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Dolutegravir (Tivicay®) 50 mg - Round, Yellow Tablet What is dolutegravir? What should I expect? Dolutegravir is used with other medicines to lower the amount of HIV virus in your blood and make your immune system stronger. In most cases dolutegravir is tolerated very well. Some more common side effects include: How do I take it? • Take with or without food • Take at the same time every day • Do not take dolutegravir at the same time as antacids, calcium, iron or magnesium What if I forget to take dolutegravir? It is very important to take dolutegravir every day to make sure that it keeps working. If you miss a dose, there is a higher chance that the virus will change to a form that is harder to treat. This is called "resistance". If you miss a dose, take it as soon as you remember unless you remember within 4 hours of your next dose. Do not take 2 doses at the same time. If you are not sure if you should take your dose, call the pharmacist. If you stop taking dolutegravir the HIV virus will begin to grow again in your body. Do not stop dolutegravir without talking to your doctor. • Trouble sleeping • Nausea • Headache • Diarrhea Less common side effects can include: • Lack of energy • Abnormal dreams • Stomach pain Dolutegravir may cause some rare, but serious side effects like: • Skin redness or rash • Signs of liver problems: o yellow eyes or skin o pale stools o dark urine o itchy rash o pain on your right side below the ribs • Mood changes, feeling sad or depressed Contact your doctor IMMEDIATELY if you have any serious side effects. Always tell your doctor or pharmacist if side effects are bothering you. Can I take dolutegravir with other medicines? What if I want to get pregnant? Dolutegravir may interact with other medicines. Drug interactions can stop your treatment from working or may cause unwanted side effects. Always tell your pharmacist or doctor if you are using: It is not yet known if dolutegravir is safe for pregnant women and their unborn babies. Talk to your doctor if you are pregnant or are thinking about becoming pregnant. • Prescription medicines • Over-the-counter medicines (such as Tylenol®, Advil®, Vitamins) • Herbal, natural or traditional medicines • Recreational drugs Some drugs that are known to interact with dolutegravir: Where do I keep dolutegravir? • Store your dolutegravir in a dry place at room temperature • Store all medicines away from children • Certain heart medications What if I have questions? • Medicines to treat seizures If you have questions or problems with • St. John's Wort your medicine, call the St. Paul’s Hospital Ambulatory Pharmacy: • Antacids, calcium, iron, aluminum and magnesium products may be used but must be taken at least 6 hours before or 2 hours after taking dolutegravir. This is not a complete list of medicines that interact with dolutegravir. Always check with your pharmacist before starting any new medicines to make sure that they are safe for you. April 2014 1-888-511-6222 To book an appointment to see a St. Paul’s Hospital pharmacist: 604-806-8060 (Monday to Friday daytime)