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Clinical Research Network West of England SWAG SSG Skin Meeting Thursday 22nd September 2016 Maxine Taylor Senior Research Delivery Manager – Cancer, Surgery, Genetics, Haematology. Workforce Development Lead Clinical Research Network & Cancer Services West ofEngland SWAG - Somerset Wiltsire Avon & Gloucestershire South West Children’s Cancer & Leukaemia Research Network 30 Clinical Specialties • Ageing • Infectious Diseases • Anaesthetics & pain • Injuries & Emergencies • Cancer • Mental Health • Cardiovascular • Metabolic & Endocrine • Children • Musculoskeletal • Critical Care • Neurological • Dementia & Neurodegenerative • Opthalmology • Dermatology • Oral & Dental • Diabetes • Primary Care • ENT • Public Health • Gastroenterology • Renal • Genetics • Reproductive Health • Haematology • Respiratory • Health Services • Stroke • Hepatology • Surgery NIHR CRN High Level Objectives • Increase number of participants into NIHR CRN portfolio studies • 650,000 in England • 21,905 in West of England • Increase the number of studies that deliver to time and target • Target 80% • Increase number of commercial studies delivered through network • 650 new studies this year • 75% of all commercial studies • Reduce NHS study set up times • Reduce time taken to recruit first participant NIHR CRN Objectives for cancer • Recruit 20% of cancer incidence • West of England 1,909 • Recruit 7.5% of cancer incidence into interventional studies • 716 • Include challenging studies • • • • • Cancer surgery – 4 recruits per 100,000 population Radiotherapy – 6 recruits per 100,000 population Rare cancers (<6 per 100,000) – 12 recruits per 100,000 population Children & young people – 3 per 100,000 population Teenagers & young adults – record number of 16-15 year olds participating in research Sub-specialty Brain and CNS Breast Children and young people Colorectal Gynaecology Haematological Oncology Including lymphoma Head and Neck Lung Sarcoma Skin Palliative Care Upper-Gastrointestinal Urology Clinical Research Sub-specialty Leads Lead Contact Email Chris Herbert Mark Beresford Mr Zenon Rayter Helen Rees Dr Steve Falk Rebecca Bowen Lisa Lowry Sally Moore Steve Thomas Adam Dangoor Adam Dangoor Chris Herbert Karen Forbes Dr Sharath Gangadhara Dr Amit Bahl [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] Organisation UH Bristol Bath NBT UH Bristol UH Bristol Bath UH Bristol Bath UH Bristol UH Bristol UH Bristol UH Bristol UH Bristol Bath UH Bristol National Clinical Studies Groups Psychosocial & Survivorship Brain Tumours Head & CSG Palliative & Supportive Neck Care CSG Sarcoma CSG Melanoma CSG Primary Care Lymphoma CSG Haematol. CSG Prostate Teenage & Young Adult Cancer CSG Breast Cancer CSG Imaging Adv. panel Lung Cancer CSG Upper GI Biomarkers Adv. panel Cancer CSG Colorectal Cancer Consumer CSG Liaison PPI Kidney Group Cancer CSG Bladder Cancer Screening, Testis CSG Prevention & Early Cancer Gynae Diagnosis Children’s Cancer CSG Cancer & CSG Leukaemia CTRad (Radiotherapy) 2016-17 to date Cancer recruitment per LCRN 2016-17 to date West of England recruitment to Cancer studies per Trust % Recruitment by Cancer Incidence per LCRN 2016/17 - to date 18.00% 16.00% 14.00% 12.00% 10.00% 8.00% 6.00% 4.00% 2.00% 0.00% North West South LondonNorth Thames Greater London Manchester Eastern Wessex West of England Thames Yorkshire and North East Valley and Humber and North South Cumbria Midlands West Midlands North West Kent, Surrey East Midlands South West Coast and Sussex Peninsula Recruitment to Skin Cancer studies and number of studies per CRN In 2016/17 - to date 45 40 35 30 25 20 42 15 21 10 20 19 19 15 5 5 6 3 3 5 7 6 6 1 1 3 2 1 1 1 1 1 1 0 Yorkshire and Humber South London North Thames Eastern Greater Manchester North West Coast Participants North West London Studies Thames Valley and South Midlands Wessex East Midlands North East and North Cumbria South West Peninsula Number of Skin Cancer Open studies per LCRN 8 7 6 Number of studies 5 4 7 3 6 5 5 2 3 3 1 2 2 1 1 1 1 1 0 North West Coast Eastern Yorkshire and Humber Greater Manchester South London North Thames Wessex LCRN West of England North West London Thames Valley East Midlands North East and and South North Cumbria Midlands South West Peninsula Open studies per Trust Project Title Chief Investigator EORTC 18081 - Adjuvant Pegylated Interferon in Ulcerated Melanoma BRAG rating Project site planned recruitment end date Recruited Project site target (total) participants Site parent organisation Principal Investigator Gloucestershire Hospitals NHS Foundation Trust Farrugia, Dr David 30/11/2017 0 8 Herbert, Dr Chris 01/08/2016 4 5 An Open-Label, Phase 1, Dose Escalation Study of MLN2480 in Patients with Relapsed or Refractory Solid Tumors Followed by a Dose Expansion Phase in Patients With Unresectable Melanoma. University Hospitals Bristol NHS Middleton, Prof Mark Foundation Trust BRAG Studies in setup Currently no studies in setup Black Red Amber Green Grey Open studies Study not reported recruitment or study has not recruited % Recruitment is more than 30 behind % time elapsed, i.e. Difference < -30 % Recruitment is less than 30 behind % elapsed time but more than 0 behind % elapsed time, i.e. -30 < Difference < 0 % Recruitment is equal to or greater than % elapsed time, i.e. Difference >= 0 Unable to calculate RAG due to record missing at least one data point Useful links • https://www.crn.nihr.ac.uk/ • National and local network information including training programmes templates, tools, contacts, videos etc • https://odp.nihr.ac.uk/ http:/ • Open data platform. Look at performance across whole CRN including all specialty areas • /csg.ncri.org.uk/portfolio/portfolio-maps/ • View current national portfolio of open, closed and ‘in set up’ studies • https://www.ukctg.nihr.ac.uk/ • See where a study in open across the country • http://public-odp.nihr.ac.uk/ • Search for a study to fit criteria. Good for horizon scanning, eligibility criteria Contacts • Research Delivery Manager – [email protected] • Cancer portfolio facilitator – [email protected]
