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Transcript 
William S. Klug
Michael R. Cummings
Charlotte A. Spencer
Concepts of Genetics
Eighth Edition
Chapter 18
Cell Cycle Regulation and
Cancer
Copyright © 2006 Pearson Prentice Hall, Inc.
Cancer Is a Genetic
Disease
About 1% are associated with germline
mutations
Figure 18-1a
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 18-1b
Copyright © 2006 Pearson Prentice Hall, Inc.
Cancer Is a Genetic
Disease
What Is Cancer?
The Clonal Origin of Cancer Cells
Cancer As a Multistep Process,
Requiring Multiple Mutations
Figure 18-2
Copyright © 2006 Pearson Prentice Hall, Inc.
Cancers often
develop in
progressive steps
Figure 18-3
Copyright © 2006 Pearson Prentice Hall, Inc.
Cancer Cells Contain
Genetic Defects Affecting
Genomic Stability and DNA
Repair
Figure 18-4a
Copyright © 2006 Pearson Prentice Hall, Inc.
Homogeneous
Figure 18-4b
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 18-5
Copyright © 2006 Pearson Prentice Hall, Inc.
Gleevec
Tomlins et al.
HNPCC (hereditary nonpolyposis colorectal cancer)
Pedigree – defects in mismatch repair
Figure 18-6
Copyright © 2006 Pearson Prentice Hall, Inc.
Cancer Cells Contain
Genetic Defects Affecting
Cell Cycle Regulation
The Cell Cycle and Signal Transduction
Cell Cycle Control and Checkpoints
Figure 18-7
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 18-8
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 18-9
Copyright © 2006 Pearson Prentice Hall, Inc.
Apoptosis may occur if damage is severe
Figure 18-10
Copyright © 2006 Pearson Prentice Hall, Inc.
Many Cancer-Causing
Genes Disrupt Control of the
Cell Cycle
Table 18-2
Copyright © 2006 Pearson Prentice Hall, Inc.
Ras proto-oncogenes
Figure 18-11
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 18-12
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 18-13
Copyright © 2006 Pearson Prentice Hall, Inc.
The p53 Tumor Suppressor Gene
(the “guardian of the genome”)
Figure 18-14
Copyright © 2006 Pearson Prentice Hall, Inc.
The RB1 Tumor Suppressor Gene
Figure 18-15
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 18-16
Copyright © 2006 Pearson Prentice Hall, Inc.
Epigentic gene silencing can play a role in cancer
from Arnold et al. (2005), Cancer 104:2035-2047
Cancer Is a Genetic
Disorder Affecting Cell–Cell
Contact
Figure 18-17
Copyright © 2006 Pearson Prentice Hall, Inc.
Predisposition to Some
Cancers Can Be Inherited
Table 18-3
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 18-18
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 18-19
Copyright © 2006 Pearson Prentice Hall, Inc.
Viruses Contribute to
Cancer in Both Humans and
Animals
Figure 18-20
Copyright © 2006 Pearson Prentice Hall, Inc.
Table 18-4
Copyright © 2006 Pearson Prentice Hall, Inc.
Table 18-5
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 18-21
Copyright © 2006 Pearson Prentice Hall, Inc.
Vaccine Prevents Most Cervical Cancer
Published: October 7, 2005
http://www.biol.sc.edu/~awaldman/HPVvaccine.htm
Cervical Cancer Vaccine Gets Injected With a Social Issue
Some Fear a Shot For Teens Could Encourage Sex
By Rob Stein
Washington Post Staff Writer
Monday, October 31, 2005; Page A03
Environmental Agents
Contribute to Human
Cancers
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