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Transcript
Neuroanatomy: Auditory Pathways (Pan)
AUDITORY SYSTEMS AND SOUND WAVES:

Auditory System: transmits information about sound waves in the environment to the CNS

Sound Waves: alternating air pressure
o Properties of Sound:

Frequency (Hz): determines the pitch of the sound
 Human range of hearing is 20-20,000 Hz
 Most sensitive in the 1000-3000 Hz range
 Females can hear higher frequencies than males

Amplitude (dB): determines the loudness of sound; decibels is a logarithmic scale
 dB= 10 log [(intensity of sound)/(intensity of standard sound)]
 dB= 20 log [(pressure of sound)/(pressure of standard sound)
 0 dB is the threshold for human hearing
 At 140 dB, sounds are both felt and heard
TRANSDUCTION OF SOUND INTO ELECTRICAL EVENTS:

Three Components to the Auditory Apparatus:
1. External Ear:
Separated from middle ear by tympanic membrane (eardrum)
Tympanic membrane receives airborne vibrations
External auditory canal acts like a resonator (natural frequency of about 3000 Hz)
2. Middle Ear:
Chain of 3 ossicles: malleus, incus and stapes
o Transmit vibration movement of the tympanic membrane to the movement of the face plate of the
stapes (attached to oval window of cochlea- inner ear)
Amplification and Impedance-Matching Device:
o Differences in the amplitude of the movement and the surface area between tympanic membrane and
face plate of the stapes cause 22 times more pressure to be placed on the cochlear fluid as was exerted
by the sound wave on the tympanic membrane
Attenuation Reflex:
o Loud sounds being transmitted through CNS result in this reflex (10 ms latency)
o Reflex causes contraction of the tensor tympani and stapedius muscles which oppose one another,
causing rigidity in ossicular system- dampens movements (decreases sensitivity)
Natural Resonant Frequency of Ossicular Chain: between 700 and 1400 Hz
o Combined with the external auditory canal, transmission of sound from air to cochlea is good between
600-6000 Hz (fades above and below these limits)
3. Inner Ear:
Cochlea: auditory portion of the inner ear
o Fluid-filled coiled tube that is 3cm long (coiled 2.5 times around the modiolus)
o Scala Media: central cavity containing endolymph (like ICF- high K+, low Na+)

Contains the Organ of Corti
o Scala Vestibuli: in contact with the oval window; contains perilymph (like ECF- high Na+, low K+)

Separated from the scala media by Reissner’s membrane

Connected to the scala tympani by a small opening at the apex called the helicotrema
o Scala Tympani: in contact with the round window; contains perilymph

Separated from the scala media by the basilar membrane
o Movements:

Inward movement of stapes increases fluid pressure in the scala vestibuli

Displaces the basilar membrane and causes a subsequent increase in the pressure of the
scala tympani

Causes bulging of the round window into the middle ear
Basilar Membrane:
o Contains cross striations- narrow and stiff at the base (high frequencies resonate here), wide and more
flexible at the apex (low frequencies resonate here)
Organ of Corti:
o Rests on the basilar membrane
o Receptor organ that generates nerve impulses in response to vibrations of the basilar membrane
Hair Cells: sensory receptor cells located in the Organ of Corti
o
o
Two Types:

Inner Hair Cells: single row, responsible for processing sound

Outer Hair Cells: 3-4 rows, responsible for amplification/moderating the inner hair cells;
separated from inner hair cells by a supporting arch
Generation of Sound Impulses:

Minute hairs project from hair cells and contact tectorial membrane

Bases of hair cells associated with endings of cochlear nerve fibers (cell bodies in spiral
ganglion of modiolus)

Movements of basilar membranes causes shearing of hairs resulting in either depolarization
or hyperpolarization
 Movement of hairs towards kinocilium results in the opening of K+ channels and
depolarization; results in influx of Ca++ and release of NT onto afferent cochlear
nerves (initiates action potential)
 Movement of hairs away from kinocilium results in closing of K+ channels and
hyperpolarization
MAJOR NUCLEAR CENTERS AND PATHWAYS:

Spiral Ganglion: located in the modiolus of the cochlea
Peripheral processes of ganglion cells receive inputs from Organ of Corti hair cells
Central processes of the ganglion form the cochlear nerve
o Enters the brainstem at the cerebellopontine angle along with vestibular nerve (together, form the
vestibulocochlear nerve or CNVIII even though they have distinct ganglia and central connections)

Cochlear Nuclei: located in the rostral medulla on the lateral surface of the inferior cerebellar peduncle (ICP)
Receive all primary auditory fibers from the cochlear nerve
Fibers bifurcate and distribute to two nuclei:
o Dorsal Cochlear Nucleus: gives rise to dorsal acoustic stria (secondary auditory fibers)

Cross midline ventral to medial longitudinal fasciculus (MLF)

Ascend in the auditory pathways (lateral lemniscus)
o Ventral Cochlear Nucleus: gives rise to intermediate acoustic stria and the ventral acoustic stria

Intermediate: from dorsal part of ventral cochlear nucleus; runs dorsal to ICP, crosses
midline and enters lateral lemniscus on the opposite side

Ventral (Trapezoid Body): from ventral part of ventral cochlear nucleus; runs ventral to ICP,
crosses the midline and enters lateral lemniscus of opposite side
 Some fibers of this pathway also terminate in the superior olivary complex and the
nuclei of the trapezoid body

Superior Olivary Nuclear Complex:
Consists of a principal and accessory nucleus
Receives binaural input (from both ears) comparing timing and intensity of auditory signals (sound localization)
Gives rise to 3rd order (tertiary) fibers that mostly cross the midline and enter the medial lemniscus on the
opposite side
o Some fibers can also ascend without crossing the midline (enters medial lemniscus on the same side)

Lateral Lemniscus (Ascending Auditory Pathways):
Located in the lateral part of the tegmentum and ascends through the pons to terminate at the inferior colliculus
at caudal midbrain levels
Made up of the following fibers:
o Crossed secondary fibers from the cochlear nuclei
o Crossed and uncrossed tertiary fibers from the superior olivary nuclear complex
Nucleus of the lateral lemniscus: small relay center that receives and contributes fibers to the main bundle

Inferior Colliculus: at lower midbrain levels
Receives connections from lateral lemniscus
Communicates with the IC of the other side via the commissure of the IC
Sends auditory fibers to the medial geniculate nucleus via the brachium of the inferior colliculus

Medial Geniculate Nucleus: part of the diencephalon
Receives fibers from the IC and sends auditory fibers to the transverse temporal gyri of Heschl located in the
temporal cortex

Transverse Temporal Gyri:
Anterior Gyrus: primary auditory area (Brodman’s area 41)
Posterior Gyrus: auditory association area (Brodman’s area 42)
CLINICAL CORRELATIONS:

Deafness:
Conductive Deafness: impaired passage of sound waves through external or middle ear
o Causes: wax, thickening of windows, ankylosis of ossicles, otosclerosis (new bone formation causing
them to be immobile), otitis media (most common cause in children)
Sensorineural Deafness: nerve deafness
o Causes: degeneration of hair cells, tumors of auditory nerve, multiple sclerosis (loss of myelin), damage
to auditory nerve with streptomycin
Central Deafness: interference with the pathway in the brain
Important Notes:
o Lesions above cochlear nuclei results only in partial deafness
o Ipsilateral deafness in one ear only results when there is conduction deafness, destruction of the
cochlea, cochlear nerve or BOTH of the cochlear nuclei
o Lesions of the lateral lemniscus will cause bilateral partial deafness due to extensive crossing (will be
greater in the contralateral ear)

Clinical Tests:
Rinne Test: compares air conduction and bone conduction
o Place the butt of the vibrating fork on the mastoid process until the patient can no longer hear it (bone
conduction); then place it near the ear without touching it (air conduction)
o Normal/Sensorineural Deafness: air better than bone (should hear the vibration longer in the air)
o Conduction Deafness: bone is better than (or equal to) air
Weber Test: test for lateralization
o Normal: vibrating fork heard equally well in both ears when placed on top of the patient’s head at
midline
o Conduction Deafness: lateralizes to the bad ear (louder on that side)
o Sensorineural Deafness: lateralizes to the good ear
Presbycusis: gradual hearing loss with aging; higher tones lost early, with declines at each successive frequency
above 2000 Hz

Auditory Evoked Potentials (AEP): electrophysiological tool which can establish evidence of abnormality when clinical
signs and symptoms are equivicol
Peaks of AEP correspond to successive anatomic way stations along the auditory pathway:
o Peak I: generated by CNVIII
o Peak II: generated at or near the cochlear nuclei
o Peak III: generated at the lower pons as impulses travel through the superior olive and trapezoid body
o Peak IV and V: generated in upper pons or lower midbrain as impulses travel through lateral lemniscus
and IC (may be one peak)
Uses:
o Examine hearing in newborns
o Preoperative diagnoses such as acoustic neuromas and coma
o Neurosurgical manipulations involving the brainstem and/or CNVIII
Preservation of wave V with relatively unchanged latencies and amplitudes is a good predictor of gross
postoperative hearing
o Transient changes of AEP occur frequently during surgery and are of little clinical significance

If detected changes return to normal within 15 minutes, there is usually no serious post-op
impairment of function

Surgeon can monitor transient changes and use them as a guide to regulate surgical
procedures