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Evaluation of Anti-Cancer Drug Utilization Among Breast Cancer Patients in University of Nigeria Teaching Hospital, (Unth) Enugu, Enugu State, Nigeria Ene N Jane1 and Ubaka M Chukwuemeka2 1,2 Department of Clinical Pharmacy, Faculty of Pharmacy, University of Nigeria, Nsukka Corresponding author: Ene N Jane [email protected] Phone +2348037509654 ABSTRACT Background: In cancer management, drug utilization indices are great determinants of the outcome of therapy and rational use of drugs. Objective: To evaluate the anti-cancer drug utilization in patients with breast cancer in UNTH Enugu within a period of 5 years by assessing the types, quantity, pattern and quality of anti-cancer drugs used, against the National Comprehensive Cancer Network (NCCN) guidelines. Methods: A five-year(2011-2015) retrospective review of case notes of breast cancer patients’, who presented at the Surgical Out- Patient (SOPD), Oncology Unit and Radio Therapy Departments (RTD), was conducted in University of Nigeria Teaching Hospital using a structured data collection form. Results: Of the 314 administered anti-cancer drugs, 27(8.6%) were hormonal therapies. The most administered chemotherapy regimen is adriamycin-cyclophosphamide regimen 107(30.9%), with a noticeable increase in the use of paclitaxel alone regimen over the given period. Despite a recorded 100% accurate dose calculations, 278 (88.5%) doses were administered at the appropriate frequency, whilst only 206(65.6%) of the appropriate cycles were completed. Generic prescriptions and injectable drugs recorded were 191(60.8%) and 275(87.57%) respectively. Conclusion: Amongst the anticancer drug options, Chemotherapy is the most prescribed (mostly Adramycin-cyclophosphamide). A good percentage of the patients did not complete their medication cycle or follow strictly, the prescribed frequency for their anti-cancer therapy. Effort should be put in place to encourage rational drug use. Keywords: drug utilization, anti-cancer, breast cancer, chemotherapy