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MAKE A GENETIC CODE FRIENDSHIP BRACELET This shows how the building blocks which make up living objects including you are put together. This is called the genetic code. WHAT YOU NEED u A selection of beads in four different colours u String WHAT TO DO 1. Each coloured bead represents a letter G,A,U,C. These stands for the building blocks that make up the genetic code. These are called adenine, guanine, cytosine and uracil. 2. Decide on a word you would like to spell out in your bracelet from the black letters shown in the table below. 3. Find the letters you need for your word in the table and note the three coloured letters beside them. E.g. The word you have chosen begins with L. The table shows the code opposite L is CUU. It could also be CUC, CUA or CUG. Pick any combination of these three letters. 4. Select the coloured beads to match. E.g. C=Green, G=Blue, U=Pink and A=Yellow, then CUC will be green, pink, green. 5. Tie a double knot in one end of the string to stop the beads falling off and thread your three beads onto the string. 6. Build up the bracelet by adding more sets of three beads until you have spelt out your word. E.g. If you choose the word ʻgeneticʼ this would be GGC,GAA,AAC,GAG,ACA,AUC,UGG,UCA. 7. If you want to make several words on the bracelet put a “stop” code represented by UAA, thatʼs Pink, Yellow, Yellow between each new word. 8. Tie the finished bracelet to your wrist. continued... UUU UUC UUA UUG F F L L UCU UCC UCA UCG S S S S UAU UAC UAA UAG Y Y stop stop UGU UGC UGA UGG C C stop W CUU CUC CUA CUG L L L L CCU CCC CCA CCG P P P P CAU CAC CAA CAG H H Q Q CGU CGC CGA CGG R R R R AUU AUC AUA AUG I I I M ACU ACC ACA ACG T T T T AAU AAC AAA AAG N N K K AGU AGC AGA AGG S S R R GUU GUC GUA GUG V V V V GCU GCC GCA GCG A A A A GAU GAC GAA GAG D D E E GGU GGC GGA GGG G G G G WHY? The word you have made on the bracelet represents a protein. Proteins are made up of building blocks called amino acids. In your bracelet the amino acids are the letters. In living cells a gene (a section of DNA) is copied to make a small message molecule called messenger RNA. The make up of RNA is what you have written on your bracelet. This is the genetic code. You can see how the code is made up of a string of chemicals which are called nucleotides in a row. These nucleotides are the beads in your bracelet (which represent the letters G,A,U,C. The different combination of beads shows how there can be loads of different amino acids. Each different type of amino acid gives the protein different properties. For example, proteins with lots of Ps in them are springy as in curly hair or knee joints. Proteins with Cs in them make coloured proteins like those in blood and eyes.