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Online Appendix:
1. Loci identified using variance components methods (LOD>2.0) in Pima Indians.
Trait
Young-Onset T2DM
Respiratory Quotient
HDL-Cholesterol
Leptin
Young-Onset T2DM
2-Hour Insulin after OGTT
Body Mass Index
Parent of Origin affect on Birth Weight
Percent Fat
Total Cholesterol
Insulin Action
Fasting Glucose
Chrom.
cM
LOD
1
1
3
6
7
9
11
11
18
19
22
22
170
105
181
54
120
99
139
88
54
0
0
46
2.5
2.8
2.6
2.1
2.0
2.2
3.6
3.4
2.3
3.9
2.1
2.4
2. Genes analyzed as positional candidates for linkage in Pima Indians.
Chromosome 1q21-24 (Young Onset T2DM)
Gene
Reference
ENSA
IL6R
PTGS2
MGST3
PLA2G4A
CRP
PRKAB2
KCNJ9
KCNJ10
LMX1A
INSRR
LMNA
PEA15
MTG8
SLC19A2
PBX1
PKLR
RXRG
MGST3
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
unpublished
unpublished
unpublished
Reference
1
2
3
4
1
5
1
6
2
3
5
5
Chromosome 11q23-24 (Body Mass Index)
Gene
Reference
DRD2
23
ORP150
24
NCAM
unpublished
PLZF
unpublished
NNMT
unpublished
IGS4
unpublished
ZNF259
unpublished
APOA1
unpublished
APOA3
unpublished
APOA4
unpublished
APOA5
unpublished
TAGLN
unpublished
PCSK7
unpublished
ARCN1
unpublished
CBL2
unpublished
C1Q TNF
unpublished
THY1
unpublished
ARHGEF12
unpublished
GRIK4
unpublished
SC5DL
unpublished
ZNF202
unpublished
SP17
unpublished
NRGN
unpublished
BCSC
unpublished
TBRG1
unpublished
PANX3
unpublished
CTH
unpublished
PKNOX2
unpublished
FEZ
unpublished
SP10
unpublished
PIG8
unpublished
NEPH-2
unpublished
ETS-1
unpublished
FLI1
unpublished
KCNJ1
unpublished
KCNJ5
unpublished
KIAA 0712
unpublished
BARX2
unpublished
NFRKB
unpublished
APLP2
unpublished
HNT
unpublished
OPCML
unpublished
B3GAT1
unpublished
2
Chromosome 7q (Young Onset T2DM)
Gene
Reference
PPP1R3
25
Chromosome 19p (Total serum cholesterol)
Gene
Reference
LDLR
unpublished
Chromosome 11p (Parent of origin effect on birth weight)
Gene
Reference
INS
26
References for Online Appendix
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Baier L, Ehm MG, Sakul H, Foroud T, Garvey WT, Burns D, Knowler WC, Bennett
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energy metabolism in Pima Indians. Am J Hum Genet. 62: 659-68, 1998.
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A locus influencing total serum cholesterol on chromosome 19p: results from an
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Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity
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24. Kovacs P, Yang X, Permana PA, Bogardus C, Baier LJ. Polymorphisms in the
oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in
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polymorphism is in linkage disequilibrium with birth weight but not Type 2 diabetes in
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