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NEUROIMAGING (A) 2009 <207>
Database EMBASE
Accession Number 2009000484
Authors Dalley J.W. Fryer T.D. Aigbirhio F.I. Brichard L. Richards H.K. Hong Y.T. Baron J.-C. Everitt B.J. Robbins
T.W.
Institution
(Dalley, Fryer, Aigbirhio, Brichard, Richards, Hong, Baron, Everitt, Robbins) Behavioural and Clinical Neuroscience
Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, United Kingdom.
(Dalley, Everitt, Robbins) Department of Experimental Psychology, University of Cambridge, Downing Street,
Cambridge, CB2 3EB, United Kingdom.
(Dalley) Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2
2QQ, United Kingdom.
(Fryer, Aigbirhio, Brichard, Hong, Baron) Wolfson Brain Imaging Centre, Department of Clinical Neurosciences,
University of Cambridge, Cambridge, CB2 2QQ, United Kingdom.
(Richards) Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2
2QQ, United Kingdom.
(Baron) Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 2QQ,
United Kingdom.
Country of Publication
United Kingdom
Title
Modelling human drug abuse and addiction with dedicated small animal positron
emission tomography.
Source
Neuropharmacology. 56(SUPPL. 1)(pp 9-17), 2009. Date of Publication: 2009.
Publisher
Elsevier Ltd
Abstract
Drug addiction is a chronically relapsing brain disorder, which causes substantial harm to the
addicted individual and society as a whole. Despite considerable research we still do not
understand why some people appear particularly disposed to drug abuse and addiction, nor
do we understand how frequently co-morbid brain disorders such as depression and
attention-deficit hyperactivity disorder (ADHD) contribute causally to the emergence of
addiction-like behaviour. In recent years positron emission tomography (PET) has come of
age as a translational neuroimaging technique in the study of drug addiction, ADHD and other
psychopathological states in humans. PET provides unparalleled quantitative assessment of
the spatial distribution of radiolabelled molecules in the brain and because it is non-invasive
permits longitudinal assessment of physiological parameters such as binding potential in the
same subject over extended periods of time. However, whilst there are a burgeoning number
of human PET experiments in ADHD and drug addiction there is presently a paucity of PET
imaging studies in animals despite enormous advances in our understanding of the
neurobiology of these disorders based on sophisticated animal models. This article highlights
recent examples of successful cross-species convergence of findings from PET studies in the
context of drug addiction and ADHD and identifies how small animal PET can more effectively
be used to model complex psychiatric disorders involving at their core impaired behavioural
self-control. copyright 2008 Elsevier Ltd. All rights reserved.
ISSN 0028-3908
Publication Type Journal: Review
Journal Name Neuropharmacology
Volume 56
Issue Part SUPPL. 1
Page 9-17
Year of Publication 2009
Date of Publication 2009