Download human immunodeficiency virus

Oseltamivir
Neuraminidase inhibitor
2013.03.22
Lee, sang-hwi
Chemical structures of antiviral drugs inhibiting the
neuraminidase of influenza A virus
Binding of sialic acid–mimic drugs zanamivir and oseltamivir to neuraminidase
zanamivir (yellow)
oseltamivir (green)
sialic acid (gray)
Nature Structural & Molecular Biology 2010, 17, 530
capsid
1)
2)
3)
4)
5)
6)
7)
8)
Attachment (부착)
Fusion (융합)
Reverse transcription (역전사)
Integration (통합)
Transcrpition (전사)
Translation (유전자암호 해독)
Viral assembly (조립)
Budding and Maturation of HIV virion
(HIV virion의 돌출과 성숙)
• Retrovirus는 lipid envelope에 의해 둘러싸여 있는
protein capsid안에 packaged된 RNA genome을 가지
는 infectious particle이다.
• lipid envelope은 infection 과정 초기에 host cell의
membrane receptor와 결합할 수 있는 receptor
binding protein을 포함하는 polypeptide chain을 가진
다.
• Retrovirus는 유전물질로서 DNA 대신 RNA와 DNA를
만드는 reverse transcriptase을 가지고 있다.
• Retrovirus가 cell에 감염되면, cytoplasm으로 reverse
transcriptase와 RNA를 주입된다.
• 그 후, chromosomal DNA를 생성하고 host DNA에
삽입되어 복제를 시작한다
JAMA. 2002;287(13):1635-1637
http://www.youtube.com/watch?v=kSLRmj0APZw&feature=youtu.be
The action of neuraminidase in the continued replication of virions in the
setting of influenza infection.
CMAJ 2011, 183,E420-E422
Neuraminidase
enzymes are glycoside hydrolase enzymes that cleave the glycosidic linkages
of neuraminic acids.
Neuraminidase enzymes are a large family, found in a range of organisms.
The best-known neuraminidase is the viral neuraminidase, a drug target for
the prevention of the spread of influenza infection.
The viral neuraminidases are frequently used as an antigenic determinants
found on the surface of the Influenza virus.
Some variants of the influenza neuraminidase confer more virulence to the
virus than others.
Other homologs are found in mammalian cells, which have a range of
functions.
At least four mammalian sialidase homologs have been described in the
human genome (see NEU1, NEU2, NEU3, NEU4).
Neuraminidases, also called sialidases, catalyze the hydrolysis of terminal sialic
acid residues from the newly formed virions and from the host cell receptors.
Sialidase activities include assistance in the mobility of virus particles through
the respiratory tract mucus and in the elution of virion progeny from the
infected cell.[
Binding mode of action