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Acute versus chronic cardiac failure Right ventricular failure/ left ventricular failure/ congestive cardiac failure Systolic failure/diastolic failure Compensated and decompensated cardiac failure CLASS -21/1/16 , TOPIC -EARLY & LATE DISTAL TUBULE TIMEâ8-9AM EARLY DISTAL TUBULE SEGMENTS TRANSPORTER FUNCTION Distal tubules MACULA DENSA senses the NaCl conc. NaCl COTRANSPORTER SODIUM UPTAKE CHLORIDE UPTAKE Ca +2 ATPase Sodium calcium exchanger Paratharmone G PROTEIN THIAZIDE DIURETICS INHIBITING NaCl co transporter S LATE DISTAL TUBULE SEGMENTS Late distal tubule SPECIAL FEATURE Principal cell Intercalated cell Dr. Anshul Sharma Date :-22.1.2016 FUNCTION Principal cells reabsorb sodium & water from the lumen secret potassium ion into lumen. Intercalated cells reabsorb potassium ions and secret hydrogen ions into tubular lumen.