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Phil. Trans. R. Soc. A. doi:10.1098/not yet assigned Supplementary material TPOsup TPOmid AMYG HIP PHG PAL PUT THA CAU OLF SOG MOG CUN LING CAL FFG IOG REC ORBsupmed ORBsup ORBmid ORBinf IFGoperc IFGtriang SFGdor MFG ACG SFGmed ROL INS HES ITG MTG STG superior temporal pole middle temporal pole amygdala hippocampus parahippocampal gyrus globus pallidus putamen thalamus caudate nucleus olfactory cortex superior occipital middle occipital cuneus lingual gyrus calcarine sulcus fusiform gyrus inferior occipital gyrus rectus superior frontal gyrus, medial orbital part superior frontal gyrus, orbital part middle frontal gyrus, orbital part orbital part of inferior frontal gyrus opercular part of inferior frontal gyrus area triangularis superior frontal gyrus, dorsolateral middle frontal gyrus, lateral part anterior cingulate gyrus superior frontal gyrus, medial part rolandic operculum Insula transverse temporal gyri inferior temporal gyrus middle temporal gyrus superior temporal gyrus PreCG PoCG SMA PCL DCG PCUN PCG ANG SPG IPL SMG CRB_C1 CRB_C2 CRB_3 CRB_4_5 CRB_6 CRB_7b CRB_8 CRB_9 CRB_10 VER_1_2 VER_3 VER_4_5 VER_6 VER_7 VER_8 VER_9 VER_10 Brainstem precentral gyrus postcentral gyrus supplementary motor area paracentral lobule middle cingulate precuneus posterior cingulate gyrus angular gyrus superior parietal lobule inferior parietal lobule supramarginal gyrus crus I of cerebellar hemisphere crus II of cerebellar hemisphere Lobule III of cerebellar hemisphere lobule IV, V of cerebellar hemisphere Lobule VI of cerebellar hemisphere lobule VIIB of cerebellar hemisphere lobule VIII of cerebellar hemisphere lobule IX of cerebellar hemisphere lobule X of cerebellar hemisphere (flocculus) Lobule I, II of vermis Lobule III of vermis Lobule IV, V of vermis Lobule VI of vermis Lobule VII of vermis Lobule VIII of vermis Lobule IX of vermis Lobule X of vermis (nodulus) Brainstem Supplementary Table 1: List of brain region names as labelled in Figs 6 and 7. 2 Brain → HF Brain Region Brain → BAL # of sub. Brain Region Brain → LF # of sub. Brain Region L middle temporal gyrus 6 R transverse temporal gyri 6 R lobule IV, V of cerebellar hemisphere Lobule X of vermis (nodulus) R middle frontal gyrus, lateral part 6 R superior frontal gyrus, dorsolateral 6 Brainstem 5 Brainstem 5 Lobule IV, V of vermis 5 Lobule IV, V of vermis 5 Lobule III of vermis 5 R Lobule VI of cerebellar hemisphere 5 5 L Lobule VI of cerebellar hemisphere 5 5 L paracentral lobule 5 L crus I of cerebellar hemisphere 4 5 5 5 L precuneus R parahippocampal gyrus L hippocampus 5 5 5 R paracentral lobule L precuneus L superior parietal lobule 4 4 4 R amygdala 5 R superior frontal gyrus, medial part 5 R middle occipital 4 L middle cingulate 5 L superior frontal gyrus, medial part 5 R cuneus 4 4 L superior frontal gyrus, dorsolateral 5 R hippocampus 4 4 Lobule VIII of vermis 4 L hippocampus 4 4 Lobule VII of vermis 4 L supplementary motor area 4 4 4 4 Lobule VI of vermis Lobule III of vermis Lobule I, II of vermis 4 4 4 R putamen 4 R lobule IX of cerebellar hemisphere 4 L supramarginal gyrus 4 L superior parietal lobule R postcentral gyrus L superior occipital L amygdala R hippocampus L hippocampus L anterior cingulate gyrus R insula L insula L superior frontal gyrus, medial part R olfactory cortex R supplementary motor area R rolandic operculum R orbital part of inferior frontal gyrus L orbital part of inferior frontal gyrus L area triangularis L opercular part of inferior frontal gyrus 4 4 4 4 4 4 4 4 4 L lobule IV, V of cerebellar hemisphere R crus II of cerebellar hemisphere L crus I of cerebellar hemisphere R inferior temporal gyrus R caudate nucleus R paracentral lobule L angular gyrus R fusiform gyrus L middle occipital R cuneus 4 L parahippocampal gyrus 4 4 4 4 R hippocampus L posterior cingulate gyrus R middle frontal gyrus, lateral part 4 4 4 4 L middle frontal gyrus, lateral part 4 R lobule IV, V of cerebellar hemisphere L lobule IV, V of cerebellar hemisphere R superior temporal pole L caudate nucleus R superior parietal lobule R lobule IX of cerebellar hemisphere R Lobule III of cerebellar hemisphere L Lobule III of cerebellar hemisphere L inferior temporal gyrus L superior temporal pole R superior temporal gyrus 7 6 R lobule IX of cerebellar hemisphere L posterior cingulate gyrus L superior frontal gyrus, medial part R lobule X of cerebellar hemisphere (flocculus) R lobule IV, V of cerebellar hemisphere R Lobule III of cerebellar hemisphere R crus II of cerebellar hemisphere # of sub. 5 5 5 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Supplementary Table 2: Brain regions that significantly (p-value<0.05) G-cause heart regressors (respectively HF, Bal, LF) in a bivariate GC approach (cutoff at 4 subjects in this Table). Phil. Trans. R. Soc. A.