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TECHNOLOGY TRANSFER OFFICE FOR BIOMEDICINE IN CZECH REPUBLIC (Europe) University Hospital Hradec Králové; Faculty of Military Health Sciences; University of Hradec Králové Kamil Kuča – Head of Department Martin Kuneš – Technology Transfer Manager Jiří Mošna - Technology Transfer Manager Lucie Bartošová - Technology Transfer Manager Martin Sedláček – Project Manager and PR [email protected] [email protected] [email protected] [email protected] [email protected] Center for Transfer of Biomedical Technologies (CTBT) www.fnhk.cz/ctbt/eng • provides intellectual property protection assistance and other commercialization support to researchers • links industrial partners interested in commercializing available technologies to researchers The technologies for transfer comprise physical and life science, human health technologies, medical devices, diagnostics. Scientific background and research topics – commercial opportunities University Hospital Hradec Králové Biomarkers in clinical medicine (gastroenterology, clinical and experimental oncology, haematology, endocrinology, rheumatology) Surgery, preparation for surgical trauma operation, consequences of post-operative conditions The issue of aging and care of the old population, improving the quality of life in old age. Use of metabolism, nutrition and nutritional pharmacology. Neurodegenerative disorders Advanced diagnostic methods (personalized medicine) o in silico molecular modeling o new drug synthesis o screening biochemical and pharmacological tests to evaluate the activity of new drugs o toxicity and pharmacokinetic studies in vivo (mouse, rat, guinea-pig, pig) – under GLP conditions Proteomics o search for new protein biomarkers allowing early detection of ongoing disease o evaluation of drug effects on the protein level to better understand their mode of action Faculty of Military Health Sciences – University of Defence Therapeutic approaches for militarily misused organophosphorus compounds o novel inhibitors and reactivators - synthesis, evaluation, penetration through blood-brain barrier - potential anti-Alzheimer´s and Myasthenia Gravis disease drugs o antidotes against nerve agents and organophosphorus pesticides Vaccination efficacy o cholinergic anti-inflammatory pathway Biosensor technology o development of new methods (detection of some mycotoxins) o using novel recombinant proteins and nanotechnology (determination of yperites) Decontaminants and disinfectants o based on micellar compounds Medical aspects of war surgery and war internal medicine Unique biomolecular markers o its identification (virulent Francisella tularensis strains and others from the BW agent list) University Hradec Králové analysis of multidimensional time series from medical diagnostic devices o human EEG analysis after evoked signals ballistocardiographic signals o methods of its detection o development of ballistocardiographic bed posturography o study of the process of keeping human balance Project Center for Transfer of Biomedical Technologies HK is funded by the European Union (ERDF) and the Czech Republic‘s state budget. (CZ.1.05/3.1.00/10.0213)