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The Mystery of Delivery & The TOZZI Peptide Injectable As the Skincare and Aesthetic Medical Industry enthusiastically embraces Amino Peptides and their Contribution to Healthy Skin, ONLY The TOZZI Peptide Injectable solves The Mystery of Delivery. Through its Patent- Pending Formula and PatentPending Delivery System by Injection, The TOZZI Peptide Injectable achieves the necessary penetration of the Dermis. This represents a Revolution in Anti-Aging through the Science of Fibroblasts.This Science is Prominent in the Method and Tutorial (Programma) Advanced by Donna Tozzi R.N, B.S.N and The TOZZI Peptide Injectable. While Traditional Mesotherapy well Established in Europe usually consists of Smaller per Treatment Dosage, The TOZZI Peptide Injectable Programma provides for a 10ml Treatment for the entire Facial Area as Compared to 3-5ml Treatments common in Europe. With an Increased Infusion of Solution, the Treatment provides benefits for the overall Architecture of the Face. The projected result provides Nutrition for Healthy Skin immediately after Treatment. A continued Improvement during the 3 weeks after Treatment extends to the next recommended Treatment interval, 3-4 months later. The Patient Perspective which relates to Cost/Benefit is one of Value Added through a Natural Treatment providing Nutrition for Healthy Skin. For the Medical Professional, the Tutorial (Programma) presents an opportunity to offer the effective delivery of Amino Peptides through a Treatment/Product that provides Exclusivity in a Competitive Aesthetic Medical Environment. Nutrition for the Skin, The TOZZI Way through The TOZZI Peptide Injectable Tozzi Peptide Injectable | 1 Q&A Ascend The TOZZI Way A Conversation with Donna Tozzi Q: What is The TOZZI Peptide Injectable? T: The TOZZI Peptide Injectable is a Patent-Pending Intradermal Injectable (Aqueous Solution). It is a Synergistic Blend in a Sequence of 7 Amino Peptides and 3 Powerful Actives in a Balanced pH, Preservative Free Formula. ll of The Natural Components are FDA Approved in the Composition which include A the following: Arginine, Carnosine, DMAE, Glucosamine, Isoleucine, Leucine, Lysine, Methionine, Proline and Pyridoxine(B6) for Healthy Tissue Structure, Increased Hydration, Clarity, Tone and Texture. Providing overall Improvements in Skin Suppleness and Luminosity. Q: How is The TOZZI Peptide Injectable different from other Aesthetic Medical Injectables such as Botulinum Toxin A? T: The TOZZI Peptide Injectable is an all Natural Intradermal Injectable that Provides Nutrition for the Skin. The TOZZI Peptide Injectable contains Amino Peptides that Naturally Stimulate Fibroblast Cells that Produce Collagen Synthesis. The TOZZI Peptide Injectable is a Treatment for the Total Architectural Structure of the Face in addition to the Neck, Cleavage, Décolleté and Back of Hands. By contrast, Botulinum Toxin A is primarily injected in the upper third facial muscles. The TOZZI Peptide Injectable is also NOT classified as a Dermal Filler which is a completely separate category of injectables. Tozzi Peptide Injectable | 2 Q: How, Where and by Whom is The TOZZI Peptide Injectable Administered? T: The TOZZI Peptide Injectable is Injected into Targeted Areas of the Dermis several millimeters deep. The Targeted Areas include Specific Facial Areas as addressed in the Medical Professionals Instruzione; Nasolabial Folds, Oral Commissures, Marionette Lines, Pre-Jowl Sulcus, Jowls, Chin, Jawline, Angle of Mandible, Preauricular, Medial Face, Cheeks, Tear Trough, Lateral Canthus, Linear Depressions, Fat Pads that Anchor Brows, Forehead, Glabella, Temples, Upper Lip Rhytides (Smokers Lines), Perioral and Extended Smile Lines (Static and Dynamic), Neck, Cleavage, Décolleté and Back of Hands. The TOZZI Peptide Injectable is ONLY injected by Licensed Medical Professionals and made available by Prescription. Q: Who is a Candidate for this Treatment? T: Individuals who are presently receiving Aesthetic Medical Procedures. The TOZZI Peptide Injectable Complements and Creates a ‘Foundation’ for other Aesthetic Treatments. This treatment is ideal for Thinning Skin in Women and Men who are experiencing Menopause and Andropause. Introductory Injectable for Women and Men who are Hesitant to try other Aesthetic Injectables. Introductory Injectable for Younger Patients who are NOT ready for Dermal Fillers and Botulinum Toxin A Injectables. The TOZZI Peptide Injectable Addresses Market Trends in Oncology Aesthetics, Pre-Post Plastic Surgery, Social Media and HD TV and Film. Tozzi Peptide Injectable | 3 Q: What are the Benefits & Results of The TOZZI Peptide Injectable? T: The TOZZI Peptide Injectable is Providing Nutrition for the Skins Structural Repair at the Cellular Level. It increases Dermal Density as Amino Peptides Naturally Stimulate Fibroblast Cells to ‘Energize’ and to Produce Collagen. There is an Immediate Result that Indicates Improvements in Tone, Texture, Firmness, Brightness and Softening of Fine Lines. Cumulative Effects include a Naturally Fueled Collagen Synthesis that helps to Clear Cellular Decay and ‘Energize’ and ‘Accelerate’ Cell Division for Healthier Skin. Q: What Type of Experience can I expect from The TOZZI Peptide Injectable? T: The TOZZI Peptide Injectable Treatment is administered using a ‘Tiny’ Specialty Needle that is Gently Injected Several Millimeters into the Dermis. The PatentPending Neutral pH Formula provides for a Comfortable Treatment Experience. Medical Professionals who Administer The TOZZI Peptide Injectable may use The TOZZI Anesthetic with Peptides, 15 minutes Prior to the Treatment. Q: How often should I have The TOZZI Peptide Injectable? T: Typically, The TOZZI Peptide Injectable Treatment is Recommended every 3-4 Months. After the Initial Treatment it is suggested that an Additional Treatment is Administered 3-4 weeks later and subsequently every 3-4 Months. This may vary due to Skin Condition and Age. The TOZZI Peptide Injectable may be injected ALONE or 2 Weeks Before or After Scheduled Aesthetic Procedures. The TOZZI Peptide Injectable may be injected FIRST before Dermal Fillers or Botulinum Toxin A Procedures in the same session. The TOZZI Peptide Injectable may be used 2 weeks PRIOR to Laser Treatments to ‘Energize’ Skin Cells The TOZZI Peptide Injectable may be used as a ‘Booster’ in Stem Cell Therapy or PRP Therapy. Tozzi Peptide Injectable | 4 Q: A re there any Side Effects and or Contraindications from The TOZZI Peptide Injectable? T: The TOZZI Peptide Injectable is Composed of Amino Peptides that occur Naturally in the Human Body to Fuel Collagen Production. As a result, there is a Minimal Risk of Allergy, Immune Reaction or Injection Induced Reaction. Bruising may occur on an individual basis. Contraindications may result when The TOZZI Peptide Injectable is used in Combination with Chemical Peels or Laser Treatments in the same session. The TOZZI Peptide Injectable is NOT recommended for Pregnant and BreastFeeding Mothers. Q: H ow does the Cost (to the Consumer) of The TOZZI Peptide Injectable Treatment Compare to other Aesthetic Medical Treatments? T: The TOZZI Peptide Injectable is a Treatment for the Total Architecture of the Face. Other Aesthetic Injectable Treatments typically are priced to the Consumer on a ‘Per Area’ Cost. The cost of The TOZZI Peptide Injectable for the Entire Face is Comparable to One Area of other Injectable treatments. The TOZZI Peptide Injectable Represents Good Value in a Much Less Invasive Treatment. Q: What other TOZZI Products Complement The TOZZI Peptide Injectable? T: The TOZZI Collection Portfolio of Products includes TOZZI Skin Care, TOZZI Hair Care and TOZZI Nutricosmetics. Please visit www.tozzicollection.com. Licensed Medical Professionals may Purchase TOZZI Peptide Peel ONLY by Prescription Q: Where can a Medical Professional Purchase The TOZZI Peptide Injectable? T: The TOZZI Peptide Injectable is a Patent-Pending Prescription available through our Authorized Licensed Compound Pharmacy, Central Drugs in La Habra, California. www.centraldrugsrx.com Tozzi Peptide Injectable | 5 The Features and Benefits for Consumers Feature Benefit • Prescription-strength injectable • Works in conjunction with, not instead of, other injectables such as Botulinum Toxin A and Dermal Fillers • Immediately delivers a higher dose of active ingredients directly to the dermis for faster results than is physically possible compared with nonprescription or prescription creams and gels that are applied to the surface of the skin. • Supplements existing procedures. Creates a ‘Foundation’ for other Aesthetic Procedures. • Administered by prescriber • Prescription strength, administered by a licensed medical professional. • Amino acid/peptide technology is at the forefront of Aesthetic Medicine • Take advantage of the latest Science-Stimulating Fibroblast Cells to Naturally Produce Collagen • Non-surgical procedure • No downtime is required before you can “show your face in public” immediately following the procedure. • Organic, Preservative Free, Neutral pH Injectable Solution. Contains • “Natural” ingredients a Sequence of 7 Amino Peptides + Glucosamine, DMAE and Pyridoxine(B6) Tozzi Peptide Injectable | 6 The Science Amino Peptides Antioxidants Hydration The Science behind The TOZZI Peptide Injectable Preparation consists primarily of a sequence of 7 Amino Acids, which are building blocks for protein. Proteins are components of all skin cells and are needed to repair damaged tissue. Amino Acids help to repair skin at the cellular level and Naturally Fuel Collagen Synthesis. Collagen synthesis, in turn, may retard aging and assist in clearing cellular decay while accelerating cell division that may contribute to Healthier, Younger-Looking Skin. The goal is to build up the dermal matrix by “Energizing” Fibroblast Cells for this activity. Amino Peptides can be viewed as the keys to biochemical pathways on the outside of the fibroblasts, unleashing the chain reaction to build and repair this supportive layer of skin (1). Fibroblasts produce Collagen by using Nutritional Support. Amino Peptides are essential to compensate for reduced Fibroblast activity associated with Aging. Physicians may prescribe Amino Peptides to women in Menopause because decreased Estrogen is related to thinning skin and the depletion of Collagen and Elastin in the skin. In men, decreased Testosterone named Andropause is related to thinning skin. The TOZZI Amino Peptide Injectable is a blend of Essential and Non-Essential Amino Acids, Antioxidants and Glucosamine for Hydration that work together and are delivered directly to the Dermis Layer of the Skin. These components provide for available Precursors that are known to be beneficial to the skin by supporting Healthy Tissue Structure, Increasing Hydration, Clarity and De-Pigmentation. Precursors are utilized as a compound in a chain of enzymatic reactions that give a more stable, definitive outcome. The TOZZI Peptide Injectable does not utilize non-cross linked hyaluronic acid in the composition. Upon injection it would provide a short duration of a positive aesthetic benefit but would eventually break down and dissipate. The TOZZI Peptide Injectable has a Sequence of 7 Amino Peptides, DMAE, Glucosamine and Pyridoxine(B6) with a Neutral pH (7.0) for Optimal Metabolic Exchanges for efficient Cellular Proliferation and to maintain Physiological Normothermia. 1. Marieb, Elaine N. (2005). Essentials of Human Anatomy and Physiology. Benjamin/Cummings Publishing, Menlo Park, CA Tozzi Peptide Injectable | 7 The Fibroblast Cell Principal Cells of the Dermis Specializing in Synthesizing Collagen and Elastin Fibers responsible for the Skin’s Structural Integrity, Elasticity and Resilience. The Proper Function of Fibroblasts is Highly Important for overall Skin Health. secretory granules intracellular granules composed of secretory proteins after their conversion by Golgi apparatus microtubule a hollow cylindrical structure which increase in number during cell division and are associated with the movement DNA material transfer vesicles a portion of the endoplasmic reticulum which encloses newly synthesized proteins and buds off and travels to and fuses with the Golgi apparatus Golgi apparatus etymology: Camillo Golgi; Italian histologist and Nobel laureate, 1843–1926; small membranous structures found in most cells, composed of various elements associated with the formation of carbohydrate side chains of glycoproteins, mucopolysaccarides, and other substances nucleus nucleolus ribosomes a small particle composed of RNA and protein that is found in the cytoplasm of living cells, it is the site of protein synthesis mitochondrion rough endoplasmic reticulum a small rodlike body bounded by a double membrane in the cytoplasm of most cells contains enzymes responsible for energy production parts are attached to ribosomes on the cytoplasmic side; involved in the biosynthesis of proteins for export to outside of the cell and enzymes to be incorporated into cellular organelles; subunit within cell with a specific function cytoplasm all of the substance of a cell other than the nucleus and the cell wall collagen fibrils delicate fibrils of collagen in connective tissue, composed of molecules of tropocollagen aggregated in a linear array polyribosomes a cluster of ribosomes connected with messenger RNA; they play a role in peptide synthesis Tozzi Peptide Injectable | 8 nucleolus a small round body of protein in a cell nucleus cell nucleus part of the cell containing DNA and RNA and responsible for growth and development Amino Peptides Antioxidants Hydration The Components The TOZZI Peptide Injectable is Composed of a Sequence of 7 Amino Acids, DMAE, Glucosamine & Pyridoxine that may provide Healthy Tissue Structure that Support the Architectural Structure of the Face, Neck, Cleavage, Décolléte and Back of Hands. Clinical and Subjective Observation indicated the following Improvements: • Tone • Texture • Elasticity • Brightness • Firmness • Hydration • Increased Dermal Density/Thickness after Subsequent Treatments • Softening of Deep and Superficial Lines and Furrows • Overall Suppleness and Luminous Skin 1. Arginine HCL • Super Antioxidant • Component of Collagen • Elastin Production Booster • Converts to Nitric Oxide for • Reparative Qualities Improved Blood Flow 2. Carnosine • Super Antioxidant • Cell Renewal and Longevity Booster • Rejuvenates Cells by Extending Cellular Life Span • A Dipeptide (beta-alanine + histidine) responsible for • May reduce Telomere Shortening Rate 3. Isoleucine • Aids in Healing and Repair of • Prevents Muscle Breakdown Cell Renewal Muscle Tissue, Skin Cells and Bones Tozzi Peptide Injectable | 9 4. Leucine • Protects against Muscle Protein Breakdown 5. Lysine HCL • A Precursor of Collagen Production • A Precursor of Elastin Production (Desmosine and Isodemonsine) • Prevents Bone Loss-Lab Studies from the University of Maryland Medical Center indicate Combining Arginine + Lysine might enhance Bone Growth by making Bone Building Cells more active and Increasing the Production of Collagen, hence Facial Bones 6. Methionine • Super Antioxidant • Essential for the Formation of Healthy • Benefits Skin Tone and Elasticity • Sulfur containing Amino Acid Collagen 7. Proline • A Precursor of Collagen Production • Improves Strength of Cellular Wall 8. DMAE • Super Antioxidant • Strong Anti-inflammatory and Age Defying Properties • A Precursor to the Neurotransmitter Acetycholine to Contract and Tighten • Protects Integrity of Cell Membranes, reinforcing the Skin’s Foundation of Skin Collagen & Elastin • Flushes excess Lipofuscin-Age Pigment from Skin Cells to reduce Age Spots 9. Glucosamine HCL • A Prominent Precursor for Hyaluronic Acid Production • Facilitates Treatment for Hyperpigmentation • Assists in Treatment of Psoriasis 10. P yridoxine (B6) • Important Role in the Metabolism • Promotes Red Cell Production • May Decrease Skin Inflammation for Hydration of Amino Acids * All of the Individual Components in The TOZZI Peptide Injectable are FDA Approved Components* Tozzi Peptide Injectable | 10 The Face (Faccia) Injection Points “The Foundation” • “The Fondazione” 8 8 7 6 5 1 9 4 2 3 1. Nasolabial Fold 2. Oral Commissures – Marionette Lines 3. Mental Crease-Jowl-Chin 4. Jaw Line 5. Medial Face 6. Cheek 7.Lateral Canthus – Linear Depressions 8. Forehead – Glabellar 9. Upper Lip Rhytides - Perioral Tozzi Peptide Injectable | 11 The Face (Faccia) Injection Points “The Foundation” • “The Fondazione” 10 10. Extended Smile Lines Static Dynamic Tozzi Peptide Injectable | 12 The Face (Faccia) Injection Points “The Details” • “The Dettagli” 14 15 12 13 11 11. Angle of Mandible 12. Preauricular 13. Tear Trough – Orbital Rim 14. Fat Pad that Anchors Brow-Above Brow 15. Temple Tozzi Peptide Injectable | 13 The Cleavage (Scissione) Injection Points The Décolleté Injection Points Tozzi Peptide Injectable | 14 The Neck (Collo) Injection Points Tozzi Peptide Injectable | 15 The Hand (Mano) Injection Points Tozzi Peptide Injectable | 16 The Thank You Message from the Creator Dear Aesthetic Client, Born out of my Ongoing Quest for Unique Anti-Aging Modalities, The TOZZI Peptide Injectable is the result of my Extensive Knowledge and Research of Aesthetic Medicine. Well established in Europe, The TOZZI Peptide Injectable brings to the US Market a Product/Treatment that fulfills the growing demand for Amino-Peptide Technology through an Injectable. It is my Great Pleasure to share this with you and Thank You for your Participation in The TOZZI Peptide Injectable Revolution. Saluté, Donna M. Tozzi Tozzi Peptide Injectable | 17