Download Aaron M. Mohs, Ph.D.

Aaron M. Mohs, Ph.D. - 1
Aaron M. Mohs, Ph.D.
Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
Omaha, NE 68198
Email: [email protected]
Phone: (402)-559-4336
APPOINTMENTS
2015-
Assistant Professor, University of Nebraska Medical Center
Department of Pharmaceutical Sciences
2015-
Adjunct Assistant Professor of Biomedical Engineering
Wake Forest University Health Sciences
2011-2015
Assistant Professor, Wake Forest University Health Sciences
Wake Forest University – Virginia Tech School of Biomedical Engineering
and Sciences, Department of Biomedical Engineering (primary), Institute for
Regenerative Medicine (joint), and Cancer Biology (joint)
2011-2012
Senior Scientific Consultant, Spectropath, Inc., Atlanta, GA
2006-2011
Center of Cancer Nanotechnology Excellence Distinguished Fellowship at Emory
University–Georgia Institute of Technology, Wallace H. Coulter Department of
Biomedical Engineering. Advisor: Dr. Shuming Nie
2002-2006
Graduate Student and Teaching Assistant at the University of Utah, Department of
Pharmaceutics and Pharmaceutical Chemistry. Advisor: Dr. Zheng-Rong Lu
2000-2002
Undergraduate Research and Teaching Assistant at St. John’s University/ College
of St. Benedict, Chemistry Department. Advisor: Dr. Chris Schaller
EDUCATION/TRAINING
2011
Postdoctoral Fellow, Biomedical Engineering, at Emory University–Georgia
Institute of Technology, Atlanta, GA. Emphasis in nanotechnology and optical imaging
for image-guided surgery. Mentor: Dr. Shuming Nie, PhD
2006
Ph.D., Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake
City, UT. Dissertation: Biodegradable Macromolecular Contrast Agents for Magnetic
Resonance Imaging. Mentor: Dr. Zheng-Rong Lu, PhD
2002
B.A., Chemistry, St. John’s University/College of St. Benedict, Collegeville, MN
RESEARCH FUNDING
On-going
2014-2018
R01 EB019449; Awarded by the National Institute of Biomedical Imaging and
Bioengineering.
Aaron M. Mohs, Ph.D. - 2
Project Title: Hyaluronic Acid Based Nanoparticles for Targeted Image-Guided
Tumor Surgery. (Role: PI)
2010-2015
R00 CA153916; Pathway to Independence Award in Cancer Nanotechnology
Research; Awarded by National Institutes of Health/National Cancer Institute.
Project Title: Nanotechnology for minimally invasive for cancer detection and
resection. (Role: PI)
2014-2015
WFU Comprehensive Cancer Center - School of Biomedical Engineering and
Sciences Joint Pilot Award.
Project Title: Nanoparticle-Based Delivery of Novel Fatty Acid Synthase Inhibitors.
(Role: co-PI)
Completed
2014-2015
Promoting Innovative Discoveries Pilot; Awarded by the Wake Forest Institute for
Regenerative Medicine
Project Title: Controlled Release Biomaterials for IL-35 Secreting Mesenchymal
Stromal Cells for the Treatment of Type I Diabetes. (Role: PI)
2011-2015
North Carolina State Grant; Goal: The North Carolina General Assembly has
authorized funds to provide support for Regenerative Medicine. The goal of this
project is to apply the science of regenerative medicine to civilians, battlefield
injuries and helping resolve the shortage of donated organs available for
transplant. (Role: co-I)
2010-2014
R01 HL098912; Awarded by National Institutes of Health/National Heart Lung
and Blood Institute
Project Title: Optical Molecular Tomography for Regenerative Medicine (Role: co-I)
2012-2013
Pilot Seed Grant; Awarded by the Wake Forest Institute for Regenerative Medicine
Project Title: New Near Infrared Imaging Method to Detect Genetically Labeled
Cells Using A Nerve/Muscle Construct Model (Role: PI)
LEADERSHIP/AWARDS
2014
Wake Forest Comprehensive Cancer Center Nominee, Pew-Stewart Scholars
Program for Cancer Research
2014
Vice-Chair, Regenerative Imaging and Sensing Working Group; Tissue Engineering
and Regenerative Medicine International Society
2011-2012
Chair, Nanomaterials/nanoformulations Working Group, NCI Alliance for
Nanotechnology in Cancer
2010
Innovation of the Year (Integrated Imaging and Spectroscopy System for ImageGuided Surgery) – awarded by the Emory Office of Technology Transfer
2006-2011
Emory-Ga. Tech Center for Cancer Nanotechnology Excellence Distinguished
Fellowship
2006
Wolf Prize – awarded to a University of Utah College of Pharmacy graduate
student for excellence in teaching, highest award given by the College of Pharmacy
Aaron M. Mohs, Ph.D. - 3
2006
Jeffrey A. Fox Award – awarded to University of Utah, Pharmaceutics graduate
student for dedication and service to department
2005
PhRMA Foundation Predoctoral Fellowship awarded by the PhRMA Foundation,
Washington, DC
2005
Vice-Chair, Student Advisory Committee, Pharmaceutics and Pharmaceutical
Chemistry, University of Utah
2002
Enzon Fellowship awarded by Enzon Inc., Pistacaway, NJ
1998-2002
President’s Scholarship – awarded by St. John’s University, based on academic
achievement, service, and leadership
1998-2002
Recognition Scholarship for Students in Science – awarded by St. John’s University,
based on academic achievement in science
1999 - 2000 Siehl Scholarship – awarded by St. John’s University for academic excellence and
leadership
2000
St. John’s University Study Abroad Program at the University of Salzburg
RESEARCH INTERESTS
Areas of Expertise
Planned and implemented development of fluorescent and Raman contrast agents and
optical instrumentation for image-guided surgical oncology
Developed self-assembled nanoparticles that solublize and stabilize fatty acid synthase
inhibitors
Developed near infrared fluorescent cell lines for in vitro and in vivo tracking in regenerating
tissue
Evaluate vascularization in regenerating tissue using novel angiographic MRI
methodologies
Evaluated the chemical and biological mechanism of toxicity of novel nanoparticles,
especially quantum dots, as a function of core elements and surface coating
Developed nanoparticles as model carriers for biomedical applications, proton-resistant
quantum dots as model carriers for oral drug delivery
Synthesized and characterized biodegradable Gd(III)-based polydisulfide magnetic
resonance imaging (MRI) contrast agents
Characterized in vivo imaging properties of blood pool MRI contrast agents, including MR
angiography and dynamic contrast-enhanced MRI techniques, pharmacokinetics, and
biodistribution
Synthesized and characterized nitrogenous bidentate ligands for molybdenum
complexation
Evaluated protein stability in injectable formulations and the possible interaction of silicon
by using DSC, fluorescence spectroscopy, and circular dichroism
Aaron M. Mohs, Ph.D. - 4
Technical Experience
Polymer and nanoparticle synthesis and surface coating development, small molecule
synthesis, oxygen free environments, including dry-box techniques and Schlenk lines
Skilled in chemical characterization techniques, including TEM, XRD, SEC/GPC/HPLC,
MRI, NMR, Raman, IR, and Fluorescence spectroscopy, ICP-OES, ICP-MS, ESI and MALDITOF MS, DSC, DLS, and circular dichroism
Skilled in tissue culture techniques, including viability assays, cell staining, DNA
microarray, confocal microscopy, flow cytometry, gel electrophoresis
Performed small animal surgical procedures, including jugular vein cannulation,
pharmacokinetic modeling, biodistribution, and in vivo metabolism studies
Experience with Microsoft Word, Excel, and PowerPoint, Prism, SigmaPlot, Origin, Matlab,
IDL, and numerous Adobe software applications
TEACHING/MENTORING EXPERIENCE
Wake Forest University Health Sciences
Course Director - Quantitate Organ Systems Physiology (BMES 606)
Lecturer, Medical Imaging II (Instructed topics included chemistry and mechanism of
contrast agents), (BMES 751)
Lecturer, Drug Discovery, Design and Development (Instructed topics included: Adsorption,
Distribution, Metabolism, Excretion, and Controlled Release) (CHM 740)
Lecturer, Introduction to Regenerative Medicine (Drug Delivery in TERM), (BMES 631)
Lecturer, Engineering Approaches to Understanding, Diagnosing, and Treating Cancer
(Cancer Nanotechnology)
Lecturer, Topics in Cancer Biology (Cancer Imaging) (MCB 723)
Project Advisor, Regenerative Medicine (Craniofacial Reconstruction) (MCB 753)
Emory - Georgia Tech
Biomedical Engineering Senior Design Project; Rigid Bronchoscope Design for Real-Time In
Vivo Acquisition and Analysis of Quantum Dot Images at Cellular and Tissue Levels.
Teaching Assistantships
Molecular Imaging; assisted in teaching fundamentals of clinical imaging modalities,
emphasis on imaging probes and contrast agents (University of Utah)
Drug Stability; assisted in teaching kinetics and mechanisms of organic reactions, structure
reactivity relationships of pharmaceutical systems, degradation and stabilization of drugs,
proteins, and DNA/RNA (University of Utah)
Organic Chemistry; taught basic laboratory methods in organic chemistry, maintained 300
MHz NMR (St. John’s University/College of St. Benedict)
Biochemistry; taught basic laboratory methods in biochemistry, gravity and electrophoresis
separations, fluorescence spectrophotometry (St. John’s University/College of St. Benedict)
Aaron M. Mohs, Ph.D. - 5
Research Training Program Mentorship
Wake Forest Institute for Regenerative Medicine Summer Scholars Program
University of Utah ACCESS program for women in science and mathematics
University of Utah Summer Undergraduate Research Program (Pharmaceutics)
SERVICE
National Service
Special Emphasis Panel (2015/05 ZCA1 TCRB-Q (M1)), Centers for Cancer Nanotechnology
Excellence (CCNE), Bethesda, MD (2015)
Scientific Review Panel, Maryland Stem Cell Research Fund, Baltimore MD (2013-current)
Scientific Review Panel, NYSTEM Program, Reston VA (2013)
Biomedical Engineering Society (BMES); Session Chair - Cancer Imaging (2012); Abstract
Reviewer - Cancer Technologies (2013,2014)
Invited Faculty Panelist on Career Development at the Biomaterials Gordon Research
Seminar, Holderness, NH, July 2013
Tissue Engineering and Regenerative Medicine International Society; Regenerative Imaging
and Sensing Working Group Vice-Chair; Wake Forest Institute of Regenerative Medicine
Young Investigator Award Selection Committee Chair (2013); Abstract Reviewer - Imaging
Technologies (2013)
Chair, Nanomaterials/nanoformulations Working Group, NCI Alliance for Nanotechnology
in Cancer (2011-2012)
Participant in two NCI working groups to set standards for nanotechnology as a chemical
and biological technology for cancer informatics, detection, and treatment (2007-2010)
Participant in NIST-ASTM sponsored interlaboratory study (ILS) on nanotechnology
standardization (2008)
Institutional and Community Service
2013-2015 BMES Wake Forest Student Chapter Faculty Advisor
2011-2015 SBES Faculty search committee
2012-2015 WFIRM Department Animal Care and Use Committee Reviewer
2012 Science fair evaluator - Sherwood Forest Elementary (Winston-Salem, NC)
Ad Hoc Reviewer (Impact Factor)
ACS Nano (12.062)
Analytical Chemistry (5.856)
Biomaterials (7.404)
Colloids and Surfaces B: Biointerfaces (3.456)
Aaron M. Mohs, Ph.D. - 6
Journal Biomedical Applications (2.082)
Nature Nanotechnology (27.27)
Pharmaceutical Research (4.742)
PLOS ONE (4.092)
Translational Research (2.986)
DISCLOSURES/PATENTS
1.
Mohs AM, Hill TK, Kridel S. Application Number 62/028,968 (July 25, 2014) FAS Inhibitors
and Methods Associated Therewith.
2.
Mohs AM, Hill TK, Kelkar S. Application Number 62/026,078 (July 18, 2014) Hyaluronic
Acid-Based Nanoparticles as Biosensors for Imaging-Guided Surgery and Drug Delivery
Vehicles and Methods Associated Therewith.
3.
Nie S, Mohs AM, Mancini MC. Intraoperative Imaging Instrumentation for Visualizing
Red, Deep-Red, and Near Infrared Fluorescent Probes Excited by Violet Light. (Disclosure:
6/8/11)
4.
Nie S, Mohs AM, Mancini MC. SpectroPen and Integrated Widefield Imaging System Can
Detect Atherosclerosis in a Mouse Model. (Disclosure: 2/1/11)
5.
Nie S, Mohs AM, Mancini MC. (Provisional Filed 11/11/2011) US 13/295,662. Additional
systems and methods for providing real-time anatomical guidance in a diagnostic or
therapeutic procedure.
6.
Nie S, Mohs AM, Mancini MC. PCT/US2010/060586 - Filed in AU, CA, CN, EU, IN, JP.
Integrated Imaging and Spectroscopy Systems for Image-Guided Surgery.
7.
Zong Y, Lu ZR, Mohs AM, Feng Y. Application number 60/814,449 (June 16, 2006).
Biodegradable macromolecular MRI contrast agents and methods of preparation and use
thereof.
PEER-REVIEWED PUBLICATIONS
1.
Stevenson AT, Reese LM, Hill TK, McGuire J, Mohs AM, Shekhar R, Bickford LR,
Whittington AR. Fabrication and Characterization of Medical Grade Polyurethane
Composite Catheters for Near-Infrared Imaging. Biomaterials. In Press.
2.
Hill TK, Abdulahad A, Kelkar SS, Marini FC, Long TL, Provenzale JM, Mohs AM.
Indocyanine Green-Loaded Nanoparticles for Image-Guided Tumor Surgery. Bioconj. Chem.
In Press. PMID: 25565445.
3.
Mohs AM*, Mancini MC, Provenzale JM, Saba CF, Cornell KK, Howerth EW, Nie S. An
integrated widefield imaging and spectroscopy system for contrast-enhanced, imageguided resection of tumors. IEEE Trans. Biomed. Eng. In Press. PMID: 25585410
*Corresponding author. Cover and Feature Article. Press Coverage: http://
www.sciencedaily.com/releases/2015/01/150120142555.htm; http://
Aaron M. Mohs, Ph.D. - 7
www.photonicsonline.com/doc/scientists-invent-system-to-improve-effectiveness-ofcancer-surgery-0001; WSJS Interview
4.
Niu G, Sapoznik E, Lu P, Criswell T, Mohs AM, Wang G, Lee SJ, Xu Y, Soker S. Fluorescent
imaging of cells in bioengineered blood vessels; the impact of cross-linking of the scaffold.
J. Tissue Eng. Regen. Med. (Accepted). PMID: 24616385.
5.
Opie AMT, Bennett JR, Walsh M, Rajendran K, Yu H, Xu Q, Butler A, Butler P, Cao G, Mohs
AM, Wang G. (2014) Study of scan protocol for exposure reduction in hybrid spectral
micro-CT. Scanning. 36(4):444-455. PMID: 24604215.
6.
Bennet JR, Opie AMT, Xu G, Yu H, Walsh M, Butler A, Butler P, Cao G, Mohs A, Wang G.
(2014) Hybrid true-color micro-CT: system design, implementation & preliminary results.
IEEE Trans. Biomed. Eng. 61(2):246-253. PMID: 23996533
7.
Mohs AM*, Mancini MC*, Provenzale JM, Singhal S, Leyland-Jones B, Wang MD, Nie S.
(2010) Hand-held spectroscopic device for in vivo and intraoperative tumor detection:
contrast enhancement, detection sensitivity, and tissue penetration. Anal. Chem. 82(21):
9058-9065. *Denotes equal contribution. PMID: 20925393
8.
Provenzale JM, Mohs AM. (2010) Nanotechnology in neurology-current status and future
possibilities. US Neurology 6(1):12-17.
9.
Mohs AM, Provenzale JM. (2010) Applications of nanotechnology to imaging and therapy
of brain tumors. Neuroimag. Clin. N. Am. 20(3):283-292. PMID: 20708547
10. Mohs AM, Duan HW, Kairdolf BA, Smith AM, Nie S. (2009) Proton-resistant quantum
dots: stability in gastrointestinal fluids and implications for oral delivery of nanoparticle
agents. Nano. Res. 2:500-508. PMID: 20379372
11. Smith AM, Mohs AM, Nie S. (2009) Tuning the optical and electronic properties of
semiconductor nanocrystals by lattice strain. Nat. Nanotech. 4(1):56-63. PMID: 19119284
12. Feng Y, Jeong EK, Mohs AM, Emerson L, Lu ZR. (2008) Characterization of tumor
angiogenesis with dynamic contrast-enhanced magnetic resonance imaging and
biodegradable macromolecular contrast agents in mice. Magn. Reson. Med. 60(6):1347-1352.
PMID: 19025902
13. Smith AM, Duan HW, Mohs AM, Nie S. (2008) Bioconjugated quantum dots for in vivo
molecular and cellular imaging. Adv. Drug. Deliv. Rev. 60(11):1226-1240. PMID: 18495291
14. Mohs AM, Nguyen T, Jeong EK, Feng Y, Emerson LL, Zong Y, Parker DL, Lu ZR. (2007)
Pegylation of Gd-DTPA cystine copolymers optimizes pharmacokinetics and tissue
retention for magnetic resonance angiography. Magn. Reson. Med. 58(1):110-118. PMID:
17659618
15. Mohs AM, Lu ZR. (2007) Gadolinium(III)-based blood pool contrast agents for magnetic
resonance imaging: current status and clinical potential. Expert Opin. Drug. Deliv. 4(2):
149-164. PMID: 17335412
16. Zong Y, Guo J, Ke T, Mohs AM, Parker DL, Lu ZR. (2006) Effect of size and charge on
pharmacokinetics and in vivo MRI contrast enhancement of biodegradable polydisulfide
Gd(III) complexes. J. Control. Release 112:350-356. PMID 16631270
Aaron M. Mohs, Ph.D. - 8
17. Lu ZR, Mohs AM, Zong Y, Feng Y. (2005) Polydisulfide Gd(III) chelates as biodegradable
macromolecular magnetic resonance imaging contrast agents. Intl. J. Nanomed. 1:31-40.
PMID: 17722260
18. Mohs AM, Zong Y, Guo J, Parker DL, Lu ZR. (2005) PEG-g-poly(GdDTPA-co-L-cystine):
effect of PEG chain length on in vivo contrast enhancement in MRI. Biomacromolecules
6:2305-2311. PMID: 16004476
19. Zong Y, Wang X, Goodrich KC, Mohs AM, Parker DL, Lu ZR. (2005) Contrast-enhanced
MRI with new biodegradable macromolecular Gd(III) complexes in tumor-bearing mice.
Magn. Reson. Med. 53:835-842. PMID: 15799038
20. Mohs AM, Wang X, Zong Y, Goodrich KC, Parker DL, Lu ZR. (2004) PEG-g-poly(GdDTPAco-L- cystine): A biodegradable macromolecular blood pool contrast agent for MR imaging.
Bioconj. Chem. 15:1424 - 1430. PMID 15546211
PUBLICATIONS SUBMITTED OR IN PREPARATION
Submitted
21. Provenzale JM, Mancini, MC, Mohs AM, Saba C, Cornell K, Howerth E, Nie S.
Intraoperative optical imaging using a very low dose of indocyanine green contrast agent.
Manuscript Under Review.
In Preparation
22. Hill TK, Davis A, Wheeler, F, Kridel SJ, Mohs AM. Orlistat-Containing Nanoparticles:
Loading Efficiency, Cytotoxicity, and Fatty Acid Synthase Inhibition. Expected Submission Jan-Feb 2015
23. Kelkar SS, Hill TK, Gao X, Marini FC, Mohs AM. Hyaluronan-Cy7.5 conjugates: effect on
self-assembly, optical properties, and enhancement of tumor cells. Expected Submission - JanFeb 2015
ORAL PRESENTATIONS
1.
Mohs AM. Near Infrared Fluorescent Nanoparticles for Image-­‐‑Guided Tumor Surgery; Invited Seminar; Pharmaceutical Sciences, University of Nebraska Medical Center; Omaha, NE, December 2014. 2.
Mohs AM, Hill TK, Kelkar SS, Marini FC, Levine, E. Hyaluronic Acid Derived Nanoparticles with Activatable Fluorescence for Image-­‐‑Guided Tumor Surgery; Biomedical Engineering Society Annual Meeting; San Antonio, TX, October 2014. 3.
Mohs AM, Raghavan S, Gilmont R, Somara S, Marini FC, Bitar KN. Near Infrared Fluorescent Neural Progenitor Cells to Track Differentiation and Tissue Innervation; Biomedical Engineering Society Annual Meeting; San Antonio, TX, October 2014. 4.
Mohs AM. Nanotechnology for Minimally Invasive Cancer Detection and Resection; NCI
Alliance for Nanotechnology in Cancer Investigators Meeting; Rockville, MD, October 2014. 5.
Mohs AM. Nanotechnology for Image-­‐‑Guided tumor Surgery; Invited Seminar; Biomedical Engineering, University of South Dakota; Sioux Falls, SD, September 2014. Aaron M. Mohs, Ph.D. - 9
6.
Mohs AM. Hyaluronic Acid Derived Nanoparticles for Image-­‐‑Guided Surgery and Drug Delivery; Invited Seminar, Chemistry, Wake Forest University; Winston-­‐‑Salem, NC, September 2014. 7.
Mohs AM. Near Infrared Fluorescent Protein Labeling of Enteric Nerve Cells: Development and Initial Characterization of IM-­‐‑FEN-­‐‑iRFP Cells, North Carolina Tissue Engineering and Regenerative Medicine Society Annual Meeting; Winston-­‐‑Salem, NC, October 2013. 8.
Mohs AM. Nanotechnology for Image-­‐‑Guided Intervention: Potential for Prostate Cancer?, Prostate Cancer Research and Translation Symposium; Winston-­‐‑Salem, NC, March 2013. 9.
Mohs AM. Nanotechnology for Emerging Biomedical Applications, Invited Seminar at the
Joint School for Nanoscience and Nanoengineering at UNC Greensboro and NC A&T,
Greensboro, NC, November 2012.
10. Mohs AM, Mancini MC, Qian X, Wang Y, Provenzale JM, Nie S. Nanotechnology for
Guided Tumor Resection, NCI Alliance for Nanotechnology in Cancer Investigators
Meeting; Houston, TX, November 2012.
11. Mohs AM, Wang Y, Qian X, Mancini MC, Provenzale J, Nie S. Nanotechnology for
Spectroscopic and Image-Guided Tumor Resection, Biomedical Engineering Society
Annual Meeting; Atlanta, GA, October 2012.
12. Mohs AM. Tumor cell marker imaging: searching for the micrometastases that change the game,
RSNA/ASTRO Cancer Imaging and Radiation Therapy Symposium; Atlanta, GA, April 2011 (copresenters Provenzale JM and Mancini MC).
13. Mohs AM. Nanotechnology for medical and surgical imaging: current status and future
possibilities, Invited speaker for Duke Radiology Grand Rounds; Durham, NC, January
2011 (co-presenter Provenzale JM).
14. Mohs AM. Wide-field optical imaging with interactive excitation and spectroscopy to
resect contrast-enhanced tumors, Invited speaker at Northeastern University; Boston, MA,
January 2011.
15. Mohs AM. Wide-field optical imaging using point excitation and spectroscopy for imageguided resection of contrast-enhanced tumors, Invited speaker at UT Southwestern
Medical Center; Dallas, TX, November 2010.
16. Mohs AM. Quantum dots for cellular and molecular imaging: unusual optical properties
and cellular toxicity, Invited speaker at UT Dallas; Richardson, TX, November 2010.
17. Mohs AM. Laser-guided widefield imaging and spectroscopy for guidance during surgical
resection of tumors, Fitzpatrick Institute for Photonics Annual Meeting; Duke University,
Durham, NC, October 2010 (co presenters Mancini MC, Provenzale JM).
18. Mohs AM, Mancini MC, Provenzale JM, Singhal S, Wang MD, Nie S. A hand-held imaging
and spectroscopy device for intraoperative, contrast-enhanced tumor detection, Biomedical
Engineering Society Annual Meeting; Austin, TX, October 2010.
Aaron M. Mohs, Ph.D. - 10
19. Mohs AM. Integrated Spectroscopy and Imaging for Intraoperative Cancer Detection and
Surgical Oncology, Invited seminar at Case Western Reserve University; Cleveland, OH,
January 2010.
20. Mohs AM, Raza SH, White, WB, Kaddi C, Mancini MC, Nie S, Wang MD, Singhal S. The
development of a novel endoscope to visualize residual tumor cells following cancer
surgery, American College of Surgeons 95th Annual Clinical Congress; Chicago, IL, October
2009.
21. Mohs AM, Smith AM, Mancini MC, Wen MM, Nie S. Investigating the Interactions,
Consequences, and Applications of Nanoparticles at Biological Interfaces, NCI Alliance for
Nanotechnology in Cancer Investigators Meeting; Chicago, IL, September 2008.
22. Mohs AM, Zong Y, Goodrich KC, Parker DL, Lu ZR. PEG-g-(GdDTPA-co-L-cystine): effect
of PEG chain length on in vivo contrast enhancement in MRI, Utah Center for Advanced
Imaging Research 17th Annual Symposium; Salt Lake City, UT, October 2005.
23. Mohs AM, Zong Y, Parker DL, Lu ZR. PEG-g-poly(GdDTPA-co-L-cystine): effect of PEG
chain length on in vivo contrast enhancement in MRI. MR Angio Club - The 17th Annual
International Conference on Magnetic Resonance Angiography; Beijing, China, September
2005.
24. Mohs AM, Zong Y, Feng Y, Guo J, Parker DL, Lu ZR. PEG-g-(GdDTPA-co-L-cystine): novel
biodegradable macromolecular contrast agents for MRI, Controlled Release Society Annual
Meeting, 32nd Annual Meeting & Exposition of the Controlled Release Society; Miami, FL,
June 2005.
25. Mohs AM, Wang X, Zong Y, Goodrich KC, Parker DL, Lu ZR. PEG-g-(GdDTPA-co-Lcystine):a biodegradable macromolecular contrast agent for blood pool MR imaging, Utah
Center for Advanced Imaging Research 16th Annual Symposium; Park City, UT, November
2004.
CO-AUTHORED CONFERENCE ABSTRACTS
1.
Kelkar SS, Hill TK, Mohs AM. Hyaluronic Acid Derived Fluorescent Imaging Agents with
Tunable NIR Emission. Biomedical Engineering Society Annual Meeting; San Antonio, TX,
October 2014.
2.
Hill TK, Wheeler FB, Davis AL, Kelkar SS, Kridel SE, Mohs AM. Development of a
Nanoparticle Formulation or Orlistat: Solubility, Stability, and Cytotoxicity. Biomedical
Engineering Society Annual Meeting; San Antonio, TX, October 2014.
3.
Kelkar SS, Hill TK, Gao X, and Mohs AM. CD-44 Targeted Biodegradable Nanoparticles
for Image-Guided Surgery. NanoDDS, 12th International Nanomedicine & Drug Delivery
Symposium, Chapel Hill, NC, October 2014.
2.
Hill TK, Kelkar S, Marini FC, Levine EA, Provenzale JM, Mohs AM. Synthesis,
Characterization, and Pre-Clinical Evaluation of Hyaluronan Based Nanoparticles for
Image-Guided Surgery. Duke University Fitzpatrick Institute for Photonics Annual
Symposium, Durham, NC, March 2014.
Aaron M. Mohs, Ph.D. - 11
3.
Rowe B, Mohs AM, Christ GJ, Harrison BS. Functional Recovery and Tissue Salvage in
Ischemic Injury Using Non-Invasive MRI as a Tool to Quantify the Extent of Tissue
Damage in a Rodent Ischemic Injury Model. North Carolina Tissue Engineering and
Regenerative Medicine Society Annual Meeting; Winston-Salem, NC, October 2013.
4.
Hill TK, Kelkar S, Marini FC, Mohs AM. Near Infrared Fluorescent Polysaccharide-Based
Nanoparticles for Image-Guided Tumor Surgery. NCI Alliance for Nanotechnology in
Cancer Annual Principal Investigators Meeting; Bethesda, MD, September 2013.
5.
Hill TK, Marini FC, Mohs AM. Near infrared image-guided tumor removal: epidermal
growth factor receptor as a target, Biomedical Engineering Society Annual Meeting;
Atlanta, GA, October 2012.
6.
Smith AM, Mohs AM, Nie S. Strain-tunable, near infrared quantum dots for in vivo
molecular imaging, Society for Molecular Imaging; Providence, RI, September 2007.
7.
Zong Y, Guo J, Feng H, Sun Y, Mohs AM, Parker DL, Lu ZR. (Gd-DTPA)-cystine
diethylester copolymers (GDCEP) as a biodegradable contrast agent for MR imaging,
Controlled Release Society Symposium; Salt Lake City, UT, February 2005.
8.
Zong Y, Wang X, Mohs AM, Goodrich KC, Lu ZR. MR imaging of a biodegradable
polymeric contrast agent, cystine-DTPA-Gd complex. Controlled Release Society;
Honolulu, HI, June 2004.
9.
Zong Y, Mohs AM, Goodrich KC, Wang X, Parker DL, Lu ZR. Synthesis of Gd(III) DTPAcystine a Gd(III) DTPA-cystine ethyl ester copolymers for MRI, Imaging in 2020; Jackson
Hole, WY, September 2003.
10. Tekavek TN, Brueske CJ, Mohs AM, Westman AL, Schaller CP. Synthesis of molybdenum
complexes of DACO’ and pzpy’. 223rd ACS National Meeting; Orlando, FL, April 2002.
POSTER PRESENTATIONS
1.
Mohs AM, Hill TK, Long TE, Marini FC, Levine EA. Targeted Near Infrared Fluorescent Nanoparticles for Image-­‐‑Guided Tumor Surgery, Drug Carriers in Medicine and Biology Gordon Research Conference; Waterville Valley, NH, August 2014. 2.
Mohs AM, Hill TK, Kelkar S, Marini FC, Levine EA. Hyaluronic acid derived fluorescent nanoparticles for image-­‐‑guided tumor surgery, 41st Controlled Release Society Annual Meeting & Exposition; Chicago, IL, July 2014. 3.
Mohs AM, Raghavan S, Gilmont RR, Somara S, Marini FC, Bitar KN. Near infrared labeling and detection of enteric nerve cells: tracking differentiating neural progenitor cells and tissue innervation, Tissue Engineering and Regenerative Medicine International Society -­‐‑ Americas; Atlanta, GA, November 2013. 4.
Mohs AM, Zarifpour M, Kelkar S, Kahlson MA, Marini FC, Christ GJ. Magnetic Resonance Imaging Characterization of Regenerating Bladder in a Murine Subtotal Cystectomy Model, Tissue Engineering and Regenerative Medicine International Society -­‐‑ Americas; Atlanta, GA, November 2013. Aaron M. Mohs, Ph.D. - 12
5.
Mohs AM, Wang Y, Mancini MC, Provenzale JM, Singhal S, Nie S. Intraoperative detection
of fluorescent nanoparticles using a handheld spectroscopic pen device to guide tumor
resection, AACR Special Conference on Nano in Cancer: Linking Chemistry, Biology, and
Clinical Applications In Vivo; Miami, FL, January 2011.
6.
Mohs AM, Singhal S, Nie S. Nanotechnology for minimally invasive cancer detection and
resection, Kick-off Meeting - NCI Alliance for Nanotechnology in Cancer; Bethesda, MD,
November 2010.
7.
Mohs AM, Smith AM, Mancini MC, Provenzale JM, Nie S. The unusual chemistry and
cellular toxicity of cadmium-free quantum dots, Fitzpatrick Institute for Photonics Annual
Meeting; Duke University, Durham, NC, October 2010.
8.
Mohs AM, Smith AM, Mancini MC, Wen MM, Nie S. Evaluating the Role of Chemical
Composition and Colloidal Stability on Quantum Dot Cytotoxicity, NCI Alliance for
Nanotechnology in Cancer Investigators Meeting; Chicago, IL, September 2008.
9.
Mohs AM, Smith AM, Mancini MC, Nie S. Investigation into the toxicology of straintunable quantum dots, NCI Alliance for Nanotechnology in Cancer Investigators Meeting;
Chapel Hill, NC, October 2007.
10. Mohs AM, Wang X, Zong Y, Goodrich KC, Parker DL, Lu ZR. Gd(III)DTPA-L-cystine-PEG
copolymers: a biodegradable macromolecular agent for blood pool MR imaging,
International Society of Magnetic Resonance in Medicine - 12th Scientific Meeting and
Exposition; Kyoto, Japan, May 2004.
PROFESSIONAL AFFILIATIONS
American Chemical Society (ACS)
Biomedical Engineering Society (BMES)
Controlled Release Society (CRS)
Institute of Electrical and Electronics Engineers (IEEE)
IEEE Engineering in Medicine and Biology Society (IEEE-EMBS)
Tissue Engineering and Regenerative Medicine International Society (TERMIS)
World Molecular Imaging Society (WMIS)
MENTORSHIP
Postdoctoral Research Associates
Dr. Sneha Kelkar, PhD
Doctor of Philosophy
Tanner Hill* (BME), PhD Candidate - Thesis Advisor - Expected PhD 2015
*2014-2015 Mike and Lucy Robbins Fellowship Award for academic, research,
and leadership excellence
Elizabeth Graham (BME), PhD Candidate - Thesis Committee co-chair
Jasmine Brown (BME) - Thesis co-Advisor
Hannah Baker (BME) - Thesis Committee Member
Aaron M. Mohs, Ph.D. - 13
Laura Hernandez-Cruz (BME) - Thesis Committee Member
Riu Wang (BME) - Thesis Committee Member
Etai Sapoznik (BME) - Thesis Committee Member
John P. McQuelling (BME) - Thesis Committee Member
John Scott (BME) - Thesis Committee Member - PhD 2015
Benjamin Rowe (Physiology/Pharmacology) - Thesis Committee Member
Christopher Stuart (Molecular Medicine) - Thesis Committee Member
Stephen Vance (Nanotechnology program at UNCG)— Thesis Committee Member
Master of Science
William Payne (BME) - Thesis Advisor
Abayomi Adeyemi - Committee Member
Riu Wang - Thesis Committee Member - MS 2012
Undergraduate Research Assistants
Erica Freund - Honors Thesis Advisor - Wake Forest University (Physics) - current
Gillian Lloyd - Wake Forest University (Biology) - Fall 2013 - Fall 2014
Joshua Copus - Clemson University (WFIRM Summer Scholar) - Summer 2014
Xiangxi Gao - Emory University (Biomedical Engineering Summer Scholar) - Summer 2014
Kindell Schmitt - Virginia Tech (Biological Systems Engineering) - Summer 2014
Martha Kahlson - Mount Holyoak College (Biochemistry) - Summer 2013
Robert C. Johnson, II - Johnson C. Smith University (Biology) - Summer 2013
Florence McCarty - Johnson C. Smith University (Biology) - Summer 2012