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Biology 207 Biology of Cancer Fall 2009 Instructor: Dr. Nancy J. Bachman Office: 322 Science Bldg. I Phone: (607) 436-3061 email: [email protected] Office hours: MWF 12 noon-1 pm or by appointment Lectures: MWF 9-9:50 am Room 314 Science Bldg. I Course materials: Kleinsmith, Lewis J. (2006) Principles of Cancer Biology. Required text. Bazell, Robert (1998) Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer. Random House, New York, NY. Optional text. Available on reserve, Milne library. Additional assigned articles available on Angel https://angel.oneonta.edu/default.asp Course description: Examination of the environmental causes of cancer, the underlying genetic and cellular changes that lead to a cancer diagnosis, and new strategies for treatments. Prerequisite: BIOL 100. Course objectives: You will learn about: 1. the environmental and viral causes of cancer 2. the cellular changes that occur in cancer 3. key genes that promote or protect from cancer 4. the role of the immune system in fighting cancer 5. clinical trials of new therapies 6. progress in the diagnosis and treatment of common human cancers You will develop your own opinion about: 1. whether environmental safeguards are sufficient to protect us from cancer 2. whether the health care industry serves the needs of cancer patients 3. whether promising new drugs should be made available to patients before clinical testing is completed 4. when we should test for cancer susceptibility genes and what patients should be told about their prospects 5. whether there should be widespread distribution of anti-cancer vaccines Emergency Evacuation/Shelter-in-Place Procedures In the event of an emergency evacuation (i.e., fire or other emergency), classes meeting in this building are directed to reassemble at Chase Gymnasium so that all persons can be accounted for. Complete details of the College’s emergency evacuation, shelter-in-place and other emergency procedures can be found at http://www.oneonta.edu/security/. 1 Course requirements: Regular class attendance is important. Many topics build on previous information, so it is important to get things first hand as much as possible. Also, we will try to use classroom discussion to get at a number of issues and we will miss your input if you’re not there. Assignments: Exams: 3 exams @ 75 pts. each In-class assignments Paper and poster on a cancer topic total 225 points 75 points 75 points 375 points Overview of the assignments: Exams will consist of multiple choice and short answer essay questions mostly over the information presented. To prepare, know definitions of key terms used in the assigned readings and how they apply to cancer. Practice exams will be posted on the course web site. The exams will be given during 2 class sessions and during the scheduled final exam period. Each will cover about one-third of the course material. The exams will be worth 75 points each. There is an optional cumulative final exam worth 75 points that can be used to replace your lowest exam score. Make-up exams must be arranged prior to the scheduled exam period; otherwise you must take the cumulative final exam. In class assignments and homework. During the course of the term, there will be a few short in-class workshops and assignments. You will receive points for each of these workshops/assignments you complete up to a total of 75 points. Paper and poster presentation on a cancer topic. You will receive handouts outlining possible topics and with paper and poster presentation guidelines. You will be writing a 6-10 page paper on a cancer-related topic of your choice, preparing a poster, and presenting during the class poster sessions. Papers are due Nov. 30; posters are due Dec. 9. Grade Levels: As % of total points A = 93-100% A- = 90-92% B+ = 87-89% B = 83-86% B- = 80-82% C+ = 77-79% C = 73-76% C- = 70-72% D+ = 67-69% D = 63-66% D- = 60-62% 2 E = <60% Tentative Course Schedule Date Day Topic Reading Assignment (A=Angel) 8/26 W What is cancer? Chap. 1 8/28 F Normal Cells INT=CellsAlive! 8/31 M Cancer cells (106SciI) Histology workshop (group 1) 9/2 W Cancer cells Chap. 2 pp. 18-28 9/4 F Cancer cells (106SciI) Histology workshop (group 2) 9/7 M Cancer stem cells 9/9 W Cell cycle Chap. 2 pp. 29-36 9/11 F Angiogenesis Chap. 3 pp. 45-50 9/14 M Metastasis Chap. 3 pp. 50-55 9/16 W Cancer Epidemiology Chap. 4 pp. 61-78 9/18 F Causes of Cancer A=Carson Rachael’s Daughters (in class video) 9/21 M DNA/Chemical carcinogens Chap. 5 pp. 81-93 9/23 W Exam I 9/25 F Chemical carcinogens 9/28 M Fall Break I (no class) 9/30 W Radiation and Cancer Chap. 6 A=Proctor, Chap. 8 10/2 F Viruses and Cancer Chap. 7 pp. 120-129 10/5 M Oncogenes Chap. 7 pp. 129-138 10/7 W Oncogenes Chap. 9 10/9 F Hereditary Cancers Chap. 8 pp. 141-151 A=Weinberg Chap. 5 pp. 93-101 3 10/12 M Carcinogenesis Chap. 10 pp. 191-197 10/14 W Cancer screening Chap. 11 pp. 201-208 10/16 F DNA testing workshop (group 1) 10/21 W DNA testing (Rm3SciI) or In the Family (video) DNA testing (Rm3SciI) or In the Family (video) Cancer treatments 10/23 F Immune therapies Chap. 2 pp. 37-40 Chap. 11 pp. 218-224 INT-Biological Therapies 10/26 M Cancer prevention Chap. 12 10/28 W Exam 2 10/30 F Brain cancers pp. 255-256 (Appendix A) A= Lemonick INT-Cancer Imaging 11/2 M Colon cancer p. 257 11/4 W Lung cancer p. 260 11/6 F Skin cancer pp. 264-265 11/9 M Leukemia/Lymphoma p. 258-259 p. 260-261 A=Landro or INT-Bone marrow transplants 11/11 W Testicular cancer p. 266; A=Armstrong 11/13 F Prostate cancer p. 263-264;INT-Prostate cancer markers 11/16 M Cervical cancer INT-CDC web site Gardasil® 11/18 W Breast cancer p. 256 INT-Breast cancer microarrays 11/20 F Her-2 Bazell Chaps 1-4 11/23 M Fall Break 2 (no class) 11/25 W Fall Break 2 (no class) 10/19 M DNA testing workshop (group 2) Chap. 11 pp. 208-217 4 11/27 F Fall Break 2 (no class) 11/30 M Her-2 Bazell Chaps. 5-8 12/2 W Her-2 Bazell Chaps. 9-12 12/4 F Cancer patients Hospice care A=Moyers or video INT-Hospice and Palliative Care 12/7 M Poster session I (Sci I lobby) 12/9 W Poster session II (Sci I lobby) 12/16 W Final Exam 8-10:30 am Angel=Articles available through Angel course management software 1. Carson, R. L. (1962) Chap. 14 “One in every four”. From Silent Spring. Houghton Mifflin, Boston, MA. pp. 219-214. 2. Proctor, R. N. (1995) Chap. 8 “Nuclear nemesis”. From Cancer Wars. Basic Books, New York, NY. pp. 174-196. 3. Weinberg, R. A. (1996) Chap. 18 “A hundred years war: Retinoblastoma and tumor suppressor genes”. From Racing to the Beginning of the Road. Harmony Books, New York, NY. pp. 229-245. 4. Landro, L. (1998) Chap. 2 “Down to the marrow”. From Survivor. Simon and Schuster, New York, NY pp. 37-55. 5. Lemonick, M. D. (1997) The tumor war. TIME 150, 46-53. Also available online: use Infotrac Expanded Academic ASAP on Milne Library web site. 6. Armstrong, L. (2000) Chap. 1 "Before and after". From It's not about the bike: My journey back to life. Berkley Books, New York, NY. pp.1-15. 7. Moyers, B. (1993) “Wounded healers”. From Healing and the Mind. Doubleday, New York, NY. INT=Internet (on-line) Readings/Homework 1. Cells alive interactive web site. http://www.cellsalive.com/toc_cellbio.htm Use to review animal cell structure/function (cell models), mitosis, and to view cancer cells dividing. 2. Cancer stem cells video. http://www.cancer.med.umich.edu/research/stemcells_two.shtml 3. National Cancer Institute (NCI). Biological therapies: Using the immune system to treat cancer. http://cis.nci.nih.gov/fact/7_2.htm 4. National Cancer Institute (NCI). Bone marrow transplants Q & As. http://cis.nci.nih.gov/fact/7_41.htm 5. Prostate cancer markers. http://www.usatoday.com/tech/science/genetics/2005-10-27-prostategenes_x.htm 6. CDC web site on Gardasil®. http://www.cdc.gov/std/hpv/STDFact-HPV-vaccine-youngwomen.htm 7. Breast cancer microarray paper: Chang, J. C., Hilsenbeck, S. G. and Faqua, S. A. W. (2005) The promise of microarrays in the management and treatment of breast cancer. Breast Cancer Res. 7, 100-104. http://www.breast-cancer-research.com search by author’s name and title. 8. Hospice and Palliative Care by Mittal, M. and Flaherty, J. H. 5 http://www.thedoctorwillseeyounow.com/articles/cancer/hpcare_6 6