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The Mystery of Delivery
&
The TOZZI Peptide Injectable
As the Skincare and Aesthetic Medical Industry enthusiastically embraces Amino
Peptides and their Contribution to Healthy Skin, ONLY The TOZZI Peptide Injectable
solves The Mystery of Delivery. Through its Patent- Pending Formula and PatentPending Delivery System by Injection, The TOZZI Peptide Injectable achieves the
necessary penetration of the Dermis. This represents a Revolution in Anti-Aging through
the Science of Fibroblasts.This Science is Prominent in the Method and Tutorial
(Programma) Advanced by Donna Tozzi R.N, B.S.N and The TOZZI Peptide Injectable.
While Traditional Mesotherapy well Established in Europe usually consists of Smaller
per Treatment Dosage, The TOZZI Peptide Injectable Programma provides for a 10ml
Treatment for the entire Facial Area as Compared to 3-5ml Treatments common in
Europe. With an Increased Infusion of Solution, the Treatment provides benefits for
the overall Architecture of the Face. The projected result provides Nutrition for Healthy
Skin immediately after Treatment. A continued Improvement during the 3 weeks after
Treatment extends to the next recommended Treatment interval, 3-4 months later.
The Patient Perspective which relates to Cost/Benefit is one of Value Added through a
Natural Treatment providing Nutrition for Healthy Skin.
For the Medical Professional, the Tutorial (Programma) presents an opportunity to offer
the effective delivery of Amino Peptides through a Treatment/Product that provides
Exclusivity in a Competitive Aesthetic Medical Environment.
Nutrition for the Skin, The TOZZI Way through The TOZZI Peptide Injectable
Tozzi Peptide Injectable | 1
Q&A
Ascend The TOZZI Way
A Conversation with Donna Tozzi
Q: What is The TOZZI Peptide Injectable?
T: The TOZZI Peptide Injectable is a Patent-Pending Intradermal Injectable (Aqueous
Solution). It is a Synergistic Blend in a Sequence of 7 Amino Peptides and 3 Powerful
Actives in a Balanced pH, Preservative Free Formula.
ll of The Natural Components are FDA Approved in the Composition which include
A
the following: Arginine, Carnosine, DMAE, Glucosamine, Isoleucine, Leucine, Lysine,
Methionine, Proline and Pyridoxine(B6) for Healthy Tissue Structure, Increased
Hydration, Clarity, Tone and Texture. Providing overall Improvements in Skin
Suppleness and Luminosity.
Q: How is The TOZZI Peptide Injectable different from other Aesthetic Medical
Injectables such as Botulinum Toxin A?
T: The TOZZI Peptide Injectable is an all Natural Intradermal Injectable that Provides
Nutrition for the Skin. The TOZZI Peptide Injectable contains Amino Peptides that
Naturally Stimulate Fibroblast Cells that Produce Collagen Synthesis. The TOZZI
Peptide Injectable is a Treatment for the Total Architectural Structure of the Face in
addition to the Neck, Cleavage, Décolleté and Back of Hands.
By contrast, Botulinum Toxin A is primarily injected in the upper third facial muscles.
The TOZZI Peptide Injectable is also NOT classified as a Dermal Filler which is a
completely separate category of injectables.
Tozzi Peptide Injectable | 2
Q: How, Where and by Whom is The TOZZI Peptide Injectable Administered?
T: The TOZZI Peptide Injectable is Injected into Targeted Areas of the Dermis several
millimeters deep.
The Targeted Areas include Specific Facial Areas as addressed in the Medical
Professionals Instruzione; Nasolabial Folds, Oral Commissures, Marionette Lines,
Pre-Jowl Sulcus, Jowls, Chin, Jawline, Angle of Mandible, Preauricular, Medial Face,
Cheeks, Tear Trough, Lateral Canthus, Linear Depressions, Fat Pads that Anchor
Brows, Forehead, Glabella, Temples, Upper Lip Rhytides (Smokers Lines), Perioral
and Extended Smile Lines (Static and Dynamic), Neck, Cleavage, Décolleté and
Back of Hands.
The TOZZI Peptide Injectable is ONLY injected by Licensed Medical Professionals
and made available by Prescription.
Q: Who is a Candidate for this Treatment?
T: Individuals who are presently receiving Aesthetic Medical Procedures. The TOZZI
Peptide Injectable Complements and Creates a ‘Foundation’ for other Aesthetic
Treatments.
This treatment is ideal for Thinning Skin in Women and Men who are
experiencing Menopause and Andropause.
Introductory Injectable for Women and Men who are Hesitant to try other
Aesthetic Injectables.
Introductory Injectable for Younger Patients who are NOT ready for Dermal
Fillers and Botulinum Toxin A Injectables.
The TOZZI Peptide Injectable Addresses Market Trends in Oncology Aesthetics,
Pre-Post Plastic Surgery, Social Media and HD TV and Film.
Tozzi Peptide Injectable | 3
Q: What are the Benefits & Results of The TOZZI Peptide Injectable?
T: The TOZZI Peptide Injectable is Providing Nutrition for the Skins Structural Repair
at the Cellular Level. It increases Dermal Density as Amino Peptides Naturally
Stimulate Fibroblast Cells to ‘Energize’ and to Produce Collagen.
There is an Immediate Result that Indicates Improvements in Tone, Texture,
Firmness, Brightness and Softening of Fine Lines. Cumulative Effects include a
Naturally Fueled Collagen Synthesis that helps to Clear Cellular Decay and ‘Energize’
and ‘Accelerate’ Cell Division for Healthier Skin.
Q: What Type of Experience can I expect from The TOZZI Peptide Injectable?
T: The TOZZI Peptide Injectable Treatment is administered using a ‘Tiny’ Specialty
Needle that is Gently Injected Several Millimeters into the Dermis. The PatentPending Neutral pH Formula provides for a Comfortable Treatment Experience.
Medical Professionals who Administer The TOZZI Peptide Injectable may use
The TOZZI Anesthetic with Peptides, 15 minutes Prior to the Treatment.
Q: How often should I have The TOZZI Peptide Injectable?
T: Typically, The TOZZI Peptide Injectable Treatment is Recommended every 3-4
Months. After the Initial Treatment it is suggested that an Additional Treatment is
Administered 3-4 weeks later and subsequently every 3-4 Months. This may vary
due to Skin Condition and Age.
The TOZZI Peptide Injectable may be injected ALONE or 2 Weeks Before or After
Scheduled Aesthetic Procedures. The TOZZI Peptide Injectable may be injected
FIRST before Dermal Fillers or Botulinum Toxin A Procedures in the same session.
The TOZZI Peptide Injectable may be used 2 weeks PRIOR to Laser Treatments to
‘Energize’ Skin Cells
The TOZZI Peptide Injectable may be used as a ‘Booster’ in Stem Cell Therapy or
PRP Therapy.
Tozzi Peptide Injectable | 4
Q: A re there any Side Effects and or Contraindications from
The TOZZI Peptide Injectable?
T: The TOZZI Peptide Injectable is Composed of Amino Peptides that occur Naturally
in the Human Body to Fuel Collagen Production. As a result, there is a Minimal Risk
of Allergy, Immune Reaction or Injection Induced Reaction. Bruising may occur on an
individual basis.
Contraindications may result when The TOZZI Peptide Injectable is used in
Combination with Chemical Peels or Laser Treatments in the same session.
The TOZZI Peptide Injectable is NOT recommended for Pregnant and BreastFeeding Mothers.
Q: H ow does the Cost (to the Consumer) of The TOZZI Peptide Injectable
Treatment Compare to other Aesthetic Medical Treatments?
T: The TOZZI Peptide Injectable is a Treatment for the Total Architecture of the Face.
Other Aesthetic Injectable Treatments typically are priced to the Consumer on a
‘Per Area’ Cost. The cost of The TOZZI Peptide Injectable for the Entire Face is
Comparable to One Area of other Injectable treatments.
The TOZZI Peptide Injectable Represents Good Value in a
Much Less Invasive Treatment.
Q: What other TOZZI Products Complement The TOZZI Peptide Injectable?
T: The TOZZI Collection Portfolio of Products includes TOZZI Skin Care, TOZZI Hair
Care and TOZZI Nutricosmetics. Please visit www.tozzicollection.com.
Licensed Medical Professionals may Purchase TOZZI Peptide Peel ONLY by
Prescription
Q: Where can a Medical Professional Purchase The TOZZI Peptide Injectable?
T: The TOZZI Peptide Injectable is a Patent-Pending Prescription available through our
Authorized Licensed Compound Pharmacy, Central Drugs in La Habra, California.
www.centraldrugsrx.com
Tozzi Peptide Injectable | 5
The Features and Benefits for
Consumers
Feature
Benefit
• Prescription-strength injectable
• Works in conjunction with, not
instead of, other injectables such
as Botulinum Toxin A and Dermal
Fillers
• Immediately delivers a higher dose of active
ingredients directly to the dermis for faster results
than is physically possible compared with nonprescription or prescription creams and gels that are
applied to the surface of the skin.
• Supplements existing procedures. Creates a
‘Foundation’ for other Aesthetic Procedures.
• Administered by prescriber
• Prescription strength, administered
by a licensed medical professional.
• Amino acid/peptide technology
is at the forefront of Aesthetic
Medicine
• Take advantage of the latest Science-Stimulating
Fibroblast Cells to Naturally Produce Collagen
• Non-surgical procedure
• No downtime is required before you can “show your
face in public” immediately following the procedure.
• Organic, Preservative Free, Neutral
pH Injectable Solution. Contains
• “Natural” ingredients
a Sequence of 7 Amino Peptides
+ Glucosamine, DMAE and
Pyridoxine(B6)
Tozzi Peptide Injectable | 6
The Science
Amino Peptides
Antioxidants
Hydration
The Science behind The TOZZI Peptide Injectable Preparation consists primarily of a sequence of 7 Amino
Acids, which are building blocks for protein. Proteins are components of all skin cells and are needed to repair
damaged tissue. Amino Acids help to repair skin at the cellular level and Naturally Fuel Collagen Synthesis.
Collagen synthesis, in turn, may retard aging and assist in clearing cellular decay while accelerating cell
division that may contribute to Healthier, Younger-Looking Skin.
The goal is to build up the dermal matrix by “Energizing” Fibroblast Cells for this activity. Amino Peptides
can be viewed as the keys to biochemical pathways on the outside of the fibroblasts, unleashing the chain
reaction to build and repair this supportive layer of skin (1).
Fibroblasts produce Collagen by using Nutritional Support. Amino Peptides are essential to
compensate for reduced Fibroblast activity associated with Aging.
Physicians may prescribe Amino Peptides to women in Menopause because decreased Estrogen is related
to thinning skin and the depletion of Collagen and Elastin in the skin. In men, decreased Testosterone named
Andropause is related to thinning skin.
The TOZZI Amino Peptide Injectable is a blend of Essential and Non-Essential Amino Acids, Antioxidants
and Glucosamine for Hydration that work together and are delivered directly to the Dermis Layer of the Skin.
These components provide for available Precursors that are known to be beneficial to the skin by supporting
Healthy Tissue Structure, Increasing Hydration, Clarity and De-Pigmentation.
Precursors are utilized as a compound in a chain of enzymatic reactions that give a more stable, definitive
outcome. The TOZZI Peptide Injectable does not utilize non-cross linked hyaluronic acid in the composition.
Upon injection it would provide a short duration of a positive aesthetic benefit but would eventually break
down and dissipate.
The TOZZI Peptide Injectable has a Sequence of 7 Amino Peptides, DMAE, Glucosamine and
Pyridoxine(B6) with a Neutral pH (7.0) for Optimal Metabolic Exchanges for efficient Cellular
Proliferation and to maintain Physiological Normothermia.
1. Marieb, Elaine N. (2005). Essentials of Human Anatomy and Physiology.
Benjamin/Cummings Publishing, Menlo Park, CA
Tozzi Peptide Injectable | 7
The Fibroblast Cell
Principal Cells of the Dermis Specializing in Synthesizing Collagen and Elastin
Fibers responsible for the Skin’s Structural Integrity, Elasticity and Resilience.
The Proper Function of Fibroblasts is Highly Important
for overall Skin Health.
secretory
granules
intracellular granules
composed of secretory
proteins after their conversion
by Golgi apparatus
microtubule
a hollow cylindrical structure which
increase in number during cell
division and are associated with the
movement DNA material
transfer
vesicles
a portion of the endoplasmic
reticulum which encloses
newly synthesized proteins
and buds off and travels to and
fuses with the Golgi apparatus
Golgi apparatus
etymology: Camillo Golgi; Italian
histologist and Nobel laureate,
1843–1926; small membranous
structures found in most cells,
composed of various elements
associated with the formation
of carbohydrate side chains of
glycoproteins, mucopolysaccarides,
and other substances
nucleus
nucleolus
ribosomes
a small particle composed of
RNA and protein that is found in
the cytoplasm of living cells, it is
the site of protein synthesis
mitochondrion
rough
endoplasmic
reticulum
a small rodlike body bounded by a
double membrane in the cytoplasm
of most cells contains enzymes
responsible for energy production
parts are attached to ribosomes
on the cytoplasmic side; involved
in the biosynthesis of proteins for
export to outside of the cell and
enzymes to be incorporated into
cellular organelles; subunit within
cell with a specific function
cytoplasm
all of the substance of
a cell other than the
nucleus and the cell wall
collagen fibrils
delicate fibrils of collagen in
connective tissue, composed
of molecules of tropocollagen
aggregated in a linear array
polyribosomes
a cluster of ribosomes
connected with messenger
RNA; they play a role in peptide
synthesis
Tozzi Peptide Injectable | 8
nucleolus
a small round body of
protein in a cell nucleus
cell nucleus
part of the cell containing
DNA and RNA and
responsible for growth
and development
Amino Peptides
Antioxidants
Hydration
The Components
The TOZZI Peptide Injectable is Composed of a Sequence of 7 Amino Acids,
DMAE, Glucosamine & Pyridoxine that may provide Healthy Tissue Structure
that Support the Architectural Structure of the Face, Neck, Cleavage,
Décolléte and Back of Hands.
Clinical and Subjective Observation indicated the following Improvements:
• Tone • Texture • Elasticity • Brightness • Firmness • Hydration
• Increased Dermal Density/Thickness after Subsequent Treatments
• Softening of Deep and Superficial Lines and Furrows
• Overall Suppleness and Luminous Skin
1. Arginine HCL
• Super Antioxidant
• Component of Collagen
• Elastin Production Booster
• Converts to Nitric Oxide for
• Reparative Qualities
Improved Blood Flow
2. Carnosine
• Super Antioxidant
• Cell Renewal and Longevity Booster
• Rejuvenates Cells by Extending Cellular Life Span
• A Dipeptide (beta-alanine + histidine) responsible for
• May reduce Telomere Shortening Rate
3. Isoleucine
• Aids in Healing and Repair of
• Prevents Muscle Breakdown
Cell Renewal
Muscle Tissue, Skin Cells and Bones
Tozzi Peptide Injectable | 9
4. Leucine
• Protects
against Muscle Protein Breakdown
5. Lysine HCL
• A Precursor of Collagen Production
• A Precursor of Elastin Production (Desmosine and Isodemonsine)
• Prevents Bone Loss-Lab Studies from the University of Maryland Medical
Center indicate
Combining Arginine + Lysine might enhance Bone Growth by making Bone Building Cells
more active and Increasing the Production of Collagen, hence Facial Bones
6. Methionine
• Super Antioxidant
• Essential for the Formation of Healthy
• Benefits Skin Tone and Elasticity
• Sulfur containing Amino Acid
Collagen
7. Proline
• A Precursor of Collagen Production
• Improves Strength of Cellular Wall
8. DMAE
• Super Antioxidant
• Strong Anti-inflammatory and Age Defying Properties
• A Precursor to the Neurotransmitter Acetycholine to Contract and Tighten
• Protects Integrity of Cell Membranes, reinforcing the Skin’s Foundation of
Skin
Collagen & Elastin
• Flushes excess Lipofuscin-Age Pigment from Skin Cells to reduce Age Spots
9. Glucosamine HCL
• A Prominent Precursor for Hyaluronic Acid Production
• Facilitates Treatment for Hyperpigmentation
• Assists in Treatment of Psoriasis
10. P
yridoxine (B6)
• Important Role in the Metabolism
• Promotes Red Cell Production
• May Decrease Skin Inflammation
for Hydration
of Amino Acids
* All of the Individual Components in The TOZZI Peptide Injectable are FDA Approved Components*
Tozzi Peptide Injectable | 10
The Face (Faccia) Injection Points
“The Foundation” • “The Fondazione”
8
8
7
6
5
1
9
4
2
3
1. Nasolabial Fold
2. Oral Commissures – Marionette Lines
3. Mental Crease-Jowl-Chin
4. Jaw Line
5. Medial Face
6. Cheek
7.Lateral Canthus – Linear Depressions
8. Forehead – Glabellar
9. Upper Lip Rhytides - Perioral
Tozzi Peptide Injectable | 11
The Face (Faccia) Injection Points
“The Foundation” • “The Fondazione”
10
10. Extended Smile Lines
Static
Dynamic
Tozzi Peptide Injectable | 12
The Face (Faccia) Injection Points
“The Details” • “The Dettagli”
14
15
12
13
11
11. Angle of Mandible
12. Preauricular
13. Tear Trough – Orbital Rim
14. Fat Pad that Anchors Brow-Above Brow
15. Temple
Tozzi Peptide Injectable | 13
The Cleavage (Scissione) Injection Points
The Décolleté Injection Points
Tozzi Peptide Injectable | 14
The Neck (Collo) Injection Points
Tozzi Peptide Injectable | 15
The Hand (Mano) Injection Points
Tozzi Peptide Injectable | 16
The Thank You Message from the Creator
Dear Aesthetic Client,
Born out of my Ongoing Quest for Unique Anti-Aging
Modalities, The TOZZI Peptide Injectable is the result
of my Extensive Knowledge and Research of Aesthetic
Medicine. Well established in Europe, The TOZZI Peptide
Injectable brings to the US Market a Product/Treatment
that fulfills the growing demand for Amino-Peptide
Technology through an Injectable.
It is my Great Pleasure to share this with you
and Thank You for your Participation in
The TOZZI Peptide Injectable Revolution.
Saluté,
Donna M. Tozzi
Tozzi Peptide Injectable | 17