Download Systemic manifestations of disease

SYSTEMIC MANIFESTATIONS
OF DISEASE
Connie Fearnley
DIABETES
Necrobiosis
lipoidica
Granuloma annulare
Leg ulcers
Acanthosis nigricans
ecythma
HYPERLIDAEMIA
Eruptive xanthoma
Xanthelasma
Tuberous xanthoma
Tendinous xanthoma
THYROID DISEASE
Hyperthyroidism
Hypothyroidism
Xerosis
Both
Hair loss
Thyroid acropathy
Pruritis
Myxoedema
EXCESS CORTISOL
- Truncal obesity
- Moon face
- Buffalo hump
- Telangiectasia
- Ecchymoses
- Striae
- hypertrichosis
DECREASED CORTISOL
increased pigment
- Mucosal sites
- Palmar creases
- Scars
- Friction sites
- Areola skin
- Genital skin
- Hair
- diffuse
GASTROENTEROLOGY
Dermatitis herpetiforms
Hereditary haemorrhagic telangiectasia
CAUSES OF VASCULITIS
Connective tissues disease
- Lupus erythematosus
- Rheumatoid
- Wegeners granulomatosis
Infection
- Meningococcal septicaemia
- Post-streptococcal infection
- Hep C
CAUSES OF ERYTHEMA NODOSUM
 IBD – UC & crohns
 Sarcoidosis
 Infection – strep, TB
 Drugs e.g. sulphonamides, OCP
 idiopathic
CAUSES OF PYODERMA GANGRENOSUM
 UC
 Crohns
 Myelodysplastic
 Myeloproliferative disorders
 Rheumatoid disease
 diabetes
DRUG ERUPTIONS
Toxic erythema
Toxic epidermal necrolysis
-
-
Measles- like
Erythematous macules
Begins on trunk
7-14 days after intro of dryg
Pruritis, malaise and fever
Rare
Can be fatal
7-21 days after initiation
Tenderness and erythema
STOP DRUGS IMMEDIATELY
Supportive care  burns
unit/ITU
- >30% body surface area
- NSAIDs, abx, anticonvulsants
A 53-YEAR-OLD DIABETIC WOMAN PRESENTS WITH A FOUR
MONTH HISTORY OF BILATERAL ERYTHEMATOUS LESIONS ON
HER SHINS SURROUNDED BY TELANGIECTASIA.
WHAT IS THE MOST LIKELY DIAGNOSIS?
A) ERYTHEMA NODOSUM
B) NEUROPATHIC ULCER
C) CANDIDIASIS
D) NECROBIOSIS LIPOIDICA
E) GRANULOMA ANNULARE
D)