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Pancreatic Cancer Michael G T Raraty Consultant Pancreatic Surgeon Pancreatic Cancer Stats http://www.cancerresearchuk.org/cancerinfo/cancerstats Incidence 2009-2011 http://www.cancerresearchuk.org/cancerinfo/cancerstats Trends over time 1975-2011 http://www.cancerresearchuk.org/cancerinfo/cancerstats Risk Factors Baseline ~ 10/100,000 population/year Risk Proportion of cancers x2 30 Genetic factors x 5-10 10 Chronic Pancreatitis x 10-20 1 Hereditary Pancreatitis x 35-70 <1 x5 - x 1.5-2 - Obesity x 1.7 - High fat diet x 1.7 - Previous gastric surgery x 1.8 - Sclerosing Cholangitis x 14 - Helicobacter Pylori x 1.8 - Smoking Age >70 Type II DM Hereditary cancer syndromes • • • • • • • • • Peutz-Jeghers FAMM Familial breast/ovarian cancer FPC Hereditary Pancreatitis Von Hippel-Lindau Cystic Fibrosis FAP HNPCC ‘Classic’ symptoms • Obstructive Jaundice – 50% – Truly ‘painless’ in about 10%, most will have some pain, but not biliary colic • Pain – 70% – Back / epigastrium – Relieved by sitting forward • Nausea / Vomiting • Weight Loss • Anorexia Other symptoms • New onset type 2 diabetes mellitus – underweight or normal weight patient, not associated with weight gain • Resistant dyspepsia/persistent epigastric pain • IBS like symptoms in those >45 years – very rare as a new onset symptom at this age • Altered bowel habit – Increased bowel movement frequency and offensive smelling stools – Suggestive of exocrine insufficiency • Venous Thromboembolism – may be a manifestation of an underlying abdominal malignancy Blood tests • Full blood count – anaemia rare except for ampullary tumours • Liver function tests – Obstructive jaundice – Elevated gamma GT / Alk Phos may precede bilirubin • Serum glucose – Diabetes or impaired glucose tolerance • CA19-9 – Sensitivity of ~80% and a specificity of 83% – Normal levels do not exclude diagnosis – Better for treatment monitoring Investigations • U/S – Often first line for jaundice – May demonstrate pancreatic mass • Contrast-enhanced CT – Gold standard – Essential for staging Referrals to Pancreatic MDT 1200 1020 1000 782 824 803 800 600 400 200 0 194 254 320 372 440 874 Referral sources 2013 Arrowe Park Aintree Whiston Southport Warrington Chester Wrexham Bangor GP Glan Clwyd Nobles Liverpool Womens’ LHCH Clatterbridge Spire Liverpool Macclesfield 198 105 95 76 75 71 37 21 20 17 17 5 3 3 1 1 Swansea Christie, Manchester Blackpool Abergele Devon & Exeter Wyre Valley Londonderry Nottingham Newcastle Bradford Leeds Turkey External referrals 2 1 1 1 1 1 1 1 1 1 1 1 774 Internal referrals from RLBUHT 246 1020 2013 Presumed Pancreas Cancers 542 Cancer or premalignant 475 Inoperable at Staging 367 Benign 67 Surgery 108 Resection 93 (resection rate 20%) Bypass 15 Surgery 44 Resection 40 No operation 23 Bypass 4 Length of pathway 2013 Referral to MDT Mean 6.5, Median 4 MDT to DTT Mean 10.6, Median 7 DTT to surgery Mean 26.2, Median 22 Referral to Surgery Mean 43.3, Median 39 NB: DTT to surgery time includes pre- operative anaesthetic assessment clinic +/- staging laparoscopy Chemotherapy • >80% now receive adjuvant chemotherapy after surgery (Gemcitabine +/- others) • Minority of unresectable patients fit for palliative chemotherapy (Folfirinox) – 50% if locally advanced – 36% if metastatic • Role of neo-adjuvant chemotherapy currently being explored – ESPAC-5 Long-term survival rates - post resection 1 year survival 61% > 75% 5 year survival X2LR =12.70 P<0.001 6% > 25% Summary • Pancreatic Cancer is the 9th commonest cancer in the UK • It is the 5th commonest cause of cancer death • Notoriously late presentation, early metastases and poor survival rates • Vague symptoms • If diagnosed early enough for surgical resection, then chances of surviving beyond five years increase ten-fold Resources • http://www.pancreaticcancer.org.uk/ • https://pancreaticcanceraction.org/ • http://www.cancerresearchuk.org/aboutcancer/type/pancreatic-cancer/ • http://elearning.rcgp.org.uk/course/info.php?id=103