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Attention Deficit Hyperactive Disorder Medication Abuse at Washington State University By Kyle W. Geiger Spring 2016 Advisor: Raymond M. Quock, Ph.D., Honors College Distinguished Professor, Washington State University, Department of Psychology Précis Since the early 1990s, amphetamine salts have been used to treat Attention Deficit Hyperactivity Disorder (ADHD). Rising numbers of diagnoses and prescriptions have been correlated with increasing rates of abuse in people with and without ADHD prescriptions (Setlik et al. 2009). The stimulant effects of these medications propose a unique demand on these “study aids” on college campuses and throughout the United States. A survey of students at Washington State University (WSU) found that the rate of ADHD medication abuse exceeds that of the national average and far exceeds the national average within the WSU Greek Community. This relates to a view of non-medical ADHD medication abuse as “acceptable.” ADHD medication abuse has also been correlated with lower academic success (Rabiner et al, 2009). Information from The Academic Opportunity Cost of Substance Abuse Report, compiled in 2013, indicates that the misuse of stimulants can eventually lead to a delayed graduation and even failure to graduate. This is expected to be associated with the compounding effects of neurostimulants on sleep and cognitive performance. Keywords: ADHD Medication, Adderall, Drug Abuse, University/ College, Stimulants, Academic Success. Table of Contents Introduction and Literature Review Thesis Statement Methodology Data Collection and Security Results Discussion Potential Biases Acknowledgments References List of Figures and Tables Figure 1 Gender of Survey Respondents Figure 2 Greek Affiliation of Survey Respondents Figure 3 Race/ Ethnicity of Survey Respondents Figure 4 Academic Class Standing of Survey Respondents Figure 5 Academic Area of Study of Survey Respondents Figure 6.1 Social Normalization Pie Chart Figure 6.2 Social Normalization Compared with Usage Table Figure 7 Motivation for ADHD Medication Use Figure 8 Mechanism of Administration Figure 9 Compound Drug Use Figure 10 GPA and Usage Table Figure 11 Differences in Use Between Academic Areas of Study Figure 12 Differences in Use Between Gender Table Figure 13 Differences in Use Between Greeks and Non - Greeks Introduction and Literature Review Attention Deficit Hyperactive Disorder (ADHD) medication affects our natural reward system through the mesolimbic dopamine pathway. This can lead to problems with misuse and abuse of these neurostimulant drugs. Adderall® has been used clinically to treat ADHD since the 1990s. By the beginning of the 21st century, Adderall® constituted 25% of the prescriptions for ADHD. Amphetamine salts and isomers are believed to promote presynaptic dopamine release in the striatum and inhibit the reuptake ability of the dopamine transporter (Joyce et al, 2007). Any drug with known dopamine-releasing and reuptake-inhibiting properties has the potential for recreational abuse. With rising numbers of ADHD diagnoses and more prescription drugs becoming available to treat ADHD, it is not a surprise that these drugs have become more commonly abused. Setlik and colleagues (2009) set out to better understand abuse patterns of ADHD medications in teenagers. Using data from the American Association of Poison Control Center's National Poison Data System (Bronstein et, al. 2006) regarding cases of ADHD medication abuse in teenagers ages 13 to 19, it was found that over the eight-year period they investigated (1998 to 2005), ADHD medication abuse rose a staggering 76% for teenagers. The study suggests that increased rates of ADHD diagnoses have led to a greater number of ADHD medication prescriptions being issued, primarily amphetamines like Adderall®. The increased availability of the drug corresponds with higher levels of abuse, especially in young individuals. This pattern of abuse also translates to later stages in life, particularly in the academic setting. Rabiner et al. (2009) concluded that the misuse of prescription ADHD medication is alive and well on college campuses. Risk factors for non-medical use include the following: being white; membership in Greek organizations; a lower GPA; engaging in other risky activities; and, interestingly, attending more competitive colleges. The authors provided a web- based survey to students at public and private universities. Of the 3,407 respondents, only 115 students (3.4%) had ADHD medication prescriptions, and these were the students who were put through a more rigorous survey process. The questions asked in the subsequent survey focused on topics such as diversion (selling) of ADHD medication, characteristics of students who misuse ADHD medications, and the use of ADHD medications with alcohol and other drugs. Of the 115 students, 69% were using their prescription drugs as described; however, 31% had misused their medication by taking larger or more frequent doses than prescribed or had used someone else's medication. Eight percent of students reported intranasal use in the previous six months, and 26% reported giving or selling their prescription drugs to peers. Enhancing academics was found to be the primary motive for misuse. ADHD medications are stimulants that can increase focus and energy; this creates a specific demand for the drug on college campuses. Because Adderall® is the most common ADHD medication for college students, it often takes the spotlight in ADHD medication discussions, especially on social media. Hanson et al. (2013) used trends on social media to analyze public health. The results from a Twitter analysis indicate that the use of the term Adderall® peaks during final examinations. The northeastern and southern regions of the United States had the highest correlation of Adderall® tweets. Alcohol was the most common drug mentioned along with Adderall®, and the most common side effect was lack of sleep followed by lack of appetite. Moore et al. (2014) found that key predictors of lifetime non-prescriptive psychostimulant use included students' perception of non-prescriptive psychostimulant use as normative on campus, self-reported procrastination and poor time-management. It is possible that students rely so heavily on the effects of stimulant medication (increased alertness, focus and energy) that there is an inherent procrastination effect. Students may elect to procrastinate on their studies simply because they know they will be able to take a drug that will allow them to study for longer periods of time. This procrastination effect may be correlated with lower academic success. Teter et al. (2006) constructed a self-administered survey in 2006 that found the primary motive for illicit use of prescription stimulants was to help with concentration (65.2%) followed by study help (59.8%) and increased alertness (47.5%). It is clear that many students take these drugs to enhance their academics performance and may view these drugs as cognitive enhancers. Advokat (2010) reported that studies in non-ADHD adults indicate that stimulants “do not promote acquisition of new information, might improve retention of previously acquired information, and facilitate memory consolidation, but may actually impair performance of tasks that require adaptation, flexibility and planning.” In a literature review done by Advokat and Scheithauer (2013), it was noted that these drugs do have negative effects on cognition and that this effect includes the use of these drugs to promote wakefulness in a last-minute study effort (procrastination). These authors hypothesized that this may explain the lack of academic benefit. Lakhan and Kirchgessner (2012) report that misuse of ADHD medications has risen in recent years based on students’ lack of understanding of the drugs and a belief that the drugs function as performance enhancers. In the same review, they concluded that the impression of these medications as “smart drugs” may be a false promise as the research suggests that these drugs function to correct deficits rather than improve performance. These factors described in this literature review were measured in an online student survey conducted at Washington State University. Thesis Statement There is substantial ADHD medication abuse among Washington State University students compared to the national average. This increased use is correlated with a social perception of abuse as “acceptable” and occurs at a higher rate within some WSU living groups. The misuse of ADHD medications leads to a decrease in performance. This is expected to be associated with the compounding effects of neurostimulants on sleep and cognitive performance. Methodology Washington State University students with internet access who either received the survey link via email, Facebook or accessed the survey through the WSU Human Subject Pool were included in the study. The following respondents were exuded from the study: individuals who reported that they are not currently enrolled at WSU and those who did not fully complete the survey. A 19- item web-based survey, administered through Qualtrics (Provo, Utah), was used to access characteristics of students at WSU (undergraduate, masters and Ph.D. candidates). The survey was created with the help of the WSU Social and Economic Sciences Research Center. The study was exempt from Institutional Review Board approval on February 24th, 2016. The specific variables assessed included the following: demographic information including race; academic major; class standing; and living-group information (e.g., Greek vs. non-Greek affiliation); diversion of prescription medication; frequency of abuse; types of abuse; other associated polydrug use; motivation for abuse; and perception of social norms on campus. The survey also used a Likert scale to measure agreement and disagreement with questions such as, “It is socially acceptable to use non-prescription ADHD on our campus.” Answer choices included ranges such as: very acceptable; somewhat acceptable; neither acceptable nor unacceptable; somewhat unacceptable; and very unacceptable. The survey was administered online via two different links. One link was generated through the WSU Human Subject Pool, which generated 37 responses. The other link was made public through Facebook and a mass email to the WSU Greek Community. This link generated 139 responses. Results were downloaded from Qualtrics into a Microsoft Excel file. The excel file was normalized to account for incomplete surveys and respondents who did not meet the requirements of the study. Tableau software and Microsoft Excel was used to create visual representations of the data. Data Collection and Security Participants were recruited via mass email, Facebook, and the WSU Human Subject Pool. No individuals were personally asked to take the survey. The link was posted to Facebook groups with a high concentration of WSU students. The survey weblink directed potential subjects to an informed consent page providing additional information about the study and ensuring that all responses were confidential and anonymous. No individually identifiable data was collected and individual results were password-protected through Qualtrics. Results When both survey links were closed on March 18th, 2016 there were (139) attempts on the public survey and (37) attempts on Subject Pool Survey. Forty attempts were excluded for either not completing the survey, or not meeting the requirement of being a WSU student, or both. A total of (n=136) Washington State University students were included on this analysis. For the purpose of displaying results the following academic majors were combined into these academic areas: Business: Finance: Hospitality Business Management; Marketing; Management; Information Systems; Business Administration; Accounting; Finance; Agricultural Business; International Business; Sports Management; and Masters of Business Administration (M.B.A). Biological Sciences: Basic Medical Sciences; Biochemistry; Biology; Genetics; Kinesiology; Microbiology; Nursing; Pharmacy; Neuroscience; Zoology; and Environmental Science. Social Sciences: Economics; Psychology; Criminal Justice; International Politics; Philosophy; Political Science; Agriculture Technology Management; Human Development; and Education. Computer Science and Engineering: Engineering; Civil Engineering; Mechanical Engineering; Mathematics; Computer Sciences; Digital Technology and Culture; and Construction Management. Communication: Communication; and Journalism and Media Production. Unspecified: General Education; not specified; and undecided. Figure 1 Gender of Survey Respondents Figure 2 Greek Affiliation of Survey Respondents Figure 3 Races/ Ethnicity of Survey Respondents Figure 4 Academic Standing of Survey Respondents Figure 5 Academic Area of Study of Survey Respondents Figure 6.1 Social Normalization Pie Chart Figure 6.2 Social Normalization Compared with Usage Table Motivation for Use Academic Purposes Increased Energy/Stay Up Later Euphoria 88% 32% 6% Figure 7 Motivations for ADHD Medication Use Mechanism of Administration Oral 96% Intranasal 49% Figure 8 Mechanism of Administration Compound Drug Use Caffeine 68% Alcohol 54% Tobacco 43% Marijuana 35% Cocaine 7% Figure 9 Compound Drug Use GPA Has Used 3.5 - 4.0 35% 3.0 - 3.5 62% 2.5 - 3.0 56% 2.0 - 2.5 50% 1.5 - 2.0 0% 1.0 - 1.5 100% n Has Never Used 18 65% 33 38% 15 44% 1 50% 0 100% 1 0% n 33 20 12 1 2 0 Figure 10 GPA and Usage Table Academic Area Biological Sciences Business Communication Computer Sciences and Engineering Social Sciences Unspecified Has Used 27% 61% 44% 63% 35% 92% Figure 11 Differences in Use Between Academic Areas of Study n 30 38 16 16 23 13 Gender Male Female Used 69% 28% Have Never Used 31% 72% Figure 12 Differences in Use Between Gender Table Greek Affiliation Greek Non-Greek Used 67% 19% Have Never Used 33% 81% Figure 13 Differences in Use Between Greeks and Non - Greeks Prescription Diversion Of the 136 respondents, only five (3.8%) reported having a prescription for ADHD medication. Of these five respondents, three reported selling or giving away the prescription, and all of them reported being Greek-affiliated. Of the five people with prescriptions, four reported using once per month, and only one reported daily use. Procrastination When asked if they often procrastinate on school work, 107 students strongly or somewhat agreed. Of those 107, over half (57%) report abusing ADHD medications. Of those who somewhat or strongly disagree that they procrastinate (21), only 5 (24%) report using ADHD medication. Discussion Because of the immediate stimulant effect and dopamine-releasing and reuptake-inhibiting properties, these drugs are extremely reinforcing proximally in both chemical effect and observational level of excitement. In a hypothetical situation, students are able to consume alcohol on Friday and Saturday night, and avoid the alcohol withdrawal on Sunday and begin studying by taking a low-dose amphetamine salt. Proximally, this works extremely well. The student may succeed academically on Monday, but the subsequent stimulant withdrawal on Tuesday through Thursday may have the student working harder cognitively to accomplish tasks and re-establish a normal sleep schedule. This cognitive decline associated with a stimulant crash may be compounded by the effects of neurostimulants and alcohol on sleep. According to the survey, alcohol was commonly abused in combination with ADHD medication (54%). This was second only to caffeine (68%). Rohers and Roth (2001) found that alcohol distributes sleep quality and impairs function (daytime alertness) on the following day. Egan and colleges (2012) reported that among non-medical prescription stimulant (NMPS) users, 46.4% used NMPS simultaneously with alcohol within the past year and that simultaneous NMPS and alcohol use was associated with low grade point averages. Egan and colleagues also concluded that simultaneous use of NMPS and alcohol was high among NMPS users in their sample of undergraduate students. Desantis and colleges (2009) discovered that students frame stimulant use as both physically harmless and morally acceptable. Of the 136 students surveyed at WSU, 103 (76%) of students report viewing non-prescription use of AHDH medication as very or somewhat acceptable. There is an obvious disconnect between student’s view of the drugs and the reality. According to Washington State’s RCW 69.50.401: Amphetamine, including its salts, isomers, and salts of isomers, is classified as a schedule II controlled substance, and unlawful possession is considered a class B felony; this is the same as methamphetamine. Of the students surveyed at WSU, only 3.8% reported having a prescription for ADHD medication. It is important to note while less than 4% of students report having a prescription for the drug, 50% of students report having used the drug. Of the 5 students who reported having a prescription, only one reported using the drug daily. This may be hinting that those who do have prescriptions are deciding to divert the drug rather than take it as prescribed. It is possible that Greek students are abusing the drug at higher rates simply because of access. The average membership of Greek chapters at WSU is 77 (taken from gogreek.wsu.edu on March 22, 2016). Students may be more likely to seek and obtain a drug from a friend who they trust. There is a failure of students to attribute academic decline to the use of AHDH medication. The procrastination effect studied in this survey may be the first layer in uncovering the problem in a way that students can understand. Of the students who report taking nonprescription ADHD medication, 88% take it for academic purposes. What students do not realize is that taking the ADHD medication may actually be hindering their academic success in the long term. The Academic Cost of Substance Abuse Report, published in 2013, states the following: “Substance abuse has an insidious way of interfering with a student’s ability to take advantage of all that college has to offer. Interventions to reduce rates of substance use should be part of any college’s plan to improve student retention.” According to Washington State University’s Strategic plan (accessed March, 22nd, 2016 at strategicplan.wsu.edu) WSU’s 2015 four-year and six-year graduations rates were 32.4% and 63.7%, respectively. This can be compared to the national average of 59% for a four-year graduation rate in 2013 (National Center for Education Statistics nces.ed.gov accessed March 22nd, 2016). This continued pattern of alcohol use, ADHD medication abuse, and sleep disruption could eventually lead to mental health disorders including anxiety and depression. It is imperative that Washington State University takes the time to educate students of this phenomenon associated with ADHD medication abuse. Potential Biases: This survey administered using Facebook as a recruitment method. We did not have a way to tell absolutely that respondents who reported being WSU students are in fact current students without recording further identifiable information. The survey link was also posted in Facebook groups with a high concentration of Greek students which resulted in a sample size with a disproportionately large Greek demographic. Acknowledgments I would like to thank Dr. Raymond M. Quock, Audra Biermann, Dr. Samantha Gizerian, Dr. Catherine Elstad, Patricia Maarhuis, and the Washington State University Social and Economic Sciences Research Center for their support and guidance throughout this project. References 1. 2. 3. Advokat, Claire (2010). "What are the cognitive effects of stimulant medications? Emphasis on adults with attention-deficit/hyperactivity disorder (ADHD)."Neuroscience & Biobehavioral Reviews 34(8): 1256-1266. Advokat, Claire, and Mindy Scheithauer (2013). "Attention-deficit hyperactivity disorder (ADHD) stimulant medications as cognitive enhancers." Front Neurosci 7: 82. Arria, Amelia M., et al (2013). "The academic opportunity costs of substance use during college." College Park, MD: Center on Young Adult Health and Development. doi:10.13140/RG.2.1.2941.2964 DeSantis, Alan D., and Hane, Audrey Curtis (2010). "“Adderall is definitely not a drug”: justifications for the illegal use of ADHD stimulants." Substance Use & Misuse 45(1-2): 31-46. 5. Egan, Kathleen L., et al (2013). "Simultaneous use of non-medical ADHD prescription stimulants and alcohol among undergraduate students." Drug and alcohol dependence 131(1): 71-77. 6. Bronstein, Alvin C., et al (2007). "2006 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS)." Clinical Toxicology 45(8): 815-917. 7. Hanson, Carl L., et al (2013). "Tweaking and tweeting: exploring Twitter for nonmedical use of a psychostimulant drug (Adderall) among college students." Journal of medical Internet research 15(4): e62. 8. Joyce, B. Matthew, et al (2007). "Adderall® produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers." Psychopharmacology 191(3): 669-677. 9. Lakhan, Shaheen E., and Annette Kirchgessner (2012). "Prescription stimulants in individuals with and without attention deficit hyperactivity disorder: misuse, cognitive impact, and adverse effects." Brain and behavior 2(5): 661-677. 10. Moore, David R., et al (2014). "Psychostimulant use among college students during periods of high and low stress: an interdisciplinary approach utilizing both self-report and unobtrusive chemical sample data." Addictive behaviors 39(5): 987-993. 4. 11. Setlik, Jennifer G., et al (2009). "Adolescent prescription ADHD medication abuse is rising along with prescriptions for these medications." Pediatrics 124(3): 875-880. 12. Teter, Christian J., et al (2006). "Illicit use of specific prescription stimulants among college students: prevalence, motives, and routes of administration. “Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 26(10): 1501-1510. 13. Rabiner, David L., et al (2009). "Motives and perceived consequences of nonmedical ADHD medication use by college students are students treating themselves for attention problems?." Journal of Attention Disorders 13(3): 259-270. 14. Rabiner, David L., et al (2009). "The misuse and diversion of prescribed ADHD medications by college students." Journal of Attention Disorders 13(2): 144-153. 15. Roehrs, Timothy, and Thomas Roth (2001). "Sleep, sleepiness, and alcohol use." Alcohol research and Health 25(2): 101-109. 16. Washington State University Strategic Plan 2014-2019, Accessed March 22nd, 2016, www.strategicplan.wsu.edu.