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Lecture 6 Humoral Immune Response The Antibody Response Antibody Protection of the Host Immunologic Memory Virgin lymphocyte pool PRIMARY RESPONSE effector cells memory cell pool SECONDARY RESPONSE effector cells memory cell pool Immunologically Naive No previous experience No memory Must be educated The Primary Immune Response antibody titer lag log phase antigen challenge plateau decline time Class Switching antibody titer IgM IgG time Four phases of the primary response a lag phase where no antibody is detected a log phase in which the antibody titer rises logarithmically a plateau phase during which the antibody titer stabilizes a phase (decline) during which the antibody is cleared or catabilized The Anamnestic Immune Response Secondary Response antibody titer 1000 100 10 Primary Response 1 Time Comparison of Primary and Secondary Responses Time course Antibody titer Antibody class Antibody affinity Terms to remember Opsonization Neutralization Complement activation Primary response Secondary/ anamnestic/ booster response Lag phase Log phase Plateau period Memory cells Class switching Affinity maturation/ change in affinity with time