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14 The human circulatory system • 14.1 Why do we need a circulatory system? • 14.2 Blood vessels • 14.3 The heart • 14.4 Blood circulation in man • 14.5 What is blood? • 14.6 The functions of mammalian blood • 14.7 What is the lymphatic system? (Extension) • Mind Map 14.1 Why do we need a circulatory system? 14.1 Why do we need a circulatory system? Unicellular organism O2 O2 O2 Cell Absorb materials from surroundings through cell surface 14.1 Why do we need a circulatory system? Multicellular organism Absorb materials from surroundings through body surface O2 O2 O2 14.1 Why do we need a circulatory system? 1 Surface area Volume Surface area to volume ratio size 2 = (1 x 1) x 6 =6 = (2 x 2) x 6 = 24 =1x1x1 =1 =2x2x2 =8 6/1 = 6 24/8 = 3 14.1 Why do we need a circulatory system? 1 Surface area for Surface area material exchange The amount of Volume materials needed Surface area to volume ratio size 2 = (1 x 1) x 6 =6 4 times = (2 x 2) x 6 = 24 =1x1x1 =1 8 times =2x2x2 =8 6/1 = 6 24/8 = 3 14.1 Why do we need a circulatory system? If the body size increases, the surface area per volume ratio Thus, it is not enough to absorb materials through the body surface Surface area for material exchange The amount of materials needed Surface area to volume ratio = (1 x 1) x 6 =6 4 times = (2 x 2) x 6 = 24 =1x1x1 =1 8 times =2x2x2 =8 6/1 = 6 24/8 = 3 14.1 Why do we need a circulatory system? For smaller animals Larger surface area to volume ratio Surface area is large enough for gaseous exchange of the whole organism ONLY simple diffusion is enough 14.1 Why do we need a circulatory system? For smaller animals Larger surface area to volume ratio Surface area is large enough for gaseous exchange of the whole organism No Transport system is needed 14.1 Why do we need a circulatory system? Larger organism 14.1 Why do we need a circulatory system? Material exchange Organ Transport system Larger organism 14.1 Why do we need a circulatory system? For larger animals Surface area to volume ratio Smaller surface area to volume ratio Transport system Simple diffusion through body surface is not enough Specialised organs such as lungs are required for effective material exchange 14.1 Why do we need a circulatory system? 1 Three components Heart Blood vessel 2 Blood 3 14.2 Blood vessels 14.2 Blood vessels Capillary Vein Artery 14.2 Blood vessels From the heart Vessel transports blood away from the heart Artery Arteriole Smaller artery Blood flow 14.2 Blood vessels To the heart Vessel transports blood to the heart Venule Vein Smaller vein 14.2 Blood vessels 2 Highly branched Capillary Artery Vein 1 Carries blood from arteriole to venule 14.2 Blood vessels Blood pressure Blood pressure / kPa Low blood pressure High blood pressure Artery arteries arterioles capillaries venules vein Relative rate of blood flow Vein 14.2 Blood vessels Vein No pulse With pulse Artery arteries arterioles capillaries venules vein Relative rate of blood flow Blood pressure / kPa Rhythmic change of pressure pulse 14.2 Blood vessels Adaptation of artery Capillary Vein Artery 14.2 Blood vessels Adaptation of artery Wall of blood vessel 1 Muscles Elastic fibres Lumen 2 14.2 Blood vessels Adaptation of artery 1 Thick Wall A continuous blood flow is maintained by High proportion of elastic fibers in artery Withstand high blood pressure 2 14.2 Blood vessels Adaptation of artery Constriction of arteriole Dilation of arteriole 14.2 Blood vessels 3 High proportion of Adaptation muscle of artery Regulates the Constriction amount of blood of arteriole flowing through 14.2 Blood vessels Adaptation of artery Thick Wall High proportion of elastic fibers High proportion of muscle Summary Withstand high blood pressure Maintain continuous blood flow Regulates the amount of blood flowing through 14.2 Blood vessels Adaptation of vein Capillary Vein Artery 14.2 Blood vessels Adaptation of vein Thin Thin or thick ? Wall 1 SmallLarge or Large ? Lumen 14.2 Blood vessels Adaptation Less resistant for of vein blood with Thin lower pressure to flow Wall 1 through Large Lumen 14.2 Blood vessels Adaptation of vein Valve Blood can only flow in one direction 2 Prevent backflow of blood 14.2 Blood vessels Squeeze the blood flowing back to the heart Adaptation of vein Valves close Skeletal muscle Vein Skeletal muscle contracts 14.2 Blood vessels Capillary Vein Deoxygenated or Oxygenated blood? Artery 14.2 Blood vessels Deoxygenated blood Vein Except pulmonary vein Capillary Oxygenated blood Artery Except pulmonary artery 14.2 Blood vessels Capillary Vein Artery Site for exchange of materials between blood and tissue cells 14.2 Blood vessels capillary Can squeeze out between the cells in the capillary wall 1 One cell thick O2 nutrients CO2 waste White blood cell 2 tissue cells Shorten the distance for diffusion Faster material exchange 14.2 Blood vessels Highly branched 3 B Greater total crosssectional Cell area Slow down the blood flow rate Longer time for Cell diffusion Cell A Increase surface area for diffusion Cell 14.2 Blood vessels Arteries Direction Away from the of blood heart flow Wall Thick Comparison Veins Capillaries To the heart Link up arteries & veins Thin Very thin, only one cell thick Lumen Small Large About the same diameter as a red blood cell Valves Absent Present Absent 14.2 Blood vessels Arteries Comparison Veins Capillaries Blood pressure High Low Falls as blood passes along Pulse With pulse No pulse No pulse Oxygenation of blood Oxygenated (except pulmonary artery) Deoxygenated (except pulmonary vein) Blood becomes deoxygenated as it passes along Deep inside Close to the Everywhere Location the body surface in the body 14.2 Blood vessels Experiment 14.1 To examine the capillary blood flow in a fish's tail fin small fish glass slide on the tail fin petri dish wet cotton wool 14.2 Blood vessels Experiment 14.1 To examine the capillary blood flow in a fish's tail fin 1. Wrap a small living fish in wet cotton wool and put it in a petri dish. 2. Cover the tail fin with a glass slide. 3. Keep the cotton wool wet all the time. 14.2 Blood vessels Experiment 14.1 To examine the capillary blood flow in a fish's tail fin 4. Put the petri dish on the stage of a microscope. 5. Observe the tail fin under the low power of a microscope. Can you see blood flowing in a network of capillaries inside the tail fin? How small are the capillaries compared with that of a red blood cell? 14.3 The heart 14.3 The heart Blood vessels A Blood vessels B Heart muscle 14.3 The heart Blood vessels B 14.3 The heart Coronary artery Supplies O2 and nutrients to the heart muscle to release energy Glucose O2 for muscle contraction 14.3 The heart Remove the wastes from the heart muscles Coronary vein Wastes Wastes 14.3 The heart Blood vessels A Blood vessels B Heart muscle 14.3 The heart Blood vessels A Coronary artery Coronary vein Heart muscle 14.3 The heart The route of blood flow through the heart 14.3 The heart Left Right 14.3 The heart Pulmonary artery 4 1 Superior vena cava Right atrium Semilunar valve 2 Tricuspid valve Right ventricle 3 Inferior vena cava 1 14.3 The heart A Chambers B Vessels Right atrium Right ventricle Pulmonary artery Vena cava C Valves Semilunar valve Tricuspid valve 14.3 The heart Left Right 14.3 The heart 4 Aorta 1 2 Pulmonary vein Left atrium Bicuspid valve Semilunar valve Left ventricle 3 14.3 The heart Left atrium Left ventricle A Chambers Pulmonary vein Aorta Semilunar valve Bicuspid valve Vessels Valves B C 14.3 The heart Lungs Pulmonary vein Pulmonary artery Aorta Vena cava Body 14.3 The heart Atria Receive blood from Right atrium Receives deoxygenated blood Vena cava Veins Pulmonary vein Left atrium Receives oxygenated blood 14.3 The heart Ventricles Pump blood out of the heart Right ventricle pump deoxygenated blood to lungs To other parts of the Lungs body The body Left ventricle pump oxygenated blood to the rest of the body 14.3 The heart Which chamber, ventricle or atrium, has a thicker heart muscle? Why? The ventricle because it pumps the blood to a longer distance than the atrium 14.3 The heart The left ventricle Which chamber, left or right ventricle, has a thicker heart muscle? Why? Because it creates a greater force to pump the blood around the body which travels longer than that to the lungs 14.3 The heart Valves Semilunar 3 valves Tricuspid 1 valves Bicuspid 2 valves 14.3 The heart Location At the entrances of the aorta and the pulmonary artery Semilunar Between atrium and ventricle Bicuspid & Tricuspid 14.3 The heart Heart tendon Not present Semilunar Prevent the valves from being turned inside out Present Bicuspid & Tricuspid 14.3 The heart Semilunar valve The valves have no tendon but they are pocket-shaped 14.3 The heart Prevent backflow of blood Prevent backflow of blood into ventricle when the ventricle relaxes Semilunar Prevent backflow of blood into the atrium when the ventricle contracts Bicuspid & Tricuspid 14.3 The heart semilunar valve bicuspid valve pulmonary artery aorta tricuspid valve Summary 14.3 The heart Experiment 14.2 To dissect and examine the heart of a pig 1. Obtain a pig's heart from the butcher. 2. Wash it with tap water. 14.3 The heart Experiment 14.2 To dissect and examine the heart of a pig 3. Identify the followings: a. the ventral and dorsal sides, b. the left and right atria, c. the left and right ventricles, d. the aorta, e. the pulmonary artery, and f. the coronary vessels. 14.3 The heart Experiment 14.2 To dissect and examine the heart of a pig first cut pulmonary artery right atrium right ventricle aorta left atrium left ventricle 14.3 The heart Experiment 14.2 To dissect and examine the heart of a pig 4. Locate the aorta, and cut into it with a pair of scissors (first cut). Open up the aorta and the left ventricle. Make a cut in the wall of the left atrium (second cut). Now you are going to display the left side of the heart. second cut pulmonary artery 14.3 The heart Experiment 14.2 To dissect and examine the heart of a pig 5. Make a third cut into the pulmonary artery. This will open up the right side of the heart. left atrium open heart tendon 6. Study the internal structure of the heart. third cut 14.3 The heart Heart beats as the heart muscle contracts & relaxes Blood is squeezed out of the heart Contracts Systole Blood flows back into the heart Relaxes Diastole Diastole 3 ventricular systole 2 14.3 The heart The cardiac cycle atrial systole 1 Diastole 3 ventricular systole 2 14.3 The heart The cardiac cycle atrial systole 1 14.3 The heart The cardiac cycle atrial systole Bicuspid and tricuspid valves open 1 and larger than that in ventricles Pressure in atria increases Atria contract Squeeze blood into 2 ventricles Diastole 3 ventricular systole 2 14.3 The heart The cardiac cycle atrial systole 1 14.3 The heart The cardiac cycle ventricular systole 1 Semilunar valves open and larger than that in arteries Pressure in ventricles increases Ventricles Ventricles contract contract 2 Squeeze blood into arteries 14.3 The heart Ventricles contract The cardiac cycle ventricular systole Blood pressure in ventricles is higher than that in atria 3 Forces the bicuspid and tricuspid valves to close First Heart Sound Diastole 3 ventricular systole 2 14.3 The heart The cardiac cycle atrial systole 1 Both Ventricles & Atria relax 14.3 The heart The cardiac cycle Diastole Bicuspid and tricuspid valves open 1 Blood flowing into atria and ventricles Both Ventricles & Atria relax 14.3 The heart The cardiac cycle Diastole Pressure in ventricles decreases and smaller than that in arteries 2 Semilunar valves close Second Heart Sound 14.3 The heart 3 The cardiac cycle O.4s 2 O.3s O.1s 0.8s per one cardiac cycle 1 14.3 The heart The cardiac cycle Systole Diastole 14.3 The heart Pressure change Pressure / kPa ? Aorta 3 Ventricle 2 Atrium 1 Time / s 14.4 Blood circulation in man Blood vessels and double circulation 14.4 Blood circulation in man Lung Heart The rest of the body Circulation between the heart & lungs Circulation between the heart & the rest of the body 14.4 Blood circulation in man Lung Heart The rest of the body Circulation Pulmonary between the circulation heart & lungs Circulation between the Systemic heart & the circulation rest of the body 14.4 Blood circulation in man 14.4 Blood circulation in man Gaseous exchange CO2 O2 Lungs 2 Pulmonary artery 3 Pulmonary 4 vein Left atrium 5 1 Right ventricle Pulmonary circulatio 14.4 Blood circulation in man 14.4 Blood circulation in man 7 Right atrium Inferior vena 6 cava 3c Hepatic vein 3b Liver Hepatic portal 4b vein Renal vein 5c Systemic circulatio Aorta 2 Left ventricle 1 3a Hepatic artery Gut Renal artery 4a 5a Kidney 5b 14.5 What is blood? 14.5 What is blood? Our blood is composed of… 14.5 What is blood? Plasma Blood 55% by volume + Blood cells 45% by volume 14.5 What is blood? Blood = Blood cells + Plasma 14.5 What is blood? Blood cells Red blood cells Phagocytes White blood cells Blood platelets Lymphocytes 14.5 What is blood? Blood = Blood cells + Plasma (liquid) 14.5 What is blood? 10% dissolved substances 90% Water 14.5 What is blood? 10% dissolved substances Gases Metabolic wastes Proteins Nutrients Mineral salts Antibodies Hormones 14.5 What is blood? Blood cells Blood Red blood platelets cells Red blood cells White blood cells Phagocytes Lymphocytes 14.5 What is blood? 1 Where are they produced? Hollow Bone marrow Bone Produces blood cells 14.5 What is blood? 3 are destroyed in Liver Life-span is about 120 days 2 14.5 What is blood? 4 Shape ? Biconcave 6 No nucleus space for carrying more haemoglobin oxygen carrying capacity of blood Surface area for diffusion of gases 5 Red pigment Haemoglobin which binds with oxygen Purplish Red Haemoglobin Oxyhaemoglobin red blood cells O2 O2 O2 O2 Bright Red red blood cells O2 O2 O2 O2 Oxyhaemoglobin Bright Red O2 O2 red blood cells O2 O2 Oxyhaemoglobin Bright Red Haemoglobin Purplish Red O2 O2 red blood cells O2 O2 Oxyhaemoglobin Bright Red 14.5 What is blood? Transport of oxygen O2 + haemoglobin Purplish red in lungs oxyhaemoglobin in tissues Bright red Transport of carbon dioxide in tissues H++ HCO3- CO2 + water in lungs 14.5 What is blood? alveolus in lung CO2 O2 Deoxygenated blood Oxygenated blood heart CO2 O2 tissue cells 14.5 What is blood? Blood cells Blood White blood platelets cells Red blood cells White blood cells Phagocytes Lymphocytes 14.5 What is blood? Size ? Larger than RBC 2WBC 1RBC 14.5 What is blood? Shape? Irregular shape 2WBC 1RBC 14.5 What is blood? Is there any nucleus? Yes 2WBC 1RBC 14.5 What is blood? Is there any haemoglobin? No 2WBC 1RBC 14.5 What is blood? Where are they produced ? In bone marrow 2WBC 1RBC 14.5 What is blood? Function ? Kill germs 2WBC 1RBC 14.5 What is blood? Which two types? 1 2 Phagocyte Lymphocyte 14.5 What is blood? 1 Capillary squeeze out through the capillary Phagocyte It performs amoeboid movement 14.5 What is blood? Its function is to 1 engulf Germs Phagocyte 14.5 What is blood? Germs 2 Remove Antibodies Produces Lymphocyte 14.5 What is blood? Blood cells Red blood cells White blood cells Blood platelets Blood Platelet Phagocytes Lymphocytes 14.5 What is blood? Blood platelets 1 2 are tiny fragments are produced in red bone marrow 3 for blood clotting 14.5 What is blood? Comparison of RBC, WBC & Platelets red blood cells Site of production white blood cells blood platelets Bone marrow Bone marrow Bone marrow Number 5,000,000/mm3 7,000/mm3 250,000/mm3 Size 8 µm 8 –12 µm Very small Shape Biconcave Irregular Irregular Structure * No nucleus * With haemoglobin * With nucleus * No haemoglobin * No nucleus * No haemoglobin Function O2 carrier Kill germs Blood clotting 14.5 What is blood? Experiment 14.3 To detect the presence of glucose in plasma 1. Collect blood from a freshly killed chicken in a bottle containing some anticoagulant such as 10% sodium oxalate solution or sodium citrate solution. 2. Centrifuge the blood sample at about 3,000 revolutions per minute for 2 minutes. 14.5 What is blood? Experiment 14.3 To detect the presence of glucose in plasma 3. Using a dropper, carefully transfer about 2cm3 of the supernatant from the centrifuge tube to a test tube. 4. Test the supernatant for glucose by using Clinistix paper. supernatant 14.5 What is blood? Experiment 14.3 To detect the presence of glucose in plasma Question 1: Name the supernatant obtained after centrifugation. Answer 1: Plasma. supernatant 14.5 What is blood? Experiment 14.3 To detect the presence of glucose in plasma Question 2: What does the precipitate in the centrifuge tube consist of? Answer 2: It consists of red blood cells, white blood cells and blood platelets. supernatant 14.5 What is blood? Experiment 14.3 To detect the presence of glucose in plasma Question 3: What do you observe when the supernatant is tested by using Clinistix paper? What does it indicate? Answer 3: The Clinistix paper changes from pink to blue (or purple), indicating that glucose is present in the plasma. 14.5 What is blood? Experiment 14.4 To investigate the effects of oxygen and carbon dioxide on citrated chicken blood (For demonstration) 1. Collect some chicken blood. You can obtain it from the market. 2. Blood clotting can be prevented by adding a little anti-coagulant such as 10% sodium oxalate solution or sodium citrate solution to the blood sample. These solutions remove calcium ions so that blood will not clot. 14.5 What is blood? Experiment 14.4 To investigate the effects of oxygen and carbon dioxide on citrated chicken blood (For demonstration) hydrogen peroxide MnO2 3. Bubble oxygen through the blood. Oxygen can be produced by adding hydrogen peroxide to manganese dioxide. Observe the colour of the blood. 20cm3 blood 14.5 What is blood? Experiment 14.4 To investigate the effects of oxygen and carbon dioxide on citrated chicken blood (For demonstration) Question 1: What do you observe when oxygen is bubbled through the blood? Explain. Answer 1: The blood turns bright red when oxygen is bubbled through it because oxyhaemoglobin is formed in red blood cells. 14.5 What is blood? Experiment 14.4 To investigate the effects of oxygen and carbon dioxide on citrated chicken blood (For demonstration) 4. Bubble carbon dioxide through the oxygenated blood. Carbon dioxide can be produced by adding dilute hydrochloric acid to marble chips. Observe the colour of the blood again. dilute HCl marble chips 20cm3 blood 14.5 What is blood? Experiment 14.4 To investigate the effects of oxygen and carbon dioxide on citrated chicken blood (For demonstration) Question 2: What do you observe when carbon dioxide is bubbled through the blood? Explain. Answer 2: The blood turns purplish red when carbon dioxide is bubbled through it because oxyhaemoglobin gives up oxygen and is changed back into haemoglobin when the carbon dioxide concentrations is high. 14.6 The functions of mammalian blood 14.6 The functions of mammalian blood Functions of blood Transport Body defence Temperature regulation 14.6 The functions of mammalian blood Functions of blood Transport Gases Food Wastes Hormone Antibody Heat 14.6 The functions of mammalian blood Functions of blood Body defence Phagocytes Engulf germs Lymphocyte Blood clotting Produce antibodies to remove germs Germs are prevented from entering 14.6 The functions of mammalian blood Functions of blood Temperature regulation Distributing heat evenly throughout the body Help to keep body temperature constant 14.7 What is the lymphatic system? 14.7 What is the lymphatic system? Arteriole end Capillary (one-cell thick) Blood Blood Cell Venule end 14.7 What is the lymphatic system? In arteriole end of Forces all the blood composition capillaries except RBC, plantlets Higher hydrostatic & large protein pressure than outside Arteriole end Blood Capillary (one-cell thick) Tissue fluid formation Blood Cell Venule end Out through the capillar y wall Tissue 14.7 What is the lymphatic system? Importance of tissue fluid: Bathes the cells and provides a suitable environment for the cells Medium for exchange of materials between blood and cells 14.7 What is the lymphatic system? Some tissue fluid returns into venule end of capillaries by osmosis Tissue fluid 14.7 What is the lymphatic system? Back to blood vessel Heart Tissue fluid Excess tissue fluid Circulatory system drains into lymph capillaries which carry lymph back to circulatory system 1 Lymphatic system Lymph capillary 2 3 Lymph node Lymph vessel 14.7 What is the lymphatic system? Back to blood vessel How does the lymphHeart move without pumping organ? Circulatory system Tissue*fluid By valves 1 Preventing backflow of lymph * By surrounding skeletal muscle Lymph capillary contraction 2 To squeeze the Lymphatic system lymph flowing forward 3 Lymph node Lymph vessel 14.7 What is the lymphatic system? Back to blood vessel Heart Kill germs Circulatory system Tissue fluid Produce antibodies Lymphocytes can be Lymphatic system Lymph capillary found inside the lymph node 3 Lymph 2 vessel Lymph node 1 14.7 What is the lymphatic system? Villus in small intestine A kind of lymph vessels Lacteal carries fat 14.7 What is the lymphatic system? Functions of the lymphatic system Carries excess tissue fluid back to circulation Lymph nodes filter the lymph to destroy the bacteria inside Summary As a medium for material exchange between blood & cell Transports fat Lymph nodes produce and store lymphocytes. Lymphocytes are very important in formation of antibodies Mind Map Circulatory system double circulation consists of 1. pulmonary circulation blood vessels heart blood 2. systemic circulation include 1. arteries divided into 2. veins 1. 2 atria 3. capillaries 2. 2 ventricles cardiac cycle auricular systole ventricular systole diastole consists of functions are 1. plasma 1. transport 2. blood cells 2. body defence include 1. red blood cells 2. white blood cells 3. platelets 3. body temperature regulation Mind Map Lymphatic system consists of 1. lymph vessels 2. lymph nodes 3. lymph flows by 1. contraction of skeletal muscles 2. pressure from the tissues