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3rd Central European Symposium on Radiation Oncology Technological and Biological Sunrise for Radiation Oncology 6-8.10.2016, Ustroń, Poland Scientific Program Thursday; 6th October 2016 19:00 – Welcome Dinner Friday; 7th October 2016 9:00 – 9:10 Opening Ceremony 9:10 – 11:30 Radiation Biology and Biomarkers (Part 1) Michael Story (UTSW, Dallas): Challenges to the implementation of predictive biomarkers in radiation oncology [30’] Annett Linge (TUD, Dresden): Biomarkers for individualisation of radiochemotherapy in HNSCC – the German DKTK experience [30’] Katalin Lumniczky (NRIRR, Budapest): Radiochemotherapy induced phenotypical changes in peripheral blood cells of cancer patients [30’] Tomasz Rutkowski (IO, Gliwice): Circulating free HPV DNA as a prognostic marker in patients with HPV-related head and neck cancer treated with radiotherapy or radio-chemotherapy [20’] Piotr Widłak (IO, Gliwice): Inflammation related to acute radiation toxicity is the major factor affecting molecular changes observed in blood of cancer patients treated with radiotherapy [20’] Łukasz Boguszewicz (IO, Gliwice): 1H NMR based metabolomics in monitoring of the head and neck cancer treatment toxicity [10‘] 11:30 – 12:00 Coffee Break (and poster viewing) 12:00 – 14:00 Particle Therapy (Part 1) Marco Schwarz (Trento Hospital, Trento): How can protons improve radiation oncology? [30’] Roberto Orecchia (CNAO, Pavia): Hadrontherapy with heavy ions: current indications and future perspectives [30’] Thomas Bjork Errickson (Skandion Clinic, Uppsala): One year of clinical practice at the Skandion Clinic - ups and downs [30’] Jiri Kubes (PTC, Prague): Radiochemotherapy with protons [30’] 14:00 – 15:00 Lunch (and poster viewing) 15:00 – 18:30 Contemporary Radiotherapy and Personalized Treatment (Part 1) Hak Choy (UTSW, Dallas): I-SABR [30’] Rafał Dziadziuszko (GUMed, Gdańsk): Stage III NSCLC – how to individualize definitive radiochemotherapy? [20’] Krzysztof Składowski (IO, Gliwice): Continuous, chronological monitoring of selected biomarkers can predict the outcome of SCCHN patients treated by RT with or without chemotherapy [20’] Bogusław Maciejewski (IO, Gliwice): Volumetric staging and molecular and image guided radiotherapy for H&N cancer [20’] 16:30 – 17:00 Coffee Break (and poster viewing) Rafał Suwiński (IO, Gliwice): Immunotherapy and the abscopal effect of radiotherapy [20’] Rafał Tarnawski (IO, Gliwice): Molecular imaging of breast cancer heterogeneity [20’] Joanna Polańska (SUT, Gliwice): Computer aided segmentation of brain tumour in MRI apparent diffusion coefficient (ADC) maps [20’] Leszek Miszczyk (IO, Gliwice): CyberKnife (CK) radioablation for prostate cancer patients – early results of 400 patients treatment [20’] Małgorzata Wyduba & Wojciech Majewski (IO, Gliwice): The efficacy of palliative radiotherapy for patients with lung cancer: the QoL analysis [10’]. 19:30 – Conference Dinner Saturday; 8th October 2016 9:00 – 11:30 Contemporary Radiotherapy and Personalized Treatment (Part 2) Asal Rahimi (UTSW, Dallas): S-PBI (Stereotactic Partial breast Irradiation) [30’] Rafał Tarnawski (IO, Gliwice): Imaging of cervical cancer recurrence (lecture sponsored by Roche) [20’] Daria Handkiewicz-Junak (IO, Gliwice): Consolidation treatment with somatostatin analogues after radiopeptide therapy [10‘] Jolanta Krajewska (IO, Gliwice): Multikinase inhibitors in patients with radioiodine-refractory thyroid cancer – the evaluation of treatment tolerance on the basis of 10-year experience [10’]. Agata Celejewska (IO, Gliwice): 10-years of CBS and IORT (INTRABEAM) combined with postoperative EXRT for early breast cancer: incidence and kinetics of local recurrence and distant metastases [10’] Piotr Wojcieszek (IO, Gliwice): High-dose-rate brachytherapy for recurrent prostate cancer – effective tool for the individualized treatment [10’] Aleksandra Napieralska (IO, Gliwice): Craniospinal irradiation – experience of Radiotherapy Department in Gliwice [10’] Dorota Gabryś (IO, Gliwice): Cardiac toxicity after breast cancer patients treatment [10’] Marek Kozicki (LUT, Lodz): Using 3D dosimetry in radiotherapy: DosLab-Poland experience [15’] Krzysztof Ślosarek (IO, Gliwice): Planning, verification and realization of gated VMAT technique [15’] Paulina Leszczyńska (IO, Gliwice): Physical aspect of total marrow irradiation (TMI) [10’] 11:30 – 12:00 Coffee Break (and poster viewing) 12:00 – 13.00 Particle Therapy (Part 2) Xun Jia (UTSW, Dallas): Fast Monte Carlo simulation on GPU platform for particle therapy [30’] Paweł Olko (IFJ, Kraków): Cooperation towards the first patient on proton scanning beam at the Bronowice Cyclotrone Centre [20’] Tomasz Kajdrowicz (IFJ, Kraków): Collaborative network for particle therapy centers in Italy, Poland, Austria, Czech Republic and Sweden (IPACS) on harmonization of modern proton therapy [10’] 13:00 – 13.40 Radiation Biology and Biomarkers (Part 2) Andrzej Gamian (WMU, Wrocław): Unconventional glycation products and their partially protective activity against DNA damage in cells irradiated with X ray [20’] Andrzej Dworak (CPCM, Zabrze): Nanocarriers of doxorubicin via thermally induced aggregation of its polymeric conjugates [20’] 13.40 – 14:00 General conclusions and closing ceremony 14:00 – Lunch Poster Presentations B. Biesaga, A. Mucha-Małecka, A. Janecka-Widła, S. Szostek, D. Słonina, A. Kowalczyk, K. Halaszka, M. Przewoźnik: Prognostic significance of HPV16 presence, its load and genome status in patients with squamous cell carcinoma of head and neck from Cracow area, Poland. M. Ros-Mazurczyk, A. Wojakowska, L. Marczak, K. Polanski, M. Pietrowska, K. Jelonek, I. Dominczyk, A. Hajduk, T. Rutkowski, K. Skladowski, P. Widlak: Ionizing radiation affects profile of serum metabolites: increased level of 3-hydroxybutyric acid in serum of cancer patients treated with radiotherapy. Ł. Boguszewicz, A. Hajduk, A. Skorupa, M Ciszek, J. Mrochem-Kwarciak, K. Składowski, M. Sokół: Early treatment response detection in head and neck cancer patients by means of 1H NMR based metabolomic. M. Pietrowska, S. Funk, M. Gawin, Ł. Marczak, P. Widłak, T. Whiteside: Molecular profiling of tumorderived exosomes in plasma of cancer patients. A. Walaszczyk, M. Pietrowska, A. Wojakowska, A. Abramowicz, P. Rodziewicz, J. Polańska, K. Behrendt, E. Nowicka, R. Tarnawski, P. Widłak: Identification of serum proteins associated with the risk of metastasis of breast cancer patients. K. Szoltysek, P. Janus, A. Walaszczyk, T. Stokowy, P. Widlak: Interplay of NF-kB- and p53-dependent signaling pathways in cellular response to ionizing radiation. E. Wolny-Rokicka, J. Wydmański, A. Tukiendorf: Comparison and estimate of the prognostic value of lipids profiles in 2 groups of patients with prostate cancer in depends on advancement. E. Wolny-Rokicka, J. Wydmański, A. Tukiendorf, P. Mróz, A. Namysł-Kaletka, K. Gramacka, J. Lipiński: Correlating parameters platelet counts (PLT) and mean platelet volume (MPV) with tumor and possibility finding his threshold of size. J. Mrochem-Kwarciak, T. Rutkowski, A. Wygoda, R. Deja, Ł. Boguszewicz, P. Widłak, K. Składowski: Osteopontin (OPN) as an instant, predictive biomarker of tumor hypoxia and distant dissemination of HNSCC in patients treated by radiation and chemotherapy. A. Abramowicz, I. Tinhofer-Keilhol, P. Widlak, M. Pietrowska: FaDu-derived radiochemotherapy-resistant clonal cell lines as an experimental model system in exosome research: preliminary study. P. Polanowski, J. Wydmanski, A. Tukiendorf, B. Masłyk: Radiation-induced injury of the exocrine pancreas after chemoradiotherapy for gastric cancer. T. Krzysztofiak, W. Majewski: The efficacy of radical radiotherapy for patients with primarily diagnosed prostate cancer with metastases to regional lymph nodes. H. Grzbiela, M. Stąpór-Fudzińska, R. Tarnawski: The efficacy and safety of stereotactic radiation therapy in patients with multiple intracranial meningiomas - a case report. M. Gawkowska, E. Chmielik, A. d' Amico, W. Bal, E. Nowicka, B. Bobek-Bilewicz, R. Tarnawski: Somatostatin receptor scintigraphic imagining and clinical decision making in advanced esthesioneuroblastoma. E. Nowicka, M. Gawkowska, W. Bal, M. Jarząb, H. Grzbiela, B. Bobek- Billewicz, R. Tarnawski: Unusual presentation of dissemination via cerebrospinal fluid in malignant gliomas-the Centre of Oncology Institute Gliwice experience. E. Nowicka, M. Gawkowska, W. Bal, M. Jarząb, H. Grzbiela, B. Bobek- Billewicz, R. Tarnawski: The feasibility of reirradiation using intensity-modulated radiation in selected patients with recurrent gliomas. K. Dębiec, I. Gorczewska, P. Leszczyńska, K. Gorczewski, W. Leszczyński, M. Kalemba, J. Wydmański: Evaluation of the 18-FDG-PET/CT in radiotherapy planning for unresectable or inoperable gastric cancer patients. B. Jochymek, L. Miszczyk: Half-body irradiation as palliative treatment of patients with multiple painful bone metastases with application tomotherapy. E. Wolny-Rokicka, A. Tukiendorf, J. Wydmański, D. Roszkowska, B. Staniul: Thyroid function after postoperative radiation therapy in patients with breast cancer. D. Księżniak-Baran, M. Stankiewicz, K. Hasse-Lazar, S. Blamek: Linac–based stereotactic radiotherapy as a salvage treatment in patients with Cushing’s disease. Is there a chance for achieving hormonal control? K. Szczepanik, M. Stąpór-Fudzińska, D. Bodusz , B. Jochymek , E. Telka, L. Miszczyk:.Detection of the GoldAnchor™ markers implanted in the liver by the CyberKnife system during the real-time image-guided robotic radiotherapy of patients with liver metastases. Z. Wygoda, D. Handkiewicz-Junak, J. Krajewska, B. Jarząb: Assessment of radiotherapy effects in treatment of anaplastic thyroid carcinoma. W. Osewski, Ł. Dolla, R. Kulik, K. Ślosarek: Dose distribution reconstruction for gated VMAT technique. I. Brąclik, W. Osewski, K. Ślosarek: Dose distribution deformation based on deformable registration. M. Pelak, K. Dębiec: Virtual versus conventional radiotherapy simulation: a single institution experience report. A. Skorupa, M. Kozicki, P. Maras, M. Ciszek, Ł. Boguszewicz, M. Sokół: Application of high field MR micro-imaging in polymer gel dosimetry – preliminary results. A. d'Amico, O. Chrabański, I. Gorczewska, M. Zieliński: Triphasic [18F]-Fluorodeoxyglucose CT-PET in the differential diagnosis of lung nodules and mediastinal lymph nodes: initial results. B. Niewiadomska, A. Bekman, A. Woźnica, Ł. Dolla, S. Blamek: Measurement of dose in the environment of cardiovascular implantable electronic devices (CIEDs) for prostate cancer patients treated by Tomotherapy. S. Blamek, M.Tajstra, E. Gadula-Gacek, D. Gabryś, B. Niewiadomska, A. Bekman, Ł. Dolla, M. Gąsior, P. Marczyński: Implantable cardioverters-defibrillators and cardiac resynchronization therapy – defibrillator devices in the setting of helical Tomotherapy: an in vitro study. L. Stolarczyk, J. Gajewski, M. Kłodowska, W. Komenda, D. Krzempek, J. Kunst, N. Mojżeszek, M. Liszka, A. Pędracka, M. Rydygier, B. Sadowski, U. Sowa, P. Olko: Commissioning of spot scanning proton therapy system in Cyclotron Center Bronowice. M. Liszka, M. Rydygier, B. Sadowski, A. Pędracka, W. Komenda, L. Stolarczyk, P. Olko: Feasibility study of patient plan verification method for scanning proton beam at the IFJ in Krakow, Poland. T. Horwacik, B. Michalec, L. Grzanka, E. Durlak, E. Ogrodowicz, T. Nowak: Commissioning of the new ocular proton radiotherapy facility at the CCB IFJ PAN. U. Sowa, T. Nowak, T. Horwacik, T. Kajdrowicz: Application of wedges in the eye line treatment facility in the IFJ CCB Kraków. A. Pędracka, L. Stolarczyk, M. Liszka, W. Komenda, B. Sadowski, K. Skowrońska, P. Olko: Dosimetric verification of treatment planning system in proton spot scanning pencil beam radiotherapy. G. Mierzwińska, B.Michalec, B. Sadowski, M. P.R. Waligórski: Alanine-based QA protocol for dose assessment in ocular melanoma proton radiotherapy. J. Gajewski, M. Bednarczyk, K. Skowrońska, L. Stolarczyk, T. Kajdrowicz, P. Olko: Machine log file analysis as a part of treatment Quality Assurance with proton scanning beams.