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Lecture 6
Humoral Immune Response
The Antibody
Response
Antibody Protection of the Host
Immunologic
Memory
Virgin lymphocyte pool
PRIMARY RESPONSE
effector cells
memory cell pool
SECONDARY RESPONSE
effector cells
memory cell pool
Immunologically Naive
No previous experience
No memory
Must be educated
The Primary Immune
Response
antibody
titer
lag
log phase
antigen
challenge
plateau
decline
time
Class Switching
antibody
titer
IgM
IgG
time
Four phases of the primary response




a lag phase where no antibody is detected
a log phase in which the antibody titer rises
logarithmically
a plateau phase during which the antibody titer
stabilizes
a phase (decline) during which the antibody is cleared or
catabilized
The Anamnestic Immune
Response
Secondary Response
antibody
titer
1000
100
10
Primary
Response
1
Time
Comparison of Primary and
Secondary Responses




Time course
Antibody titer
Antibody class
Antibody affinity

Terms to
remember










Opsonization
Neutralization
Complement activation
Primary response
Secondary/ anamnestic/ booster
response
Lag phase
Log phase
Plateau period
Memory cells
Class switching
Affinity maturation/ change in
affinity with time
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