lateral cephalograms taken at the linear measurements were measured as follows (Figs. 3,4): beginning and after an overbite of 1 to 2 mm was obtained. The mean period between the initial and follow 1- Dentoalveolar measurements up radiographs was 6.5 months. The lateral cephalograms Upper incisor Inclination were obtained in centric occlusion, with the lips in a relaxed and passive position. The radiographs were taken using the same cephalostat with standardized settings and traced by one investigator using a 0.3-mm pointed pencil. Different cephalometric landmarks are shown in Fig. (2). (U1/PP): maxillary incisor long axis to palatal plane angle. Lower incisor Inclination (L1/MP): mandibular incisor long axis to mandibular plane angle. Interincisal angle (U1/L1): the angle formed by the long axis of the upper and lower incisors. (88) C.D.J. Vol. 24. No. (I) Amany Hassan Abdel Ghany Incisor overbite (OB): the distance between incisal edges of maxillary and mandibular central incisors, perpendicular to occlusal plane. Incisor overjet (OJ): the distance between incisal edges of maxillary and mandibular central incisors, parallel to occlusal plane. 2- Soft Tissue measurements Soft tissue upper anterior facial height (UAFH) : the distance from soft tissue Nasion (N) to subnasale (Sn). Soft tissue lower anterior facial height (LAFU): the distance from (Sn) to soft tissue Menton (M). Soft tissue upper anterior facial height / Soft tissue lower anterior facial height ratio (UAFH/LAFH). Upper lip length (ULL): the vertical distance between subnasale (Sn) and stomion superious (Stms). Lower lip length (LLL): the vertical distance between stomion inferious (Stmi) and soft tissue gnathion(Gn). Fig. (2) Dentoskeletal and soft tissue cephalometric landmarks. S, sella turcica; N, nasion; ANS, anterior nasal spine; A, subspinale; B, supramentale; Me, menton; U1, maxillary central incisor edge; L1, mandibular central incisor edge, N’ soft tissue nasion; Sn, subnasale; Stms, Stomion Superious; Ls, Labrale Superious; Stmi, Stomion Inferious; Li, Labrale Inferious; Pg’ , Soft tissue Pogonion; Gn’, soft tissue gnathion; Me’, soft tissue menton. Upper lip thikness (ULT): the linear distance from the most facial point of the maxillary incisor to the laberale superious. Lower lip thicknes (LLT)s: the linear distance from the labial surface of the most protrusive mandibular incisor to labrale inferius. Position of the upper lip (UL-E Line): the distance between labarale superious and the esthetic line (line extended between Pronasale; tip of nose and soft tissue pogonion). Position of the lower lip (LL-E Line): the distance between labarale inferius and the esthetic line. Interlabial gap (ILG): the vertical distance between stomion superious. and stomion inferious. Fig. 3: Soft tissue profile measurements: 1, UAFH; 2, LAFH; 3 , ILG; 4, ULL; 5, LLL; 6, ULT; 7, LLT; 8, E-Line Statistical Analysis The collected data was statistically analyzed. The mean values of different variables were calculated and Nasolabial angle (NLA): the angle formed between a tangent to the lower border of the nose and labrale superius. the significance of difference for treatment changes was Mentolabial angle (MLA): the anterior angle formed between labrale inferious (Li) and soft-tissue pogonion (Pog) difference/mean before treatment x 100. A correlation computed using Wilcoxon signed rank test. Percentage of treatment changes was calculated by dividing mean analysis between each pair of variables used in this study was also performed. (89) Soft Tissue Profile Changes Associated .. RESULTS Clinical observation: Figs (5A & B) demonstrated the obvious closure of open bite after the six months study period. Subsequently, an improvement in soft tissue was observed as illustrated in fig.(5B). Fig. (4) Dentoalveolar and soft tissue Angular measurements:1,U1/PP; 2, L1/MP; 3, U1/L1; 4, NLA; 5, MLA (A) (B) Fig. (5) A. Pretreatment photographs showing open bite and subsequent facial appearance. B. Posttreatment photographs showing closure of open bite and subsequent facial appearance. (90) C.D.J. Vol. 24. No. (I) Amany Hassan Abdel Ghany Statistical results: Soft Tissue Changes: A significant increase (P<0.05) Descriptive statistics; means and standard deviations for the pretreatment and posttreatment parameters are shown in table I. The significance of difference for treatment changes over the six months observation period is computed using Wilcoxon signed rank test (Table I). Dental Changes: a significant improvement in anterior was observed in upper facial height as shown by the 3mm increase in UAFH. However, an insignificant increase was observed in the lower anterior facial heights LAFH (0.6mm) respectively. A significant improvement in the interlabial gap was observed by the significant decrease in ILG (4mm) (P<0.001). A significant increase in lengths of both upper lip (2.07mm) and lower lip (3.87mm) open bite was observed by the significant increase in the (P<0.05) were found. The thickness of the upper lip was overbite (5.13 mm) (P < .001), and the significant decrease significantly increased (1.28) (P<0.001) however, no of overjet (3.80mm) (P < .001). The Upper incisors were significant differences were found in LLL, UL- E line uprighted as shown by the decrease in U1/PP(-11.47°) and LL- E line. The nasolabial angle was significantly (P<.001). The inter-incisal angle was improved as shown increased (9.20°) (P<0.01) while no significant increase by the significant increase in U1/L1(15.4°) (P < .001). was found in the mentolabial angle. Table (I) Descriptive statistics and significance of dentoalveolar and soft tissue treatment changes. Variables Pretreatment Mean SD Posttreatment Mean SD Treatment changes P value Dentoalveolar measurements U1/PP (º) 122.40 7.62 110.93 11.16 -11.47 0.001* L1/MP (º) 95.67 5.26 94.13 5.35 -1.53 0.15 U1/L1 (º) 108.33 11.34 123.80 10.6 15.4 0.001* Over bite (mm) -3.00 2.10 2.13 0.63 5.13 0.001* Over jet (mm) 5.00 2.73 1.20 0.86 3.80 0.001* Soft tissue measurements UAFH (mm) 55.00 5.90 58.00 6.76 3 0.05* LAFH (mm) 69.73 4.39 70.33 3.87 0.6 0.142 UAFU/LAFH( %) 0.78 0.1 0.82 0.1 0.04 0.08 ILG (mm) -4.07 4.51 -0.07 1.03 4 0.002* ULL (mm) 22.67 3.57 24.73 3.05 2.07 0.001* LLL (mm) 44.67 4.16 48.53 4.68 3.87 0.037* ULT (mm) 9.33 1.54 10.60 1.84 1.27 0.008* LLT (mm) 15.33 1.44 14.73 1.03 -0.60 0.25 UL- E Line (mm) 0.20 3.14 -0.40 2.87 -0.60 0.123 LL- E Line (mm) 4.07 3.82 4.00 4.15 0.70 0.83 NLA (º) 95.13 13.71 104.33 11.99 9.20 0.009* MLA (º) 124.47 18.67 130.87 17.64 6.40 0.083 (91) Soft Tissue Profile Changes Associated Table (II) Percentage of treatment change for soft tissue parameters. Soft tissue measurements Mean difference SD Percent changes % UAFH 3 5.60 5.5 LAFH 0.6 1.62 0.9 UAFH/LAFH 0.04 8.97 6.1 ILG ULL 4 5.07 -77.7 2.07 1.58 9.9 LLL 3.87 5.82 9.3 ULT 1.27 1.48 14.9 LLT -0.60 1.68 -3.1 UL- E -0.60 1.59 -19.7 LL- E -0.70 2.18 -10.9 NLA 9.20 11.12 10.8 MLA 6.40 12.51 5.9 Table (III) Correlation between different dentoalveolar and soft tissue parameters. Variables U1/PP L1/MP U1/L1 Over bite Over jet r p r p r p r p R p ILG 0.03 0.90 0.53 0.06 -0.62 0.01* 0.38 0.15 0.41 0.12 ULL 0.20 0.47 0.30 0.27 0.38 0.15 0.20 0.47 0.04 0.87 LLL 0.09 0.72 0.12 0.65 0.07 0.79 0.06 0.98 0.07 0.80 ULT 0.33 0.22 0.22 0.41 0.13 0.62 0.19 0.47 0.21 0.44 LLT 0.03 0.90 0.03 0.89 0.02 0.92 0.32 0.24 0.17 0.52 UL- E Line 0.39 0.15 0.26 0.34 0.34 0.21 0.12 0.66 0.11 0.62 LL- E Line 0.10 0.71 0.16 0.56 0.35 0.19 0.04 0.99 0.34 0.21 NLA 0.32 0.23 0.12 0.65 0.27 0.32 0.23 0.40 0.15 0.57 MLA 0.11 0.69 0.07 0.98 0.14 0.61 0.10 0.70 0.21 0.43 — — — — — — ULT LLT UL- E LL- E NLA — — r LLL ULL ILG variables ILG — — — — — — — — -0.48 r — — — — — — — 0.06 p — — — — — — 0.15 0.02 r p — — — — — — 0.57 0.91 LLL — — — — — 0.15 0.35 0.21 r p — — — — — 0.58 0.19 0.44 ULT — — — — 0.09 0.52 0.11 0.19 r — — — — 0.74 0.04* 0.69 0.48 p LLT — — — 0.07 0.29 0.07 0.43 0.12 r — — — 0.79 0.29 0.79 0.10 0.64 p UL- E — — 0.26 0.42 0.16 0.42 0.30 0.07 r p — — 0.34 0.11 0.54 0.11 0.16 0.80 LL- E 0.07 p 0.48 r 0.19 p MLA — 0.54 0.43 0.85 0.31 0.38 — 0.06 0.10 0.85 0.25 0.15 0.45 0.42 0.13 0.12 0.32 0.34 0.09 0.11 0.63 0.65 0.23 0.20 0.74 0.001* 0.56 0.02* 0.47 r NLA Amany Hassan Abdel Ghany — — — — — — — p ULL Table (V) Correlation between different soft tissue parameters. (92) C.D.J. Vol. 24. No. (I) (93) Soft Tissue Profile Changes Associated Table II demonstrate the percentages of treatment history of oral habits. The proposed treatment protocol changes. The highest percentage of positive change aimed to correct the anterior open bite and eliminate the was fond for the upper lip thickness (14.9 %), while the tongue thrusting habit. least positive change was recorded for the lower anterior using a fixed appliance with an extrusion upper arch wire, facial height (0.9 %). The highest percentage of negative together with a head gear and a transpalatal arch with a change was fond for the interlabial gap (-77.7 %), while tongue guard. the least negative change was recorded for the lower lip length (-3.1 %). Treatment was accomplished Dentoalveolar changes at the anterior region of the dental arches are factors that usually lead to correction of Correlation coefficients relating the movement of the hard tissue and subsequent change of the soft tissue are presented in table III. No correlations were found except for the interlabial gap which was found to have a significant correlation with the interincisal angle (r= -0.62) (P<0.01). Correlation coefficients relating different soft tissue variables are presented in table V. The upper lip length was anterior open bite malocclusions.8,42 In the present study, almost all dentoalveolar variables showed statistically significant changes after treatment. Assessment of the results obtained demonstrated a mean closure of 5.13 mm in the anterior open bite, resulting in a mean final overbite of 2.13mm (Table I). The correction of anterior open bite was possibly due to the extrusion and uprighting of the maxillary incisors, as demonstrated by the U1/PP, U1/L1 and overbite variables (Table I). These variables showed found to be significantly correlated to both the nasolabial statistically significant changes during treatment; the angle (r= 0.74) (P<0.001) and the mentolabial angle (r= maxillary incisors showed statistically significant lingual 0.56) (P<0.05) , while the lower lip length was significantly tipping (-11.47º), though not significant, the mandibular correlated with lower lip thickness (r= 0.52) (P<0.05). incisors were slightly uprighted (-1.53 º). .. significant improvement was achieved in the interincisal Discussion angle (15.4º). These changes were also observed by Considering the importance of providing not only a pleasant smile but also a balanced profile, this study involved cephalometric evaluation of the soft tissue profile effects secondary to treatment of anterior open bite in a group of adult Egyptian females. Adult females were specifically chosen (17-20 years old with a mean age of 18.3 years), to exclude the factor of growth since most of the soft tissue measurements in females attain their adult size at 15 years. Because of the complex nature, etiology, and dentofacial pattern Thus a of open bite malocclusion, treatment strategies range from behavior modification most other authors.5,14,43-46 These modifications may be due to fixed appliance treatment mechanics together with normalization of functions by elimination of tongue thrusting habit encouraged by the tongue guard. The effectiveness of tongue guard wear for anterior open-bite closure was demonstrated by various cephalometric and clinical investigations.19,27,29 As for the soft tissue, eleven variables were used in an attempt to understand the possible changes in different aspects of the face, such as upper and lower anterior facial heights, interlabial gap, upper and lower lip lengths, upper and lower lip thickness, upper and lower lip position in relation to E-line and finally naso- and to orthodontic and orthopedic therapy. Pretreatment mentolabial angles (Table I). Assessment of the results cephalometric analysis revealed that all patients were obtained demonstrated a significant increase (4mm) in having dentoalveolar or mild skeletal anterior open bite the soft tissue upper anterior facial height, this was in greater than 1mm. Moreover, all subjects were having a agreement with Taher.37 This improvement is probably (94) Amany Hassan Abdel Ghany C.D.J. Vol. 24. No. (I) due to treatment mechanics applied not due to growth lower lips respectively, for girls between 7-18 years factors since according to Nanda et al.40 and Andersen old. Consequently, the significant changes observed et al. the soft tissue vertical measurements had almost in this study is probably due to treatment strategy and reached their adult size. lip training instead of being related to growth. This 41 Regarding the soft tissue lower anterior facial height, an insignificant increase ( 0.6 mm ) was found. Also this variable exhibited the least positive percentage of treatment change (0.9 % ) as shown in table II. Consequently, though not statistically significant an improvement was observed in the ratio between upper and lower facial heights (UAFH/LAFH) which is expected to worsen if no treatment was encountered as stated by came in accordance with Taher37 who found statistically significant increase in lower lip length after skeletal open bite treatment and also with El-Sayed and El-bokle50 where a significant increase in upper lip length was found to be correlated with reduction in inclination of upper incisors. However, this came in disagreement with Torres et al.8 this may be due to the difference in treatment methodology and in the age of the sample. Mizrahi.47 This may also be attributed to the effect of Concerning lip thickness, a significant increase was the head gear in controlling the extrusion of the upper encountered in upper lip thickness 1.27mm, this increase molars leading to redirecting of the mandible in a counter of lip thickness could related to the lingual inclination of clockwise direction. This was in accordance with Janson the upper incisors as previous studies reported increase et al. were they found a significant correlation between in upper lip thickness after lingual inclination of upper UAFH/LAFH ratio and both maxillary and mandibular incisors.51,52 However, the lower lip thickness showed non molar heights in open bite malocclusions. significant decrease after treatment ( -0.60mm) this may be 48 Concerning the interlabial gap, a significant decrease (-4mm) was observed following treatment. Moreover, the interlabial gap showed the highest negative percentage due insignificant change in the inclination of lower incisors. A significant correlation was found between lower lip length and lower lip thickness (r= 0.52) (Table V). of treatment change (-77.7%) as displayed in table II. Regarding the position of the upper and lower lips This came in agreement with Gehring et al., however, to the esthetic line, no significant change was observed Torres et al. did not find any change in the interlabial in these parameters. This was in agreement with Taher37 gap after open bite treatment. The interlabial gap was and Torres et al.8 where similar results were obtained also found to be correlated with the interincical angle (r indicating that treatment of anterior open bite have no =-0.62) (Table III). The improvement in the interlabial significant effect on such soft tissue parameters. 15 8 gap encountered in this study may be partly due to the lip seal training effect, as Ingervall and Eliasson49 previously found a significant decrease in the interlabial gap after lip training. As for the nasiolabial angle, a significant increase (9.20º) was observed after treatment (Table I). This is almost attributed to improvement of upper incisors inclination as shown by the significant decrease of U1/PP Lip length and thickness are important elements of angle. A significant correlation was observed between the the facial profile. Lip position is affected by the position nasolabial angle and the upper lip length (r= 0.74) (Table and inclination of the maxillary and mandibular incisors V). No significant change was observed in the mentolabial and hence is responsive to orthodontic treatment. As angle, this could be attributed to the insignificant change for the lip lengths, the upper and lower lip lengths in the inclination of the lower incisors. This came in showed statistically significant increase 2.07mm and accordance with Nanda et al.40 where they stated that 3.8mm respectively. Such increase was expressed by uprighting the maxillary and mandibular incisors enlarges Nanda et al.40 to be 1.1mm and 1.5mm in upper and the nasolabial and mentolabial angles. (95) Soft Tissue Profile Changes Associated .. Conclusion and Clinical Implications On the basis of the results drawn from this study, it could be concluded that the upper extrusion arch wire 7. diagnosis and some aspects of treatment. Angle Orthod;61:247260, 1991. 8. Torres F, Almeida R, Almeida M R, Pedrin R, Pedrin F, Henriques J. Anterior open bite treated with a palatal crib and combined with fixed tongue guard in addition to lip high-pull chin cup therapy. A prospective randomized study. seal training exercises, showed clinical effectiveness in Eur J Orthod. 28:610-617, 2006. correcting the dental open bite and in improving the soft tissue profile in dentoalveolar open bite malocclusion. Nielsen H. Vertical malocclusions: etiology, development, 9. Huang GJ, Justus R, Kennedy DB, Kokich VG. Stability of Such improvement was demonstrated by the significant anterior open bite treated with crib therapy. Angle Orthod. changes of; interlabial gap, upper and lower lip lengths, 60:17-26, 1990. upper lip thickness and nasolabial angle. Since correlation coefficients showed no significant correlation between hard- and soft tissue variables. Therefore, it seems that lip response to orthodontic tooth movement might depend on other factors such as pretreatment lip strain or variation in lip structure and thickness. .. 1. References Kiekens R M, Maltha J C, Hof M. A. Kuijpers-Jagtman A. M. 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