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INTEGRAL UNIVERSITY Department of Chemistry Evaluation Scheme M.Sc. (INDUSTRIAL CHEMISTRY) SEMESTER-II S. Course N code . 1. IC-121 Subject Periods Theory Chemical Process Industry L 03 T 01 P 00 Evaluation Scheme Sessional ESE CT TA Total 15 10 25 75 Subject Total 100 2. IC-122 Physical Chemistry, Industrial Applications 03 01 00 15 10 25 75 100 3. IC-123 Pharmaceutical Chemistry 03 01 00 15 10 25 75 100 4. IC-124 Modern Analytical Techniques 03 01 00 15 10 25 75 100 00 00 06 15 10 25 75 100 Practical 5. IC-12 P Industrial Chemistry Lab-II Total 500 REVISED SYLLABUS 2013 M.Sc. (Industrial Chemistry) Semester II CHEMICAL PROCESS INDUSTRY (IC-121) LTP310 UNIT I 08 hours Ceramics: Introduction, Classification , General Properties, Basic raw materials and Manufacturing Process, Manufacturing of Earthenwares & Stonewares. Refractories: Classification, General properties, Basic raw materials and Manufacturing process. Manufacturing of Fire Clay Bricks & High Alumina refractories. UNIT II 08 hours Glass: Introduction, Physical & Chemical Properties, Raw Mateirals , Chemical Reactions and Methods of Manufacturing. Cement: Introduction, Composition , Types, Basic raw Materials, manufacturing by wet & Dry process, Reaction in the Kiln, setting of cement. UNIT III 08 hours Sugar: Intruduction , Raw materials, Manufacture of sugar from Cane sugar, Cane sugar refining, By-products from sugar industries and their uses. Pulp & paper: Various types of Pulps, Manufacture of pulps, Papers, Polymer modified papers, Board and structural materials. UNIT IV 08 hours Adhesives: Introduction, Process of bonding, Classification of adhesives, Preparation of adhesives like Animal glue, Starch adhesives, Synthetic resin adhesives, Cellulose and silicate adhesives, Applications of various adhesives. UNIT V 08 hours Leather: Introduction, Animal skins, Manufacture of leather, Byproducts, Chemicals used in leather industries. Fertilizers: Introduction, Classification, Manufacturing of: Urea, Ammonium nitrate, Normal super phosphate & Triple super phosphate. Books recommended: . Chemical process industries N.R Nerris shreve Chemical process principales: part 1 & II – O.A / Hougen, K.M Watson RA Ragatz (CBS) Shrev’s Chemical process Industries: 5th edition – George T. Austin, Mc Graw Hill Book Co. Handbook of industrial chemistry: Volume I & II , KH Davis , FS Berner, CBS Publication. Plastic Additives Technology Hand Book: Himadri Panda, Engineers India Research Institute. Industrial Chemistry B.K.Sharma, goel publishing house REVISED SYLLABUS 2013 M.Sc. (Industrial Chemistry) Semester- II PHYSICAL CHEMISTRY, INDUSTRIAL APPLICATIONS IC-(122) LTP310 UNIT-I 08 hours Thermodynamics: Combined form of the First and Second laws of Thermodynamics; Concept of free energy, Free energy functions and their discussion; Thermodynamic equilibrium and free energy functions; Free energy of the system and entropy of the universe; Chemical Potential, Gibbs-Duhem equation; Chemical potential and thermodynamic functions; Chemical potential of a pure substance; Chemical potential of ideal gas mixture; Fugacity and its determination; Thermodynamic criteria for non-equilibrium states, Entropy production and Entropy Flow. UNIT-II 08 hours Statistical Thermodynamics: Common terms; Thermodynamical probability; Probability of entropy; The Boltzmann Distribution law; The partition function, Thermodynamic properties in terms of partition function; Partition function of polyatomic molecules; Translational, Rotational and Vibrational partition functions; Equilibrium constant and partition function. UNIT-III 08 hours Chemical Kinetics: Theory of reaction rates; Collision theory of reaction rates; Steric factor and activated complex theory; Arrhenius equation and activated complex theory; Dynamics of unimolecular reaction (Lindemann-Hinshelwood and Rice-Ramsperger Kessel ); Marcus theories of unimolecular reaction; Kinetics of enzyme reactions. UNIT-IV 08 hours Electrochemistry: Electrochemistry of solutions; Electro catalysis Bioelectrochemistry; NernstPlank Equation; Electrocardiography; Activity and activity coefficient; Debye-Huckel Theory for activity Coefficient of electrolytic solution; Determination of activity coefficient; Ionic strength. UNIT-V 08 hours Photochemistry: Laws of Photochemistry; Quantum Efficiency and its determination; Photochemical relations and their kinetics (Hydrogen-Bromine and Hydrogen-Chlorine reaction); Flame photometry; Quantitative Fluorescence analysis. Books recommended: Physical Chemistry, P.W. Atkins, ELBS Quantum Chemistry, Ira N. Levine, Prentice Hall Thermodynamics – J. Rajaram and J.C. Kuriacose – Educational Publishers. Physical Chemistry of Surfaces – A.W. Adamson – John Wiley Sons. Quantum Chemistry – Eyring, Walter, Kinball Statistical Physics (Part I) (Course of Theoretical Physics Vol. 5) – L.D. London. & E.M. Lefshitz Perganion Zpress, London. Chemical Thermodynamics by R.P.Rastogi et al Principles of Physical Chemistry by Puri, Sharma and Pathan REVISED SYLLABUS 2013 M.Sc. (Industrial Chemistry) Semester II PHARMACEUTICAL CHEMISTRY (IC-123) LTP310 Unit-I 10 hours Antibiotics and Sulpha Drugs:Introduction and classification of antibiotics; beta lactam antibiotics: penicillins, its structure and mode of action, synthesis of Penicillin-v. Cephalosporins: classification, structure and mode of action of first, second, third and fourth generation cephalosporins. Aminoglycoside antibiotics: structure and mode of action of Streptomycin, Neomycin and Kenamycin. Chloramphenicol: its structure, synthesis and mode of action. Synthesis and uses of sulphathiazole, sulphaguanidine, sulphadiazine, sulphamethazine and sulphaacetamide. Unit-II 06 hours Antipyretics analgesics: Introduction, classification, structure, synthesis and uses of analogues of p-aminophenol: Paracetamol, Phenacetin and antifebrin; Salicylic acid analogues: Aspirin, Salol, Salsalate and benorilate; Pyrazolones and Pyrazolodinones analogues: Antipyrine, Aminopyrin, Dipyrone, Phenylbutazone, Oxyphenbutazone and Sulphinpyrazone Unit-III 08hours Anesthetic drugs: Introduction, Classification, Synthesis and mode of action of: Inhalation anesthetics: Vinyl ether, Cyclopropane and Fluoroxene; Intravenous anesthetics: Thiopental Sodium & Methohexital Sodium; Basal anesthetics: Procanine hydrochloride, Tetracaine hydrochloride, Butacaine hydrochloride, Benzamine hydrochloride and Pyrocanine hydrochloride. Unit-IV 10hours Cardiovascular drugs: Introduction, classification, structure and mode of action of cardiac glycosides Digoxin, and Digitoxin; Anti-hypertensive and hypotensive drugs: structure, synthesis and mode of action of Losartan, Clonidine, Hydralazine, Methyldopa and Diazoxide; Antiarrhythmic agents: structure, synthesis and mode of action of Diisopyramide, Procainamide, Propranolol, Beritylium Tosilate;Vasopressor drugs: structure, synthesis and mode of action of Isoxsupurine, Prenyl amine. Unit-V 06hours Drug Design: Introduction; analogues and prodrugs; concept of lead; factors governing drug design; rational approach to drug design; Drug design: the method of variation; Drug design and development: preamble, revolutions in drug discovery, research and development strategies. Books recommended: Burger’s Medicinal Chemistry: Mangrove E. Wolff, 4th Edition, John Wiley and Sons Medicinal Chemistry by Asutosh Kar , New Age International publication Principles of Medicinal Chemistry: W.O. Foye. The Pharmacological Basis of Theraputics : L.S. Goodman and A. Gilman Wilson’s Medicinal Chemistry The Organic Chemistry of Drug Synthesis: D. Lednicer and L.A. Mitscher, REVISED SYLLABUS 2013 M.Sc. (Industrial Chemistry) Semester II MODERN ANALYTICAL TECHNIQUES (IC-124) LTP310 Unit-I 08 hours UV Spectroscopy Wave-like propagation of light, absorption of electromagnetic radiation by organic molecules allowed and forbidden transitions, instrumentation, effect of solvents on electronic transitions, formation and designation of absorption bands, conjugated systems and transition energies, unsaturated carbonyl compounds, dienes and conjugated polyenes, Woodward – Fieser rules. Unit-II 08 hours IR Spectroscopy Introduction, absorption in the infrared region, theory of infrared spectroscopy, instrumentation, molecular vibrations, calculation of vibrational frequencies, factors affecting vibrational frequencies, characteristic absorptions in common classes of compounds, fingerprint region, characteristic vibrational frequencies of alkanes, alkenes, alkynes, aromatic compounds, alcohols, ether, phenols and amines. Detailed study of vibrational frequencies of carbonyl compounds (ketones, aldehydes, esters, acids, anhydrides), applications of infrared spectroscopy. Unit-III 08 hours NMR Spectroscopy Introduction, theory of NMR spectroscopy, instrumentation, chemical shift, equivalent and nonequivalent protons, spin-spin splitting, vicinal coupling and stereostructure, proton exchange reactions, nuclear overhauser effect (NOE), shift reagents, principle of C-13 NMR spectroscopy, Relaxation and dynamic processes - Spin lattice relaxation (T1) and Spin - spin relaxation (T2) measurements. Interpretation of NMR spectra of some representative compounds. Unit-IV 08 hours Mass Spectrometry Introduction, basic theory, instrumentation, important useful terms in mass spectrometry, various modes of ionization (EI, CI, FD and FAB) and their applications, fragmentation patterns of various functional groups (alkanes, alkenes, alkynes, alcohols, ether, phenols and amines, ketones, aldehydes, esters, acids, anhydrides), molecular ion peak, metastable peak, Mclafferty rearrangements, Nitrogen rule. Unit-V 08 hours Atomic Absorption Spectrophotometry: Introduction, Principle, Instrumentation, Interferences- Spectral, Ionization, Physical and Refractory compound formation, Sample preparation, Internal standard and standard addition calibration and applications of AAS. Books recommended: Introduction to spectroscopy: Pavia, Lampman & Kriz, 3rd Ed, Books/cole. Spectroscopic methods in organic chemistry: H. Williams and Ian fleminig, V Edition Tata Mc Grawhills Organic spectroscopy: William Kemp, 3rd Edition, Palgrave publications. Fundamentals of Analytical chemistry, Douglas A. Skoog, Donald M. West, F. James Holler, 7th edition, Harcourt college publications. Principles and practice of analytical chemistry, F. W. Fifield, D. Kealey, 5th edition, Blackwell publication. Analytical chemistry, Gary D. Christian, 6th edition, Wiley and sons publication. Spectrometric identification of organic compounds, R. M. Silverstein, 6th edition, John Wiley and sons. Basic concepts of analytical chemistry, S. M. Kopper, New Age International Publishers. Analytical chemistry, D. Kealey, P.J.Haines, Viva books Pvt. Ltd Analytical Chemistry – Instrumental techniques Vol. I, Mahindu singh, Dominent publication.