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TUESDAY, 30 AUGUST 2011 – MORNING 08:30-10:00 | London - Zone A THE GREAT DEBATE – LEFT MAIN IN 2011: CABG OR PCI? Chairperson(s): G. Wimmer-Greinecker (Bad Bevensen, DE) In collaboration with EuroPCR - EAPCI Focus Imaging Intervention Panel for the great debate. – A. Erglis (Riga, LV), V. Falk (Zurich, CH), D. Hildick-Smith (Brighton, GB), M.C. Morice (Massy, FR), D. Taggart (Oxford, GB), L. Torracca (Ancona, IT) 3667 08:30-10:00 | The Hague - Zone A CHALLENGING ISSUES IN PRIMARY PREVENTION Chairperson(s): P. Giannuzzi (Veruno, IT); L. Tokgozoglu (Ankara, TR) Focus Cardiology Practice 16 year old obese male: focusing on prevention in young adult. 50 year old male with high risk score: focusing on global risk modification. Elderly man: focusing on whether prevention is worthy in elderly. Panel. – I. Daullxhiu (Prishtina, KS), S. Gielen (Leipzig, DE), J.W. Jukema (Leiden, NL), D. Milicic (Zagreb, HR) 3668 08:30-10:00 | Rabat - Zone A (QR 508*) EMERGING BIOLOGICAL MECHANISMS OF CARDIOMYOPATHIES Chairperson(s): B. Crozatier (Chatenay-Malabry, FR); M. Piper (Dusseldorf, DE) 08:30 08:45 09:00 09:15 09:30 09:45 Abstract Session Spontaneous cardiac hypertrophy and adverse LV remodelling in a novel human relevant mouse model of diabetes; a mechanistic insight. – S. Gibbons, Z. Hegab, M. Zi, S. Prehar, T.M.A. Mohamed, R. Cox, E.J. Cartwright, L. Neyses, M.A. Mamas (Manchester and Oxford, GB) Dishevelled-induced cardiomyopathy is rescued by deletion of CaMKII. – M. Zhang, M. Hagenmueller, P. Malekar, J. Riffel, C. Weiss, M. Ochs, J. Backs, S.E. Hardt, H.A. Katus (Heidelberg, DE) Matrix metalloproteinase inhibitors enhance hypertrophic growth and reduce apoptosis in ventricular cardiomyocytes of rats. – G. Euler, Y. Osygus, C. Sprejz, J. Heger (Giessen, DE) Real-time imaging of cAMP dynamics in an in vitro model of cardiac hypertrophy. – A. Zoccarato, M. Zaccolo (Glasgow, GB) Dyxin mediates cardiac hypertrophic response during angiotensin II -induced hypertension. – T. Karvonen, A.-M. Moilanen, E. Mustonen, J. Aro, H. Ruskoaho, J. Rysa (Oulu, FI) Protein kinase A -mediated stimulation of activating transcription factor 3 by hypertrophic stimuli in cardiomyocytes. – E. Koivisto, A.-M. Moilanen, H. Tokola, J. Aro, H. Pennanen, H. Sakkinen, L. Kaikkonen, H. Ruskoaho, J. Rysa (Oulu, FI) 3669 3670 3671 3672 3673 3674 08:30-10:00 | Stockholm - Zone A (QR 518*) 08:30 08:45 09:00 09:15 09:30 09:45 Abstract Session Distinct entity of heart failure in the very elderly as compared with younger based on swedish national heart failure registry. – A. Holmstrom, L. Ma, R. Sigurjonsdottir, M. Edner, Å. Jonsson, U.G. Dahlstrom, M. Fu (Gothenburg, SE) Differential expression of collagen turn-over markers in heart failure patients with preserved and reduced ejection fraction. – J.-M. Lin, J.-L. Ro, C.-T. Tsai, L.-P. Lai, J.-L. Lin (Keelung and Taipei, TW) Diastolic heart failure and reduction in global longitudinal strain: a study with strain imaging and NT-pro-BNP level in patients with rheumatoid arthritis. – D. Ridjab, T. Schau, M. Zaenker, C. Butter (Bernau bei Berlin, DE) Comparison between Framingham risk profile and NT-proBNP for predicting asymptomatic left ventricular dysfunction in a population at high cardiovascular risk (DAVID-Berg study). – A. Fontana, A. Grosu, S. Guideri, M. Gori, A. Iacovoni, P. Ferrari, A. Filippi, R. De Maria, M. Senni, A. Gavazzi (Bergamo and Milan, IT) Inflammation and left ventricular diastolic dysfunction. – C.-K. Wu, J.-K. Lee, C.-T. Tsai, J.-J. Hwang, F.-T. Chiang (Taipei, TW) GDF-15 levels but not NTproBNP levels predict diastolic heart failure in morbid obesity. – M. Fischer, C. Strack, J. Bruxmeier, F. Wagner, E. Rousseva, G. Schmitz, G. Riegger, A. Baessler (Regensburg, DE) *Abstracts can be accessed at: QR 508 TUESDAY – MORNING DISSECTING DIASTOLIC DYSFUNCTION FOR THE CLINICIAN Chairperson(s): C. Tschoepe (Berlin, DE); P. de Groote (Lille, FR) 3675 3676 (W) 3677 3678 3679 3680 QR 518 225 TUESDAY, 30 AUGUST 2011 – MORNING 08:30-10:00 | Tel Aviv - Zone A INSULIN RESISTANCE OF THE FAILING HEART Chairperson(s): S. Chlopicki (Krakow, PL); D.J. Hausenloy (London, GB) 08:30 08:52 09:15 09:37 Clinical Seminar Mitochondrial reactive oxygen species. – C. Maack (Homburg/Saar, DE) Redox regulation in calcium and sodium handling. – S. Wagner (Göttingen, DE) Insulin resistance. – M. Mamas (Manchester, GB) Diabetes. – B.M. Pieske (Graz, AT) 3681 3682 3683 3684 08:30-10:00 | Tripoli - Zone A (QR 520*) PREDICTING PROGNOSIS IN HEART FAILURE Chairperson(s): C. Mueller (Basel, CH); P. Kalra (Portsmouth, GB) 08:30 08:45 09:00 09:15 09:30 09:45 Abstract Session Relation of serum sodium concentration to mortality in a large spectrum of heart failure patients with preserved and reduced ejection fraction: results from the MAGGIC meta-analysis. – D. Rusinaru, C. Tribouilloy, C. Berry, M. Richards, N. Earle, K. Poppe, M. Guazzi, S. Macin, M. Komajda, R. Doughty (Amiens and Paris, FR; Glasgow, GB; Christchurch and Auckland, NZ; Milan, IT; Corrientes, AR) The prognostic value of troponins in patients with heart failure: a meta-analysis. – E. Gardini, F. Ottani, L. La Vecchia, D. Ferrini, M. Galvani (Forlì and Vicenza, IT) Delayed recovery in peripartum cardiomyopathy: an indication for long-term follow-up and sustained therapy. – M. Biteker, E. Ilhan, D. Duman, M. Can, A. Dayan (Istanbul, TR) Role of lung impedance monitoring in the outpatient clinic for predicting and preventing of hospitalizations patients with chronic heart failure. – M. Shochat, A. Shotan, M. Kazatsker, V. Gurovich, E. Noiman, I. Shochat, I. Dahan, Y. Levy, D. Blondheim, S. Meisel (Hadera, IL) Mid-region proHormone adrenomedullin identifies acutely dyspneic emergency department patients with high 90 day mortality: results from the Biomarkers in Acute Heart Failure (BACH) trial. – R.M. Nowak, W.F. Peacock, C. Mueller, S.X. Neath, S. Disomma, C. Hogan, M. Richards, O. Hartmann, S.D. Anker, A. Maisel (Detroit, Cleveland, San Diego and Richmond, US; Basel, CH; Rome, IT; Hennigsdorf/Berlin, DE) Five-year survival and predictors of mortality after hospitalization for acute heart failure. – J.P.E. Lassus, K. Siirila-Waris, K. Peuhkurinen, M.S. Nieminen, V.-P. Harjola (Helsinki and Kuopio, FI) 3685 3686 3687 3688 3689 3690 08:30-10:00 | Vienna - Zone A NO ROLE IN THE CLINIC? Chairperson(s): J. Bauersachs (Hannover, DE); E. Cerbai (Florence, IT) 08:30 08:52 09:15 09:37 Nitric oxide and ischaemia-reperfusion. – A. Bogdanova (Zurich, CH) Nitric oxide and cardiac stem cells differentiation. – J.L. Balligand (Brussels, BE) Nitric oxide synthase and atrial fibrillation. – B. Casadei (Oxford, GB) The therapeutic potential of nitric oxide-cGMP signalling in cardiac disease. – S. Janssens (Leuven, BE) Symposium 3691 3692 3693 3694 08:30-10:00 | Warsaw - Zone A CARDIORENAL SYNDROME, AN INEVITABLE CONSEQUENCE OF HEART FAILURE? Chairperson(s): S.D. Anker (Berlin, DE); A.P. Maggioni (Florence, IT) 08:30 08:52 09:15 09:37 Pathophysiology of cardiorenal interactions. – C. Ronco (Vicenza, IT) New biomarkers for risk identification. – A.A. Voors (Groningen, NL) Anaemia and iron deficiency. – P. Ponikowski (Wroclaw, PL) Therapeutic options. – G.S. Filippatos (Athens, GR) *Abstracts can be accessed at: 226 QR 520 Clinical Seminar 3695 3696 3697 3698 TUESDAY, 30 AUGUST 2011 – MORNING 08:30-10:00 | Moscow - Zone B MANAGEMENT OF SYNCOPE PATIENTS. STILL A CHALLENGE Chairperson(s): E. Simantirakis (Heraklion, GR); P. Kulakowski (Warsaw, PL) 08:30 08:52 09:15 09:37 Clues from clinical history. – R. Sutton (Monte Carlo, MC) Syncope evaluation unit: organisation and benefits. – A. Moya I Mitjans (Barcelona, ES) Implantable loop recorders. – M. Brignole (Lavagna, IT) Pitfalls in the management of syncope. – R.A. Kenny (Dublin, IE) Clinical Seminar 3699 3700 3701 3702 08:30-10:00 | Oslo - Zone B ESC GUIDELINES FOR THE MANAGEMENT OF CARDIOVASCULAR DISEASES DURING PREGNANCY Chairperson(s): C. Gohlke-Baerwolf (Ballrechten-Dottingen, DE); J.-M. Foidart (Liège, BE) The Committee for Practice Guidelines 08:30 08:52 09:15 09:37 New aspects in the pregnancy guidelines. – V. Regitz-Zagrosek (Berlin, DE) Identification and management of the high-risk patient. – J.W. Roos-Hesselink (Rotterdam, NL) Which arrhythmias need treatment. – C. Blomstrom-Lundqvist (Uppsala, SE) How to manage anticoagulation in pregnant women. – P.G. Pieper (Groningen, NL) Symposium 3703 3704 3705 3706 08:30-10:00 | Prague - Zone B PREVENTING SUDDEN DEATH Chairperson(s): H.J. Wellens (Maastricht, NL); I. Fernandez Lozano (Madrid, ES) 08:30 08:52 09:15 09:37 Scope of the problem and risk stratification. – X. Jouven (Paris, FR) Autonomic testing. – P.J. Schwartz (Pavia, IT) Genetic testing. – S. Kaab (Munich, DE) Where to place automatic external defibrillators and who pays? – H.-J. Trappe (Herne, DE) Symposium 3707 3708 3709 3710 08:30-10:00 | Riga - Zone B (QR 646*) ATRIAL FIBRILLATION AND ISCHAEMIC HEART DISEASE Chairperson(s): M.H. Crawford (San Francisco, US); J. Kautzner (Prague, CZ) 08:45 09:00 09:15 09:30 09:45 Comparison of CHADS2 score with CHADSVASC-Score in a prospective multicenter registry on 3711 patients with atrial fibrillation undergoing coronary artery stenting (AFCAS-trial). – A. Schlitt, A. Rubboli, J. Valencia, P. Karjalainen, M. Weber, M. Puurunen, P. Kirchhof, M. Niemelae, G.Y.H. Lip, J. Airaksinen (Halle, Bad Nauheim and Münster, DE; Bologna, IT; Alicante, ES; Satakunta, Helsinki, Oulu and Turku, FI; Birmingham, GB) Transient atrial fibrillation complicating acute myocardial infarction: implications for future risk of 3712 ischemic stroke. – D. Aronson, H. Hammerman, M. Kapeliovich, R. Dragu, R. Bishara (Haifa, IL) Influence of new onset atrial fibrillation on long-term prognosis in patients aged >89 years with 3713 acute myocardial infarction. – M. Martinez-Selles, T. Datino, L. Figueiras-Graillet, H. Bueno, F. Fernandez-Aviles (Madrid, ES) The effect of acute onset atrial fibrillation and rapid atrial rates on markers of thrombogenesis in 3714 the human left atrium. – H.S. Lim, S.R. Willoughby, C. Schultz, C. Gan, A.G. Brooks, M. Alasady, D.H. Lau, M.I. Worthley, G.D. Young, P. Sanders (Adelaide, AU) Reversal of rivaroxaban mediated anticoagulation in animal models by a recombinant antidote 3715 protein (r-Antidote, PRT064445). – G. Lu, F.R. Deguzman, M.J. Karbarz, S.J. Hollenbach, P.B. Conley, A. Hutchaleelaha, U. Sinha (South San Francisco, US) Impact of atrial fibrillation on 5-year-mortality of patients with stable angina and documented 3716 coronary artery disease in clinical practice: results of the STAR-Registry. – A.K. Gitt, F. Towae, A. Papp, R. Zahn, C. Juenger, J. Senges (Ludwigshafen am Rhein and Ludwigshafen, DE) *Abstracts can be accessed at: TUESDAY – MORNING 08:30 Abstract Session QR 646 227 TUESDAY, 30 AUGUST 2011 – MORNING 08:30-10:00 | Rome - Zone B (QR 642*) HEART RATE MATTERS Chairperson(s): H. Darius (Berlin, DE); J.T. Parissis (Athens, GR) 08:30 08:45 09:00 09:15 09:30 09:45 Abstract Session Heart rate and cardiac allograft vasculopathy in heart transplant recipients. – M.T. La Rovere, F. Olmetti, G.D. Pinna, R. Maestri, D. Lilleri, A. D’Armini, M. Vigano, O. Febo (Montescano and Pavia, IT) Impact of radiofrequency catheter ablation on echocardiographic and cardiopulmonary performance in patients with ventricular extrasystolic beats and suspected arrhythmia-induced cardiomyopathy. – T. Krynski, S.M. Stec, S. Szmit, B. Zaborska, P. Kulakowski (Warsaw, PL) Selective heart rate reduction with ivabradine improves left ventricular remodeling and function: insights from the SHIFT echocardiography sub-study. – J.-C. Tardif, E. O’Meara, M. Komajda, M. Böhm, J.S. Borer, I. Ford, L. Tavazzi, K. Swedberg (Montreal, CA; Paris, FR; Homburg/Saar, DE; Brooklyn, US; Glasgow, GB; Cotignola, IT; Gothenburg, SE) Effects of ivabradine plus beta blockers as first step therapy on heart rate, compliance, quality of life and exercise tolerance in patients with chronic heart failure. – A. Macchi, I. Franzoni, I. Rosa, M.C. Pedrigi, F. Buzzetti, R. Gorla, G.V. Gaudio, P.G. Camici, A. Margonato (Milan and Somma Lombardo, IT) Restoration of vagal tone by donepezil, on top of losartan treatment, markedly suppresses ventricular dysfunction and improves long-term survival in chronic heart failure rats. – M. Li, C. Zheng, T. Kawada, M. Inagaki, H. Takaki, M. Sugimachi (Osaka and Kochi, JP) Vagus nerve stimulation improves left ventricular function in heart failure: results of a 6 month investigation with a cross-over design in dogs with experimental heart failure. – H.N. Sabbah, M. Wang, R.C. Gupta, S. Rastogi, S.B. Ruble, J.J. Hamann (Detroit and St. Paul, US) 3717 3718 3719 (W) 3720 3721 3722 08:30-10:00 | Sofia - Zone B (QR 650*) EVERY HEART BEAT COUNTS Chairperson(s): U.C. Hoppe (Cologne, DE); G. Parcharidis (Thessaloniki, GR) 08:30 08:45 09:00 09:15 09:30 09:45 The relationship between baseline resting heart rate and death and cardiovascular complications in patients with type 2 diabetes mellitus. – G.S. Hillis, M. Woodward, A. Rodgers, C. Chow, S. Zoungas, A. Patel, R. Webster, G. Batty, T. Ninomiya, J. Chalmers (Sydney, AU; London, GB; Fukuoka, JP) Modest weight-loss in moderately overweight postmenopausal woman improves heart rate variability. – M.R. Mouridsen, N.T. Bendsen, A. Astrup, S.B. Haugaard, Z. Binici, A. Sajadieh (Copenhagen, DK) Epicardial fat thickness predicts blunted heart rate recovery in patients with metabolic syndrome. – C. Sengul, D. Duman (Istanbul, TR) The Influence of body-mass index on outcomes in subjects with atrial fibrillation and heart failure: data from the AF-CHF study. – A. Nigam, P. Khairy, M. Talajic, S. Levesque, D. Roy (Montreal, CA) Increased incidence of atrial fibrillation associated with the use of cyclooxygenase-2 inhibitors in a nationwide cohort study of 7 million individuals. – M. Back, L. Yin, E. Ingelsson (Stockholm, SE) Influence of atrial fibrillation on cardiopulmonary function during exercise in patients with cardiac disease. – H. Tsuneoka, A. Koike, O. Nagayama, K. Sakurada, H. Sawada, K. Aonuma, T. Aizawa (Tsukuba and Tokyo, JP) *Abstracts can be accessed at: 228 Abstract Session QR 642 QR 650 3723 3724 3725 3726 3727 3728 TUESDAY, 30 AUGUST 2011 – MORNING 08:30-10:00 | Brussels - Zone D (QR 536*) HOW TO ACHIEVE BETTER BLOOD PRESSURE CONTROL? Chairperson(s): A.M. Heagerty (Manchester, GB); V.S. Ram (Dallas, US) 09:45 09:30 08:45 09:00 08:30 09:15 Abstract Session Patient persistence with antihypertensive drugs in France, Germany and the UK. – B. Ehlken, K. Kostev, A. Sandberg, B. Holz, A. Oberdiek (Munich and Frankfurt, DE) Genetic variation in renin predicts the effects of thiazide diuretics. – C.-C. Huang, C.-M. Chung, S.-I. Hung, H.-B. Leu, T.-C. Wu, P.-H. Huang, S.-J. Lin, W.-H. Pan, J.-W. Chen (Taipei, TW) Effects of valsartan and amlodipine on home blood pressure and cardiovascular events in Japanese hypertensive patients: a subanalysis of the VART. – H. Hasegawa, H. Takano, H. Narumi, S. Shindo, H. Mizuma, Y. Kuwabara, Y. Kobayashi, I. Komuro (Chiba and Osaka, JP) Effective hemodynamically guided antihypertensive therapy with use of impedance cardiography a randomized, controlled trial. – P. Krzesinski, G.G. Gielerak, J.J. Kowal (Warsaw, PL) Prediction of response to spironolactone treatment in patients with resistant arterial hypertension: insights from the ASPIRANT trial. – J. Vaclavik, E. Kocianova, R. Sedlak, M. Plachy, K. Navratil, J. Plasek, J. Jarkovsky, T. Vaclavik, M. Svestak, M. Taborsky (Olomouc, Prostejov, Brno, Ostrava and Prague, CZ) Individualized programming demonstrates feasibility of unilateral approach to delivery of baroreflex activation therapy. – A. Kroon, D. Sica, J. Bisognano, M. Nadim, L. Sanchez, G. Bakris (Maastricht, NL; Richmond, Rochester, Los Angeles, St. Louis and Chicago, US) 3729 3730 3731 3732 3733 3734 08:30-10:00 | Copenhagen - Zone D CARDIOVASCULAR RISK – CHALLENGE OF THE FUTURE Chairperson(s): F.J. Pinto (Lisbon, PT); H.K. Najm (Riyadh, SA) The European Society of Cardiology and the Saudi Heart Association 08:30 08:52 09:15 09:37 Symposium Hypertension and diabetes in arabic countries. – M.B. Bdeir (Riyadh, SA) Concept of prevention. – I.M. Graham (Dublin, IE) Crisis management of diabetes tsunami in Saudi Arabia, prevention before treatment. – K. Al Rubeaan (Riyadh, SA) New strategies for resistant hypertension with metabolic syndrome. – F. Mahfoud (Homburg/Saar, DE) 3735 3736 3737 3738 08:30-10:00 | Damascus - Zone D (QR 554*) 08:30 08:45 09:00 09:15 09:30 09:45 Abstract Session The impact of sFAS on mortality in patients with carotid atherosclerosis. – M. Hoke, M. Schillinger, A. Wonnerth, W.S. Speidl, G. Maurer, R. Koppensteiner, E. Minar, J. Wojta, A. Niessner (Vienna, AT) Cause-specific cardiovascular risk associated with use of nonsteroidal anti-inflammatory drugs among patients with prior myocardial infarction - a nationwide study. – A.M. Olsen, E.L. Fosbol, J. Lindhardsen, F. Folke, M. Charlot, J.B. Olesen, P.R. Hansen, L. Kober, C. Torp-Pedersen, G.H. Gislason (Hellerup and Copenhagen, DK; Durham, US) NT-proBNP, CRP, and the prediction of cardiovascular events: results from 15-year follow-up of the WOSCOPS study. – P. Welsh, O. Doolin, C. Packard, I. Ford, N. Sattar (Glasgow, GB) Elevated cardiac troponin T and C-reactive protein interactively increased cardiovascular and all-cause mortality risk in chronic hemodialysis patients -10-year prospective study. – T. Aoyama, H. Ishii, H. Takahashi, Y. Kumada, M. Tanaka, D. Kamoi, Y. Kawamura, K. Kawashima, J. Ishii, T. Murohara (Nagoya and Toyoake, JP) A new cardiovascular score for the low risk and aged mediterranean population: the ERICE-SCORE. – R. Gabriel Sanchez, C. Brotons, M.J. Tormo, A. Segura, F. Rigo, R. Elosua, J. Carbayo, J. Tuomilehto, A. Ortega, J. Muniz (Madrid, Barcelona, Murcia, Toledo, Palma de Mallorca, Albacete and La Coruña, ES) The impact of gout and hyperuricaemia on total and cardiovascular mortality in the general population. – A. Hanley, A. Stack (Letterkenny, IE) *Abstracts can be accessed at: QR 536 3739 3740 TUESDAY – MORNING THE COMPLEXITY OF RISK IN HEART DISEASE Chairperson(s): T. Zdrojewski (Sopot, PL); P. Kala (Brno, CZ) 3741 3742 3743 3744 QR 554 229 TUESDAY, 30 AUGUST 2011 – MORNING 08:30-10:00 | Helsinki - Zone D NOVEL TARGETS TO ATTACK EXERCISE INTOLERANCE IN HEART FAILURE Chairperson(s): A. Mezzani (Veruno, IT); L.E.M. Vanhees (Leuven, BE) 08:30 08:52 09:15 09:37 Symposium Cardiomyocytes. – O.J. Kemi (Glasgow, GB) Skeletal muscle. – R.F. Ventura-Clapier (Chatenay-Malabry, FR) Bone marrow. – A.H.P. Linke (Leipzig, DE) Cellular effects of iron. – V. Conraads (Edegem, BE) 3745 3746 3747 3748 08:30-10:00 | Lisbon - Zone D CAN THE POLYPILL SAVE THE WORLD? Chairperson(s): D.A. Wood (London, GB); S. Smith (Chapel Hill, US) The European Society of Cardiology and the World Heart Federation 08:30 08:52 09:15 09:37 Symposium Cardiovascular prevention; a global problem. – U. Keil (Münster, DE) Polypill for primary prevention. – S. Yusuf (Hamilton, CA) Polypill for secondary prevention. – V. Fuster (New York, US) Alternatives to polypills. – A.J. Taylor (Washington, US) 3749 3750 3751 3752 08:30-10:00 | Madrid - Zone D (QR 557*) EVOLVING EVIDENCE FOR PSYCHOSOCIAL ISSUES IN HEART DISEASE Chairperson(s): L. Kopin (Rochester, US); G.S. Tell (Bergen, NO) 08:30 08:45 09:00 09:15 09:30 09:45 Endothelial function and circulating adhesion molecules and in depressed subjects with coronary risk factors. – C. Pizzi, L. Manzoli, G.M. Costa, L. Santarella, R. Bugiardini (Bologna and Chieti, IT) Anger predicts long-term mortality in patients with myocardial infarction. – F. Bonaguidi, C. Michelassi, C. Carpeggiani, M.G. Trivella, E. Picano, D. Rovai, A. L’Abbate (Pisa, IT) Stressful life events and depression are predictors of fatal and nonfatal events in patients with arterial hypertension and coronary heart disease. – N. Pogosova, R.G. Oganov, Y.M. Yufereva, I.E. Koltunov, A.D. Deev (Moscow, RU) Cognitive behaviour therapy benefits depressed cardiac patients: results of a randomised controlled trial. – M. Worcester, B. Murphy, A. Turner, R. Higgins, P. Elliott, H. Navaratnam, M. Le Grande, A. Goble (Melbourne, AU) Increased levels of psychological stress in a population undergoing family heart screening for inheritable cardiac diseases. – C. McShane, C. McGorrian, C. O’Donnell, O. Constant, T. Keelan, J. Galvin, J. O’Neill, N.G. Mahon (Dublin, IE) Does cardiac resynchronisation therapy affect the burden of depression in patients with heart failure? – V. Nayar, F.Z. Khan, T. Robinson, P. Cantelon, D.P. Dutka, P.J. Pugh (Cambridge, GB) *Abstracts can be accessed at: 230 Abstract Session QR 557 3753 3754 3755 3756 3757 3758 TUESDAY, 30 AUGUST 2011 – MORNING 08:30-10:00 | Beirut - Zone E (QR 560*) PEDIATRIC PULMONARY ARTERIAL HYPERTENSION Chairperson(s): M. Beghetti (Geneva, CH); M.A. Gomez Sanchez (Pozuelo de Alarcon, ES) 08:30 08:45 09:00 09:15 09:30 09:45 Abstract Session Hemodynamic characterization at diagnosis in children with Pulmonary Hypertension (PH): insights from the global TOPP registry (Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension). – I. Schulze-Neick, T. Humpl, R.M.F. Berger, G. Raskob, R. Weintraub, B. Saji, D. Yung, R.J. Barst, M. Beghetti (London, GB; Toronto, CA; Groningen, NL; Oklahoma City, Seattle and New York, US; Melbourne, AU; Tokyo, JP; Geneva, CH) Pediatric pulmonary hypertension: insights from the Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension (TOPP) global registry. – R.M.F. Berger, T. Humpl, I. Schulze-Neick, G. Raskob, D.D. Ivy, Z.-C. Jing, D. Bonnet, M. Beghetti, R.J. Barst (Groningen, NL; Toronto, CA; London, GB; Oklahoma City, Denver and New York, US; Shanghai, CN; Paris, FR; Geneva, CH) Current era survival in patients with pediatric pulmonary arterial hypertension. – F. Sciarra, E. Leci, M. Palazzini, E. Conficoni, F. Sgro’, E. Beciani, C. Bachetti, A. Manes, A. Branzi, N. Galie’ (Bologna, IT) Pulmonary arterial stroke volume: a new and strong prognostic factor in pediatric pulmonary arterial hypertension. – J.M. Douwes, M.T.R. Roofthooft, M. Talsma, H.L. Hillege, R.M.F. Berger (Groningen, NL) Prognostic implications of cardiac MRI in paediatric patients with pulmonary hypertension. – S. Moledina, S.G. Haworth, A.M. Taylor, I. Schulze-Neick, V. Muthurangu (London, GB) Palliative Potts shunt in children with idiopathic pulmonary arterial hypertension: short and mid -term results. – A.-E. Baruteau, D. Bonnet, M. Humbert, J. Petit, M. Levy, X. Jais, A.-E. Serraf, P. Vouhe, G. Simonneau, E. Belli (Le Plessis-Robinson, Paris and Clamart, FR) 3759 3760 3761 3762 3763 3764 08:30-10:00 | Berne - Zone E GENETIC BACKGROUND OF DILATED CARDIOMYOPATHIES Chairperson(s): P.M. Elliott (London, GB); H. Seggewiss (Schweinfurt, DE) 08:30 08:48 09:06 09:24 3765 3766 3767 3768 3769 TUESDAY – MORNING 09:42 Lessons from animal models. – W. Rottbauer (Ulm, DE) Phenotypic and genetic heterogeneity: an overview. – E. Arbustini (Pavia, IT) Laminopathies: from genetic defect to treatment. – Y. Pinto (Amsterdam, NL) Genome wide approach in dilated cardiomyopathy. – P. Charron (Paris, FR) Familial forms of inflammatory cardiomyopathy. – A.L.P. Caforio (Padua, IT) Symposium *Abstracts can be accessed at: QR 560 231 TUESDAY, 30 AUGUST 2011 – MORNING 08:30-10:00 | Bratislava - Zone E (QR 576*) RIGHT VENTRICULAR FUNCTION: NEW TECHNOLOGY FOR BETTER PROGNOSIS Chairperson(s): A. Vonk Noordegraaf (Amsterdam, NL); M.M. Barbosa (Nova Lima, BR) 08:30 08:45 09:00 09:15 09:30 09:45 Abstract Session Greater accuracy of two-dimensional strain measures of right ventricle for diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy. – M. Iacoviello, A. Puzzovivo, C. Forleo, I. Nalin, F. Monitillo, S. Sorrentino, P. Guida, M. Anaclerio, V. Marangelli, S. Favale (Bari, IT) Detection of right ventricular involvement by speckle tracking derived longitudinal strain imaging in patient with acute inferior ST elevation myocardial infarction and proximal right coronary artery. – M. Hutyra, T. Skala, J. Precek, D. Vindis, D. Richter, D. Horak, Z. Tudos, M. Koecher, M. Taborsky (Olomouc, CZ) Feasibility and accuracy of 3-dimensional echocardiography for measurements of the right ventricular volumes and function in adult patients: validation with magnetic resonance imaging. – E. Ostenfeld, K. Shahgaldi, A. Roijer, M. Carlsson, J. Holm (Malmo, Stockholm and Lund, SE) Right ventricular free wall strain has a closer correlation with right ventricular ejection fraction than other echocardiographic indices of right ventricular function: A comparison with cardiac MRI. – R.F. Duncan, A.J. Nelson, J. Schuster, B.K. Dundon, M.I. Worthley, A. Carbone, A. Zaman, S.G. Worthley (Newcastle-upon-Tyne, GB; Adelaide, AU) Importance of right ventricular function in patient referred for cardiac surgery. – M. Berry, J. Nahum, L. Macron, J.P. Couetil, O. Zaghden, O. Lairez, T. Damy, J.L. Dubois Rande, P. Gueret, P. Lim (Toulouse and Créteil, FR) Prognostic value of right ventricular function assessed by the tricuspid annular plane systolic excursion in acute myocardial infarction. – G. Bedetti, L. Gargani, C. Pizzi, R. Sicari, E. Picano (Imola, Pisa and Bologna, IT) 3770 3771 3772 3773 3774 3775 08:30-10:00 | Bucharest - Zone E CONTROVERSIAL ISSUES: DOES IMAGING IMPROVE OUTCOME? Chairperson(s): M.J. Zellweger (Basel, CH); M. Lombardi (Pisa, IT) 08:30 08:52 09:15 09:37 Main Session Cardiac magnetic resonance. – J. Schwitter (Lausanne, CH) Nuclear techniques. – F.M. Bengel (Hannover, DE) Echocardiography. – L.A. Pierard (Liège, BE) Computed tomography coronary angiography. – P.J. De Feyter (Rotterdam, NL) 3776 3777 3778 3779 08:30-10:00 | Budapest - Zone E REMOTE MONITORING OF CARDIAC RYTHM DEVICES: PRESENT AND FUTURE Chairperson(s): D.L. Scher (Harrisburg, US); B. Gorenek (Eskisehir, TR) 08:30 08:52 09:15 09:37 Symposium Pacemakers and implantable cardioverter-defibrillators. – P. Mabo (Rennes, FR) Heart failure. – F. Braunschweig (Stockholm, SE) Patient management and legal issues. – G. Boriani (Bologna, IT) Data exchange between remote monitoring databases and local electronic patient record system. – E.T. van der Velde (Leiden, NL) 3780 3781 3782 3783 08:30-10:00 | Cairo - Zone E CONTROVERSIAL ISSUES ON TRANSCATHETER AORTIC VALVE IMPLANTATION Chairperson(s): H. Eltchaninoff (Rouen, FR); F.W. Mohr (Leipzig, DE) 08:30 08:52 09:15 09:37 What are the current indications? – G.C. Schuler (Leipzig, DE) Very high-risk patients with aortic stenosis: TAVI, balloon or nothing? – J. Rodes Cabau (Sainte-Foy, CA) Is it time to expand indications to include low-risk patients? – N. Piazza (Munich, DE) Is valve-in-valve the preferred treatment for bioprosthesis failure? – D. Himbert (Paris, FR) *Abstracts can be accessed at: 232 QR 576 Clinical Seminar 3784 3785 3786 3787 TUESDAY, 30 AUGUST 2011 – MORNING 08:30-10:00 | Ankara - Zone F (QR 591*) A FRESH LOOK AT OLD AND NEW RISK FACTORS Chairperson(s): J.-P. Bassand (Besançcon, FR); S.D. Wiviott (Boston, US) 08:30 08:45 09:00 09:15 09:30 09:45 Abstract Session Comparison of known genetic variants to coronary heart disease risk between Indian Asians and Europeans. – D. Das, J. Sehmi, N. Ahmed, A. Kooner, K. Miller, J. Scott, P. Elliot, J.C. Chambers, J.S. Kooner (London, GB) Plasma lipidomic analysis of stable and unstable coronary artery disease. – B.A. Kingwell, D. Tsorotes, B. Goudey, A. Kowolczyk, I. Haviv, A. White, A. Dart, S. Duffy, G.L.R. Jennings, P. Meikle (Melbourne, AU) Low levels of IgM antibodies to oxidized cardiolipin increase but high levels decrease risk of cardiovascular disease in 60-year olds from Stockholm County. – J. Frostegard, J. Su, X. Hua, M. Vikstrom, K. Leander, B. Gigante, M.L. Hellenius, U. De Faire (Stockholm, SE) Interleukin 18 gene variation is associated with myocardial infarction. – W. Koch, A. Schatke, H. Wolferstetter, W. Latz, M. Eichinger, A. Schoemig, A. Kastrati (Munich, DE) Do diabetic patients really have a higher threshold for ischemic pain? – J.C. Nicolau, M. Franken, F.G. Lima, C.V. Serrano Jr, R.R. Giraldez, L.M. Baracioli, F. Ganem, T.F. Pinto, R. Kalil Filho, J.A.F. Ramires (São Paulo, BR) Impact of carotid artery ultrasound and ankle-brachial index for prediction of the severity of the SYNTAX score. – N. Ikeda, N. Kogame, R. Iijima, M. Nakamura, K. Sugi (Tokyo, JP) 3788 3789 3790 3791 3792 3793 08:30-10:00 | Athens - Zone F PRIMARY PERCUTANEOUS CORONARY INTERVENTION: FROM EVIDENCE TO PRACTICE Chairperson(s): A.H. Gershlick (Leicester, GB); P. Widimsky (Prague, CZ) 08:30 08:52 09:15 09:37 Controversies in antithrombotic treatment. – A. Kastrati (Munich, DE) Drug-eluting or bare metal stents? – M. Valgimigli (Ferrara, IT) The challenge of multi-vessel disease. – C. Di Mario (London, GB) Dealing with microvascular obstruction. – F. Crea (Rome, IT) Clinical Seminar 3794 3795 3796 3797 08:30-10:00 | Belgrade - Zone F 08:30 08:52 09:15 09:37 Surgical strategies. – M. De Bonis (Milan, IT) Percutaneous edge to edge technique. – O.W. Franzen (Copenhagen, DK) Percutaneous coronary sinus annuloplasty. – J. Harnek (Lund, SE) The bird’s eye view. – A. Vahanian (Paris, FR) Clinical Seminar 3798 3799 3800 3801 TUESDAY – MORNING NEW THERAPIES FOR MITRAL REGURGITATION Chairperson(s): M. Sousa Uva (Lisbon, PT); F. Weidinger (Vienna, AT) 08:30-10:00 | Berlin - Zone F CONTROVERSIAL ISSUES IN MYOCARDIAL REVASCULARISATION Chairperson(s): P.H. Kolh (Liège, BE); J. Fernandes E Fernandes (Lisbon, PT) 08:30 08:52 09:15 09:37 Functional evaluation as a guidance for revascularisation: non-invasive aproach. – P.A. Kaufmann (Zurich, CH) Functional evaluation as a guidance for revascularisation: invasive aproach. – B. De Bruyne (Aalst, BE) Percutaneous coronary intervention for left main stenosis. – F.J. Neumann (Bad Krozingen, DE) Surgery for left main stenosis. – P.T. Sergeant (Bertem, BE) *Abstracts can be accessed at: Symposium 3802 3803 3804 3805 QR 591 233 TUESDAY, 30 AUGUST 2011 – MORNING 08:30-10:00 | Tunis - Zone F (QR 599*) PREDICTORS OF OUTCOME IN HIGH RISK CORONARY INTERVENTIONS Chairperson(s): A. Hoye (Hull, GB); U. Limbruno (Grosseto, IT) 08:30 08:45 09:00 09:15 09:30 09:45 Abstract Session Long-term safety and efficacy of drug eluting and bare metal stents implanted in saphenous vein grafts in sweden. – F. Schersten, S.K. James, U. Stenestrand, J. Carlsson, O. Frobert, B. Lagerqvist (Lund, Uppsala, Linköping, Kalmar and Örebro, SE) Merging SYNTAX score with EuroSCORE improves risk stratification of patients undergoing left main angioplasty. – J.D. Brito, R. Teles, P. Goncalves, P. Sousa, M. Santos, F. Costa, P. Santos, L. Raposo, M. Almeida, M. Mendes (Carnaxide, PT) Long-term benefit of drug-eluting compared to bare-metal stents in patients with versus without chronic renal insufficiency, a BASKET-PROVE substudy. – M. Wanitschek, A. Hvelplund, F. Nietlispach, R. Jeger, A. Iversen, J.S. Jensen, S. Galatius, C.H. Kaiser, M. Pfisterer, H.F. Alber (Innsbruck, AT; Gentofte, DK; Basel, CH) 5-year outcomes of the MISSION intervention study; a randomized comparison of sirolimus-eluting to bare-metal stent implantation in patients with STEMI. – H. Boden, B.L. Van Der Hoeven, J.Z. Atary, S.S. Liem, E.E. Van Der Wall, M.J. Schalij (Leiden, NL) Five year follow-up of DIABETES trial: the final results. – P. Jimenez-Quevedo, L. Hernando, J.A. Gomez-Hospital, A. Iniguez, A. Sanroman, F. Alfonso, D. Angiolillo, J. Escaned, C. Macaya, M. Sabate (Madrid, Barcelona, Vigo and Valladolid, ES; Jacksonville, US) Clinical outcomes following stent thrombosis occurring in-hospital versus out-of-hospital; results of the HORIZONS-AMI trial. – B.E.P.M. Claessen, G.D. Dangas, R. Mehran, B. Witzenbichler, G. Gaugliumi, J. Peruga, K. Xu, G.W. Stone (New York, US) 3806 3807 3808 3809 3810 3811 08:30-10:00 | Zagreb - Zone F (QR 597*) UPDATE ON VASCULAR TREATMENT Chairperson(s): M. Roffi (Geneva, CH); F. Vermassen (Ghent, BE) 08:30 08:45 09:00 09:15 09:30 09:45 Vardenafil in patients with raynaud’s syndrome. – E. Caglayan, S. Axmann, M. Hellmich, P. Moinzadeh, M. Huntgeburth, N. Hunzelmann, T. Krieg, E. Erdmann, S. Rosenkranz (Cologne, DE) Immediate results of subclavian and innominate artery angioplasty and factors influencing stent patency. – T. Przewlocki, A. Kablak-Ziembicka, P. Pieniazek, P. Musialek, A. Kozanecki, L. Wrotniak, P. Podolec (Krakow, PL) Renal fractional flow reserve and hypertension response after renal artery stenting. – J.M. Kadziela, A. Witkowski, A. Januszewicz, A. Prejbisz, I. Michalowska, K. Cedro, L. Kalinczuk, E. Florczak, B. Norwa-Otto, E. Warchol (Warsaw, PL) LDL-cholesterol: the lower, the better: is it true for plaque regression? Statin alone versus combination of ezetimibe and statin. – K. Miyauchi, N. Nakajima, T. Kojima, T. Yokoyama, K. Yokoyama, T. Kurata, H. Tamura, S. Suwa, H. Daida (Tokyo and Shizuoka, JP) Transradial vascular access for proximal iliofemoral percutaneous interventions: a single-center experience. – F. Marcos-Sanchez, S. Rodriguez De Leiras-Otero, C. Carrrascosa-Rosillo, M. Vizcaino-Arellano, P. Cerrato-Garcia, R.J. Ruiz-Salmeron (Seville, ES) Simultaneous hybrid revascularization of carotid and coronary disease in patients with acute coronary syndrome: initial results of a new therapeutic approach. – M. Ponte, R. Fontes Carvalho, G. Pires De Morais, A. Albuquerque, P. Braga, A. Rodrigues, M. Veloso, L. Simoes, L. Vouga, V. Ribeiro (Vila Nova de Gaia, PT) *Abstracts can be accessed at: 234 Abstract Session QR 599 QR 597 3812 3813 3814 3815 3816 3817 TUESDAY, 30 AUGUST 2011 – MORNING 09:00-10:20 | Hands-On Tutorial Room 1 - Zone B 3D GUIDED INTERVENTIONS FOR STRUCTURAL AND CORONARY HEART DISEASE Chairperson(s): G. Brockmann (Munich, DE); H. Rittger (Coburg, DE) Hands-On Tutorial organised by Siemens AG, Healthcare Sector (on-site registration) Hands-On Tutorial 09:00-10:30 | Hands-On Tutorial Room 2 - Zone B A FAST NEW HYBRID TOOL FOR COMPREHENSIVE IMAGING OF CAD: CZT SPECT COMBINED WITH 64 SLICE CT Hands-On Tutorial organised by GE Healthcare (on-site registration) Hands-On Tutorial Review of clinical cases where hybrid imaging has impacted patient management. – M.G. Goldstein (Brussels, BE) 3818 09:00-10:30 | Hands-On Tutorial Room 3 - Zone B IMPROVING CARDIAC CARE BY PATIENT-SPECIFIC MODELING – FOCUS ON CARDIAC Hands-On Tutorial RESYNCHRONIZATION THERAPY Chairperson(s): R. Razavi (London, GB); J. Weese (Hamburg, DE); M. Sermesant (Sophia Antipolis, FR) Hands-On Tutorial organised by Philips Healthcare (on-site registration) 10:00-11:00 | Moderated Posters - Poster Zone C (QR 351*) OUTCOME, PROCEDURES AND TREATMENT IN ACUTE CORONARY SYNDROME Chairperson(s): D.L. Bhatt (Newton, US); E. Giannitsis (Heidelberg, DE) Moderated Posters Posters must be set up between 08:00 and 08:30, removed between 12:30 and 13:00 and be on display from 08:30 to 12:30.The following abstracts were chosen for their outstanding quality and will be discussed in a special area in the Poster hall during the Moderated Poster Session chaired by the two above-mentioned chairpersons between 10:00 and 11:00. 10:07 10:15 10:22 10:30 10:37 10:45 10:52 Clinical criteria for early invasive strategy in non-STE acute coronary syndrome in the real world. Development and validation of a decision model. – M. De Abreu, A. Silberstein, J. Mariani, J. Gagliardi, H. Doval, C. Tajer (Buenos Aires, AR) Contrast induced nephropathy predicts later mortality among patients with non-ST-segment elevation acute coronary syndrome undergoing PCI: a sub-analysis from the EARLY ACS study. – G.M. De Ferrari, F. Van De Werf, P. Armstrong, C. Bode, B.S. Lewis, P. Tricoci, J. Guo, C. Contant, K. Newby, R.P. Giugliano (Pavia, IT; Leuven, BE; Edmonton, CA; Freiburg, DE; Haifa, IL; Durham and Boston, US) Impact on short- and long-term mortality of invasive vs. conservative strategy in non-ST elevation acute coronary syndromes: a meta-analysis. – S. Stavrakis, J.A. Stoner, U. Thadani (Oklahoma City, US) Long-term outcomes after procedure-related or spontaneous myocardial infarction in patients presenting with non-ST-elevation acute coronary syndrome. – P. Damman, F. Windhausen, A. Hirsch, K.A.A. Fox, T. Clayton, S.J. Pocock, B. Lagerqvist, L. Wallentin, J.G.P. Tijssen, R.J. De Winter (Amsterdam, NL; Edinburgh and London, GB; Uppsala, SE) Temporal trends in treatment and outcomes of patients with non-ST-segment elevation myocardial infarction (NSTEMI) in clinical practice - analysis from the PL-ACS registry. – L. Polonski, M. Gasior, M. Gierlotka, P. Buszman, W. Ruzyllo, J. Dubiel, W. Banasiak, Z. Kalarus, M. Zembala, G. Opolski (Zabrze, Katowice, Warsaw, Krakow and Wroclaw, PL) Non-invasive assessment of atherosclerotic plaque inflammation by microwave radiometry: an experimental and histopathological study. – K. Toutouzas, C. Grassos, M. Drakopoulou, A. Synetos, A. Michelongona, C. Patsa, G. Agrogiannis, E. Patsouris, E. Siores, C. Stefanadis (Athens, GR; Bolton, GB) Percutaneous left ventricular support with the Impella 2.5 in cardiogenic shock - Results of the INTERPELLA-shock-registry. – A. Lauten, A. Engstroem, C. Jung, K. Empen, S. Cook, M. Bergmann, M. Haude, J.P. Henriques, H.R. Figulla, M. Ferrari (Jena, Greifswald, Hamburg and Neuss, DE; Amsterdam, NL; Berne, CH) Effects of early and late re-infarction on mortality in patients with re-canalized or conservatively treated occluded coronary arteries in long term follow up of the Occluded Artery Trial (OAT). – C. Adlbrecht, K. Huber, H.R. Reynolds, A.C. Carvalho, H.D. White, P.G. Steg, L. Liu, C.A. Pearte, P. Marino, J.S. Hochman (Vienna, AT; New York and Owings Mills, US; São Paulo, BR; Auckland, NZ; Paris, FR; Novara, IT) *Abstracts can be accessed at: P3819 (W) P3820 P3821 P3822 P3823 TUESDAY – MORNING 10:00 P3824 P3825 P3826 QR 351 235 TUESDAY, 30 AUGUST 2011 – MORNING 10:00-11:00 | Moderated Posters - Poster Zone C (QR 352*) DIASTOLIC FUNCTION Chairperson(s): P. Poredos (Ljubljana, SI); J.-W. Ha (Seoul, KR) Moderated Posters Posters must be set up between 08:00 and 08:30, removed between 12:30 and 13:00 and be on display from 08:30 to 12:30.The following abstracts were chosen for their outstanding quality and will be discussed in a special area in the Poster hall during the Moderated Poster Session chaired by the two above-mentioned chairpersons between 10:00 and 11:00. 10:00 10:07 10:15 10:22 10:30 10:37 10:45 10:52 Phasic left atrial volumes changed before and after hemodialysis. – W.W. Lin, K.Y. Wang, P.S. Lin, T.L. Jou, M.C. Chen, C.T. Ting, Y.T. Chen (Taichung, TW) Global left ventricular circumferential strain is a marker for both systolic and diastolic myocardial function. – T. Onishi, S.K. Saha, D. Ludwig, E. Schelbert, D. Schwartzman, J. Gorcsan (Pittsburgh, US; Sundsvall, SE) Validation of European association of echocardiography/American Society of echocardiography decision-making algorithm for the estimation of filling pressures. – Z.B. Popovic, K. Negishi, J.D. Thomas, T. Marwick (Cleveland, US) Predictive value of strain diastolic index in detecting elevated N-terminal-pro BNP level in asymptomatic hypertensive patients with preserved left ventricular ejection fraction. – S.J. Chiang, M. Daimon, S. Miyazaki, Y. Koiso, H. Suzuki, M.-H. Yeh, B.-T. Huang, H. Daida (Taipei, TW; Tokyo, JP) Utility of global strain by 2D and 3D speckle tracking in assessing diastolic function: comparison with pressure-volume loop analysis. – S.-H. Shin, S.-D. Park, W.-I. Woo, D.-H. Kim, K.-S. Park, J. Kwan (Incheon, KR) Estimation of left ventricular stiffness by three-dimensional echocardiography in comparison with conductance catheter measurements. – M. Kasner, D. Westermann, D.L. Sinning, H.P. Schultheiss, C. Tschoepe (Berlin, DE) Relationship between new diastolic strain rate indexes of left ventricular filling pressure and exercise capacity in patients with chronic heart failure. – K. Suzuki, S. Kou, M. Izumo, K. Mziukoshi, R. Kamijima, M. Takai, N. Osada, Y.J. Akashi, K. Omiya, F. Miyake (Kawasaki, JP) A novel global tissue Doppler index in the assessment of cardiac diastolic adaptive changes in athletes is dependent on body composition. – D. Popovic, M. Ostojic, M. Petrovic, B. Vujisic-Tesic, A. Arandjelovic, A. Kocijancic, B. Popovic, S. Damjanovic (Belgrade, RS) P3827 P3828 P3829 P3830 P3831 P3832 P3833 P3834 10:05-10:55 | Sofia - Zone B THE BEST OF THE EUROPEAN HEART JOURNAL – ACUTE CORONARY SYNDROME Chairperson(s): F. Crea (Rome, IT); U. Landmesser (Zurich, CH) 10:05 10:10 10:20 10:30 10:40 10:50 Introduction: acute coronary syndrome. – F. Crea (Rome, IT) In vivo critical fibrous cap thickness for rupture-prone coronary plaques assessed by optical coherence tomography. – T. Yonetsu (Tsuchiura, JP) Non-culprit coronary artery PCI during acute ST-segment elevation myocardial infarction: insights from the APEX-AMI trial. – M. Toma (Vancouver, CA) Assessment of multiple cardiac biomarkers in non-ST-segment elevation acute coronary syndromes - Observations from the MERLIN-TIMI 36 Trial. – B. Scirica (Boston, US) Effect of the direct renin inhibitor Aliskiren on left ventricular remodeling following myocardial infarction with systolic dysfunction. – M. Pfeffer (Boston, US) Conclusion. *Abstracts can be accessed at: 236 Special Session QR 352 3835 3836 3837 3838 3839 TUESDAY, 30 AUGUST 2011 – MORNING 10:10-10:50 | Oslo - Zone B MEET THE GUIDELINES TASK FORCE I Chairperson(s): J.J. Bax (Leiden, NL); U. Sechtem (Stuttgart, DE) 10:10 10:10 10:20 10:30 Special Session Acute coronary syndrome and non ST-elevation: questions and answers to the panellists. – C.W. Hamm (Bad Nauheim, DE), J.-P. Bassand (Besançon, FR) Panelists. – M. Ohman (Durham, US), R.F. Storey (Sheffield, GB), D. Zahger (Beer Sheva, IL) Pregnancy: questions and answers to the panellists. – V. Regitz-Zagrosek (Berlin, DE) Panelists. – C. Gohlke-Baerwolf (Ballrechten-Dottingen, DE), A.H.E.M. Maas (Zwolle, NL), P. Presbitero (Rozzano, IT) 3840 3841 3842 3843 10:45-12:05 | Hands-On Tutorial Room 1 - Zone B RIGHT VENTRICULAR ASSESSMENT BY REAL-TIME 3-DIMENSIONAL ECHOCARDIOGRAPHY Chairperson(s): H.B. van der Zwaan (Rotterdam, NL); J. Vletter-McGhie (Schipluiden, NL) Hands-On Tutorial organised by Siemens AG, Healthcare Sector (on-site registration) Hands-On Tutorial 10:45-12:15 | Hands-On Tutorial Room 2 - Zone B HOME HEALTH APPLICATIONS FOR HEART FAILURE MANAGEMENT Chairperson(s): C. Medd (Troinex, CH) Hands-On Tutorial organised by GE Healthcare (on-site registration) Hands-On Tutorial 11:00-12:30 | London - Zone A MULTIMODALITY IMAGING IN PATIENTS WITH CORONARY ARTERY DISEASE – LIVE FROM SPAIN Chairperson(s): V. Fuster (New York, US); J.L. Zamorano Gomez (Madrid, ES) Focus Imaging Intervention Patient 1 - Patient with chest pain, intermediate probability of coronary heart disease and inconclusive exercise stress test. What to do next? - LIVE. Patient 1 - 3D stress echo assessment of ischemia. The new “independent observer” of automatic quantitative 3D stress echo - LIVE. Patient 2 - CT scan. Patient preparation and acquisition - Role of CT scan in the clinical scenario. Practical reading with step by step approach - LIVE. Live interventionists in clinic San Carlos University Hospital, Madrid. – C. Fernandez-Gofin Loban (Madrid, ES), A. Goncalves (Porto, PT), P. Marcos-Alberca Moreno (Madrid, ES) Panel. – V. Delgado (Leiden, NL), F.E. Rademakers (Leuven, BE) 3844 3845 11:00-12:30 | The Hague - Zone A Focus Cardiology Practice TUESDAY – MORNING SPORT AND THE HEART Chairperson(s): A. La Gerche (Brussels, BE); L. Mont (Barcelona, ES) Cardiac evaluation of the million dollar heart: assessment of the elite athlete. Too much of a good thing . . . atrial arrhythmias in ultra-endurance. Cardiac rehabilitation: exercise is the magic bullet! Panel. – A.J. Camm (London, GB), V. Conraads (Edegem, BE), F. Carre (Rennes, FR) 3846 237 TUESDAY, 30 AUGUST 2011 – MORNING 11:00-12:30 | Rabat - Zone A (QR 509*) MODULATORS OF INJURY AND PROTECTION IN ISCHAEMIA AND REPERFUSION Chairperson(s): D.J. Hausenloy (London, GB); M. Ovize (Lyon, FR) 11:00 11:15 11:30 11:45 12:00 12:15 Abstract Session Secretome of apoptotic peripheral blood cells reduces myocardial damage after acute ischaemia and prevents ventricular remodelling: a preclinical study. – M. Lichtenauer, M. Mildner, K. Hoetzenecker, M. Zimmermann, B.K. Podesser, W. Sipos, E. Berenyi, E. Tschachler, M. Gyoengyoesi, H.J. Ankersmit (Vienna, AT; Debrecen, HU) miR-223 is critically involved in cardiac remodelling after myocardial infarction in mice. – C. Troidl, H. Moellmann, F. Rybinsky, J. Wilhelm, S. Szardien, S. Voss, J. Hoffmann, K. Troidl, C.W. Hamm, H. Nef (Bad Nauheim and Giessen, DE) Ischaemic postconditioning confers protection via TNF-alpha: identifying the cellular origin of TNF-alpha. – L. Lacerda, M. Jacobs, L.H. Opie, S. Lecour (Cape Town, ZA) Cardioprotective potential of heme oxygenase-1 in models of acute myocardial infarction. – R. Hinkel, E. Gottlieb, B. Petersen, M. Thormann, J.C. Horstkotte, S. Lee, D. Qin, P. Wenzel, H. Niemann, C. Kupatt (Munich, neaustadt a. Rgbe. and Mainz, DE) Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: A predominant role of anti-inflammation. – X.-M. Gao, Y. Liu, D. White, Y.D. Su, B.G. Drew, C.R. Bruce, R. Bucala, G. Fingerle-Rowson, A.M. Dart, X.-J. Du (Melbourne, AU; New Haven, US; Cologne, DE) Asialoerythropoietin, a nonerythropoietic derivative of erythropoietin, displays broad anti-heart failure activity. – T. Takeyama, G. Takemura, H. Kanamori, A. Ogino, T. Kawaguchi, T. Watanabe, T. Fujiwara, H. Fujiwara, S. Minatoguchi (Gifu, Kyoto and Hyogo, JP) 3847 3848 3849 3850 3851 3852 11:00-12:30 | Stockholm - Zone A (QR 519*) BASICS IN HEART FAILURE Chairperson(s): E.K. Iliodromitis (Athens, GR); S. Janssens (Leuven, BE) 11:00 11:15 11:30 11:45 12:00 12:15 Abstract Session Gain-of-function defect in the RyR2 promotes myocardial remodeling and heart failure in murine hearts under pressure-induced overload. – S. Sedej, A. Schmidt, S. Walther, M. Denegri, E. Bisping, F.R. Heinzel, C. Napolitano, S. Priori, J. Kockskamper, B. Pieske (Graz, AT; Pavia, IT) Nuclear export of HDAC4 mediates histone demethylation at H3K9 in the promoter region of ANF in response to elevated preload. – M. Hohl, J.-C. Reil, M. Tauchnitz, A.M. Zimmer, S.-A. Mueller, L.H. Lehmann, M.M. Kreusser, J. Backs, M. Böhm, C. Maack (Homburg/Saar and Heidelberg, DE) Dysregulation of microRNAs in diabetic post-ischemic heart failure patients. – S. Greco, P. Fasanaro, S. Castelvecchio, Y. D’Alessandra, L. Menicanti, D. Arcelli, M. Di Donato, A. Malavazos, C.M. Capogrossi, F. Martelli (San Donato Milanese, Rome and Milan, IT) The activation of natural killer T cells ameliorates post-infarct heart failure in mice. – M.A. Sobirin, S. Kinugawa, M. Takahashi, T. Ono, A. Fukushima, T. Yokota, T. Homma, N. Ishimori, K. Iwabuchi, H. Tsutsui (Semarang, ID; Sapporo, JP) STAT3 preserves dynamic control of mitochondrial NAD(P)H redox state to prevent ROS-production after beta-adrenergic stimulation. – M. Kohlhaas, A. Nickel, J.A. Saar, B. Stapel, M. Hohl, I. Bogeski, R. Kappl, M. Böhm, D. Hilfiker-Kleiner, C. Maack (Homburg and Hannover, DE) Mitochondrial transhydrogenase is a key regulator of antioxidative capacity in cardiac myocytes. – A. Nickel, A. Von Hardenberg, M. Kohlhaas, J.-C. Reil, M. Hohl, S.-L. Puhl, A. Kasakov, B. Pasieka, I. Bogeski, C. Maack (Homburg, DE) 3853 3854 3855 3856 3857 3858 11:00-12:30 | Tel Aviv - Zone A EXPERIMENTAL TREATMENT OF HEART FAILURE Chairperson(s): M.S. Nieminen (Helsinki, FI); P. de Groote (Lille, FR) 11:00 11:22 11:45 12:07 Soluble guanylate cyclase activators. – V. Mitrovic (Bad Nauheim, DE) Novel natriuretic peptides. – F. Ruschitzka (Zurich, CH) Ranolazine in heart failure with preserved ejection fraction. – L.S. Maier (Göttingen, DE) Cardiac myosin activators. – J.R. Teerlink (San Francisco, US) *Abstracts can be accessed at: 238 QR 509 QR 519 Symposium 3859 3860 3861 3862 TUESDAY, 30 AUGUST 2011 – MORNING 11:00-12:30 | Tripoli - Zone A (QR 521*) REVISITING PROGNOSIS IN HEART FAILURE? Chairperson(s): W. Banasiak (Wroclaw, PL); V. Mareev (Moscow, RU) 11:00 11:15 11:30 11:45 12:00 12:15 Abstract Session Heart failure mortality has more than halved in young adults: a Swedish registry study from 1987 to 2006. – A. Barasa, A. Rosengren, K. Swedberg, M. Schaufelberger (Gothenburg, SE) Impaired fasting glucose: a predictor of increased morbidity and mortality in patients with heart failure. – I. Gotsman, D. Zwas, D. Admon, C. Lotan, A. Keren (Jerusalem, IL) Frequency and timing of heart failure readmissions in the netherlands. – J.A. Overbeek, F.J.A. Penning-Van Beest, R.M.C. Herings, I. Agodoa (Utrecht, NL; Thousand Oaks, US) Depressive symptoms and antidepressants in heart failure: a prospective long-term mortality follow-up study. – C. Diez, J. Lupon, B. Gonzalez, L. Cano, R. Cabanes, M. De Antonio, A. Urrutia, S. Altimir, R. Coll, A. Bayes-Genis (Badalona, ES) Why and how do patients with heart failure die? Insights from the TIME-CHF trial. – P. Rickenbacher, M. Pfisterer, T. Burkard, W. Kiowski, F. Follath, D. Burckhardt, R. Schindler, H.-P. Brunner-La Rocca (Bruderholz, Basel and Zurich, CH; Maastricht, NL) Lipopolysaccharide responsiveness is an independent predictor of death in chronic heart failure. – N. Ebner, T. Kung, G. Foeldes, A. Sandek, J. Springer, E. Jankowska, S. Genth-Zotz, W. Doehner, S.D. Anker, S. Von Haehling (Berlin, DE; London, GB) 3863 (W) 3864 3865 3866 3867 3868 11:00-12:30 | Vienna - Zone A HIGH THROUGHPUT TECHNOLOGY IN CONGENITAL HEART DISEASE Chairperson(s): D. Franco (Jaen, ES); B.D. Keavney (Newcastle-upon-Tyne, GB) 11:00 11:22 11:45 12:07 Next generation sequencing to map mutations. – A. Postma (Amsterdam, NL) Meta-analysis of microarray data. – S. Sperling (Berlin, DE) High throughput phenotyping in mouse models. – S. Bhattacharya (Oxford, GB) Screening for mutations in the zebrafish. – W. Rottbauer (Ulm, DE) Symposium 3869 3870 3871 3872 11:00-12:30 | Warsaw - Zone A 11:00 11:22 11:45 12:07 Invasive and non-invasive monitoring. – J.T. Parissis (Athens, GR) Pathophysiology: impact on management. – J.S. Hochman (New York, US) Medical therapy. – G. Jondeau (Paris, FR) Mechanical support. – E. Roig (Barcelona, ES) Symposium 3873 3874 3875 3876 TUESDAY – MORNING CARDIOGENIC SHOCK Chairperson(s): V.-P. Harjola (Helsinki, FI); A. Mebazaa (Paris, FR) 11:00-12:30 | Hands-On Tutorial Room 3 - Zone B HYPOTHERMIA FOR CARDIAC PROTECTION IN ACUTE MYOCARDIAL INFARCTION Chairperson(s): D. Erlinge (Lund, SE) Hands-On Tutorial organised by Philips Healthcare (on-site registration) *Abstracts can be accessed at: Hands-On Tutorial QR 521 239 TUESDAY, 30 AUGUST 2011 – MORNING 11:00-12:30 | Moscow - Zone B (QR 531*) IMPROVING CARE FOR PATIENTS WITH CHANNELOPATHIES: WHAT’S NEW? Chairperson(s): S.G. Priori (Pavia, IT); R. Brugada Terradellas (Girona, ES) 11:00 11:15 11:30 11:45 12:00 12:15 Abstract Session Phenotype variability in patients carrying KCNJ2 mutations. – H. Kimura, J. Zhou, H. Itoh, Y. Mizusawa, A. Miyamoto, M. Kawamura, T. Makiyama, M. Ito, H. Matsuura, M. Horie (Otsu and Kyoto, JP) Clinical outcome and therapeutic strategies in non proband children with genetically confirmed LQTS. – V. Probst, A. Brondex, F. Kyndt, J.J. Schott, S. Chatel, S. Beziau, H. Le Marec (Nantes, FR) Mechanism of the Brugada syndrome: a novel loss of cAMP-dependent protein kinase A-mediated Na channel Phosphorylation. – T. Aiba, F. Farinelli, G. Hesketh, D. Edwards, R. Sekar, S. Biswas, W. Shimizu, G.F. Tomaselli (Suita, JP; Baltimore, US) N-3 fatty acids is associated with preventing ventricular arrhythmia in patients with Brugada-type electrocardiogram. – M. Tanaka, K. Nakamura, K. Nakagawa, M. Murakami, D. Miura, N. Nishii, S. Nagase, H. Morita, K. Kusano, H. Ito (Okayama, JP) Comparison of efficacy and safety of intravenous ajmaline vs. intravenous flecainide for the diagnosis of Brugada syndrome among first-degree family members. – P. Berne, J.M. Porres, I. Fernandez-Lozano, J.A. Arnaiz, L. Mont, A. Berruezo, R. Brugada, J. Brugada (Barcelona, San Sebastian, Madrid, Valencia and Girona, ES) Value of C-reactive protein in patients with asymptomatic and symptomatic Brugada syndrome. – A. Bonny, F. Hidden-Lucet, I. Ditah, F. Larrazet, R. Frank, G. Fontaine (Paris and Bry sur marne, FR; Detroit, US) 3877 3878 3879 3880 3881 3882 11:00-12:30 | Oslo - Zone B JOINT GUIDELINES FOR THE DETECTION AND TREATMENT OF DYSLIPIDEMIAS Chairperson(s): A. Catapano (Milan, IT); Z. Reiner (Zagreb, HR) The Committee for Practice Guidelines 11:00 11:18 11:36 11:54 12:12 Symposium Plasma lipids and global cardiovascular risk. – I.M. Graham (Dublin, IE) Controlled clinical trials and cardiovascular risk. – G. De Backer (St. Martens Latem, BE) The new joint Guidelines: an overview. – M.-R. Taskinen (Helsinki, FI) New biomarkers for atherosclerosis. – O. Wiklund (Gothenburg, SE) Panel discussion. 3883 3884 3885 3886 11:00-12:30 | Prague - Zone B CONTROVERSIAL ISSUES IN IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS Chairperson(s): B. Merkely (Budapest, HU); J.G.F. Cleland (Kingston-upon-Hull, GB) 11:00 11:22 11:45 12:07 Should implantable cardioverter-defibrillator replacement be performed in octogenarians and/or severe comorbidities? – J.C. Daubert (Rennes, FR) Implantable cardioverter-defibrillator replacement in patients with improved left-ventricular ejection fraction. – E. Erdmann (Cologne, DE) Are implantable cardioverter-defibrillators overused in non-ischaemic cardiomyopathies? – M.J. Schalij (Voorschoten, NL) How appropriate are MADIT II criteria for patient selection? – W. Zareba (Rochester, US) *Abstracts can be accessed at: 240 Clinical Seminar QR 531 3887 3888 3889 3890 TUESDAY, 30 AUGUST 2011 – MORNING 11:00-12:30 | Riga - Zone B (QR 648*) YOU NEED PLUMBERS AND ELECTRICIANS TO BUILD A HOUSE Chairperson(s): D. Himbert (Paris, FR); F.R. Eberli (Zurich, CH) 11:00 11:15 11:30 11:45 12:00 12:15 Abstract Session Transcatheter left atrial appendage occlusion in atrial fibrillation: comparison of non-dedicated versus dedicated amplatzer devices. – S. Gloekler, M. Schmid, A.A. Saguner, A.A. Khattab, A. Wahl, P. Wenaweser, S. Windecker, B. Meier (Berne, CH) Using the HAS-BLED bleeding risk score in patients with atrial fibrillation undergoing coronary stenting: useful or not? – J.M. Ruiz Nodar, F. Marin, V. Roldan, J. Valencia, S. Manzano-Fernandez, L. Caballero, J.A. Hurtado, F. Sogorb, M. Valdes, G.Y.H. Lip (Alicante and Murcia, ES; Birmingham, GB) Complete atrioventricular block after percutaneous closure of perimembranous ventricular septal defect with modified double-disk occluder. – Y. Bai, Y.W. Qin, X.X. Zhao, X. Zheng, H. Wu, S.P. Chen, J.Q. Hu, X.M. Huang, X.H. You, W.P. Li (Shanghai, CN) Changes in QRS duration during trans-catheter aortic valve implantation strongly predicts the risk of permanent pacing. – G. Mouillet, N. Lellouche, P. Lim, J.L. Monin, E. Fougeres, P.F. Lesault, B. Gellen, S. Champagne, J.L. Dubois-Rande, E. Teiger (Créteil, FR) Incidence and clinical significance of new bundle branch block in patients undergoing transcatheter aortic valve implantation with the Medtronic corevalve and Edwards’ Sapien prosthesis. – A. Radinovic, S. Sala, A. Latib, M. Mussardo, N. Sora, G. Paglino, M. Montorfano, M. Gullace, P. Della Bella, A. Colombo (Milan, IT) Permanent pacemaker implantation and cardiac conduction disorders following transcatheter aortic valve implantation with the Medtronic-CoreValve bioprosthesis. – K. Boerlage-Van Dijk, Z.Y. Yong, K.T. Koch, M.M. Vis, B.J. Bouma, J.P.S. Henriques, R. Cocchieri, J.J. Piek, J. Baan (Amsterdam, NL) 3891 3892 3893 3894 3895 3896 11:00-12:30 | Rome - Zone B (QR 644*) 11:00 11:15 11:30 11:45 12:00 12:15 Abstract Session The extent of right ventricular electroanatomic scar predicts malignant arrhythmic events in patients with arrhythmogenic right ventricular cardiomyopathy. – F. Migliore, A. Zorzi, L. Leoni, B. Bauce, M. Perazzolo, C. Basso, G. Buja, G. Thiene, S. Iliceto, D. Corrado (Padua, IT) Prognostic value of QRS fragmentation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia. – S. Peters, M. Truemmel, B. Koehler (Gronau and Quedlinburg, DE) Multidisciplinary approach to exercise-related sudden death families: a multicentric registry. – E. Zorio Grima, J.R. Gimeno Blanes, T. Ripoll Vera, L. Monserrat Iglesias, P. Garcia Pavia, B. Aguilera Tapia, A. Boraita Perez, J. Giner Blasco, J.P. Hernandez Rincon, X. Fosch Mur (Valencia, Murcia, Palma de Mallorca, A Coruña and Madrid, ES) Reduced risk of sudden cardiac death after alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy. – M. Jensen, C. Prinz, D. Horstskotte, F. Buuren, T. Bitter, L. Faber, H. Bundgaard (Copenhagen, DK; Bad Oeynhausen, DE) High risk of sudden death in hypertrophic cardiomyopathy caused by mutations in troponin T gene: a cohort study of 161 families. – D. Muniz Tolivia, T. Ripoll Vera, B. Garcia De La Villa, N. Govea, J.M. Gamez, R. Moreno, X. Fosch, A. Grau, D. Cremer, J. Torres (Palma de Mallorca and Manacor, ES) Complications in the clinical course of tako-tsubo cardiomyopathy: results of the German Tako-Tsubo registry. – B. Schneider, A. Athanasiadis, W. Pistner, J. Schwab, U. Gottwald, R. Schoeller, W. Toepel, K.-D. Winter, T. Mueller-Honold, U. Sechtem (Lübeck, Stuttgart, Aschaffenburg, Nuremberg, Celle, Berlin, Idar-Oberstein, Erkelenz and Augsburg, DE) *Abstracts can be accessed at: QR 648 3897 3898 3899 3900 TUESDAY – MORNING DETERMINANTS OF SUDDEN DEATH AND ARRHYTHMIAS IN CARDIOMYOPATHIES Chairperson(s): E. Aliot (Vandoeuvre-lès-Nancy, FR); A. Keren (Jerusalem, IL) 3901 3902 QR 644 241 TUESDAY, 30 AUGUST 2011 – MORNING 11:00-12:30 | Sofia - Zone B (QR 533*) BLEEDING – THE DARK SIDE OF ANTI-THROMBOTIC THERAPY Chairperson(s): F. Arribas Ynsaurriaga (Madrid, ES); L.C. Wallentin (Uppsala, SE) 11:00 11:15 11:30 11:45 12:00 12:15 Abstract Session Predicting bleeding risk in “real world” patients with atrial fibrillation with or without anticoagulation: a comparison of two established bleeding prediction schemes in a nationwide cohort study. – J.B. Olesen, G.Y.H. Lip, P.R. Hansen, J. Lindhardsen, O. Ahlehoff, C. Andersson, P. Weeke, M.L. Hansen, G.H. Gislason, C. Torp-Pedersen (Copenhagen, DK; Birmingham, GB) Apixaban in patients with atrial fibrillation and their risk for cardiovascular hospitalization: insights from the AVERROES trial. – S. Hohnloser, S. Yusuf, J. Eikelboom, G. Steg, D. Atar, A. Budaj, D. Halon, C.P. Lau, L.S. Piegas, S.J. Connolly (Frankfurt, DE; Hamilton, CA; Paris, FR; Oslo, NO; Warsaw, PL; Haifa, IL; Hong Kong, HK; São Paulo, BR) VKA treatment and bleeding rate of patients aged older than 80 years: results from a prospective collaborative study. – D. Poli, E. Antonucci, L. Di Gennaro, A. Falanga, F. Marongiu, S. Pedrini, S. Testa, W. Ageno, G. Palareti (Florence, Rome, Bergamo, Cagliari, Brescia, Varese and Bologna, IT) Warfarin and the risk of major bleeding events in patients with atrial fibrillation: a population-based study. – L. Azoulay, S. Dell’Aniello, T. Simon, C. Renoux, S. Suissa (Montreal, CA; Lawrenceville, US) Combination therapy with warfarin and amiodarone increases risk of bleeding in patients with atrial fibrillation - a nationwide study. – S.S. Andersen, J. Raunso, M. Schmiegelow, J. Olesen, C.L.W. Selmer, M. Lambert, G.H. Gislason, C. Torp-Pedersen, M.L. Hansen (Copenhagen, DK) Clopidogrel or apixaban in atrial fibrillation patients unsuitable for vitamin-K antagonists for stroke prevention in atrial fibrillation? Lessons from the recent aspirin-controlled trials. – F.W.A. Verheugt, J. Jaspersfocks, M.A. Brouwer (Amsterdam and Nijmegen, NL) 3903 3904 3905 3906 3907 3908 11:00-12:30 | Brussels - Zone D EUROBSERVATIONAL RESEARCH PROGRAMME OF THE ESC. ONGOING REGISTRIES Chairperson(s): M.A. Alonso Garcia (Madrid, ES); D.V. Cokkinos (Athens, GR) 11:00 11:22 11:45 12:07 EORP: what and why. – L. Tavazzi (Cotignola, IT) General Registry: Heart Failure. – A.P. Maggioni (Florence, IT) Sentinel Registry: Ablation in Atrial Fibrillation. – J. Brugada Terradellas (Barcelona, ES) Special Registry: Pregnancy in Cardiac Disease. – J.W. Roos-Hesselink (Rotterdam, NL) Symposium 3909 3910 3911 3912 11:00-12:30 | Copenhagen - Zone D MEET THE CHALLENGE ALONG THE CARDIOVASCULAR CONTINUUM Chairperson(s): M. Tendera (Katowice, PL); D. Hu (Beijing, CN) The European Society of Cardiology and the Chinese Society of Cardiology 11:00 11:22 11:45 12:07 High risk - how to identify atherosclerosis. – H. Li (Beijing, CN) What to treat in diabetics: blood pressure, glucose or lipids. – T.F. Luescher (Zurich, CH) Treatment strategies for coronary artery disease in China. – Y. Yang (Beijing, CN) Heart failure treatment: focus on comorbidities. – R.A. De Boer (Groningen, NL) *Abstracts can be accessed at: 242 QR 533 Symposium 3913 3914 3915 3916 TUESDAY, 30 AUGUST 2011 – MORNING 11:00-12:30 | Damascus - Zone D (QR 555*) IMPROVING RISK ASSESSMENT Chairperson(s): L. Tokgozoglu (Ankara, TR); D. Vanuzzo (Udine, IT) 11:00 11:15 11:30 11:45 12:00 12:15 Abstract Session Effect of hypercholesterolemia on cardiovascular function in children. – G. Di Salvo, A.F. D’Aiello, L. Baldini, B. Castaldi, F. Del Gaizo, A. Mormile, G. Pacileo, L. Perrone, M.G. Russo, R. Calabro (Milan and Naples, IT) Improving cardiovascular risk prediction by adding parental history of myocardial infarction to the SCORE risk function. – I. Van Dis, D. Kromhout, J.M. Geleijnse, J.M.A. Boer, W.M.M. Verschuren (The Hague, Wageningen and Bilthoven, NL) Socio-economic risk factors in the community-based PEP Family Heart Study. – G.-M. Haas, E. Liepold, P. Schwandt (Munich, DE) Contribution of known genetic variants to increased risk of type-2 diabetes in Indian Asians. – J. Sehmi, I.Y. Yeo, S. Salaheen, W. Zhang, D. Das, J. Danesh, E.S. Tai, M.I. McCarthy, J.C. Chambers, J.S. Kooner (London, Cambridge and Oxford, GB; Singapore, SG) Socioeconomic factors and concomitant diseases are related to the risk for venous thromboembolism during 13 years of prospective follow-up. – A. Gottsater, N. Isma, P.J. Svensson, B. Lindblad, J. Merlo, H. Ohlsson (Malmo, SE) Serum beta2-microglobulin levels predict cardiovascular and all-cause mortality in patients on chronic hemodialysis. – Y. Kumada, H. Ishii, H. Takahashi, T. Aoyama, M. Tanaka, D. Kamoi, Y. Kawamura, K. Kawashima, T. Murohara (Nagoya, JP) 3917 3918 3919 3920 3921 3922 11:00-12:30 | Helsinki - Zone D LET’S TALK ABOUT SEX Chairperson(s): D. Fitzsimons (Belfast, GB); L. Braun (Chicago, US) 11:00 11:22 11:45 12:07 Symposium The physician’s role: what is effective management? – G. Jackson (Croydon, GB) Sexual dysfunction in men and women with heart disease - what do we know? – E. Steinke (Wichita, US) What is the current practice of cardiovascular nurses in Europe? – T.M. Norekval (Bjoroyhamn, NO) Do we have enough evidence to guide practice? – T. Jaarsma (Norrkoping, SE) 3923 3924 3925 3926 11:00-12:30 | Lisbon - Zone D (QR 556*) 11:00 11:15 11:30 11:45 12:00 12:15 Abstract Session Trends of increasing medical radiation exposure in a population hospitalized for cardiovascular disease (1970-2010). – C. Carpeggiani, P. Landi, C. Michelassi, P. Marraccini, E. Picano (Pisa, IT) Constructing a composite quality score for the care of acute myocardial infarction patients at discharge. – F. Schiele, M. Couralet, S. Guerin, C. Gardel, P. Loirat, E. Minvielle (Besançon, Villejuif and Saint Denis, FR) Selection of aortic valve replacement versus transcatheter aortic valve implantation in high-risk patients: a Markov model. – H.G. Gada, T.M. Marwick (Cleveland, US) Cost analysis of early cardiac device infections. – B. Saberwal, S.Y. Ahsan, P. Lambiase, O. Segal, M. Lowe, C. Koo, L. Nunn, A.B. Gopalamurugan, E. Rowland, A.W.C. Chow (London, GB) Recent time trends in the incidence and case-fatality of coronary heart disease: the contribution of interrupted-MIs in men and women 35-74 years old. – M. Ferrario, G. Veronesi, L.E. Chambless, A. Borsani, S. Conti, C. Fornari, G. Cesana (Varese and Milan, IT; Chapel Hill, US) Cost evaluation of cardiac magnetic resonance imaging versus coronary angiography for the work-up of coronary artery disease. – K. Moschetti, C. Pinget, S. Muzzarelli, D. Locca, O. Bruder, H. Mahrholdt, J. Schwitter (Lausanne, CH; Essen and Stuttgart, DE) *Abstracts can be accessed at: QR 555 3927 3928 3929 TUESDAY – MORNING NEW APPROACHES FOR BETTER QUALITY OF CARE Chairperson(s): P. Giannuzzi (Veruno, IT); J. Perk (Kalmar, SE) 3930 3931 3932 QR 556 243 TUESDAY, 30 AUGUST 2011 – MORNING 11:00-12:30 | Madrid - Zone D SUBCLINICAL ATHEROSCLEROSIS – HOW TO DETECT AND WHEN TO TREAT Chairperson(s): M. Naghavi (Houston, US); H. Saner (Berne, CH) 11:00 11:22 11:45 12:07 Symposium Detection of subclinical carotid atherosclerosis. – J.D. Spence (London, CA) Detection of subclinical coronary atherosclerosis. – G. Nickenig (Bonn, DE) Can serum biomarkers add to decision making? – W. Koenig (Ulm, DE) How do current guidelines apply to subclinical atherosclerosis. – D.A. Wood (London, GB) 3933 3934 3935 3936 11:00-12:30 | Beirut - Zone E (QR 559*) CURRENT CLINICAL ASPECTS AND IMAGING OF PULMONARY ARTERIAL HYPERTENSION Chairperson(s): J.S.R. Gibbs (London, GB); N. Galie (Bologna, IT) 11:00 11:15 11:30 11:45 12:00 12:15 Abstract Session The changing picture of patients with pulmonary arterial hypertension in France. – O. Sitbon, A. Yaici, V. Cottin, E. Bergot, G. Prevot, L. Rottat, V. Gressin, M. Humbert, G. Simonneau (Clamart, Lyon, Caen, Toulouse and Paris, FR) Survival in patients with pulmonary arterial hypertension associated with connective tissue disease over the past decade. – C.J. Valerio, B.E. Schreiber, C. Handler, C.P. Denton, J.G. Coghlan (London, GB) Long-term survival in pulmonary arterial hypertension: the REVEAL registry. – R.L. Benza, D.P. Miller, R.J. Barst, D.B. Badesch, A.E. Frost, M.D. McGoon (Pittsburgh, San Francisco, New York, Denver, Houston and Rochester, US) ESC-ERS 2009 pulmonary hypertension guidelines: an evaluation study in 9 European countries (the guide to PH study). – E. Leci, M. Palazzini, F. Sgro’, A. Manes, E. Conficoni, E. Beciani, C. Bachetti, E. Gotti, A. Branzi, N. Galie’ (Bologna, IT) Right ventricular longitudinal peak systolic strain and long-term outcome of patients with pulmonary hypertension. – M.L.A. Haeck, R.W.C. Scherptong, N. Ajmone Marsan, E. Holman, H.W. Vliegen, M.J. Schalij, J.J. Bax, V. Delgado (Leiden, NL) Novel application of phase-contract cardiac magnetic resonance imaging in assessment of right ventricle contractile status with maximal ventricular power divided by the square of end-diastolic volume. – H. Ide, T. Ueno, K. Ishimaru, M. Taira, S. Hamada, T. Kuratani, T. Sakaguchi, Y. Sawa (Osaka, JP) 3937 3938 3939 3940 3941 3942 11:00-12:30 | Berne - Zone E ADVANCES IN ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY Chairperson(s): D.T. Kremastinos (Athens, GR); P. Charron (Paris, FR) 11:00 11:22 11:45 12:07 Clinical Seminar Recent advances in genetics. – P. Van Tintelen (Groningen, NL) Pathophysioloy and contribution of histology. – M. Delmar (New York, US) New insights into the electrophysiology of arrhythmogenic right ventricular cardiomyopathy. – P. Lambiase (London, GB) Long-term outcomes and indications for defibrillator. – D. Corrado (Padua, IT) 3943 3944 3945 3946 11:00-12:30 | Bratislava - Zone E NEUROCARDIAC IMAGING: AT THE HEART OF ELECTRICAL DISTURBANCES Chairperson(s): P. Chevalier (Lyon, FR); N. Bruining (Rotterdam, NL) 11:00 11:22 11:45 12:07 Innervation of the heart. – S.Y. Ho (London, GB) Positron emission tomography. – M.P. Law (Münster, DE) Nuclear cardiology MIBG scintigraphy. – D. Le Guludec (Paris, FR) Cardiac magnetic resonance. – A.P. Wijnmaalen (Leiden, NL) *Abstracts can be accessed at: 244 QR 559 Symposium 3947 3948 3949 3950 TUESDAY, 30 AUGUST 2011 – MORNING 11:00-12:30 | Bucharest - Zone E FUNCTIONAL VERSUS ANATOMIC DIAGNOSTIC ASSESSMENT OF CORONARY ARTERY DISEASE Chairperson(s): L. Badano (Padua, IT); A.N. Kitsiou (Athens, GR) 11:00 11:22 11:45 12:07 Clinical Seminar Morphology. – G. Korosoglou (Heidelberg, DE) Function. – F. Carreras Costa (Barcelona, ES) Perfusion. – D. Neglia (Pisa, IT) A combined approach. – O. Gaemperli (Zurich, CH) 3951 3952 3953 3954 11:00-12:30 | Budapest - Zone E IMAGING IN PERCUTANEOUS VALVE THERAPY Chairperson(s): O.W. Franzen (Copenhagen, DK); J.J. Bax (Leiden, NL) 11:00 11:22 11:45 12:07 Symposium Update on percutaneous mitral valve therapy. – A. Vahanian (Paris, FR) Update on percutaneous aortic valve therapy. – R. Erbel (Essen, DE) Imaging in percutaneous mitral valve therapy. – E.M. Tuzcu (Cleveland, US) Imaging in percutaneous aortic valve therapy. – S.R. Kapadia (Cleveland, US) 3955 3956 3957 3958 11:00-12:30 | Cairo - Zone E CONGENITAL AORTIC VALVE DISEASE AND AORTOPATHY: RECENT ADVANCES Chairperson(s): P. Trigo Trindade (Basel, CH); M.J. Antunes (Coimbra, PT) 11:00 11:22 11:45 12:07 Symposium Bicuspid aortic valve: from congenital heart disease to active valve remodelling. – J.J. Kaden (Mannheim, DE) Management of ascending aortic aneurysms. – A. Evangelista Masip (Barcelona, ES) Management of aortic coarctation and recoarctation in adults. – M. Carminati (San Donato, IT) Sub- and supravalvular aortic stenoses. – H. Baumgartner (Münster, DE) 3959 3960 3961 3962 11:00-12:30 | Ankara - Zone F (QR 588*) 11:00 11:15 11:30 11:45 12:00 12:15 Abstract Session The late consequences of acute coronary syndromes: 2-year follow-up outcomes, procedures, and treatment of patients from the Global Registry of Acute Coronary Events (GRACE). – S. Goodman, W. Huang, J.M. Gore, P.G. Steg, K.A. Eagle, F.A. Anderson, K.A.A. Fox (Toronto, CA; Worcester and Ann Arbor, US; Paris, FR; Edinburgh, GB) Long-term survival after AMI according to anti-anginal therapy at discharge: the FAST-MI registry. – E. Puymirat, N. Aissaoui, L. Lorgis, L. Bonello, V. Bataille, G. Mulak, E. Drouet, J. Ferrieres, T. Simon, N. Danchin (Paris, Dijon, Marseille and Toulouse, FR) Lack of effect of beta-blocker therapy in patients with ST-elevation acute myocardial infarction in PCI era. – B. Bao, N. Ozasa, T. Morimoto, Y. Furukawa, M. Shirotani, H. Ogawa, C. Tei, H. Fujiwara, K. Mitsudo, T. Kimura (Kyoto, Kobe, Nara, Kumamoto, Kagoshima, Amagasaki and Kurashiki, JP) Prediction of long-term survival in patients receiving optimal secondary prevention therapy after acute myocardial infarction: the FAST-MI registry. – E. Puymirat, N. Aissaoui, G. Lemesle, L. Lorgis, J.J. Dujardin, E. Drouet, G. Mulak, J. Ferrieres, T. Simon, N. Danchin (Paris, Lille, Dijon, Douai and Toulouse, FR) Effect of postconditioning on infarct size and ejection fraction in patients with ST elevation myocardial infarction - one year follow-up. – P. Sorensson, H. Arheden, L. Ryden, N. Saleh, P. Tornvall, J. Pernow (Stockholm and Lund, SE) QRS score at discharge from hospital is still an independent predictor of survival during ten-year follow-up of patients with acute myocardial infarction treated with thrombolytic therapy. – B. Stefanovic, P. Mitrovic, Z. Vasiljevic, G. Matic, N. Radovanovic, A. Karadzic, A. Milosevic, M. Radovanovic, J. Jankovic, A. Novakovic (Belgrade, RS) *Abstracts can be accessed at: 3963 TUESDAY – MORNING POST MYOCARDIAL INFARCTION – CAN WE DO MORE? Chairperson(s): U. Zeymer (Ludwigshafen, DE); B. Lindahl (Uppsala, SE) 3964 3965 3966 3967 3968 QR 588 245 TUESDAY, 30 AUGUST 2011 – MORNING 11:00-12:30 | Athens - Zone F CONTROVERSIAL ISSUES ON LATE-COMERS WITH STEMI Chairperson(s): D. Dudek (Krakow, PL); D. Milicic (Zagreb, HR) 11:00 11:22 11:45 12:07 Clinical Seminar The dimension of the problem. – P. Widimsky (Prague, CZ) When is late too late? – F. Van de Werf (Leuven, BE) The open-artery hypothesis revisited. – V. Dzavik (Toronto, CA) Options beyond revascularisation. – A.M. Zeiher (Frankfurt, DE) 3969 3970 3971 3972 11:00-12:30 | Belgrade - Zone F HOW TO PERFORM HYBRID MYOCARDIAL REVASCULARISATION Chairperson(s): A. Repossini (Brescia, IT); R.M.C. Cruz Ferreira (Barreiro, PT) 11:00 11:45 How-to Session Surgical perspective. – J.O. Bonatti (Baltimore, US) Interventional perspective. – G.C. Schuler (Leipzig, DE) 3973 3974 11:00-12:30 | Berlin - Zone F ANTIPLATELET THERAPY: HOW, WHY, WHEN Chairperson(s): C. Patrono (Rome, IT); R.F. Storey (Sheffield, GB) 11:00 11:22 11:45 12:07 Clinical Seminar In primary prevention. – C. Bode (Freiburg, DE) In acute coronary syndromes. – G. Montalescot (Paris, FR) For coronary stenting. – D.J. Angiolillo (Jacksonville, US) In patients with transient ischemic attack/stroke. – P. Amarenco (Paris, FR) 3975 3976 3977 3978 11:00-12:30 | Paris - Zone F HOT LINE III – ACUTE CORONARY SYNDROMES Chairperson(s): R. Ferrari (Ferrara, IT); C. Stefanadis (Athens, GR) 11:00 11:13 11:18 11:31 11:36 11:49 11:54 12:07 12:12 12:25 246 Hot Line PRODIGY: Randomized comparison of six versus twenty-four months clopidogrel therapy after balancing anti-intimal hyperplasia stent potency in all comer patients undergoing percutaneous coronary intervention. Results of the PRODIGY trial. – M. Valgimigli (Ferrara, IT) Discussant. – A. Kastrati (Munich, DE) The RUBY-1 trial: Safety, tolerability and efficacy of YM150, an oral factor Xa inhibitor, in secondary prevention of ischaemic vascular events in patients following a acute coronary syndrome. – P.G. Steg (Paris, FR) Discussant. – S.D. Kristensen (Aarhus, DK) EXAMINATION: A randomized comparison between everolimus-eluting stent and bare metal stent in patients with ST-segment elevation myocardial infarction: the EXAMINATION trial. – M. Sabate Tenas (Barcelona, ES) Discussant. – W. Wijns (Aalst, BE) Newer generation everolimus-eluting stents eliminate the risk of very late stent thrombosis compared with early generation sirolimus-eluting and paclitaxel-eluting stents. – L. Raber (Berne, CH) Discussant. – J. Fajadet (Toulouse, FR) CRISP AMI: A multi-center, randomized, controlled study of mechanical left ventricular unloading with counterpulsation to reduce infarct size pre-PCI for acute myocardial infarction: rationale and design of the CRISP AMI trial. – M. Patel (Durham, US) Discussant. – K. Huber (Vienna, AT) 3979 3980 3981 3982 3983 3984 3985 3986 3987 3988 TUESDAY, 30 AUGUST 2011 – MORNING 11:00-12:30 | Tunis - Zone F (QR 598*) TAGGING THE RISK IN VASCULAR DISEASE Chairperson(s): P. Poredos (Ljubljana, SI); P.A. Sirnes (Moss, NO) 11:00 11:15 11:30 11:45 12:00 12:15 Abstract Session Increased thermal heterogeneity in carotid arteries as a surrogate marker for coronary artery disease: first clinical application of microwave radiometry. – M. Drakopoulou, K. Toutouzas, A. Synetos, H. Nikolaou, K. Masoura, E. Tsiamis, K. Stathogiannis, C. Grassos, E. Siores, C. Stefanadis (Athens, GR; Bolton, GB) Progression of asymptomatic carotid stenosis: a risk factor for ipsilateral neurological events. – L. Hirt (London, GB) Do vascular markers predict cardiovascular death in primary prevention? – E. Berard, V. Bongard, J.B. Ruidavets, J. Ferrieres (Toulouse, FR) Risk factors for intima-media thickening and atherosclerotic plaque development in carotid arteries. – B. Sobien, G. Kopec, M. Podolec, H. Dziedzic, J. Zarzecka, B. Loster, P.J. Touboule, M. Desvarieux, A. Pajak, P. Podolec (Krakow, PL; Paris, FR; New York, US) Carotid intima-media thickness: differences between aneurysmatic and occlusive disease. – K.M. Van De Luijtgaarden, M.T. Voute, S.E. Hoeks, E.J. Bakker, T.M. Valentijn, N.J. Ravensbergen, F. Bastos Goncalves, D. Goei, H.J. Verhagen, D. Poldermans (Rotterdam, NL) Long term prognosis value of ankle brachial index in coronary artery disease. – F. Bouisset, V. Bongard, J.B. Ruidavets, D. Taraszkiewicz, M. Galinier, D. Carrie, M. Elbaz, J. Ferrieres (Toulouse, FR) 3989 3990 3991 3992 3993 3994 11:00-12:30 | Zagreb - Zone F (QR 596*) PREDICTING THE RISK AND ASSESSING THE PROGNOSIS: UPDATE FROM LARGE STROKE STUDIES Chairperson(s): M.V. Huisman (Leiden, NL); G. Agnelli (Perugia, IT) 11:00 11:15 11:30 11:45 12:00 Rates and risk predictors of stroke and its subtypes among people with diabetes mellitus. – R. Ting, G.J. Hankey, N.E. Anderson, A.-S. Veillard, M. Romo, M. Wosik, D. Sullivan, R. O’Connell, D. Hunt, A.C. Keech (Sydney, Perth and Melbourne, AU; Auckland, NZ; Helsinki, FI) The risk of stroke in patients with acute myocardial infarction treated invasively and concomitant impaired renal function. – T. Podolecki, J. Kowalczyk, R. Lenarczyk, M. Mazurek, A. Sedkowska, G. Mencel, T. Was, G. Honisz, L. Polonski, Z. Kalarus (Zabrze, PL) Fasting serum glucose and risk of stroke in men and women: a 11-year longitudinal study. – S.V. Ahn, H.C. Kim, I. Suh (Seoul, KR) The impact of first stroke on the vital prognosis; Akita stroke registry. – M. Izumi, K. Suzuki, K. Kario (Shimotsuke-city and Akita, JP) Prognostic value of ambulatory ECG in prediction of stroke. – Z. Binici, M.R. Mouridsen, L. Kober, A. Sajadieh (Copenhagen, DK) The association between MMP-9 serum levels and progression of carotid artery atherosclerosis is modified by statin treatment. – W.S. Speidl, M. Hoke, J. Amighi, W. Mlekusch, A. Niessner, G. Maurer, R. Koppensteiner, E. Minar, J. Wojta, M. Schillinger (Vienna, AT) 3995 3996 3997 (W) 3998 3999 4000 TUESDAY – MORNING 12:15 Abstract Session *Abstracts can be accessed at: QR 598 QR 596 247 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS 08:30-12:30 | Posters - Poster Zone C POSTER SESSION 5 Poster Session Posters must be set up between 08:00 and 08:30, removed between 12:30 and 13:00 and be on display from 08:30 to 12:30.The presenter should be present throughout the coffee break (10:00 to 11:00) in order to discuss the Poster. METABOLIC DYSREGULATION AND CONTROL MECHANISMS (QR 30501*) Soluble epoxide hydrolase inhibition improves myocardial perfusion and function in experimental heart failure. – N. Merabet, J.B. Bellien, E.G. Glevarec, L.N. Nicol, C.T. Thuillez, P.M. Mulder (Rouen, FR) PPAR-gamma in coronary atherosclerosis: in vivo expression pattern and correlations with hyperlipidemic status and statin treatment. – A. Pucci, L. Formato, E. Brscic, S. Pizzimenti, F. Ferroni, G. Barrera, M. Rinaldi, I. Sheiban, L. Bergamasco, M.T. Spinnler (Pisa, Moncalieri and Turin, IT) EPA (eicosapentaenoic acid) levels were lower in the Advanced Stage of Chronic Kidney Disease with Diabetic Patients. – Y. Nakano, U. Ueeda, S. Hirohata, S. Kawada, K. Takagaki, A. Takaishi, S. Kusachi, H. Ito, T. Mima (Imabari, Kanonji and Okayama, JP) High serum uric acid level is associated with penile vascular disease severity and increased aortic stiffness in erectile dysfunction patients with metabolic syndrome. – N. Ioakeimidis, C. Vlachopoulos, P. Xaplanteris, D. Terentes-Printzios, A. Samentzas, K. Rokkas, A. Aggelis, K. Siama, G. Lazaros, C. Stefanadis (Athens, GR) Prevalence and prognostic significance of metabolic syndrome in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. – I. Stankovic, M. Tesic, V. Kovacevic, V. Giga, S. Aleksandric, Z. Mehmedbegovic, M. Zivkovic, V. Dedovic, M.M. Ostojic, M.C. Ostojic (Belgrade, RS) Effect of DAXXK on cardiomyopathy in type 2 diabetic rats. – Y. Kang, X. Liu (Tianjin, CN) Acute effects of salt on rat adipose tissue and heart gene expression in vivo. – M. Caprio, A. Armani, M.J. Young, A. Antelmi, E.Y. Lam, J. Morgan, P. Fuller, G. M.C. Rosano (Rome, IT; Clayton, AU) Beneficial effects of ezetimibe on visceral fat in patients with metabolic syndrome. – H. Takase, Y. Dohi, T. Toriyama, T. Okado, H. Sonoda, A. Hagikura, Y. Goto, T. Hashimoto, G. Kimura (Hamamatsu and Nagoya, JP) Insulin resistance increases the incidence of new cardiovascular events in patients with manifest arterial disease without known diabetes. The SMART study. – S.N. Verhagen, P.M. Gorter, Y. Van Der Graaf, F.L.J. Visseren (Utrecht, NL) Impact of metabolic syndrome on arterial stiffness and carotid intima-media thickness in adolescents. – A. Gonzalez, J. Ferrer, L. Chacin, E. Silva, G. Bermudez, J.J. Villasmil, C. Esis, M. Bracho, S. Briceno (Maracaibo, VE) Cardiac effects of DPP-4-inhibition in db/db mice. – M. Lenski, A. Kazakov, M. Böhm, U. Laufs (Homburg, DE) Acute and chronic hyperglycaemia: looking for its true meaning. – L.V. Paiva, R. Providencia, S. Barra, P. Gomes, A.C. Faustino, A.M. Leitao-Marques (Coimbra, PT) Regular physical exercise training partially corrects metabolic alterations and improves peripheral endothelial function in pre-diabetic, adipose patients with coronary artery disease. – R. Hoellriegel, E. Beck, F. Woitek, V. Adams, S. Erbs, M. Blueher, M. Stumvoll, G. Schuler, A.H.P. Linke (Leipzig, DE) Adiponectin improves TG-rich lipoprotein metabolism by inhibiting VLDL synthesis via COUP-TF2-dependent pathway. – K. Tsubakio-Yamamoto, M. Nishida, D. Masuda, T. Ohama, Y. Nakagawa-Toyama, M. Ishigami, I. Komuro, S. Yamashita (Osaka, JP) Anti-inflammatory effects of oleic acid and hydroxytyrosol in murine 3T3-L1 adipocytes: a key for protective mechanisms of mediterranean diets in obesity-related inflammation. – E. Scoditti, M. Massaro, M.A. Carluccio, A. Gastaldelli, C. Storelli, R. De Caterina (Lecce, Pisa and Chieti, IT) Role of posttranslational modification of CD36 in cardiac fatty acid utilization: lessons from the spontaneously hypertensive rat. – B. Lauzier, C. Merlen, F. Vaillant, B. Bouchard, P.C. Beguin, V.W. Dolinsky, J.R.B. Dyck, B.G. Allen, G. Charron, C. Des Rosiers (Montreal and Edmonton, CA) Chronic heart rate reduction in vivo with ivabradine preserves function and glucose metabolism of ex vivo working hearts from dyslipidemic mice. – F. Vaillant, B. Lauzier, D. Lachance, V. Bolduc, E. Thorin, J.C. Tardif, C.H. Des Rosiers (Montreal, CA) Comparison of epicardial adipose tissue and abdominal visceral adipose tissue for the predictor of atherosclerosis in thoracic and abdominal aorta using 320-MDCT. – T. Matsushita, H. Hayashi, C. Kato, H. Miyabe, K. Kaigawa, T. Sato, T. Miyake, T. Hibino (Ichinomiya, Aichi, JP) *Abstracts can be accessed at: 248 QR 30501 P4001 P4002 P4003 P4004 P4005 P4006 P4007 P4008 P4009 P4010 P4011 P4012 P4013 P4014 P4015 P4016 P4017 P4018 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Continuous positive airway pressure therapy positively affects AFABP level in patients with obstructive sleep apnea. – E. Sovova, M. Hobzova, M. Sova, V. Kolek, D. Stejskal, J. Zapletalova (Olomouc, CZ) PPAR-gamma regulates trans-endothelial fatty acid transport via induction of fatty acid binding protein 4 in capillary endothelial cells in heart, red skeletal muscles and adipose tissue. – K. Goto, T. Iso, H. Hanaoka, T. Suga, H. Matsui, M. Arai, K. Endo, F.J. Gonzalez, M. Kurabayashi (Gunma, JP; Bethesda, US) Lipocalin-type prostaglandin D synthase-mediated biosynthesis of PGD2 and its metabolites 15-deoxy-delta 12,14-PGJ2 synergistically stimulate nrf2 and protect hearts from ischemia/reperfusion injury. – Y. Katsumata, M. Sano, T. Matsuhashi, H. Ito, J. Endo, K. Shinmura, T. Tsugu, S. Yan, S. Toyama, K. Fukuda (Tokyo, JP) The presence of sphingosine-1 phosphate in reconstituted HDL is required for better protection against lethal reperfusion injuries. – M. Frias, S. Somers, X. Moren, L. Lacerda, L. Opie, R.W. James, S. Lecour (Geneva, CH; Cape Town, ZA) P4019 P4020 P4021 P4022 INJURY AND PROTECTION IN ISCHEMIA/REPERFUSION AND OTHER CARDIAC PATHOLOGIES (QR 30502*) *Abstracts can be accessed at: P4023 P4024 P4025 P4026 P4027 P4028 P4029 P4030 P4031 P4032 TUESDAY – MORNING Functional consequences of myofilament protein alterations in a mouse model of post-infarction remodeling. – A. Balogh, D. Czuriga, E.T. Pasztor, D. Santer, B. Podesser, Z. Papp (Debrecen, HU; Vienna, AT) Diastolic adaptive response to acute myocardial stretch: unraveling the role played by PKG and actin-myosin interaction in the normal and ischemic heart. – R. Ladeiras-Lopes, R. Castro-Ferreira, J. Neves, R. Fontes Carvalho, P. Castro-Chaves, A. Leite-Moreira (Porto, PT) Anthracycline-induced cytotoxicity: protective role of metformin. – M.C. Asensio-Lopez, J. Sanchez-Mas, D.A. Pascual-Figal, S. Abenza, M.T. Perez-Martinez, I.P. Garrido-Bravo, F. Pastor-Perez, M. Valdes, A. Lax (Murcia, ES) The GRK2 inhibitor beta-ARKct potentiates the pro-contractile function of beta2-adrenergic receptor in vivo under normal conditions and post-myocardial infarction. – A. Lymperopoulos, G. Rengo, E. Gao, W.J. Koch (Ft. Lauderdale and Philadelphia, US; Naples, IT) Assessment of circulating microRNAs as potential biomarkers for the diagnosis of acute coronary syndrome. – T. Zeller, T. Keller, F. Ojeda Echevarria, B. Stradmann-Bellinghausen, S. Tzikas, K. Perius, K.J. Lackner, T.J. Munzel, S. Blankenberg (Mainz, DE) Midregional pro-A-type natriuretic peptide for diagnosis and prognosis in patients with suspected acute myocardial infarction. – C. Meune, B. Drexler, P. Haaf, T. Reichlin, M. Reiter, J. Meissner, C. Stelzig, M. Freese, K. Winkler, C. Mueller (Basel, CH; Barcelona, ES) First identification of preproANP signal peptide in plasma: initial assessment as a biomarker of cardiac ischemia. – C.J. Pemberton, T. Kleffmann, M. Siriwardena, P. Ruygrok, A.M. Richards (Christchurch, Dunedin and Auckland, NZ) Regulation of CCN genes in the heart after myocardial infarction - transcriptional and posttranscriptional mechanisms. – K. Kaminski, T. Bonda, M. Kozuch, S. Litvinovich, I. Bialuk, A. Taranta, E. Waszkiewicz, L. Chyczewski, W.J. Musial, M.M. Winnicka (Bialystok, PL; Grodno, BY) CyP, a toll-like receptor 4 antagonist, protects the heart from ischemia/reperfusion injury. – A. Soldo, M. Molteni, C. Rossetti, S. Maggioni, A. Biondi, S. Gemma, R. Latini (Milan and Varese, IT) Metastin/kisspeptin-10, tumor metastasis suppressor peptide, impairs postnatal angiogenesis in rat hindlimb ischemia possibly due to induction of endothelial senescence. – S. Yamaya (Yokohama, JP) Safety of outpatient management of patients with acute chest pain and mildly elevated cardiac troponin levels. – C. Meune, T. Reichlin, A. Irfan, R. Twerenbold, J. Meissner, M. Reiter, P. Haaf, B. Drexler, K. Winkler, C. Mueller (Basel, CH; Barcelona, ES) Novel experimental protocol to study area at risk, infarct size, immunohistochemisty, and tissue protein content on the same rodent heart. – M.C. Ciuffreda, L. Calvillo, F. Pisano, M. Gnecchi (Pavia and Milan, IT) Comparison of two different myocardial infarction models in porcine utilizing electromechanical mapping system validated by cardiovascular magnetic resonance imaging. – E. Lukacs, B. Magyari, Ö. Petnehazy, Z.S. Petrasi, L. Toth, I. Repa, I. Horvath (Pécs and Kaposvár, HU) Dissipation of beta-dystroglycan with resultant hypercontracture of sarcomeres is culprit for formation of contraction bands in rat injured hearts. – H. Tanaka, H. Mani, T. Adachi, Y. Jiang, T. Takamatsu (Kyoto, JP) Remote ischemic preconditioning releases a circulating cardioprotective factor but target tissue response is attenuated due to an intrinsic cardioprotective activation in diabetic patients. – R.V. Jensen, S.B. Kristiansen, P.H. Nielsen, T.T. Nielsen, H.E. Botker (Aarhus, DK) P4033 P4034 P4035 P4036 P4037 QR 30502 249 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Genetic deletion of the E3 ubiquitin ligase SIAH2 lowers hypoxia-induced apoptosis and reduces infarct size after coronary artery ligation. – G. Pironti, C. Perrino, G.G. Schiattarella, G. Gargiulo, A. Cannavo, A. Franzone, A. Sannino, L. Scudiero, A. Scognamiglio, G. Esposito (Naples, IT) Normoxic cardiopulmonary bypass is associated with reduced transcriptomic changes in comparison to hyperoxic procedure in cyanotic paediatric patients undergoing corrective congenital heart surgery. – M.T. Ghorbel, G.D. Angelini, M. Caputo (Bristol, GB) MicroRNA 375: new prognostic marker in acute myocardial infarction. – N. Cortez-Dias, C. Jorge, P. Carrilho Ferreira, D. Silva, J. Silva Marques, R. Placido, S. Robalo Martins, P. Canas Da Silva, F.J. Pinto, A. Nunes Diogo (Lisbon, PT) Myocardial protection with retrograde coronary venous administration of adenosine in the setting of a porcine coronary artery occlusion-reperfusion model. – M.R. Torres, J.A. Ramires (São Paulo, BR) Alleviation of peripheral and myocardial ischemia in mice by novel GRP78 activating peptides. – B. Hardy, A. Raiter, A. Battler (Petach-Tikva, IL) Inhibition of RIP1-mediated necrosis ameliorates myocardial ischemia-reperfusion injury and attenuates adverse remodeling. – M.I.F. Oerlemans, J. Liu, K. Den Ouden, B. Van Middelaar, H. Clevers, P.A.F.M. Doevendans, J.P.G. Sluijter (Utrecht, NL; Jinan, CN) The cardioprotective nucleoside adenosine inhibits autophagy in murine cardiomyocytes. – M. Saric, E. Hamad, Y. Devaux, T. Chan, A.M. Feldman, D.R. Wagner (Luxembourg, LU; Philadelphia, US) (Pro)renin receptor blockade improves cardiac function and reduces ventricular remodeling following myocardial infarction in mice. – L.J. Ellmers, A.M. Richards, C.J. Charles, M.T. Rademaker (Christchurch, NZ) SAFE survival pathway is involved in the cardioprotective effect of remote ischemic preconditioning and local ischemic postconditioning. – V. Mateus, S. Tamareille, N. Ghaboura, J. Jeanneteau, A. Croue, D. Henrion, A. Furber, F. Prunier (Angers, FR) Ischaemic cardioprotection: pathogenic mechanism in type 2 diabetes mellitus? – J.A. Povlsen, B. Loefgren, C. Dalgas, N.B. Stoettrup, H.E. Boetker, T.T. Nielsen (Aarhus, DK) GLP-1(9-36)a and exendin-4 attenuate reoxygenation injury in isolated rat cardiomyocytes acting by distinct signaling pathways. – M. Treiman, L.B. Qian, N.L. Find, T. Engstrom (Copenhagen, DK) P4038 P4039 P4040 P4041 P4042 P4043 P4044 P4045 P4046 P4047 P4048 CORONARY FLOW, MYOCARDIAL PERFUSION AND ISCHAEMIA (QR 30503*) Mechanisms of coronary flow velocity reserve impairment in hypertrophic cardiomyopathy. – H.-K. Kim, S.-P. Lee, G.-Y. Cho, Y.-J. Kim, D.-W. Sohn (Seoul, KR) In vivo measurements of myocardial viscoelasticity by a new ultrasound method: validation and changes with infarction. – C. Pislaru, M.W. Urban, J.F. Greenleaf (Rochester, US) Acute effects of biventricular pacing on myocardial perfusion detected by Doppler-derived coronary flow reserve. – E.M. Pasanisi, R. Sicari, U. Startari, L. Panchetti, A. Rossi, M.A. Piacenti, M.A. Morales (Pisa, IT) The additive prognostic value of two-dimensional echo, lung ultrasound and C-reactive protein over global registry of acute coronary events (GRACE) risk score in patients with acute coronary syndromes. – G. Bedetti, L. Gargani, M. Scalese, C. Pizzi, R. Sicari, E. Picano (Imola, Pisa and Bologna, IT) Long-term prognostic value of myocardial perfusion stress echocardiography in diabetic patients. – P. Wejner-Mik, P. Lipiec, J.D. Kasprzak (Lodz, PL) Elevation of hs-troponin T after CMR stress testing, another indicator of myocardial ischemia? – M. Farazandeh, H.C. Eberle, D. John, A. Wolf, C. Jensen, T. Schlosser, K. Nassenstein, C.K. Naber, G.V. Sabin, O. Bruder (Essen, DE) Echocardiographic differentiation of hypo-perfused from normally perfused segments: comparison of 3D strain imaging with 2D speckle tracking. – R. Jasaityte, B. Heyde, D. Barbosa, D. Loeckx, P. Claus, J. D’hooge (Leuven, BE) Impact on embolic particles during coronary interventional procedures on regional myocardial wall motion in patients with stable angina pectoris. – Y. Higuchi, K. Iwakura, A. Okamura, M. Date, H. Nagai, M. Ozawa, K. Fujii (Osaka, JP) Diagnostic performance of pocket ultrasound system for fast-track evaluation of cardiology outpatients. – H.M. El-Naggar, E. Abate, N.A. Marsan, E.R. Holman, E.E. Van Der Wall, J.J. Bax, V. Delgado (Leiden, NL) Acute functional ischemic mitral regurgitation and systolic function of left ventricle in patients with first ST-segment elevation myocardial infarction treated by percutaneous interventions. – J. Kochanowski, P. Scislo, R. Piatkowski, M. Marchel, D. Kosior, G. Opolski (Warsaw, PL) Mild afterload augmentation allows reappearance of post-systolic thickening in previously ischemic myocardium. – K. Masuda, T. Asanuma, A. Hioki, D. Sakurai, S. Nakatani (Suita, JP) Negative stress echocardiography in severely obese patients has good prognostic value. – M. Murphy (Augusta, US) *Abstracts can be accessed at: 250 QR 30503 P4049 P4050 P4051 P4052 P4053 P4054 P4055 P4056 P4057 P4058 P4059 P4060 (W) TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Prediction of overall mortality and major cardiac events by means of exercise echocardiography and coronary angiography in patients with severe ischaemia. – J. Peteiro, A. Bouzas-Mosquera, F. Broullon, A. Perez-Perez, O. Prada, E. Barge-Caballero, A. Castro-Beiras (A Coruña, ES) Comparison of peak supine bicycle, post-treadmill, and peak treadmill exercise echocardiography for the detection of coronary artery disease. – J. Peteiro, A. Bouzas-Mosquera, R. Estevez-Loureiro, G. Barge-Caballero, F. Garcia-Lopez, M. Lopez-Perez, A. Castro-Beiras (A Coruña, ES) Upright T wave in precordial lead V1 indicates the presence of significant coronary artery disease in patients undergoing coronary angiography with otherwise unremarkable ECG. – I. Stankovic, K. Milekic, B. Putnikovic, M. Panic, R. Vidakovic, P. Milicevic, A. Vlahovic Stipac, A. Aleksic, A.N. Neskovic (Belgrade, RS) Utility of the ST-segment deviation score in the risk prediction of patients with suspected acute myocardial infarction. – R. Twerenbold, M. Reiter, R. Reichlin, C. Balmelli Cattelan, B. Drexler, A. Irfan, K. Winkler, C. Heinisch, S. Osswald, C. Mueller (Basel, CH; Barcelona, ES) ST-segment deviation score in the early diagnosis of acute myocardial infarction. – R. Twerenbold, T. Reichlin, R. Abaecherli, A. Irfan, M. Reiter, C. Balmelli Cattelan, P. Haaf, B. Drexler, S. Osswald, C. Mueller (Basel, CH) Diagnostic accuracy and feasibility of bedside pocket-sized ultrasound examination in patients admitted to an internal medicine department. – G.N. Andersen, B.O. Haugen, T. Graven, O.C. Mjoelstad, H. Dalen (Levanger and Trondheim, NO) Common carotid artery kinking is predictor of cardiovascular events: long term follow-up study using by carotid sonography. – T. Watanabe, M. Iwai-Takano, Y. Takeishi (Fukushima, JP) Novel four-dimensional speckle-tracking strain imaging for the assessment of myocardial viability after acute myocardial infarction: validation study with myocardial contrast echocardiography. – E. Abate, M.L. Antoni, G.E. Hoogslag, G. Nucifora, V. Delgado, D. Auger, T.G. Witkowski, M.J. Schalij, J.J. Bax, N. Ajmone Marsan (Leiden, NL) No-reflow phenomenon at patients with acute myocardial infarction - value of 3D echo perfusion assessment. – P. Scislo, J. Kochanowski, R. Piatkowski, M. Roik, M. Postula, G. Opolski (Warsaw, PL) Accuracy of real time 3 dimensional speckle tracking in ischemic patients: comparison to magnetic resonance imaging. – D. Hayat, M. Kloeckner, J. Nahum, A. Bensaid, L. Macron, R. Gallet, J.L. Dubois-Rande, P. Gueret, P. Lim (Créteil, FR) Fragmented QRS complex on a 12-lead ECG in patients with acute myocardial infarction: a MRI study. – M.A. Angue, L.L. Lorgis, C.A. Cochet, C.R. Richard, A.L. Lalande, M.Z. Zeller, A.G. Gudjoncik, P.B. Buffet, F.B. Brunotte, Y.C. Cottin (Dijon, FR) Comparison of coronary plaque characterization by spectral radiofrequency of intravascular ultrasound signals (VH-IVUS and i-MAP). – A. Hirohata, K. Yamamoto, E. Hirose, F. Sano, Y. Kobayashi, H. Takafuji, Y. Toyama, M. Ohara, K. Ohkawa, T. Ohe (Okayama, JP) P4061 P4062 P4063 P4064 P4065 P4066 P4067 P4068 P4069 P4070 P4071 P4072 MISCELLANEOUS (QR 30504*) *Abstracts can be accessed at: P4073 P4074 TUESDAY – MORNING The peer review process of the ESC - impact on cardiovascular science in Europe. – S. Winnik, D.A. Raptis, M. Komajda, J.J. Bax, M. Tendera, K. Fox, F. Van De Werf, T.F. Luescher, F. Ruschitzka, C.M. Matter (Zurich, CH; Paris, FR; Leiden, NL; Katowice, PL; London, GB; Leuven, BE) Earthquake 2010 in Chile: impact on the incidence of subepicardial lesions, experience with telelectrocardiography. – F. Bello, E. Escobar, D. Lama, G. Mezzano, S. Pavlov (Santiago, CL) Acute changes in circulating high sensitive troponin T during exercise induced myocardial ischemia. – T. Reichlin, M. Zellweger, C. Maushart, M. Potocki, R. Twerenbold, M. Pansini, F. Forrer, S. Osswald, C. Mueller (Basel, CH) Myocardial perfusion imaging in asymptomatic patients with rheumatoid arthritis. – M. Bernardes, H. Fernandes, E. Martins, P. Oliveira, M.J. Martins, T. Georgina, A. Oliveira, T. Faria, J. Pereira, F. Ventura (Porto, PT) Predicting the response to cardiac resynchronization therapy by regional wall motion analysis of ECG-gated myocardial perfusion SPECT with cardioGRAF. – I. Morishima, T. Sone, H. Tsuboi, H. Mukawa, M. Uesugi, Y. Kanzaki, H. Nagai, S. Ogasawara, Y. Shibata, Y. Yura (Ogaki, JP) Erythropoietin reduces LV perfusion defects measured by [99mTc]-sestamibi pinhole SPECT and enhances migration of bone marrow-derived cells after myocardial infarction in mice. – S. Brunner, B.C. Huber, T. Weinberger, M. Vallaster, T. Wollenweber, A. Gerbitz, M. Hacker, W.-M. Franz (Munich and Erlangen, DE) P4075 P4076 P4077 P4078 QR 30504 251 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Real-time dobutamine gated-SPECT myocardial perfusion imaging with an ultrafast gamma camera: validation against MRI. – R. Nkoulou, M. Wolfrum, S.M. Kueest, A.P. Pazhenkottil, J.R. Ghadri, L. Husmann, R.R. Buechel, B.A. Herzog, O. Gaemperli, P.A. Kaufmann (Zurich, CH) The usefulness of telemonitoring in an early detection and assessment of low pacing burden in patients undergoing cardiac resynchronization therapy. – M. Mazurek, E. Jedrzejczyk, A. Liberska, A. Wozniak, S. Pluta, A. Sokal, P. Pruszkowska, R. Lenarczyk, O. Kowalski, Z. Kalarus (Zabrze, PL) Do we need ECG telemonitoring during home-based cardiac rehabilitation? – E. Piotrowicz, I. Korzeniowska-Kubacka, J. Wolszakiewicz, A. Chrapowicka, M. Batogowski, B. Dobraszkiewicz-Wasilewska, A. Jasionowska, J. Gwilkowska, M. Banaszak-Bednarczyk, R. Piotrowicz (Warsaw, PL) Automated visceral and subcutaneous abdominal fat volume measurement: a validation study. – F. Bastos Goncalves, M. Koek, N. Ravensbergen, M. Voute, H. Verhagen, W. Niessen, D. Poldermans (Rotterdam, NL) Impact of imaging parameters on the assessment of intra-cardiac blood flow by echocardiographic tracking: simulations using computer-generated datasets. – H. Gao, P. Claus, J. D’hooge, J.U. Voigt (Leuven, BE) Echocardiographic prognostic implications in tako-tsubo cardiomyopathy. Insights from the tako tsubo italian network (TIN). – R. Citro, F. Rigo, Q. Ciampi, G. Provenza, M. Patella, E. Tagliamonte, C. Zito, O. Vriz, F. Silvestri, E. Bossone (Salerno, Mestre-Venice, Benevento, Terni, Nocera Inferiore, Messina and Udine, IT) Important change in the diagnosis of 1 in 5 patients admitted to a medical department after screening with pocket-sized ultrasound. – O.C. Mjolstad, T. Graven, G.N. Andersen, B. Haugen, H. Dalen (Trondheim and Levanger, NO) Left ventricle apical rotation under exposure to hypobaric hypoxia at very high altitude: a sign of subendocardial ischemia? Data from the HIGHCARE project. – M. Revera, G. Osculati, G. Branzi, F. Ciambellotti, A. Faini, G. Bilo, G. Mancia, G. Parati (Milan, IT) Dual microbubble targeting improves capture efficiency of an ultrasound contrast agent towards activated platelets: an ex-vivo study. – F. Guenther, A.L. Klibanov, M. Kramer, T. Heidt, M. Schwarz, E.A. Ferrante, K.H. Peter, C. Bode, C. Von Zur Muhlen (Freiburg, DE; Charlottesville, US; Melbourne, AU) Impaired systolic left ventricular strain rate reserve in patients with HFpEF. – P. Lindqvist, K. Lindmark, S. Morner, C. Backman, M. Henein (Umeå, SE) Influence of microbubble shell design on attachment efficiency in targeted ultrasound molecular imaging. – E. Khanicheh, M. Mitterhuber, K. Kinslechner, J.R. Lindner, B. Kaufmann (Basel, CH; Portland, US) 3D fusion echocardiography improves transoeosphageal left ventricular assessment. – D.X. Augustine, K. Rajpoot, C. Biasagianis, H. Pavolopoulous, X. Jin, S. Myerson, J. Newton, A. Noble, H. Becher, P. Leeson (Oxford, GB) The role of myocardial imaging in acute myocarditis: correlation of 2D speckle tracking strain rate and strain imaging with myocardial biopsy findings. – D. Sinning, M. Kasner, J.K. Gueffroy, U. Kuehl, H.P. Schultheiss, C. Tschoepe (Berlin, DE) Echo-based differentiation of cardiac amyloidosis and hypertrophic cardiomyopathy: a 3D-speckle-tracking-study. – H. Baccouche, M. Maunz, T. Beck, E. Gaa, M. Banzhaf, U. Knayer, P. Fogarassy, M. Beyer (Kirchheim unter Teck, DE) Ultrasound comets in healthy athletes performing prolonged strenuous sea-level exercise: an early and subclinical sign of increased interstitial edema. – A. Pingitore, E. Garbella, P. Piaggi, D. Menicucci, F. Frassi, W. Lubrano, M. Passera, R. Bedini, A. Gemignani, A. L’Abbate (Pisa, IT) Experimental validations of a new echocardiographic method for depicting blood flow patterns in the left ventricle. – T. Uejima, A. Walkers, C. Prinz, J.U. Voigt, A. Fraser (Cardiff, GB; Västerås, SE; Leuven, BE) Chronic kidney disease and its early progression are associated with the status of coronary microcirculation. – K. Nakanishi, S. Fukuda, K. Shimada, C. Miyazaki, S. Ehara, H. Taguchi, T. Muro, T. Kawarabayashi, J. Yoshikawa, M. Yoshiyama (Osaka and Nishinomiya, JP) Effects of caffeine on ischemia detection in myocardial perfusion scintigraphy associated with adenosine stress. – W. Azem Chalela, L. Vissotto Garchet Santos Reis, A. Falcao, L. Azouri, M. Izaki, J. Soares Junior, C. Meneghetti, A. Farah, N. Nunes (São Paulo, BR) P4079 P4080 P4081 P4082 P4083 P4084 P4085 P4086 P4087 P4088 P4089 P4090 P4091 P4092 P4093 P4094 P4095 P4096 UBIQUITOUS EFFECTS OF OBESITY AND THE METABOLIC SYNDROME (QR 30505*) Has an abnormal lipid profile the same impact in obese patients compared to non-obese patients? – A.T. Timoteo, A. Toste, B. Valente, M. Mota Carmo, R.C. Ferreira (Lisbon, PT) What is the real impact of obesity in coronary heart disease? – B.C. Picarra, A.R. Santos, R. Fernandes, A. Bento, M. Celeiro, A.F. Damasio, P. Dionisio, P. Semedo, A. Caeiro, M. Trinca (Évora, PT) *Abstracts can be accessed at: 252 QR 30505 P4097 P4098 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS P4099 P4100 P4101 P4102 P4103 P4104 P4105 P4106 P4107 P4108 P4109 P4110 P4111 P4112 P4113 P4114 TUESDAY – MORNING Screening for coronary artery disease in asymptomatic obese patients with erectile dysfunction. – N. Ioakeimidis, C. Vlachopoulos, D. Terentes-Printzios, A. Samentzas, K. Baou, A. Aggelis, K. Rokkas, C. Fassoulakis, C. Aggeli, C. Stefanadis (Athens, GR) Non-invasive detection of vascular dysfunction in sleep apnea syndrome by cardio-ankle vascular index and flow-mediated dilatation. – A. Yoshihisa, M. Miyata, T. Sato, S. Suzuki, K. Sugimoto, H. Kunii, K. Nakazato, H. Suzuki, S. Saitoh, Y. Takeishi (Fukushima, JP) Do measures of arterial function and atherosclerotic burden add incremental benefit to Framingham risk alone in predicting outcome in obese patients? – B.A. Haluska, L. Jeffriess, T.H. Marwick (Brisbane, AU; Cleveland, US) Weight loss effect on adiponectin and hs-CRP levels in patients with metabolic syndrome. – E. Paschalidou, I. Efthimiadis, K. Makedou, S. Pavlidou, F. Dogramatzi, I. Klonizakis, A. Efthimiadis (Thessaloniki, GR) Low levels of IgM antibodies against phosphorylcholine (anti-pc) are related to abdominal obesity and impaired fibrinolysis in the elderly. – K. Pettersson, A. Siegbahn, H. Lettesjo, I. Dahlbom, J. Frostegard, L. Lind (Solna, Uppsala and Stockholm, SE) Obesity and cardiovascular disease (CVD): an association or a cause and effect relationship? – M. El Shahawy, M. Entcheva, J. Cohn (Sarasota and Minneapolis, US) Effect of an FTO polymorphism on overweight and obesity in the polish WOBASZ study - the preliminary results. – A. Piwonska, W. Piotrowski, R. Ploski (Warsaw, PL) Significant cardiovascular risk factor burden seen in young, asymptomatic, and physically active subjects with a normal and elevated adjusted Asian body mass index. – G.K. Lee, H.W. Sim, Y. Tan, T. Ma, K.H. Lew, E.C. Tan, L.C. Lee, H.Y. Ong (Singapore, SG; Penang, MY) Rapid increase in abdominal obesity and deteriorating cardiometabolic risk profile in Poland LIPIDOGRAM 2004 and 2006 nation-wide surveys of 32,683 individuals. – B.M. Kaess, J. Jozwiak, C.P. Nelson, W. Lukas, M. Mastej, N.J. Samani, M. Tomaszewski (Leicester, GB; Czestochowa and Katowice, PL) Reducing cardiovascular risk factors in an obese population - preliminary findings from a community based cardiovascular disease prevention programme in Ireland. – I. Gibson, G. Flaherty, J. Jones, S. Connolly, J. Crowley (Galway, IE; London, GB) Metabolic syndrome predicts incidence of coronary artery disease but not stroke in essential hypertensive subjects: Data from a Greek 6-year-follow-up study. – C. Tsioufis, K. Dimitriadis, A. Kasiakogias, C. Thomopoulos, D. Syrseloudis, D. Tsiachris, M. Almyroudi, K. Kintis, I. Kallikazaros, C. Stefanadis (Athens, GR) Identification of ARIA as novel factor in the pathophysiology of metabolic syndrome. – Y. Akakabe, K. Ikeda, Y. Kitamura, M. Koide, M. Uraoka, Y. Nakagawa, H. Matsubara (Kyoto, JP) Association of metabolic syndrome and arterial stiffness with angiographic coronary artery disease. – A. Bechlioulis, K. Vakalis, K.K. Naka, N.D. Papamichael, C. Bourantas, A. Kotsia, C.S. Katsouras, L.K. Michalis (Ioannina, GR) Impact of metabolic syndrome on functional recovery after cardiac rehabilitation. – N. Russo, L. Compostella, T. Setzu, G. Fadini, S. Iliceto, A. Avogaro, F. Bellotto (Padua and Cortina D’Ampezzo, IT) Predictive accuracy of metabolic syndrome definitions for the coronary artery disease. – B. Parapid, N. Milic, M.C. Ostojic, N.M. Lalic, D. Micic, S. Damjanovic (Belgrade, RS) Is height an independent marker of metabolic syndrome in a developing society? A cross-sectional study of 22,180 Chilean adults. – E. Koch, T. Romero, D. Sandoval, C.X. Romero, M.A. Bravo, O. Henriquez, L. Urrutia (Santiago, CL; San Diego, US) Respective contributions of traditional cardiovascular risk factors and metabolic syndrome in the prediction of coronary heart disease. – V. Bongard, D. Taraszkiewicz, K. Vazoumana, M. Galinier, D. Carrie, M. Elbaz, J.B. Ruidavets, J. Ferrieres (Toulouse, FR) Blood pressure variability and subclinical organ damage in metabolic syndrome. – S.I. Dumitrescu, I. Tintoiu, V. Greere, G. Cristian, L. Chiriac, F. Pinte, G. Neagoe, M. Vicol, S. Stanciu, V.A. Voicu (Bucharest, RO) Aerobic capacity and endothelial function in patients with metabolic syndrome. – J.A. Manfredi, C. Bermudez, M. Gutierrez, R. Pisabarro (Montevideo, UY) P4115 P4116 P4117 HOW AND WHERE TO REDUCE BODY FAT – RUN OR CUT? (QR 30506*) Visceral adipose amount as epicardial fat measure rather than body fat composition contributes to insulin P4118 resistance, metabolic derangement and systemic inflammation: study validated by CT. – Y.H. Lai, C.H. Yun, C.C. Liu, J.Y. Hou, T.C. Hung, H.I. Yeh, S.C. Shih, C.L. Hung, C.H. Tsai (Taipei, TW) The risk of general and abdominal adiposity in the occurrence of new vascular events and mortality in P4119 patients with various manifestations of vascular disease. – D.A. Kanhai (Utrecht, NL) *Abstracts can be accessed at: QR 30506 253 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Which parameter is more related to angiographic coronary disease: waist circumference or body mass index? – A.T. Timoteo, H. Hamad, N. Santos, M. Mota Carmo, R.C. Ferreira (Lisbon, PT) When essential hypertension is combined with visceral adiposity there is discordance between arterial stiffness and peripheral wave reflections. – V. Katsi, G. Souretis, D. Barlagiannis, I. Vlasseros, N. Alexopoulos, C. Stefanadis (Athens, GR) Impact of body mass index and body composition on long term mortality of patients with heart failure. – A.L. Gamez Lopez, J.L. Bonilla Palomas, M. Anguita Sanchez, J.C. Castillo Dominguez, D. Garcia Fuertes, M. Crespin-Crespin, J. Suarez De Lezo (Córdoba, ES) Body- mass index and late mortality in a general surgery population. – T.M. Valentijn, S.E. Hoeks, E.J. Bakker, M.T. Voute, N.J. Ravensbergen, K.M. Van De Luijtgaarden, F. Bastos Goncalves, D. Goei, H.J.M. Verhagen, D. Poldermans (Rotterdam, NL) Waist circumference versus other obesity indices as determinants of coronary artery disease in essential hypertensive patients: a 6-year-follow-up study. – K. Dimitriadis, C. Tsioufis, A. Kasiakogias, I. Bafakis, M. Almyroudi, K. Kintis, I. Andrikou, I. Anastasopoulos, I. Kallikazaros, C. Stefanadis (Athens, GR) Abdominal fat in association with cardio-metabolic disturbances in men of European, African-Caribbean and South Asian origin. – R. Hajhosseiny (London, GB) Correlation between waist circumference and hip circumference in patients with non-ST-elevation acute coronary syndrome. – S. Ribeiro, A. Gaspar, C. Vieira, V. Ramos, C. Braga, P. Azevedo, M.A. Pereira, A. Correia (Braga, PT) The relationship between body mass index, obesity and cardiovascular risk. – S.K. Malyutina, G. Simonova, Y.U. Nikitin, V. Gafarov, E. Veryovkin (Novosibirsk, RU) Long term lifestyle intervention and optimized high intensity interval training program improve body composition, cardiovascular risk and exercise parameters in obese patients with or without metabolic syndrome. – V.G. Gremeaux, J.D. Drigny, A.N. Nigam, M.J. Juneau, V.G. Guilbeault, M.G. Gayda (Montreal, CA) Long-term high-intensity interval training improves QT dispersion parameters in metabolic syndrome patients. – J.D. Drigny, T. Guiraud, V.G. Gremeaux, M. Gayda, M. Juneau, A.N. Nigam (Montreal, CA; Saint Orens de Gameville, FR) Exercise training effectiveness in young patients who associate obesity and sleep apnea. – C. Avram, M. Oravitan, B. Almajan-Guta, M. Marc, L. Hoble, M. Iurciuc, D. Gaita (Timisoara, RO) Right ventricle in obesity - a supine exercise echocardiographic and radionuclide study. – C.M. Stanescu, K. Branidou, D.A. Stanescu, G.A. Dan, V. Manoliu, A. Dan, C. Stan, C. Chirion, D. Gologanu (Bucharest, RO) Cardiometabolic risk reduction in morbidly obese patients six months after bariatric surgery. – J. Domienik, O. Dzikowska-Diduch, W. Lisik, Z. Wierzbicki, P. Pruszczyk (Warsaw, PL) Adrenergic and metabolic effects of bariatric surgery in obese subjects: a longitudinal study. – G. Seravalle, F. Quarti Trevano, M. Colombo, P. Perego, V. Giardini, M. Volpe, V. Vella, S. Muraro, G. Mancia, G. Grassi (Milan and Monza, IT) The positive effect of surgical obesity intervention on cardiac structure and function is related to concomitant alleviation of sleep apnoea. – D. Kardassis, J. Hedner, L. Sjostrom, L. Grote, K. Karason (Gothenburg, SE) Diastolic dysfunction in obesity cardiomyopathy may be permanent after bariatric surgery. A DTI study. – M. Luaces Mendez, A. Antequera-Perez, M. Medina, A. Garcia-Munoz-Najar, E. Cancer-Minchot, G. Canovas-Molina, A. Rodriguez-Robles, N. Gonzalez-Perez De Villar (Fuenlabrada, ES) P4120 P4121 P4122 P4123 P4124 P4125 P4126 P4127 P4128 P4129 P4130 P4131 P4132 P4133 P4134 P4135 WHAT SHOULD WE EAT TO STAY HEALTHY? (QR 30507*) Fatal and non-fatal outcomes, incidence of hypertension, and blood pressure changes in relation to urinary sodium excretion. – K. Stolarz-Skrzypek, T. Kuznetsova, L. Thijs, V. Tikhonoff, A. Olszanecka, S. Malyutina, E. Casiglia, J. Filipovsky, K. Kawecka-Jaszcz, J.A. Staessen (Krakow, PL; Leuven, BE; Padua, IT; Novosibirsk, RU; Pilsen, CZ) Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis. – O.H. Franco Duran, A. Buitrago Lopez, J. Sanderson, L. Johnson, E. Di Angelantonio, S. Warnakula, A. Wood, J. Danesh (Cambridge, GB) Red wine consumption and low- or high-dose resveratrol treatment improve aging biomarkers but do not extend life span in rats. – L.Y. Tanaka, D. Favarato, P.C. Brum, J.E. Krieger, F.R.M. Laurindo, P.L. Da Luz (São Paulo, BR) Red grape extracts protective effects on endothelial progenitor cells function and improvement of their polyphenols bioavailability. – F. Felice, R. Di Stefano, Y. Zambito, G. Di Colo, C. D’onofrio, A. Balbarini (Pisa, IT) Beneficial effects of cranberry juice on osteogenic endothelial progenitor cells in patients with early atherosclerosis. – A. Flammer, M. Gossl, E.A. Martin, R.J. Widmer, S. Khosla, L.O. Lerman, A. Lerman (Rochester, US) *Abstracts can be accessed at: 254 QR 30507 P4136 P4137 P4138 P4139 P4140 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS P4141 P4142 P4143 P4144 P4145 P4146 P4147 P4148 P4149 P4150 P4151 P4152 P4153 P4154 P4155 P4156 TUESDAY – MORNING Acute and mid-term effects of tomato paste diet supplementation on endothelial function: a randomized, cross-over study. – P. Xaplanteris, C. Vlachopoulos, D. Terentes-Printzios, D. Kardara, N. Ioakeimidis, P. Pietri, N. Alexopoulos, K. Aznaouridis, C. Stefanadis (Athens, GR) Effects of coffee consumption on metabolic parameters in healthy volunteers and in patients with coronary artery disease. – B.M. Mioto, M.A. Moretti, J.A.F. Ramires, R.V. Amato, D. Tarasoutchi, K.M. Dias, L.A. Machado Cesar (São Paulo, BR) Long term coffee consumption is associated with improved endothelial function in elderly individuals: ikaria study. – E. Oikonomou, G. Siasos, C. Chrysohoou, D. Tousoulis, M. Zaromitidou, E. Gialafos, K. Zisimos, G. Marinos, C. Pitsavos, C. Stefanadis (Athens, GR) Influence of different vitamin D doses on structure, function, energy metabolism and inflammatory mediators in the heart of Wistar rats. – P.P. Santos, H.B. Assalin, B.P.M. Rafacho, M.F. Minicucci, P.S. Azevedo, F. Chiuso-Minicucci, M.G. Roscani, A.A.H. Fernandes, L.A.M. Zornoff, S.A.R. Paiva (Botucatu, BR) Plasma vitamin D levels and myopathic complications among statin users. – A. Eisen, E. Lev, Z. Iakobishvili, A. Porter, D. Brosh, D. Hasdai, A. Mager (Petah Tikva, IL) Determinants and cardiovascular correlates of vitamin D deficiency in australian women. – D.T.M. Ngo, W.P.A. Chan, A.L. Sverdlov, J.D. Horowitz (Adelaide, South Australia, AU) Impact of MTHFR C677T gene polymorphism, folate, B6 and B12 vitamin intake on homocysteine concentration in Polish adult population. – A. Waskiewicz, W. Piotrowski, G. Broda, A. Sobczyk-Kopciol, R. Ploski (Warsaw, PL) Plant sterols and cardiovascular disease: a meta-analysis of 17 studies. – B. Genser, G. Silbernagel, G. De Backer, E. Bruckert, R. Carmena, J. Chapman, J.E. Deanfield, O.S. Descamps, E.R. Rietzschel, W. Marz (Graz, AT; Tübingen and Heidelberg, DE; Ghent and Brussels, BE; Paris, FR; Valencia, ES; London, GB) Carotenoid levels in plasma: can dietary intake and inflammation explain variability? – M. Ryden, P. Leanderson, P. Garvin, M. Kristenson, L. Jonasson (Linköping, SE) Social differences in nutrient intake in three CEE countries: the HAPIEE study. – H. Pikhart, A. Peasey, S. Malyutina, A. Pajak, R. Kubinova, S. Boylan, M. Bobak (London, GB; Novosibirsk, RU; Krakow, PL; Prague, CZ; Sydney, AU) Impact of abdominal obesity and insulin resistance on cardiovascular events in Japanese obesity-endemic area: Okinawa Tomishiro Cohort Study. – M. Shimabukuro, M. Higa, K. Yamakawa, H. Masuzaki, M. Sata (Tokushima and Okinawa, JP) Nutrition and cardiovascular risk factors in children: the PEP Family Heart Study. – P. Schwandt, T. Bertsch, E. Liepold, G.M. Haas (Munich and Nuremberg, DE) Effect of an FTO polymorphism on dietary habits in the Polish Wobasz study - the preliminary results. – A. Piwonska, E. Sygnowska, R. Ploski (Warsaw, PL) Living longer, living better; which are the secrets? The Ikaria study. – D.B. Panagiotakos, C. Chrysohoou, G. Siasos, K. Zisimos, J. Skoumas, C. Pitsavos, C. Stefanadis (Athens, GR) Long-term adherence to the mediterranean diet seems to confer to a lower risk of hyperuricaemia in elderly individuals. The ikaria study. – C. Chrysohoou, J. Skoumas, V. Metaxa, G. Siasos, C. Zisimos, C. Mylonakis, N. Galiatsatos, A. Valatsou, C. Pitsavos, C. Stefanadis (Athens and Ikaria, GR) Fish consumption is associated with lower prevalence of depressive symptomatology, in elderly men and women from the IKARIA study. – C. Chrysohoou, G. Tsitsinakis, M. Zaromytidou, C. Sykaras, S. Plytaria, M. Xynogala, S. Lagoudakou, B. Psaroudaki, C. Pitsavos, C. Stefanadis (Athens, GR) Saturated fatty acids intake, polyunsaturated fatty acid intake and coronary heart disease mortality in Japan: NIPPON DATA90 1990-2005. – Y. Nakamura, Y. Kiyohara, T. Okamura, A. Higashiyama, M. Watanabe, A. Kadota, S. Nagasawa, K. Miura, H. Ueshima (Kyoto, Fukuoka, Nishinomiya, Suita, Osaka and Otsu, JP) Time duration between dinner and sleep and likelihood of developing acute coronary syndrome or stroke: results of a case/case-control study. – C.M. Kastorini, H. Milionis, D. Kandas, G. Papagiannopoulou, A. Litsardopoulou, E. Ntziou, V. Nikolaou, K. Vemmos, J. Goudevenos, D.B. Panagiotakos (Ioannina and Athens, GR) Adherence to the mediterranean diet reduces the likelihood of developing acute coronary syndrome and stroke: a case/case-control study. – C.M. Kastorini, H. Milionis, K. Kalantzi, A. Ioannidi, E. Georgousopoulou, M. Kostapanos, K. Vemmos, V. Nikolaou, J. Goudevenos, D.B. Panagiotakos (Ioannina and Athens, GR) The mediating effect of the mediterranean diet on serum protein levels, among apparently healthy individuals. – V. Bountziouka, A. Evangelopoulos, N. Vallianou, C. Katsagoni, M. Bonou, P. Avgerinos, E. Vogiatzakis, J. Barbetseas, D.B. Panagiotakos (Athens, GR) P4157 P4158 P4159 P4160 255 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS ACUTE CARDIAC CARE (QR 30508*) The ASia-Pacific Evaluation of Chest pain Trial (ASPECT): two-hour emergency department rule-out evaluation for chest pain. – L.A. Cullen, M.P. Than, C.M. Reid, S.H. Lim, S. Aldous, M. Ardagh, A.M. Richards (Brisbane and Melbourne, AU; Christchurch, NZ; Singapore, SG) Are intra-aortic balloon pumps harmful in cardiogenic shock? – D.A. Stub, W. Chan, D.J. Clark, A.E. Ajani, N. Andrianopoulos, A. Brennan, A. Black, G. New, C.M. Reid, S.J. Duffy (Melbourne, AU) Improving perioperative cardiac risk assessment and beta-blocker use for non-cardiac surgery (INCREASE): the INCREASE quality improvement project. – A. Rajamanickam, A. Usmani, P. Anbazhagan, A. Ramasamy, M. Pecic, E. Hixson, A. Jaffer, B. Harte (Newark, Louisville, Cleveland and Miami, US) Mid regional pro-atrial natriuretic peptide levels for dynamic risk stratification of patients with acute coronary syndromes. – O.S. Dhillon, S.Q. Khan, P.A. Quinn, I.B. Squire, A. Bergmann, J.E. Davies, L.L. Ng (Leicester, GB; Henningsdorf, DE) Quantification of endothelial dysfunction using c-terminal pro-endothelin in the early diagnosis and risk-stratification of patients with suspected acute myocardial infarction. – P. Haaf, C. Balmelli, T. Reichlin, B. Drexler, A. Irfan, M. Reiter, R. Twerenbold, C. Meune, S. Osswald, C. Mueller (Basel, CH; Paris, FR) Mechanisms of acute diastolic heart failure in an experimental model of no-reflow infraction. – M. Schwarzl, P. Steendijk, S. Huber, H. Maechler, M. Truschnig-Wilders, B.M. Pieske, H. Post (Graz, AT; Leiden, NL) Acute myocardial infarction type 2: incidence and prognosis. – B. Drexler, T. Reichlin, C. Balmelli, P. Haaf, R. Twerenbold, W. Hochholzer, M. Reiter, S. Osswald, C. Mueller (Basel, CH) The significance of each traditional WHO criterion used to diagnose acute myocardial infarction. – A. Irfan, T. Reichlin, R. Twerenbold, M. Reiter, C. Balmelli, J. Meissner, P. Haaf, B. Drexler, S. Osswald, C. Mueller (Basel, CH) Comparison of 2 and 6 hour time intervals in the diagnosis of acute myocardial infarction. – L.A. Cullen, J.H. Greenslade, A.F.T. Brown, C.J.K. Hammett, M.P. Than, K.H. Chu, J.P.J. Ungerer, W.A. Parsonage (Brisbane, AU; Christchurch, NZ) Appropriateness criteria for left ventricle wall stress measurement in patients with a myocardial infarction. – S. Barra, L. Paiva, R. Providencia, P. Gomes, C. Faustino, F. Caetano, A. Leitao Marques (Coimbra, PT) Direct comparison of high-sensitive and sensitive cardiac troponin assays for risk stratification in patients with acute chest pain. – C. Balmelli, M. Reiter, T. Reichlin, R. Twerenbold, P. Haaf, A. Irfan, B. Drexler, C. Meune, S. Osswald, C. Mueller (Basel, CH; Paris, FR) Trauma induced secondary cardiac injury. – H.D. De’ Ath, C. Rourke, J. Manson, R. Davenport, S. Khan, I. Raza, C. Spoors, C. Davies, M. Rothman, K. Brohi (London, GB) Impact of presentation time on the management and clinical outcomes of acute myocardial infarction in Korea. – K.-Y. Chen, S.W. Rha, Y.-J. Li, B.-G. Choi, C.-U. Choi, C.-G. Park, H.-S. Seo, D.-J. Oh, M.-H. Jeong, G.-P. Li (Tianjin, CN; Seoul and Gwangju, KR) Myocardial infarction fatality rates: an eastern European perspective from the international registry of acute coronary syndromes in transitional countries. – B. Xhyheri, S. Boystov, D. Becker, M. Dilic, Z. Vasiljevic, R. Bugiardini (Bologna, IT; Moscow, RU; Budapest, HU; Sarajevo, BA; Belgrade, RS) Myeloid-related protein 8/14 in the risk stratification of patients with suspected acute myocardial infarction. – B. Drexler, T. Reichlin, A. Irfan, C. Balmelli, R. Twerenbold, P. Haaf, M. Potocki, N. Schaub, S. Osswald, C. Mueller (Basel, CH) Intra-aortic balloon pump use, does the final balloon tip position matter? – M. Siriwardena, A. Pilbrow, C. Frampton, G.W. Wilkins, A.M. Richards (Christchurch and Dunedin, NZ) High-sensitive cardiac troponin T (hs-cTnT) assay is not superior to a previous cTnT assay generation for the diagnosis of acute myocardial infarctions in a real-world emergency department. – J. Mair, T. Ploner, A. Hammerer-Lercher, P. Schratzberger, A. Griesmacher, O. Pachinger (Innsbruck, AT) Rule out acute myocardial infarction algorithm among patients with increased high sensitive troponin levels. – A. Irfan, T. Reichlin, R. Twerenbold, M. Reiter, C. Balmelli, J. Meissner, P. Haaf, B. Drexler, S. Osswald, C. Mueller (Basel, CH) The impact of metabolic status on therapeutic strategy decision and long term prognosis in patients with acute myocardial infarction. – R. Dragu, M. Kapeliovich, H. Hammerman, D. Aronson (Haifa, IL) *Abstracts can be accessed at: 256 QR 30508 P4161 P4162 P4163 P4164 P4165 P4166 P4167 P4168 P4169 P4170 P4171 P4172 P4173 P4174 P4175 P4176 P4177 P4178 P4179 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS P4180 P4181 P4182 P4183 P4184 P4185 P4186 P4187 P4188 P4189 P4190 P4191 P4192 P4193 P4194 P4195 (W) TUESDAY – MORNING Endothelial NO-synthase gene polymorphism as a genetic marker of unfavorable outcome in patients with non-ST-segment elevation myocardial infarction against the background of metabolic syndrome. – T. Glebovskaya, N. Burova, N. Solovjova (Saint Petersburg, RU) Diabetes mellitus in acute coronary syndrome: an new independent marker of atrioventricular block and need of pacemaker. – C. Ferreira, P. Mateus, H. Ribeiro, A. Ferreira, S. Carvalho, I. Moreira, on behalf of Portuguese National Registry Acute Coronary Syndrome Investigators (Vila Real, PT) Multiple-biomarkers assessment offers additive risk prediction in patients with acute coronary syndrome. – J.-K. Lee, W.-C. Yu, S.-J. Lin, F.-T. Chiang (Taipei, TW) Characteristics and outcome of patients with or without history of coronary artery disease presenting with an acute coronary syndrome in a chest pain unit: results of the german CPU registry. – C.A. Correia De Freitas, S. Schneider, E. Giannitsis, T. Muenzel, C. Schmitt, L.S. Maier, H. Mudra, M. Oef, J. Senges, M. Haude (Neuss, Ludwigshafen, Heidelberg, Mainz, Karlsruhe, Göttingen, Munich and Brandenburg, DE) Analysis of depolarization abnormalities in the evaluation of patients with chest pain. – O. Galante, G. Amit, O. Luria, L.R. Davrath, S. Abboud, D. Zahger (Beer-Sheva, Tel-Aviv and Tel Aviv, IL) Evaluating a nurse-led triage process in treating patients with Left Bundle Branch Block (LBBB) referred for primary Percutaneous Coronary Intervention (pPCI). – N. Joshi, B.R. Bawamia, S. Jamieson, A. Zaman, R. Edwards (Edinburgh and Newcastle-upon-Tyne, GB) Changes in clinical profile, treatment and mortality in patients hospitalised for acute myocardial infarction between 1985 and 2008. – S.T. Nauta, J.W. Deckers, M. Akkerhuis, M. Lenzen, M.L. Simoons, R.T. Domburg (Rotterdam, NL) Prognostic value of soluble ST2 in unselected cardiac patients admitted to the intensive care unit. – B. Dieplinger, M. Egger, W. Koehler, F. Firlinger, W. Poelz, L. Hengst, K. Lenz, M. Haltmayer, T. Mueller (Linz and Innsbruck, AT) Risk scores prognostic effectiveness in patients presenting to the emergency department with chest pain and nondiagnostic electrocardiogram. – A. Conti, C. Poggioni, G. Viviani, M. Luzzi, E. Canuti, Y. Mariannini, G. Cerini, M. Zanobetti, F. Innocenti, R. Pini (Florence, IT) Association between circulating oxidized low-density lipoprotein and premature coronary artery disease extent in men. – K. Triantafyllou, F. Symeonides, S. Pastromas, H. Anninos, A. Papapanagiotou, C. Nounopoulos, A. Kalofoutis, S. Koulouris (Athens, GR) The German CPU registry: comparison of troponin positive to troponin negative patients. – J.B. Schuettert, H. Darius, E. Giannitsis, M. Haude, G. Heusch, H. Mudra, T. Muenzel, J. Senges, T. Voigtlaender, L.S. Maier (Göttingen, Berlin, Heidelberg, Neuss, Essen, Munich, Mainz, Ludwigshafen and Frankfurt, DE) Chest pain and its relation to acute coronary syndrome (ACS) in the Emergency Department (ED). – M. Mockel, J. Searle, R. Muller, A.C. Slagman, H. Storchmann, P. Oestereich, W. Wyrwich, J.O. Vollert, M. Koch, R. Somasundaram (Berlin, DE; Townsville, AU) The efficacy of ivabradin in patients hospitalized with acute coronary syndrome. – V. Moiseev, L. Dyatchuk, A. Potapenko, A. Abdulazizov, G. Kiyakbaev, Z.H. Kobalava (Moscow, RU) The impact of hyperglycemia as a risk factor in patients with acute myocardial infarction is homogeneous across different age groups? – J.C. Nicolau, M. Franken, F.G. Lima, L.M. Baracioli, R.R. Giraldez, C.V. Serrano, T.F. Pinto, R. Holanda, H. Graner, J.A.F. Ramires (São Paulo, BR) Acute myocardial infarction in the ninth decade of life. – M. Correia, C. Araujo, S. Mendes, L. Martins (Santa Maria Da Feira, PT) Multicenter prospective continuous registry of 51217 CCU patients: feasibility and results with a digital discharge record form. – C. Tajer, H.C. Doval, J. Gagliardi, M. De Abreu, J. Mariani, M.A. Silberstein (Buenos Aires, AR) Prognostic value of high sensitive troponin I (hsTnI) in unselected patients with acute dyspnea in the Emergency Department. – J. Searle, A.C. Slagman, F. Holert, B. Karow, A. Pinkowski, J.O. Vollert, R. Muller, S. Datwyler, C. Mueller, M. Mockel (Berlin, DE; Townsville, AU; Abbott Park, US) Cardiogenic shock complicating acute myocardial infarction is an indicator of increased mortality not only during hospital stay but also one year after discharge. Results from the MITRA plus registry. – K. Kouraki, A.K. Gitt, C. Juenger, R. Zahn, J. Senges, U. Zeymer (Ludwigshafen am Rhein, DE) P4196 P4197 ACUTE CORONARY SYNDROME (QR 30509*) Anti-connective tissue antibodies in pathogenesis and diagnosis of acute coronary syndrome. – A.R. Babaeva, S.I. Davidov, A.A. Tarasov (Volgograd, RU) The long term prognostic value of the troponin I level following acute coronary syndromes. – I.R. Pearson, C.P. Gale, R. Das, E. Metcalf, N. Kilcullen, K. Viswanathan, C. Morrell, J.H. Barth, A.S. Hall (Leeds, GB) Patients with cerebral lacunar infarction should be regarded as vulnerable patients for coronary artery disease. – K. Otsui, N. Inoue, T. Mori, T. Ozawa, D. Isaka, K. Domoto, S. Inamoto, K. Onishi (Kobe, JP) *Abstracts can be accessed at: P4198 P4199 P4200 QR 30509 257 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Mid-regional pro-adrenomedullin as a novel predictor of mortality in patients with acute chest pain. – P. Haaf, B. Drexler, T. Reichlin, R. Twerenbold, M. Reiter, J. Meissner, C. Balmelli, C.H. Meune, S. Osswald, C.H. Mueller (Basel, CH; Paris, FR) 123I-BMIPP/99m-Tc SPECT mismatch after primary percutaneous coronary intervention is strongly associated with functional recovery only in anterior ST segment elevation myocardial infarction. – H. Shibata, S. Yamada, Y. Taniguchi, S. Iwata, A. Shimane, T. Takaya, N. Miyoshi, K. Yokoi, T. Hayashi (Himeji, JP) Improved prognosis for patients with acute myocardial infarction and a decreasing “weekend-effect” from 1997 to 2009. – K.W. Hansen, A. Hvelplund, S.Z. Abildstrom, E. Prescott, M. Madsen, J.K. Madsen, J.S. Jensen, C. Nordenberg, S. Galatius (Copenhagen, DK) Cardiovascular mortality in post-myocardial infarction patients undergoing antidepressive pharmacotherapy. – J.K. Jensen, P. Weeke, G. Gislason, C. Torp-Pedersen (Gentofte, DK) Utility and reliability of the REACH risk score in evaluating the risk of post-discharge bleeding in a contemporary cohort of patients with ACS patients. – E. Abu-Assi, S. Raposeiras Roubin, R.M. Agra-Bermejo, P. Cabanas-Grandio, S. Gestal Romari, E. Pereira Lopez, J.M. Martinez Cereijo, J.M. Garcia Acuna, C. Pena Gil, J.R. Gonzalez-Juanatey (Santiago de Compostela, ES) Intracoronary infusion of mononuclear stem cells after acute revascularized myocardial infarction is not associated with increased prevalence of late ventricular arrhythmias. – L.F.H. Robbers, R. Delewi, Y. Van Beurden, R. Nijveldt, A.M. Beek, M.J.B. Kemme, A. Hirsch, F. Zijlstra, J.J. Piek, A.C. Van Rossum (Amsterdam and Groningen, NL) Wide fluctuations in capillary glucose levels during acute coronary syndrome predicts poor prognosis. – G.K. Lee, W.T. Yeo, M.Y. Chan, K.K. Poh, C.S. Lau, R.C. Lee, T.C. Yeo (Singapore, SG) The rs1333049, rs10757278 and rs4977574 polymorphisms of the locus 9p21- the association with 5-year prognosis in patients with ST-elevation myocardial infarction. – A. Kozieradzka, W. Pepinski, E. Waszkiewicz, M. Olszewska, D. Maciorkowska, M. Skawronska, A. Niemcunowicz-Janica, S. Dobrzycki, W.J. Musial, K.A. Kaminski (Bialystok, PL) Causes and pattern of death of non ST elevation acute coronary syndromes: ten year outcome of prospective registry of acute ischaemic syndromes in the UK (PRAIS-UK). – G. Erdem, A. Bakhai, A.K. Taneja, J. Colllinson, W. Banya, M.D. Flather (London, GB) The impact of microvascular damage in the reverse left ventricular remodeling with reperfused anterior myocardial infarction. – S. Hosokawa, Y. Hiasa, N. Mizobe, T. Nakagawa, S. Miyazaki, K. Mahara, R. Ogura, T. Takahashi, K. Kishi, R. Otani (Komatsushima, JP) Incidence and prognostic implications of central sleep apnea in the subacute phase of myocardial infarction. – H. Bonnemeier, A. Reshetnik, T. Demming, W. Maeuser, S. Puppe, A. Ziomka, N. Frey (Kiel, DE) Body surface potential mapping predicts recovery of acute ischemic left ventricular dysfunction. – M.M. Kylmala, T. Konttila, P. Vesterinen, M. Lindholm, M.S. Nieminen, M. Stenroos, H. Vaananen, H. Hanninen, L. Toivonen (Helsinki, FI) Prognostic value of soluble receptor for advanced glycation end products in acute coronary syndrome with normal renal function. – S. Raposerias-Roubin, B.K. Rodino-Janeiro, P. Aguiar-Souto, J.M. Garcia-Acuna, M.V. Reino-Maceiras, L. Rey-Gonzalez, J.R. Gonzalez-Juanatey, E. Alvarez Castro (Santiago de Compostela, ES) Prevalence, predictors, and 5-years mortality of patients with NSTEMI and insignificant coronary artery disease. – P. Cabanas Grandio, E. Abu Assi, S. Gestal Romani, S. Raposeiras Roubin, R. Agra Bermejo, E. Pereira Lopez, J.M. Martinez Cereijo, J.M. Garcia Acuna, M. Rodriguez Cordero, J.R. Gonzalez Juanatey (Santiago de Compostela, ES) Gender difference in the prognostic value of estimated glomerular filtration rate at admission in ST-segment elevation myocardial infarction. – M.J.D. Grundeken, P. Damman, W.J. Kikkert, P. Woudstra, W.J. Kuijt, R.E. Harskamp, J.P. Van Straalen, J. Fischer, J.G.P. Tijssen, R.J. De Winter (Amsterdam, NL) Phase I clinical trial of TRO40303, a new mPTP inhibitor for reducing reperfusion injury. – S. Schaller, S. Le Lamer, J. Afxantidis, C. Chaimbault, M. Michaud, P. Berna, R. Pruss, M. Latreille, Y. Donazzolo, J.L. Abitbol (Marseille and Lyon, FR) Effects of angiotensin II blockade on cardiomyocyte regeneration after myocardial infarction in rats. – H. Segersvard, P. Lakkisto, H. Forsten, K. Immonen, R. Kosonen, J. Lakkisto, E. Palojoki, E. Kankuri, M. Laine, I. Tikkanen (Helsinki, FI) Incremental predictive value of red cell distribution width for 12-month clinical outcome after acute myocardial infarction. – J.H. Lee, K.H. Kim, W.S. Choi, S.H. Park, M.H. Bae, D.H. Yang, H.S. Park, Y. Cho, S.C. Chae, J.E. Jun (Daegu, KR) Predictors of reinfarction following PCI or medical management using the universal definition in patients with total occlusion after myocardial infarction: results from OAT long term follow up. – H.D. White, H.R. Reynolds, A.C. Carvalho, L. Liu, C.A. Pearte, V. Dzavik, M. Kruk, P.G. Steg, G.A. Lamas, J.S. Hochman (Auckland, NZ; New York, Owings Mills and Miami Beach, US; São Paulo, BR; Toronto, CA; Warsaw, PL; Paris, FR) Predictors of working status in the long-term after acute myocardial infarction. – J.C. Nicolau, R.R. Giraldez, F.G. Lima, M. Franken, L.M. Baracioli, T.F. Pinto, C.V. Serrano, R. Holanda, H. Graner, F. Ganem (São Paulo, BR) 258 P4201 P4202 P4203 P4204 P4205 P4206 P4207 P4208 P4209 P4210 P4211 P4212 P4213 P4214 P4215 P4216 P4217 P4218 P4219 P4220 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS The coronary angiographic analysis of 16573 patients for coronary artery origination and course anomalies. – S. Yuksel, M. Meric, K. Soylu, O. Gulel, H. Zengin, S. Demircan, O. Yilmaz, M. Sahin (Kurupelit-Samsun, TR) Sleep disordered breathing in patients with acute coronary syndromes. – E. Kallergis, E. Simantirakis, S. Schiza, S. Chrysostomakis, I. Bouloukaki, D. Arfanakis, N. Tzanakis, P. Vardas (Heraklion, GR) Are novel markers of cardiovascular risk worth of measure in already high risk patients? – A. Kablak-Ziembicka, T. Przewlocki, D. Sliwiak, E. Stepien, P. Pieniazek, P. Musialek, D. Rzeznik, W. Tracz, P. Podolec (Krakow, PL) Clopidogrel can be safely continued until coronary artery bypass grafting in patients with acute coronary syndrome: a meta-analysis. – S.S. Nijjer, G. Watson, T. Athanasiou, I. Malik (London, GB) P4221 P4222 P4223 P4224 NEW INSIGHTS IN CORONARY INTERVENTIONS (PART I) (QR 30510*) *Abstracts can be accessed at: P4225 P4226 P4227 P4228 P4229 P4230 P4231 P4232 P4233 P4234 TUESDAY – MORNING Trends in pre-hospital delay and door-to-balloon time in patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention in Switzerland 2000-2010. – D. Radovanovic, P. Urban, G. Pedrazzini, H. Rickli, P. Erne (Zurich, Geneva, Lugano, St. Gallen and Lucerne, CH) In vitro comparison of EP217609, unfractionated heparin, enoxaparin and fondaparinux in the prevention of cardiac catheter thrombosis. – A. Kaeberich, U. Raaz, A. Vogt, L. Maegdefessel, C. Bal Dit Sollier, L. Drouet, E. Neuhart, C. Krezel, K. Werdan, A. Schlitt (Halle, DE; Stanford, US; Paris and Romainville, FR) Manual thrombus aspiration and abciximab administration in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention - preliminary results. – S. Pyxaras, A. Perkan, S. Santangelo, M. Cinquetti, G. Barbati, G. Vitrella, S. Rakar, E. Della Grazia, A. Salvi, G. Sinagra (Trieste and Padua, IT) The efficacy of percutaneous coronary intervention in STEMI - differences by age. – P. Buchta, A. Lekston, M. Gasior, D. Pres, M. Gierlotka, M. Tajstra, M. Hawranek, L. Polonski (Zabrze, PL) Protective effect of telmisartan for impairment of endothelial function after coronary drug-eluting stent implantation in hypertensive patients. – M. Terashima, K. Nasu, H. Kaneda, M. Habara, T. Ito, N. Tanaka, Y. Kinoshita, M. Kimura, Y. Suzuki, T. Suzuki (Toyohashi and Tokyo, JP) Head-to-head comparison of sirolimus eluting stent vs. bare metal stent evaluating the endothelial dysfunction in the same patient with multiple coronary artery lesions. – A.N. Mischie, M.S. Nazzaro, F. De Felice, C. Musto, R. Fiorilli, C. Sinescu, R. Violini (Rome, IT; Bucharest, RO) Endothelial cell behaviour in response to DES drugs shows significant species differences: a comparison of human, swine and rabbit endothelium. – A.S.A. Autar, N. Faber, G. Ertas, W.J. Van Der Giessen, H.M.M. Van Beusekom (Rotterdam and Utrecht, NL; Kocaeli, TR) Differences in neointimal thickness between the adluminal and the abluminal sides of malapposed and side branch struts: indirect evidence about the role of shear stress in healing after stenting. – J.L. Gutierrez-Chico, F. Gijsen, E. Regar, J. Wentzel, B. De Bruyne, L. Thuesen, J. Ormiston, D. Mcclean, S. Windecker, P.W. Serruys (Rotterdam, NL; Aalst, BE; Aarhus, DK; Auckland and Christchurch, NZ; Berne, CH) Different risk models predict markedly different probability of death for the same patient: implications of using risk models for individual patients. – H.S. Gurm, S.R. Kaufman, D.E. Smith, M. Moscucci, D. Share, R. Stern (Ann Arbor and Miami, US) Prognostic value of inflammation markers on postoperative outcome in patients with non-significant coronary artery disease. – T.M. Valentijn, M.T. Voute, D. Goei, D. Poldermans (Rotterdam, NL) Improvement of the global left ventricular function in patients with chronic coronary artery occlusion after intracoronary adenosine administration. – I. Petrenko, M.A. Popova, K.V. Gorbatikov, S.I. Mamedova, M.V. Krivov (Surgut and Tumen, RU) Transcoronary pacing in a porcine model - impact of guidewire insulation. – K.M. Heinroth, S. Unverzagt, M. Buerke, J. Carter, D. Mahnkopf, K. Werdan, R. Prondzinsky (Halle, Rottmersleben and Merseburg, DE) Different implantation sequences of hybrid overlapping drug-eluting stents have distinctive influence on the endothelialization and arterial responses in rabbit iliac arteries. – K.-Y. Chen, S.W. Rha, Y.-J. Li, Z. Jin, K.-L. Poddar, B.-G. Choi, D.-J. Oh, J.-H. Kim, Y.-J. Hong, M.-H. Jeong (Tianjin, CN; Seoul and Gwangju, KR) A novel drug-eluting balloon/drug-eluting stent system eluting sirolimus nanoparticles is safe in a porcine coronary model. – O. Sorop, I. Krabbendam-Peters, R. Van Duin, H.M.M. Van Beusekom, W.J. Van Der Giessen (Rotterdam and Utrecht, NL) P4235 P4236 P4237 P4238 QR 30510 259 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Initial clinical results of the TITANIC-XV prospective randomized trial: the titan vs everolimus stent in diabetic patients. – J.M. Nogales, J.R. Lopez-Minguez, L.J. Doncel Vecino, F. Pomar Domingo, P. Martinez Romero, J.A. Fernandez Diaz, J.F. Diaz Fernandez, J. Moreu Burgos, M.R. Gonzalez Fernandez, A. Merchan Herrera (Badajoz, Valencia, Cadiz, Madrid, Huelva and Toledo, ES) Long-term clinical outcomes after percutaneous coronary intervention for chronic total occlusions in elderly patients: five-year outcomes from a 1,791 patient multi-national registry. – B.E.P.M. Claessen, J.W. Suh, G.D. Dangas, K. Obunai, C. Godino, J.H. Kim, C. Dimario, A. Colombo, S.J. Park, R. Mehran (New York, US) Does the presence of diabetes mellitus have differential impact in patients treated with everolimus-eluting (Xience) stents versus paclitaxel-eluting (Taxus) stents? – R. Byrne, J. Mehilli, S. Massberg, K.L. Laugwitz, S. Kufner, J. Pache, A. Schoemig, A. Kastrati (Munich, DE) Nicorandil attenuates sirolimus increased thrombogenicity in FeCl3-induced in vivo thrombus model. – H. Ishida, Y. Takahari, N. Higashijima, K. Aizawa, K. Serizawa, Y. Ishizuka (Isehara and Gotenba, JP) Non-invasive parameter of flow mediated dilatation in brachial artery is associated with pan-coronary plaque vulnerability in patients with coronary artery disease. – T. Sawada, T. Emoto, Y. Motoji, T. Mizoguchi, T. Mizuguchi, K. Taira, H. Okamoto, S. Kim, A. Takarada, M. Yokoyama (Sumoto, JP) Tenascin-C level is related to coronary plaque rupture in patients with acute coronary syndrome. – N. Sakamoto, K. Nakazato, H. Mizukami, S. Suzuki, K. Sugimoto, T. Yamaki, H. Kunii, H. Suzuki, S. Saitoh, Y. Takeishi (Fukushima, JP) P4239 P4240 P4241 P4242 P4243 P4244 NEW INSIGHTS IN CORONARY INTERVENTIONS (PART II) (QR 30511*) Differences in clinical presentation of in-stent restenosis between bare metal versus drug-eluting stents. – I. Villanueva Benito, I. Solla Ruiz, E. Paredes Galan, G. Bastos Fernandez, I. Gomez Blazquez, A. De Miguel, V. Jimenez Diaz, A. Ortiz Saez, J.A. Baz Alonso, A. Iniguez Romo (Vigo, ES) Quantitative optical coherence tomography signal analysis for in-stent restenotic tissue. – N. Suzuki, K. Kozuma, T. Saito, N. Hosogoe, K. Naito, S. Otsuki, S. Ishikawa, H. Kyono, A. Miyazawa, T. Isshiki (Tokyo, JP) Specific criteria of exercise test in evaluation of patients after percutaneous coronary intervention. – I. Mintale, M. Zabunova, D. Lurina, I. Narbute, S. Jegere, I. Zakke, A. Erglis (Riga, LV) Difference of in-stent restenosis pattern of drug-eluting stent in early and late phase restenosis. – T. Domei, S. Kuramitsu, M. Hyodo, Y. Soga, S. Shirai, K. Ando, H. Yokoi, M. Iwabuchi, M. Nobuyoshi (Kitakyusyu, JP) In-stent restenosis is not simply a benign clinical entity as it presents as ACS in 40% of cases. – O.P. Guttmann, D.A. Jones, K. Rathod, T. Pain, A. Jain, A. Knight, A. Mathur, A. Wragg (London, GB) Late restenosis after percutaneous coronary interventions with drug-eluting stent implantation in real clinical practice. – A. Omarov, I. Lazarev, T. Batyraliev, I. Pershukov, E. Merkulov, D. Fettser, J. Ramazanov, B. Kadyrov, Z. Karben, B. Sidorenko (Almaty, KZ; Moscow, RU; Gaziantep, TR; Baku, AZ) Clinical impact of restenotic patterns after femoropopliteal stenting. – A. Tosaka, Y. Soga, O. Iida, T. Ishihara, K. Hirano, T. Suzuki, K. Sakai, H. Yokoi, M. Iwabuchi, M. Nobuyoshi (Fukuoka, Amagasaki, Yokohama and Sendai, JP) The morphological findings of early and late in-stent restenosis after drug-eluting stent implantation: optical coherence tomography analysis. – H. Yamaguchi, J. Takaoka, A. Miyamura, N. Atsuchi, H. Shirasawa, R. Arikawa, Y. Atsuchi (Kagoshima City, JP) Serial angiographic follow-up after successful implantation of sirolimus, paclitaxel, everolimus and zotarolimus-eluting stent for chronic total occlusions: multicenter registry in asia. – S. Nakamura, H. Ogawa, J.H. Bae, Y.H. Cahyadi, W. Udayachalerm, D. Tresukosol, S. Tansuphaswadikul (Chiba and Kumamoto, JP; Daejeon, KR; Jakarta, ID; Bangkok, TH) Efficacy and safety of everolimus eluting stent implantation for the treatment of in-stent restenosis within bare-metal stent and drug-eluting stent. – M. Almalla, J. Schroeder, V. Pross, N. Marx, R. Hoffmann (Aachen, DE) Coronary artery disease severity and localization are not associated with family history of myocardial infarction or stroke. – A. Banerjee, C.C.S. Lim, L.E. Silver, S.J.V. Welch, A.P. Banning, P.M. Rothwell (Birmingham and Oxford, GB) Instruction to interventional cardiologists decrease radiation administered to patients during coronary stenting. – J.R. Azpiri, J.L. Assad, A. Davila, R. Garcia, R. Trevino (Monterrey, MX) Evaluation of the endothelial function and intima-media thickness in Mexican children with metabolic syndrome. – N. Espinola Zavaleta, E. Molina Bello, M.E. Soto (Mexico City and Mexico, MX) An average daily physical activity is an independent determinant of local carotid stiffness and myocardial performance. – M. Kozakova, C. Palombo, C. Morizzo, E. Muscelli, N. Guraschi, S. Pedri, E. Ferrannini, B. Balkau (Pisa and Genoa, IT; Villejuif, FR) *Abstracts can be accessed at: 260 QR 30511 P4245 P4246 P4247 P4248 P4249 P4250 P4251 P4252 P4253 P4254 P4255 P4256 P4257 P4258 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Histopathological validation of optical coherence tomography analysis for lipid-rich plaque and thin-cap fibroatheroma. – K. Fujii, H. Hao, M. Fukunaga, T. Nakata, H. Sawada, M. Ohyanagi, T. Masuyama (Nishinomiya, JP) Neointimal coverage of zotarolimus-eluting stent at 4, 6, 8 and 10 weeks follow-up: evaluation by optical coherence tomography. – M. Nishinari, T. Shimohama, T. Tojo, T. Shiono, R. Kameda, T. Izumi (Sagamihara, JP) Effects of Waon therapy on peripheral hemodynamics, sympathetic nervous activity and oxidative stress in patients with severe arteriosclerosis obliterans. – C. Noda, T. Masuda, M. Kawano, Y. Takahashi, M. Kurashima, K. Miida, K. Kamiya, N. Aoyama, T. Izumi (Sagamihara, JP) The impact of the serum eicosapentaenoic acid to arachidonic acid ratio on periprocedural microcirculatory damage in patients undergoing percutaneous coronary intervention. – T. Nakata, K. Fujii, H. Sawada, M. Fukunaga, T. Iwasaku, D. Kawasaki, M. Masutani, M. Kawabata, M. Ohyanagi, T. Masuyama (Nishinomiya, JP) Genetic deletion of protein tyrosine phosphatase 1B protects against endotoxinic shock and improves endothelial dysfunction. – D. Coquerel, E.G. Gomez, R.S. Renet, V.R. Richard, F.T. Tamion (Rouen, FR) Carotid echo-tracking shows improvement of vascular function after percutaneous aortic valve replacement. – G. Feltes, C. Almeria, C. Brito, A. Goncalves, R. Hernandez-Antolin, E. Garcia Fernandez, J. Heredia, J.L. Rodrigo, C. Macaya, J.L. Zamorano (Madrid, ES) Unrecognized myocardial infarction in the London Life Sciences Population (LOLIPOP) study. – J. Sehmi, D. Das, N. Ahmed, A. Kooner, K. Miller, M. Kooner, H.S. Sidhu, A. Kirresh, J. Kooner, J. Chambers (London, GB) P4259 P4260 P4261 P4262 P4263 P4264 P4265 LONG-TERM OUTCOME AFTER DRUG ELUTING STENTING (QR 30512*) *Abstracts can be accessed at: P4266 P4267 P4268 P4269 P4270 P4271 P4272 TUESDAY – MORNING Real-world outcomes of percutaneous coronary intervention in the drug eluting stent (DES) era: analyses from catholic university of korea-percutaneous coronary intervention (COACT) registry. – S.M. Seo, K.Y. Chang, M.K. Kang, B.H. Whang, T.H. Kim, C.J. Kim, H.Y. Kim, P.J. Kim, W.S. Chung, K.B. Seung (Seoul and Bucheon, KR) Body mass index is inversely correlated to risk of definite stent thrombosis after percutaneous coronary intervention with drug-eluting stent implantation - a register-based study. – M. Schmiegelow, C. Torp-Pedersen, G. Gislason, C. Andersson, S. Pedersen, P. Riis Hansen (Copenhagen, Denmark, DK) Do obese patients need a higher daily dose of clopidogrel after percutaneous intervention? – A. Rajamanickam, S. Butler, S. Ellis, J.B. Young, S. Kapadia (Newark and Cleveland, US) Five-year clinical outcomes of sirolimus-eluting stent implantation for chronic total occlusion including multivessel disease. – H. Tanaka, K. Kadota, S. Habara, S. Hosogi, Y. Fuku, T. Goto, K. Mitsudo (Kurashiki, JP) The influence of stent implantation on 5-year mortality in patients with ST-segment elevation myocardial infarction. – D. Pres, M. Gasior, M. Gierlotka, M. Hawranek, M. Tajstra, K. Wilczek, P. Buchta, A. Lekston, L. Polonski (Zabrze, PL) Clinical, procedural, cardiometabolic and laboratory correlates of platelet reactivity to clopidogrel and aspirin on multiplate analyser in patients with coronary stenting. – C. Kaymaz, I.H. Tanboga, H.C. Tokgoz, N. Poci, M.M. Can, N. Kirca, T. Aktemur, M. Saglam, N. Ozdemir (Istanbul and erzurum, TR) Periprocedural hsCRP reduction is a significant predictor for clinical outcome after drug-eluting stent implantation. – C.J. Kim, H.J. Park, S.M. Suh, T.H. Kim, S.Y. Jung, S.H. Ahn, P.J. Kim, K.Y. Chang, K.B. Seung (Seoul, KR) Long term outcome of the second generation drug eluting stents in the real world setting - paclitaxel versus zotarolimus eluting stent. – S. Kasim, D. Moran, P. Kearney, E. McFadden (Cork, IE) Differential response of local persistent hypercoagulability after zotarolimus-eluting, paclitaxel-eluting, sirolimus-eluting and bare-metal stent implantation in patients with stable angina. – K. Yamaguchi, T. Wakatsuki, T. Niki, Y. Taketani, S. Bando, K. Kusunose, T. Iwase, H. Yamada, T. Soeki, M. Sata (Tokushima, JP) Impact of acute kidney injury following percutaneous coronary intervention on clinical outcomes in patients with ST-segment elevated myocardial infarction. – K. Kume, Y. Yasuoka, R. Araki, T. Imanaka, R. Matsutera, H. Adachi, Y. Noda, S. Hattori, T. Sasaki (Kawachinagano, JP) Long-term serial angiographic outcomes after sirolimus-eluting stent implantation: contemporary practice in real world population. – E. Ko, K. Nasu, T. Itou, M. Habara, T. Kurita, Y. Kinoshita, E. Tsuchikane, Y. Asakura, O. Katoh, T. Suzuki (Toyohashi, JP) P4273 P4274 P4275 P4276 QR 30512 261 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Extracranial and lower extremity artery lesions as predictors of adverse one year outcome after ST elevation myocardial infarction. – M.V.Z. Zykov, D.S.M. Meshcheriakova, K.S.S. Shafranskaya, V.V.K. Kashtalap, O.L.B. Barbarash (Kemerovo, RU) Drug-eluting stents have no dramatic effects on dialysis patients. – S. Oshima, K. Noda, H. Ogawa, S. Hokimoto, H. Shimomura, K. Nakao, R. Tsunoda, T. Matsumura, K. Fijimoto, N. Yamamoto (Kumamoto, Kasuga, Yatsushiro and Nobeoka, JP) Risk of bleeding in patients treated with vitamin k antagonists that undergo percutaneous coronary interventions with stent implantation. – G. Denas, S. Padayattil Jose, P. Gresele, V. De Micheli, S. Testa, R. Quintavalla, D. Poli, F. Marongiu, V. Pengo (Padua, Perugia, Merate, Cremona, Parma, Florence and Cagliari, IT) Very-late (8 years) clinical outcomes after unrestricted sirolimus-eluting stent implantation for severe coronary artery disease. – A. Ielasi, A. Latib, M.A. Gullace, J. Cosgrave, M. Mussardo, C. Godino, A. Chieffo, M. Carlino, M. Montorfano, A. Colombo (Milan, IT) Impact of stress testing before percutaneous coronary interventions on outcomes in patients with chronic ischemic left ventricular dysfunction. – E. Ammirati, V. Guida, F. Arioli, G. Calori, A. Latib, A. Colombo, P.G. Camici (Milan, IT) Long term clinical outcomes after drug-eluting stent implantation for diffuse disease of the left anterior descending coronary artery. – C. Graidis, D. Dimitriadis, A. Ntatsios, V. Psifos, V. Karasavvides, J. Neroladakis, G. Karakostas, E. Anagnostou, K. Gourgiotis, J. Voloudakis (Thessaloniki, GR) Can we translate the high and low on-treatment platelet reactivity to early, mid and long term risks for ischemic and bleeding events following the stent placement. – C. Kaymaz, H.C. Tokgoz, I.H. Tanboga, N. Poci, T. Aktemur, N. Kirca, M.M. Can, M. Saglam, N. Ozdemir (Istanbul and erzurum, TR) The time-dependent loss in platelet response to aspirin and clopidogrel: Implications for patient compliance to antiplatelets. – C. Kaymaz, I.H. Tanboga, H.C. Tokgoz, N. Poci, N. Kirca, T. Aktemur, M.M. Can, M. Saglam, N. Ozdemir (Istanbul and erzurum, TR) Comparison of three-year clinical outcomes after transradial versus transfemoral percutaneous coronary intervention. – M. Natsuaki, T. Morimoto, Y. Furukawa, Y. Nakagawa, K. Kadota, M. Iwabuchi, S. Shizuta, T. Kita, T. Kimura (Kyoto, Kobe, Tenri, Kurashiki and Kitakyushu, JP) Effect of single long DES implantation on clinical outcomes in AMI patients undergoing PCI. – K. Ahmed, M.H. Jeong, Y.K. Ahn, Y.J. Hong, D.S. Sim (Gwangju, KR) Impact of insulin resistance on 1-year clinical outcomes in non-diabetic patients with drug-eluting stent implantation. – Y.K. Kim, S.W. Rha, A. Elnagar, K.Y. Chen, B.G. Choi, C.U. Choi, J.W. Kim, C.G. Park, H.S. Seo, D.J. Oh (Seoul, KR) Effect of percutaneous coronary intervention on 1-year outcomes of STEMI and NSTEMI patients: data from the AMI-florence 2 registry. – N. Carrabba, G.M. Santoro, A. Barchielli, D. Balzi, A. Zuppiroli, A. Santini, C. Landini, S. Valente, G. Marchionni, G.F. Gensini (Florence, IT) P4277 P4278 P4279 P4280 P4281 P4282 P4283 P4284 P4285 P4286 P4287 P4288 HYPERTENSION – MISCELLANEOUS (QR 30513*) Impact of hypertension on progression of left ventricular hypertrophy and cardiovascular events in patients with aortic valve stenosis. – A.E. Rieck, D.C. Cramariuc, M.T.L. Lonnebakken, B.P.L. Lund, A.B.R. Rossebo, E.G. Gerdts (Bergen and Oslo, NO) Eicosapentaenoic acid suppresses adverse effects of C-Reactive protein overexpression on pressure overload-induced cardiac remodeling. – T. Nagai, T. Anzai, Y. Mano, H. Kaneko, A. Anzai, Y. Sugano, Y. Maekawa, T. Takahashi, T. Yoshikawa, K. Fukuda (Tokyo, JP) Incident chronic kidney disease in a hypertensive cohort: prospective results. – E. Andrikou, C. Tsioufis, C. Thomopoulos, A. Kasiakogias, M. Almyroudi, I. Bafakis, K. Kintis, D. Syrseloudis, D. Tsiachris, C. Stefanadis (Athens, GR) Exercise testing as a tool for guiding therapy among prehypertensives/normal or high normal blood pressure groups. – V. Kothiwale, M. Mahajan (Belgaum, IN) Administration time-dependent antihypertensive effects of low dose aspirin in well-controlled hypertensive patients. – J.H. Lee, S.C. Chae, S.H. Baek, C.W. Nam, D.J. Choi, J.B. Park, N.S. Chung, Y.J. Kim, D.S. Kim (Daegu, Seoul and Busan, KR) Assessment of target organ damage in patients with resistant hypertension. – M. Salvetti, M.L. Muiesan, A. Paini, C. Agabiti Rosei, C. Aggiusti, F. Bertacchini, D. Stassaldi, C. Monteduro, M. Castellano, E. Agabiti Rosei (Brescia, IT) *Abstracts can be accessed at: 262 QR 30513 P4289 (W) P4290 P4291 P4292 P4293 P4294 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS P4295 P4296 P4297 P4298 P4299 P4300 P4301 P4302 P4303 P4304 P4305 P4306 P4307 P4308 P4309 TUESDAY – MORNING Resistant hypertension prevalence and associated cardiovascular risk factors and renal disease: the I-DEMAND study. – M. Salvetti, E. Ambrosioni, A. Pessina, B. Trimarco, M. Volpe, G. Deferrari, R. Pontremoli, G. Leonetti, F. Costa, E. Agabiti Rosei (Brescia, Bologna, Padua, Naples, Rome, Genoa and Milan, IT) An unforgotten predictor of perioperative outcome in patients undergoing noncardiac surgery: pulmonary hypertension. – M. Biteker, M. Can, F. Biteker, E. Ilhan, A. Dayan, D. Duman (Istanbul, TR) What threshold of body mass index is indicative of the presence of hypertension? – F. Tanaka, S. Makita, T. Onoda, K. Tanno, M. Ohsawa, K. Itai, K. Sakata, A. Ogawa, A. Okayama, M. Nakamura (Morioka and Tokyo, JP) Incidence of sleep disorders and depression in relation to metabolic abnormalities in patients with true resistant hypertension. – E. Florczak, A. Prejbisz, A. Januszewicz, E. Szwench, P. Oleksiuk, E. Warchol, P. Sliwinski, P. Bielen, I. Michalowska, K. Narkiewicz (Warsaw and Gdansk, PL) Is vascular ventricular coupling in malignant phase hypertension abnormal? An echocardiographic assessment of arterial and systolic elastance in patients with malignant hypertension. – A. Shantsila, G. Dwivedi, M. Butt, A. Blann, D.G. Beevers, R.P. Steeds, G.Y.H. Lip (Birmingham, GB) Impaired coronary microcirculation is accompanied by increased urine albumin excretion rate in untreated hypertensives. – D. Tsiachris, C. Tsioufis, K. Dimitriadis, I. Tatsis, D. Rousos, D. Syrseloudis, G. Latsios, C. Stefanadis (Athens, GR) Hypertensive emergencies and urgencies in an emergency department in Northern Italy. – A. Paini, M. Salvetti, C. Agabiti Rosei, C. Aggiusti, D. Zotti, S. Cobelli, D. Stassaldi, C. Concoreggi, E. Agabiti Rosei, M.L. Muiesan (Brescia, IT) What does urinary albumin tell us in the management of hypertension? – S. Murai, S. Tanaka, H. Sonoda, S. Yamashita, T. Sugiura, Y. Dohi, G. Kimura (Nagoya, JP) Lack of regression of left ventricular hypertrophy is accompanied by adverse prognosis in essential hypertensives. The role of clinical characteristics. – D. Tsiachris, C. Tsioufis, A. Kasiakogias, K. Dimitriadis, I. Andrikou, A. Kordalis, I. Bafakis, C. Stefanadis (Athens, GR) Decreased circulating endothelial progenitor cell levels and function in essential hypertensive patients with electrocardiographic left ventricular hypertrophy. – C.W. Lee, P.H. Huang, S.S. Huang, H.B. Leu, C.C. Huang, T.C. Wu, J.W. Chen, S.J. Lin (Taipei, TW) Effect of strong lipophilic statin on left ventricular diastolic function and left atrial function: results of prospective study of one year follow-up in hypertension with preserved systolic function. – T. Watanabe, R. Tanaka, K. Ono, R. Tanaka, A. Tanaka, S. Warita, T. Noda, S. Watanabe, M. Kawasaki, S. Minatoguchi (Gifu, JP) In hypertensive patients without LVH, adverse functional micro-circulation changes precede morphological changes. A CFR/OCT study. – G. Latsios, C. Tsioufis, D. Tsiachris, K. Dimitriadis, D. Rousos, D. Syrseloudis, I. Tatsis, C. Stefanadis (Athens, GR) Effect of intensive versus moderate blood pressure lowering on toll-like receptors 4 gene expression in patients with essential hypertension. – M. Marketou, J. Kontaraki, E. Zacharis, A. Giaouzaki, K. Stokos, G. Kochiadakis, P. Vardas (Heraklion, GR) Fibrin clot properties in arterial hypertension and their modification by antihypertensive treatment. – M. Rajzer, A. Undas, W. Wojciechowska, K. Kawecka-Jaszcz (Krakow, PL) Salt intake adjusted for body weight is a strong predictor of cardiovascular damage in the general population. – H. Takase, Y. Dohi, T. Toriyama, T. Okado, H. Sonoda, A. Hagikura, T. Hashimoto, G. Kimura (Hamamatsu and Nagoya, JP) Exaggerated exercise blood pressure response is accompanied by increased levels of C-reactive protein, osteoprotegerin and urinary albumin excretion in essential hypertensive subjects. – K. Dimitriadis, C. Tsioufis, A. Aggelis, I. Bafakis, M. Almyroudi, A. Miliou, A. Michaelides, C. Stefanadis (Athens, GR) There is a parallel escalation between retinal vascular alterations and arterial stiffness in essential hypertension. – V. Katsi, G. Souretis, I. Vlasseros, N. Alexopoulos, A. Koumoulidis, C. Stefanadis, I. Kallikazaros (Athens, GR) Risk of cardiovascular events after a first admission to the emergency department for an hypertensive emergency or urgency: a two years follow up. – M. Salvetti, A. Paini, L. Tarozzi, C. Agabiti Rosei, C. Aggiusti, A. Bazza, F. Bertacchini, C. Concoreggi, E. Agabiti Rosei, M.L. Muiesan (Brescia, IT) P4310 P4311 P4312 PRESENTATION, DIAGNOSIS AND PROGNOSIS OF AORTIC VALVE DISEASE (QR 30514*) The modern epidemiology of valvular aortic stenosis. – G.W. Eveborn, H. Schirmer, P.I. Lunde, G. Heggelund, K. Rasmussen (Tromsø, NO) *Abstracts can be accessed at: P4313 QR 30514 263 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Another approach to main clinical characteristics of patients with aortic stenosis: A population based study. – E. Garbaz, B. Iung, G. Caranhac, G. Jondeau, A. Vahanian (Paris, FR) Cardiac CT and 3D echocardiography reveals oval LVOT, leading to underestimation of LVOT and aortic valve area by 2D echocardiography. – A. Shiran, S. Adawi, R. Sachner, I. Asmer, M. Ganaeem, R. Rubinshtein, M. Shnapp, T. Gaspar (Haifa, IL) Prognostic value of valvulo-arterial impedance (Zva) in patients with symptomatic severe aortic valve stenosis undergoing to transcatheter aortic-valve implantation (CoreValve). – C. Giannini, C. Cucco, A.I. Corciu, M.G. Delle Donne, C. Nardi, M. De Carlo, F.L. Dini, M. Marzilli, A.S. Petronio, V. Di Bello (Pisa, IT) Early changes of left ventricular deformation after interventional trans-femoral aortic valve replacement in aortic stenosis: a speckle tracking strain analysis. – S. Schattke, G. Baldenhofer, I. Prauka, W. Sanad, M. Laule, V. Stangl, G. Baumann, K. Stangl, F. Knebel (Berlin, DE) Determinants of non invasive coronary flow reserve in severe aortic stenosis. – P. Meimoun, A.L. Germain, F. Elmkies, T. Benali, J. Boulanger, J. Clerc, H. Zemir, A. Luycx-Bore, C. Tribouilloy (Compiegne and Amiens, FR) Evaluation of subendocardial contractile function in aortic stenosis. – B.M. Van Dalen, A. Tzikas, O.I.I. Soliman, H.B. Van Der Zwaan, W.B. Vletter, F.J. Ten Cate, M.L. Geleijnse (Rotterdam, NL) Assessment of anatomical regurgitant orifice in aortic regurgitation by real-time three-dimensional transesophageal echocardiography. – H. Mihara, H. Watanabe, M. Aikawa, M. Nagayama, R. Asano, M. Takayama, J. Umemura, M. Kanashiro, S. Ichimiya, T. Sumiyoshi (Yokkaichi and Tokyo, JP) Limitations of aortic Doppler diastolic backflow for the diagnosis and grading of aortic regurgitation: comparison with magnetic resonance validated echocardiographic regurgitant fraction. – P. Barbier, A. Staron, C. Cefalu’, G. Berna, P. Gripari, D. Andreini, G. Pontone (Milan, IT; Katowice, PL) Transaortic flow velocity can be calculated from from dual source MDCT for diagnosis of aortic stenosis. Proof of concept. – C.J. Schultz, S.L. Papadopoulou, A. Moelker, A. Tzikas, R.J. Nuis, G.J.R. Ten Kate, M.L. Geleijnse, P.J. De Feyter, P.P.T. De Jaegere, P.W. Serruys (Rotterdam, NL) Predictors for cardiac death in patients with aortic valve stenosis. – S. Herrmann, S. Stoerk, M. Niemann, K. Hu, J. Strotmann, W. Voelker, G. Ertl, F. Weidemann (Wurzburg and Kiel, DE) Prognostic value of brain natriuretic peptide in elderly patients with aortic stenosis. – C. Cimadevilla, C. Cueff, N. Berjeb, B. Iung, A. Vahanian, D. Messika-Zeitoun (Paris, FR) Clinical outcome in asymptomatic severe aortic stenosis: insights from the new aortic stenosis grading classification. – J. Magne, E. Donal, L. Davin, K. O’Connor, C. Pirlet, M. Rosca, C. Szymanski, B. Cosyns, L.A. Pierard, P. Lancellotti (Liège, BE; Rennes, FR; Quebec, CA) Clinical and echocardiographic characteristics and prognosis of patients with low flow severe aortic stenosis despite preserved ejection fraction. – C. Izumi, S. Takahashi, M. Miyake, S. Nakajima, M. Nishiga, J. Sakamoto, T. Tamura, H. Kondo, K. Kaitani, Y. Nakagawa (Tenri, JP) Echocardiographic score for risk stratification in asymptomatic moderate-severe aortic stenosis. – C. Mazzone, N.B. Berlinghieri, M.T. Triggiani, P.F. Faggiano, C.P. Pandullo, A.D.L. Di Lenarda, L.T. Tarantini, C.S. Stefenelli, F.F. Furlanello, G.C. Cioffi (Trieste, Brescia, Belluno and Trento, IT) Left ventricular contractility in patients with low-flow, low-gradient severe aortic stenosis with normal ejection fraction. – R. Migliore, M.E. Adaniya, M. Barranco, G. Miramont, H. Tamagusuku (San Martin, AR) Low-gradient severe aortic stenosis: a 5 years retrospective analysis. – M. Moretti, M. Merlo, G. Barbati, E. Fabris, M. Morosin, L. Massa, B. Pinamonti, A. Pappalardo, G. Sinagra (Trieste, IT) Influence of aortic valve dysfunction and aortic diameters on the need for surgery after the diagnosis of bicuspid aortic valve. – J.M. Alegret, C. Ligero, O. Palazon, I. Duran, J.M. Vernis, A. Hernandez Aparicio, L. Krsticevic (Reus, ES) Long-term prognosis of patients with severe aortic stenosis and atrial fibrillation. – G.E. Hoogslag, M.L. Antoni, A.C.T. Ng, F. Van Der Kley, S.H. Ewe, N. Ajmone Marsan, M.J. Schalij, E.E. Van Der Wall, J.J. Bax, V. Delgado (Leiden, NL) Excess 1 year mortality ratios of elderly patients admitted for congestive heart failure according to the presence of aortic stenosis: a comparison with normal age and gender matched individuals. – J.H.A.J. De Sutter, N.I.C.O. Van De Veire, C. Weytjens, D. Debacquer, B. Van De Kerckhove, N. De Laet, G. Van Camp (Ghent and Brussels, BE) Metabolic syndrome is associated with more pronounced concentric LV hypertrophy in patients with severe calcific aortic stenosis undergoing aortic valve replacement. – M.-A. Clavel, R. Capoulade, J.G. Dumesnil, P. Mathieu, J.P. Despres, P. Pibarot (Quebec, CA) Predictors of mortality in mixed aortic stenosis and regurgitation. – N. Rashedi, B.P. Griffin, W.J. Stewart, T.H. Marwick (Cleveland, US) Asymptomatic severe aortic stenosis and preserved left ventricular ejection fraction: role of the interaction between longitudinal function and valvulo-arterial impedance in the risk stratification. – C. Zito, M. Cusma Piccione, J. Salvia, F. Antonini-Canterin, D. Donato, E. Alati, A. Pardeo, G. Di Bella, G. Oreto, S. Carerj (Messina and Pordenone, IT) 264 P4314 P4315 P4316 P4317 P4318 P4319 P4320 P4321 P4322 P4323 P4324 P4325 P4326 P4327 P4328 P4329 P4330 P4331 P4332 P4333 P4334 P4335 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Outcome of patients with severe aortic stenosis and poor left ventricular function, high trans valvular gradient versus low trans valvular and response to treatment. – I. Ben-Dor, R. Torguson, G. Maluenda, P. Okubagzi, Z. Xue, K. Kent, J. Lindsay, L. Satler, A. Pichard, R. Waksman (Washington, US) Low-gradient severe aortic stenosis despite preserved left ventricular ejection fraction: a 5 years retrospective analysis. – M. Moretti, M. Merlo, G. Barbati, E. Fabris, M. Morosin, L. Massa, B. Pinamonti, A. Pappalardo, G. Sinagra (Trieste, IT) The predictive value of troponin, C-reactive protein and brain natriuretic peptide in patients with symptomatic aortic stenosis. – O.G. Solberg, T. Ueland, R. Wergeland, C.P. Dahl, S. Aakhus, P. Aukrust, L. Gullestad (Oslo, NO) Impact of myocardial fibrosis on left ventricular hypertrophy in symptomatic severe aortic stenosis patients. – C. Bergamini, G. Golia, A. Milano, M. Dodonov, G. Faggian, A. Tomezzoli, C. Vassanelli (Verona, IT) Validation of a new score for asymptomatic aortic stenosis. – N. Farre, M. Gomez, M. Cladellas, L. Molina, A. Ramirez, J. Vila, M. Cainzos-Achirica, M. Ble, S. Ascoeta, J. Bruguera (Barcelona, ES) Impact of concomitant aortic regurgitation on the prognosis of severe aortic stenosis. – S. Honda, T. Kitai, T. Tani, Y. Okada, T. Kita, Y. Furukawa (Kobe, JP) Clinical outcomes of high-risk patients with severe aortic stenosis according to treatment modality. – P. Wenaweser, T.M. Pilgrim, A. Kadner, C. Huber, S. Stortecky, H. Brinks, B. Meier, P. Jueni, T. Carrel, S. Windecker (Berne, CH) Lower left ventricular stroke volume predicts cardiovascular events in asymptomatic aortic stenosis (the SEAS study). – M.T. Lonnebakken, D. Cramariuc, K. Boman, A.B. Rossebo, K. Egstrup, S. Ray, C. Gohlke-Baerwolf, E. Gerdts (Bergen and Oslo, NO; Skelleftea, SE; Svendborg, DK; Manchester, GB; Bad Krozingen, DE) Angiotensin-receptors blockers but not angiotensin-converting enzyme inhibitors delay the progression of aortic stenosis. – R. Capoulade, M.A. Clavel, P. Mathieu, N. Cote, J.G. Dumesnil, M. Arsenault, E. Bedard, P. Pibarot (Quebec, CA) P4336 P4337 P4338 P4339 P4340 P4341 P4342 P4343 P4344 NEW INSIGHTS INTO THE PATHOPHYSIOLOGY OF AORTIC VALVE DISEASE (QR 30515*) *Abstracts can be accessed at: P4345 P4346 P4347 P4348 P4349 P4350 TUESDAY – MORNING Statin use reduces neoangiogenesis and intraleaflet haemorrhage in the aortic valve of degenerative aortic stenosis. – H. Akahori, T. Tsujino, Y. Naito, C. Yoshida, N. Sasaki, M.L. Kawabata, M. Ohyanagi, M. Mitsuno, Y. Miyamoto, T. Masuyama (Nishinomiya and Kobe, JP) Increased thrombin generation and platelet activation as a compensatory mechanism in patients with aortic stenosis and acquired deficiency in high-molecular-weight vWF multimers. – A. Undas, J. Natorska, K. Bykowska, M. Hlawaty, G. Marek, J. Sadowski (Krakow and Warsaw, PL) Growth differentiation factor-15 AND ST2 levels in patients undergoing elective aortic valve surgery. – K. Ang, L.L. Ng, D. Chin, J. Khoo, D. Chan, A. Sosnowski, M. Galinanes (Leicester, GB) The severity of myocardial fibrosis in aortic stenosis is related to upregulation of procollagen type I C-terminal proteinase. – F. Valencia Serrano, B. Lopez Salazar, J.J. Gomez-Doblas, J. Diez Martinez, E. De Teresa Galvan (Malaga and Pamplona, ES) Serum osteoprotegerin and RANKL levels in patients with bicuspid and tricuspid aortic stenosis. – O. Irtyuga, E. Zhiduleva, E. Vasilyeva, E. Kazakova, M. Budanova, O. Moiseeva (Saint- Repersburg, RU) Active aortic valve calcification and inflammation in patients with aortic stenosis: a PET-CT study. – M. Dweck, C. Jones, N. Joshi, A. Fletcher, H. Richardson, G. McKillop, E. Van Beek, N. Boon, J.H. Rudd, D.E. Newby (Edinburgh and Cambridge, GB) Wall shear stress in the ascending aorta in patients with bicuspid aortic valves differs significantly from tricuspid aortic valves. – C. Meierhofer, E.P. Schneider, C. Lyko, S. Martinoff, M. Markl, J. Hess, H. Stern, S. Fratz (Munich and Freiburg, DE) The association between bicuspid aortic valve function on circulating endothelial progenitor cells. – M. Vaturi, L. Perl, D. Leshem-Lev, T. Bental, Y. Shapira, I. Yedidya, G. Greenberg, A. Sagie, A. Battler, E.I. Lev (Petah Tikva, IL) Echocardiography and collagen markers in “low flow and high gradient” aortic stenosis. – K. Piestrzeniewicz, K. Luczak, M. Maciejewski, J. Drozdz (Lodz, PL) Angiogenesis in degenerative aortic valve disease. – A. Panzenboeck, J. Jakowitsch, R. Seitelberger, D. Bonderman, R. Rosenheck, H. Baumgartner, I. Lang (Vienna, AT) Association of sclerostin serum levels with the severity of aortic valve calcification. – R. Koos, A.H. Mahnken, N. Marx, V. Brandenburg (Aachen, DE) Neoangiogenesis, intraleaflet haemorrhage and macrophage infiltration are more remarkable in bicuspid aortic valve stenosis than in tricuspid aortic valve stenosis. – H. Akahori, T. Tsujino, Y. Naito, C. Yoshida, N. Sasaki, M.L. Kawabata, M. Ohyanagi, M. Mitsuno, Y. Miyamoto, T. Masuyama (Nishinomiya and Kobe, JP) P4351 P4352 P4353 P4354 P4355 P4356 QR 30515 265 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS The imbalance between proliferation and apoptosis contributes to degeneration of aortic valves and bioprostheses - implications for FKBP12 therapeutic modulations. – I. Tuleta, K. Alghaddioui, S. Pabst, N. Wernert, C.J. Preusse, A. Welz, G. Nickenig, D. Skowasch (Bonn, DE) Insights into the initiation of aortic stenosis: roles of ACE-inhibitors and vitamin D. – A.L. Sverdlov, D.T.M. Ngo, Y.Y. Chirkov, J.D. Horowitz (Adelaide, AU) Tissue factor expressed by aortic valve interstitial cells is able to generate thrombin in vitro. – J. Breyne, E. Jeanpierre, D. Corseaux, F. Juthier, C. Banfi, C. Zawadzki, A. Vincentelli, T. Le Tourneau, B. Jude, S. Susen (Lille and Nantes, FR) Relationship between insulin resistance and progression of left ventricular hypertrophy in patients with aortic stenosis: a substudy of the ASTRONOMER trial. – R. Capoulade, M.A. Clavel, J.G. Dumesnil, K.L. Chan, J.W. Tam, K.K. Teo, N. Cote, P. Mathieu, J.P. Despres, P. Pibarot (Quebec, Ottawa, winnipeg and Hamilton, CA) Phenotypes of bicuspid aortic valve disease and correlations with ascending aortic dilatation by cardiovascular magnetic resonance. – D. Domingo Valero, B. Igual Munoz, J. Estornell Erill, A. Maceira Gonzalez, M. Rodriguez Serrano, F. Buendia Fuentes, D. Tejada Ponce, A. Andres Lahuerta, M.A. Arnau Vives, A. Salvador Sanz (Valencia, ES) MicroRNA expression profile of human aortic valve stenosis. – P.J. Ohukainen, P. Taskinen, T. Peltonen, T. Juvonen, J. Satta, H. Ruskoaho, J. Rysa (Oulu, FI) Differences in the secretome of ascending aortic aneurysms from patients with bicuspid or tricuspid valves. – S. Rocchiccioli, I. Foffa, S. Franceschi, S. Bevilacqua, M. Mariani, M.G. Andreassi, L. Citti, A. Cecchettini (Pisa and Massa, IT) CTGF regulates VSMC phenotypic differentiation and ECM organization, and contributes to the development of thoracic aortic aneurysm in bicuspid and trileaflets aortic valve patients. – G. Ferrari, E. Branchetti, K.R. Milewski, W.F. Seefried, R. Sainger, J.B. Grau, A. Parolari, J.E. Bavaria (Philadelphia, US; Milan, IT) Systematic familial screening identified a high frequency of heritability in calcific aortic valve disease. – V. Probst, F.V. Valleix, T.L.T. Le Tourneau, F.K. Kyndt, H.L.M. Le Marec, J.J.S. Schott (Nantes, FR) Expression of TFPI-2 in diseased aortic valves. – J. Breyne, C. Zawadzki, F. Juthier, C. Banfi, D. Corseaux, A. Ung, A. Vincentelli, T. Le Tourneau, B. Jude, S. Susen (Lille and Nantes, FR) Aortic stenosis is as much a disease of the myocardium as of the valve - the role of diffuse myocardial fibrosis as measured by EQ-CMR. – A.S. Flett, D.M. Sado, G. Quarta, O. Huttin, D.J. Hausenloy, S.M. Banypersad, D. Pellerin, C. McGregor, A.M. Taylor, J.C. Moon (London, GB) Platelet derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis. – Z. Motovska, D. Odvodyova, M. Karpisek, R. Petr, H. Hrabakova, V. Kocka, I. Simkova, S. Katina, P. Widimsky (Prague and Brno, CZ; Bratislava, SK) P4357 P4358 P4359 P4360 P4361 P4362 P4363 P4364 P4365 P4366 P4367 P4368 HEART FAILURE – LEFT VENTRICULAR DYSFUNCTION (QR 30516*) Impact of levosimendan treatment, in acute heart failure patients, on mortality and re-hospitalization rate: a long term follow-up. – N. Bruno, M. Mancone, C. Caira, B. Brasolin, A. D’Ambrosi, F. Fedele (Rome, IT) VE/VCO2 slope: What is the most powerful independent predictor of survival: overall, initial or final VE/VCO2 slopes? A study in 786 consecutive patients with left ventricular systolic dysfunction. – A. Musschoot, P. de Groote, M. Fertin, C. Goeminne, S. Peyrot, F. Mouquet, C. Bauters, N. Lamblin (Lille, FR) Selective HDL raising gene transfer increases survival, attenuates remodeling, and enhances cardiac function following myocardial infarction in mice. – S.C. Gordts, I. Muthuramu, F. Jacobs, E. Van Craeyveld, E. Nefyodova, B. De Geest (Leuven, BE) How valid are the European Society of Cardiology echocardiographic diastolic criteria in diagnosing heart failure with normal ejection fraction? – G. Mahadevan, G. Dwivedi, D. Jiminez, L. Williams, M.P. Frenneaux (Birmingham, GB) Acute beneficial impact of adaptive servo ventilation on hemodynamic data in heart failure patients with Cheyne-Stokes respiration. – A. Yoshihisa, M. Miyata, T. Sato, S. Suzuki, K. Sugimoto, H. Kunii, K. Nakazato, H. Suzuki, S. Saitoh, Y. Takeishi (Fukushima, JP) Physical exercise attenuates diabetes-induced left ventricular and myocardial dysfunction in rats. – C. Gimenes, R. Gimenes, G.N. Guirado, M.D.M. Cezar, D.H.S. Campos, A.H.R. Takamoto, B.T. Nakatani, R.T. Bueno, M.P. Okoshi, K. Okoshi (Botucatu, BR) Remodelling of left ventricular mechanic in dilated cardiomyopathy: a two-dimensional speckle tracking echocardiography study. – B. Goebel, K. Haugaa, K. Meyer, A. Lauten, C. Jung, S. Otto, H.R. Figulla, T. Edvardsen, T.C. Poerner (Jena, DE; Oslo, NO) Evidence for impaired left ventricular contractility during normal pregnancy. – M.E. Estensen, J.O. Beitnes, G. Grindheim, O.A. Smiseth, T. Henriksen, S. Aakhus (Oslo, NO) *Abstracts can be accessed at: 266 QR 30516 P4369 P4370 P4371 P4372 P4373 P4374 P4375 P4376 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS P4377 P4378 P4379 P4380 P4381 P4382 P4383 P4384 P4385 P4386 P4387 P4388 P4389 P4390 P4391 TUESDAY – MORNING Cavopulmonary shunt after LVAD implantation improves haemodynamics in patients having relatively impaired right heart: an in-silico analysis. – S. Shimizu, T. Shishido, T. Kawada, Y. Sata, A. Kamiya, M. Sugimachi (Osaka, JP) Effects of intraaortic balloon pump counterpulsation on left ventricular systolic and diastolic function in a porcine model of acute ischemic heart failure;differences between ischemia and reperfusion. – K. Malliaras, J. Terrovitis, A. Ntalianis, E. Charitos, N. Diakos, I. Pozios, E. Tseliou, L. Katsaros, S. Vakrou, J. Nanas (Athens, GR) Hyperdehydroepiandrosterone in hemodynamically instable neonates with refractory hypotension. – A. Khashana, M. Hallman, A. Abdelwahab, S. Elsharkawy, H. Atwa, A. Ahmed (Ismailia, EG; Oulu, FI) Alterations in ventriculo-arterial coupling and systemic arterial properties during normal pregnancy. – M.E. Estensen, G. Grindheim, E.W. Remme, A. Swillens, O.A. Smiseth, P. Segers, T. Henriksen, S. Aakhus (Oslo, NO; Ghent, BE) Diagnostic value of Doppler transthoracic echocardiography in the estimation of left ventricular filling pressure in patients with severe symptomatic systolic heart failure. – B. Gellen, P.F. Lesault, F. Canoui Poitrine, P. Lim, P. Gueret, E. Teiger, J.L. Dubois Rande, L. Hittinger, T. Damy (Créteil, FR) Assessment of right ventricular regional and global function in asymptomatic patients with repaired tetralogy of Fallot by ultrasound speckle tracking imaging. – M. Xie, Y. Li (Wuhan, CN) Non invasive hemodynamic evaluation of patients with acute heart failure in emergency department: impedance cardiography compared with clinical evaluation and B type natriuretic peptide (BNP). – M.W. Montera, S.B. Pereira, A. Volschan, M.S. Diniz, Y. Pereira, E.T. Mesquita (Rio de Janeiro, BR) Aortic stiffness and left atrial volume index in adult dialyzed patients: dependence - compliance and pressure. – T. Zapolski, A. Jaroszynski, A. Drelich-Zbroja, A. Wysokinski, A. Ksiazek, M. Szczerbo-Trojanowska (Lublin, PL) Pressure volume relationship is related to coronary flow reserve in non-ischemic dilated cardiomyopathy. – Q. Ciampi, F. Rigo, L. Pratali, S. Gherardi, B. Villari, E. Picano, R. Sicari (Benevento, Mestre-Venice, Pisa and Cesena, IT) Obese heart failure patients have less cardiac impairment than thinner counterparts. – S. Chinnappa, N. Lewis, D. Barker, D. Goldspink, L.B. Tan (Leeds, GB) Determinants of right ventricular mass in heart failure patients with reduced ejection fraction: a MRI based study. – J. Vormbrock, J. Liebeton, M. Hosseini, C. Schilling, A. Meissner, H. Yeni, H.-J. Trappe, G. Plehn (Herne, DE) Invasive evaluation of whether decline in pressure after initial immediate increment on improving AV delay of CRT is due to vasodilatation or decline in cardiac function. – P.A. Pabari, A. Kyriacou, Z.I. Whinnett, I. Wright, K. Willson, J. Mayet, A.D. Hughes, D.P. Francis (London, GB) Impact the transcatheter aortica valve implantation in patients with severe aortic stenosis with reduced left ventricular ejection fraction. – A.J. Munoz Garcia, P. Losada Mora, M.J. Molina Mora, M.F. Jimenez Navarro, I. Rodriguez Bailon, J.H. Alonso Briales, M. Such Martinez, A.J. Dominguez Franco, J.M. Hernandez Garcia, E. De Teresa Galvan (Malaga, ES) Evaluation of systolic-diastolic left ventricular function in competitive athletes: study by two-bidimensional speckle tracking. – K. Savino, A. Lilli, C. Riccini, E. Bordoni, G. Ambrosio (Perugia and Lido Di Camaiore, IT) Chronic GLP-1 treatment preserves diastolic function and improves survival in rats with pressure overload. – T.D. Nguyen, Y. Shingu, P.A. Amorim, M. Schwarzer, T. Doenst (Jena and Leipzig, DE) Inhibition of ASK1 attenuates angiotensin II- or TGF-beta-stimulated cardiomyocyte hypertrophy and fibroblast collagen synthesis: therapeutic potential of ASK1 inhibitors in myocardial remodelling. – B. Wang, G.Y. Xu, P.Y. Ho, A. Kompa, B.M. Jucker, R.N. Willette, H. Krum (Melbourne, AU; King of Prussia, US) Asymptomatic left ventricular systolic dysfunction is prevalent and undertreated prior to diagnosis: a report from the STOP-HF study. – G. Murtagh, I.R. Dawkins, M.T. Ledwidge, E. Tallon, R. O’Hanlon, K. McDonald (Dublin, IE) Levosimendan as a weaning strategy from inotropes. – D. Bresson, F. Sibellas, C. Petitpe, O. Bastien, J.-J. Lehot, V. Cart-Regal, L. Sebbag, E. Bonnefoy (Bron, FR) Lung impedance guided preemptive treatment of evolving acute heart failure in course of acute myocardial infarction reduces use of furosemide. – M. Shochat, A. Shotan, M. Kazatsker, V. Gurovich, E. Noiman, A. Asif, Y. Levy, L. Vasilenko, D. Blondhaim, S. Meisel (Hadera, IL) Natriuretic peptide inhibition in the presence of angiotensin receptor blockade following short-term treatment with LCZ696 in heart failure patients: effect on ANP, BNP, NT-proBNP and cGMP. – Z. Kobalava, O. Averkov, I. Meray, L. Alexandriya, V. Moiseev, D. Albrecht, A. Feng, P. Chandra, P.J. Jordaan (Moscow, RU; Basel, CH) Insulin treatment retards post-ischemic heart failure by inhibition of myocardial CaMKII via PI3K-Akt activation in rats. – F. Gao, W.J. Xing, W.J. Yan, F. Fu, H.F. Zhang, J. Zhang, W.Y. Guo, H.C. Wang (Xi’an, CN) P4392 P4393 P4394 P4395 P4396 P4397 267 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Excessive extracellular matrix metabolism identify a sub-group of post-myocardial infarction patients with preserved left ventricular dysfunction who may benefit from eplerenone. – N. Kambouridis, D.N. Tziakas, G. Chalikias, D. Stakos, S. Apostolakis, D. Papazoglou, A. Thomaidi, A. Lantzouraki, D. Simeonidis, S.V. Konstantinides (Kavala and Alexandroupolis, GR) Efficacy and safety of recombinant human Atrial Natriuretic Peptide (rhANP) for acute decompensated heart failure: a multicenter randomized controlled dose-finding study. – G. Wang (Beijing, CN) Low-dose of beta-blocker in combination with milrinone improves cardiac function in patients with acute decompensated heart failure. – S. Kobayashi, T. Susa, T. Tanaka, W. Murakami, S. Okuda, M. Doi, T. Nao, Y. Wada, M. Yano, M. Matsuzaki (Ube, JP) The differences of hemodynamic response between nicorandil and carperitide in patients with acute decompensated heart failure. – H. Hattori, Y. Minami, H. Arashi, M. Higashitani, D. Yumino, J. Yamaguchi, F. Mori, T. Shiga, N. Hagiwara (Tokyo, JP) Administration of the cyclic peptide COR-1 in humans neutralizes anti-beta1 receptor-antibodies, but does not induce other immune effects. – M. Ungerer, V. Boivin, H.P. Holthoff, K. Adler, H. Degen, M.J. Lohse, R. Jahns, G. Munch (Martinsried and Wurzburg, DE) Ivabradin compare with bisoprolol reduces segmental diastolic dysfunction and improves diastolic functional reserve in patients with diastolic heart failure. – K.G. Adamyan, A.L. Chilingaryan (Yerevan, AM) 3’,4’-dihydroxyflavonol (DIOHF) attenuates diastolic dysfunction and cardiac remodelling in streptozotocin-induced diabetic m(Ren2)27 rats. – F.L. Khong, Y. Zhang, W. Qi, O.L. Woodman, D.J. Kelly (Melbourne, AU) Effects of aliskiren on Left ventricular remodeling in patients with dilated cardiomyopathy. – H. Sakai, T. Tsutamoto, C. Kawahara, M. Fujii, M. Yamaji, M. Ohnishi, T. Matsumoto, A. Wada, M. Horie (Otsu, Inugami and Kusatsu, JP) When conventional heart failure therapy is not enough: angiotensin receptor blocker or aldosterone antagonist? – S. Bangalore, S. Kumar, F.H. Messerli (New York and Omaha, US) Comparative trial of efficacy and safety of cardosten, valsartan and their combination in patients with chronic heart failure. – Y.U. Zabolotneva, M. Kachanova, V.I. Petrov, G.P. Arutyunov, A.V. Yevzirikhina, S.V. Nedogoda, Y.U.M. Lopatin, V.V. Tsoma, S.A. Sergeeva, O.I. Epstein (Moscow and Volgograd, RU) Evaluating the trial strategy for dosage application of beta-blockers and their impact on the quality of life using the Minnesota Living with Heart Failure Questionnaire (MLHFQ). – D.S.B. Melo, A.C.P. Barretto, A.I. Oliveira, A.H. Uchida, M.E. Ochiai, J.N. Cardoso, P.C. Morgado, J.A.F. Ramires (São Paulo, BR) Clinic blood pressure in stable heart failure patients treated with the dual-acting neprilysin and angiotensin receptor inhibitor LCZ696. – Z. Kobalava, Y. Kotovskaya, I. Meray, A. Globenko, V. Moiseev, D. Albrecht, A. Feng, P. Chandra, P. Jordaan (Moscow, RU; Zurich, CH) Optimum or maximum, that is the question: a retrospective analysis of pharmacological therapy achieved in a hospital based, nurse led heart failure clinic. – A. Birchall, D. Barnett, N. Buckley, K. Drewry, L. O’Toole, A. Al-Mohammad (Sheffield, GB) Influence of eplerenone treatment on the number of endothelial progenitor cells in patients with chronic heart failure. – C. Jung, A. Floorvag, V. Oberle, M. Fritzenwanger, A. Lauten, M. Franz, B. Goebel, D. Barz, M. Ferrari, H.R. Figulla (Jena, DE) Renal effects of a novel dual acting V1a/V2 vasopressin receptor antagonist: comparison with furosemide. – P. Kolkhof, J.P. Stasch, E. Pook, C. Schmeck, C. Fuerstner, B. Albrecht-Kuepper (Wuppertal, DE) Alternate anticoagulation with the parenteral anti-Xa agent otamaxiban in heparin compromised conditions. – I. Thethi, J. Fareed, W. Jeske, O. Iqbal, D. Hoppensteadt, B. Lewis, J.M. Walenga (Maywood, US) Dose titration of the oral potassium binder RLY5016 to maintain normal serum potassium in heart failure and chronic kidney disease patients on aldosterone antagonists. – B. Pitt, D. Bushinsky, S. Halfon, D. Kitzman, M. Lainscak, V. Mathur, Y. Stasiv, I. Huang (Ann Arbor, Rochester, Santa Clara, Winston-Salem and Woodside, US; Golnik, SI) Evidence of altered isovolumic contraction during diastolic dysfunction with preserved ejection fraction in chronic hypertensive pigs. – M. Rienzo, D. Pongas, A. Bize, H.L. Chan, L. Sambin, L. Hittinger, J.B. Su, A. Berdeaux, B. Ghaleh (Créteil, FR) Assessment of both time-left atrial volume curve and left atrial emptying function by speckle tracking echocardiography is useful to evaluate left ventricular diastolic function in elderly patients. – T. Watanabe, R. Tanaka, K. Ono, M. Nagaya, N. Onishi, M. Iwama, T. Noda, S. Watanabe, M. Kawasaki, S. Minatoguchi (Gifu, JP) Albumin levels predict survival in patients with heart failure with normal ejection fraction. – M. Liu, G.W.K. Yip, B.P.Y. Yan, C.P. Chan, Q. Zhang, Y.Y. Lam, R.J. Li, J.E. Sanderson, J.P. Sun, C.M. Yu (Hong Kong, HK; Chengdu, CN) Chronic inhibition of protein tyrosine phosphatase 1B improves diastolic function and limits endothelial dysfunction in insulin resistant/obese mice. – E. Gomez, N. Harouki, P. Mulder, F. Bauer, R. Hooft, C. Thuillez, V. Richard (Rouen, FR; Geneva, CH) 268 P4398 P4399 P4400 P4401 P4402 P4403 P4404 P4405 P4406 P4407 P4408 P4409 P4410 P4411 P4412 P4413 P4414 P4415 P4416 P4417 P4418 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Impact of left ventricular diastolic dysfunction on screening for left ventricular systolic dysfunction using b-type natriuretic peptide: a report from the STOP - HF study. – G. Murtagh, I.R. Dawkins, M.T. Ledwidge, R. O’Hanlon, E. Tallon, K. Md Donald (Dublin, IE) Assessment of single ventricle diastolic function during stress echocardiography in adult patients after fontan operation. – L. Tomkiewicz-Pajak, L. Drabik, M. Olszowska, P. Rubis, M. Komar, W. Plazak, P. Podolec (Krakow, PL) Prevalence of diastolic left ventricular dysfunction in European populations based on cross-validated diagnostic thresholds. – M. Kloch-Badelek, T. Kuznetsova, W. Sakiewicz, A. Ryabikov, S. Malyutina, K. Stolarz-Skrzypek, E. Casiglia, K. Narkiewicz, K. Kawecka-Jaszcz, J.A. Staessen (Krakow and Gdansk, PL; Leuven, BE; Novosibirsk, RU; Padua, IT) Myeloperoxidase is critically linked to the development of diastolic heart failure following pressure overload. – F. Deuschl, A. Klinke, K. Friedrichs, F. Weinberger, B. Geertz, V. Rudolph, D. Lau, K. Klingel, T. Eschenhagen, S. Baldus (Hamburg and Tübingen, DE) SERCA2a gene transfer improves diastolic function in ischemic heart failure. – K. Ishikawa, L. Tilemann, D. Ladage, K. Fish, Y. Kawase, R.J. Hajjar (New York, US) Angiotensin II-induced diastolic dysfunction is associated with cardiac inflammation and peripheral monocytosis. – J. Hoffmann, H. Moellmann, D. Kraft, S. Voss, C. Troidl, S. Szardien, C. Liebetrau, A. Rolf, C.W. Hamm, H.M. Nef (Bad Nauheim, DE) P4419 P4420 P4421 P4422 P4423 P4424 FROM ELECTROCARDIOGRAPHY TO INVASIVE ELECTROPHYSIOLOGY (QR 30517*) *Abstracts can be accessed at: P4425 P4426 P4427 P4428 P4429 P4430 P4431 P4432 P4433 TUESDAY – MORNING Fragmented QRS signifies all cause mortality in left ventricular noncompaction cardiomyopathy. – X.H. Ning, M. Tang, J. Sha, Z.M. Liu, R.H. Chen, K.P. Chen, S. Zhang (Beijing, CN) The presence of J waves in 12-leads electrocardiogram is associated with the enlargement and functional abnormality of right ventricular - evaluation by using cardiac magnetic resonance imaging. – T. Takeuchi, T. Tomita, K. Shimada, A. Okada, K. Aizawa, A. Izawa, Y. Miyashita, S. Kumazaki, J. Koyama, U. Ikeda (Matsumoto, JP) Prevalence and prognosis impact of early repolarisation pattern in a general population. – A. Rollin, J.B. Ruidavets, P. Maury, V. Bongard, M. Delay, A. Duparc, P. Mondoly, J. Ferrieres, D. Carrie (Toulouse, FR) Stepwise increasing levels of hsCRP are associated with atrial fibrillation and long QT in a general population study. – C. Ellervik (Copenhagen, DK) Insights into location of type I ECG in patients with Brugada syndrome - correlation of ECG and cardiovascular magnetic resonance imaging. – C. Veltmann, T. Papavassiliu, T. Konrad, C. Doesch, F. Streitner, J. Kuschyk, C. Wolpert, M. Borggrefe, R. Schimpf (Mannheim and Ludwigsburg, DE) Increased Tpeak-Tend interval in Brugada syndrome is highly related to symptoms and mortality. Validation of this marker in a large series of Brugada syndrome patients. – A. Rollin-Garderes, P. Maury, F. Sacher, A. Duparc, P. Mondoly, M. Delay, J.L. Pasquie, F. Raczka, V. Bongard, D. Carrie (Toulouse, Bordeaux and Montpellier, FR) Prevalence and predictors of early repolarization and J wave in the general population. – R. Mollo, A. Cosenza, G. Pinnacchio, G. Careri, M. Laurito, I. Coviello, A. Stazi, G.A. Lanza, F. Crea (Rome, IT) Electrocardiographic features of non-compaction cardiomyopathy. – H. Xu, P. Fang, J. Deng, S. Zhao (Beijing, CN) Circadian variations of ST segment elevation in Brugada syndrome: comparison between symptomatic and asymptomatic patients. – N. Behar, G. Kervio, B. Petit, S. Bodi, P. Maison-Blanche, P. Mabo (Rennes, FR) Distinct role of electrocardiographic criteria in echocardiographic diagnosis of left ventricular hypertrophy and its regression in essential hypertension. – D. Tsiachris, C. Tsioufis, A. Kasiakogias, K. Dimitriadis, C. Thomopoulos, D. Syrseloudis, L. Lioni, I. Bafakis, G. Chlapoutakis, C. Stefanadis (Athens, GR) Localised and spatially constrained sources in human atrial fibrillation. – D.E. Krummen, R. Sehra, C. Briggs, S. Narayan (San Diego, US) Endocardial voltage mapping is superior to contrast-enhanced magnetic resonance for imaging of myocardial substrate of right ventricular tachycardia. – M. Perazzolo Marra, A. Zorzi, F. Migliore, B. Bauce, L. Leoni, C. Basso, G. Buja, G. Thiene, S. Iliceto, D. Corrado (Padua, IT) Respiratory, cardiac cycle and patient movement compensation in a new 3D sensor guided navigation-system. – T. Gaspar, P. Sommer, S. Rolf, C. Piorkowski, G. Hindricks (Leipzig, DE) Non-fluoroscopic sensor guided navigation of intracardiac EP catheters within pre-recorded cine loops. – C. Piorkowski, G. Hindricks (Leipzig, DE) P4434 P4435 P4436 P4437 P4438 QR 30517 269 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS Feasibility and acute efficacy of radiofrequency ablation of cavotricuspid isthmus dependent atrial flutter guided by real-time 3-dimensional echocardiography. – F. Regoli, F. Faletra, G. Nucifora, E. Pasotti, T. Moccetti, C. Klersy, A. Auricchio (Lugano, CH; Pavia, IT) The complications of lead extraction with infected vegetations: a single-center experience and consequences of transvenous extraction. – M. Nagashima, M. Goya, Y. Soga, K. Hiroshima, K. Andou, M. Iwabuchi, H. Yokoi, M. Nobuyoshi (Kitakyushu, JP) Hurdles in ablation of atrial tachycardia in Fontan patients. – I. Suman Horduna, M. Gujic, S. Ernst (London, GB) Genetic deletion of the p66Shc adaptor protein protects against age-related cardiac arrhythmias. – P. Francia, A. Ricotta, A. Uccellini, C. Balla, C. Adduci, S. Carosio, L. Barberi, A. Musaro’, F. Cosentino, M. Volpe (Rome, IT) Assessment of atrioventricular conduction intervals during percutaneous aortic valve implantation. – J. Segura, J. Suarez De Lezo Jr, F. Mazuelos, M. Pan, M. Romero, E. Caballero, D.J. Pavlovic, H. Mendoza, A. Medina, J. Suarez De Lezo (Córdoba and Las Palmas de Gran Canaria, ES) P4439 P4440 P4441 P4442 P4443 VENTRICULAR ARRHYTHMIAS AND CATHETER ABLATION (QR 30518*) Impact of accelerated ventricular tachyarrhythmias on mortality in patients with implantable cardioverter-defibrillator therapy. – C. Schukro, L. Leitner, J. Siebermair, T. Pezawas, G. Stix, J. Kastner, M. Wolzt, H. Schmidinger (Vienna, AT) Performance of a new ICD algorithm to detect lead failure noise and prevent inappropriate therapy. – S. Beau, S. Greer, C. Ellis, C.O. West, J. Keeney, S. Asopa (Little Rock, Nashville and Sylmar, US) Short-term enhancement of gap junctional coupling during early myocardial infarction modifies late susceptibility to ventricular arrhythmias. – F.S. Ng, S.A. Cooper, R.A. Chowdhury, P.M. Patel, E. Dupont, A.R. Lyon, N.S. Peters (London, GB) Prevalence of syncope with a neuromediated profile in patients with the Brugada syndrome and relation with ICD shocks. – J.M. Rubio Campal, P. Sanchez-Borque, H.P. Gaebelt, S. Del Castillo, J. Benezet-Mazuecos, E. Macia, M.A. Quinones, P.P. Perez, J.J. De La Vieja, J. Farre (Madrid, ES) Predictors of long- term outcome after effective ablation of electrical storm in ischaemic cardiomyopathy: implications for the ablation strategy. – A. Dello Russo, M. Casella, G. Pelargonio, C. Carbucicchio, M. Zucchetti, P. Santangeli, S. Bartoletti, L. Di Biase, A. Natale, C. Tondo (Milan and Rome, IT; Austin, US) Ventricular arrhythmias are the major cause of death in patients with classical phenotype of fabry disease. – M. Niemann, T. Hartmann, S. Herrmann, K. Hu, D. Liu, M. Beer, G. Ertl, C. Wanner, F. Weidemann (Wurzburg, DE) Myocardial scar visualized by contrast-enhanced cardiac magnetic resonance predicts mayor arrhythmic events in patients with non-ischemic dilated cardiomyopathy over a long-term follow-up. – M. Perazzolo Marra, M. De Lazzari, F. Corbetti, F. Tona, F. Migliore, A. Zorzi, G. Thiene, C. Basso, D. Corrado, S. Iliceto (Padua, IT) Combined endocardial and epicardial catheter ablation in patients with arrhythmogenic right ventricular dysplasia: The scar dechanneling technique. – A. Berruezo, J. Fernandez-Armenta, L.L. Mont, D. Andreu, E. Arbelo, E. Diaz, C. Herzcku, J. Brugada (Barcelona, ES) Two different ablation strategies in patients with paroxysmal atrial fibrillation: a randomized comparison. – E. Pokushalov, A. Romanov, S. Artemenko, A. Turov, V. Shabanov, I. Stenin (Novosibirsk, RU) Left atrial appendage isolation to improve the outcome in patients with long standing persistent atrial fibrillation and severe scarring. – L. Di Biase, P. Mohanty, R. Bai, J. Sanchez, P. Santangeli, J.D. Burkhardt, S. Beheiry, D.J. Lakkireddy, W. Lewis, A. Natale (Austin, San Francisco, Kansas City and Cleveland, US) Ablation of peri-mitral flutter after ablation of long standing persistent AF: results from the PROPOSE multicenter study. – L. Di Biase, R. Bai, P. Mohanty, A. Dello Russo, S. Themistoclakis, A. Raviele, J.E. Sanchez, J.D. Burkhardt, C. Tondo, A. Natale (Austin, US; Milan and Mestre, Venice, IT) Periprocedural continuous anticoagulant therapy does not increase complication rate in ablation of atrial fibrillation when compared to bridging therapy. – J.M. Tapanainen, H. Bastani, F. Braunschweig, N. Drca, K. Gudmundsson, P. Insulander, M. Jensen-Urstad, G. Kenneback, B. Sadighi, J. Schwieler (Stockholm, SE) No permanent AV block after cryoablation of 1.303 substrates adjacent to the AV node, transient AV block is a benign finding. – P. Insulander, H. Bastani, F. Braunschweig, N. Drca, K. Gudmundsson, G. Kenneback, B. Sadigh, J. Schwieler, J. Tapanainen, M. Jensen-Urstad (Stockholm, SE) Ablation of paroxysmal and persistent atrial fibrillation: 12 months follow-up through continuous subcutaneous monitoring. – A. Romanov, E. Pokushalov, G. Corbucci, S. Artemenko, A. Turov, V. Shabanov (Novosibirsk, RU; Maastricht, NL) *Abstracts can be accessed at: 270 QR 30518 P4444 P4445 (W) P4446 P4447 P4448 P4449 P4450 P4451 P4452 P4453 P4454 P4455 P4456 P4457 TUESDAY, 30 AUGUST 2011 – MORNING POSTERS P4458 P4459 P4460 P4461 P4462 P4463 P4464 P4465 P4466 P4467 P4468 P4469 P4470 P4471 P4472 P4473 P4474 TUESDAY – MORNING Human atrial fibrillation may be caused by right atrial drivers. – S. Narayan, D.E. Krummen, C. Briggs, R. Sehra (San Diego, US) Conversion to sinus rhythm does not predict the efficacy of the ablation of persistent and long-standing atrial fibrillation. – E. Arbelo, N. Calvo, D. Andreu, R. Borras, A. Berruezo, E. Guiu, J. Brugada, L. Mont (Barcelona, ES) The magnetic navigation system improves safety and allows high efficacy for ablation of arrhythmias. – F. Akca, T. Bauernfeind, B. Schwagten, N.M.S. De Groot, L. Jordaens, T. Szili-Torok (Rotterdam, NL) The risk of cerebrovascular events after ablation for paroxysmal atrial fibrillation. – S. Fichtner, U. Czudnochowsky, T. Reents, J. Wu, C. Jilek, S. Ammar, H.L. Estner, G. Hessling, I. Deisenhofer (Munich, DE) Gastroparesia as an unusual complication of cryoballoon pulmonary vein isolation. – A. Guiot, A. Savoure, B. Godin, H. Eltchaninoff, F. Anselme (Rouen, FR) Haemoptysis after pulmonary vein isolation with a cryoballoon: an increased risk is associated with extreme low freezing temperatures. – R. Bhagwandien, P. Knops, Y. Van Belle, T. Szili-Torok, N. De Groot, L. Jordaens (Rotterdam, NL) Atrial fibrillation triggers from the coronary sinus: comparison between isolation versus focal ablation. – L. Di Biase, R. Bai, P. Mohanty, J.E. Sanchez, R. Horton, P. Santangeli, A. Dello Russo, J.D. Burkhardt, C. Tondo, A. Natale (Austin, US; Milan, IT) Rapid termination and elimination of human atrial fibrillation: ablation at rotors and focal drivers. – S. Narayan, D.E. Krummen, C. Briggs, R. Sehra (San Diego, US) One-year clinical outcome after pulmonary vein isolation using the novel endoscopic ablation system in patients with paroxysmal atrial fibrillation. – A. Metzner, B. Schmidt, A. Fuernkranz, E. Wissner, R. Tilz, M. Konstantinidou, A. Rillig, S. Mathew, F. Ouyang, K.-H. Kuck (Hamburg, DE) Analysis of factors influencing left atrial lesion formation following catheter ablation of atrial fibrillation using delayed-enhancement MRI. – T. Badger, N. Akoum, N.S. Burgon, P.A. Anderson, T.S. Haslam, C. Tek, G.P. Gardner, C.J. McGann, E. Kholmovski, N.F. Marrouche (Salt Lake City, US) Esophageal lesions following pulmonary vein isolation with a new duty-cycled phased radiofrequency ablation catheter. – D. Grosse-Meininghaus, O. Al-Taie, H. Zuenckel, W. Fischbach, J.C. Geller (Aschaffenburg and Bad Berka, DE) Ablation of atrial fibrillation using a novel duty-cycled phased radiofrequency ablation system. – T. Deneke, K. Buenz, O. Balta, H. Anders, M. Horlitz, M. Paesler, R. Haberkorn, E. Berenjkoub, B. Orth, D.I. Shin (Cologne, DE) Remote magnetic navigation is a high effective method for ablation of arrhythmias in patients with complex congenital heart disease. – F. Akca, T. Bauernfeind, N.M.S. De Groot, B. Schwagten, M. Witsenburg, L. Jordaens, T. Szili-Torok (Rotterdam, NL) Prospective randomized evaluation of efficacy and safety of cluster ECG-based versus linear ablation for long-standing persistent atrial fibrillation. – M. Fiala, J. Chovancik, V. Bulkova, O. Toman, R. Nevralova, L. Sknouril, J. Pindor, R. Labrova, J. Januska, J. Spinar (Trinec, Prague and Brno, CZ) Catheter ablation of atrial fibrillation under therapeutic coumadin: prevalence of pericardial effusion comparing paroxysmal and non paroxysmal atrial fibrillation. – L. Di Biase, J.D. Burkhardt, D.J. Lakkireddy, W. Lewis, P. Mohanty, S. Beheiry, P. Santangeli, B. Bai, J.E. Sanchez, A. Natale (Austin, Kansas City, Cleveland and San Francisco, US) Changing patient characteristics and pharmacotherapy in atrial fibrillation patients undergoing radiofrequency ablation - a nationwide study. – D. Karasoy, G.H. Gislason, J. Hansen, P. Soegaard, C. Torp-Pedersen, M.L. Hansen (Copenhagen, DK) Asymptomatic stroke related to pulmonary vein isolation with irrigated tip ablation catheter. – A. Mizukami, M. Suzuki, W. Nagahori, M. Ohno, A. Matsumura, Y. Hashimoto (Kamogawa, JP) The close anatomical relationship between the coronary arteries and the myocardial infundibulum of the right ventricle: a potential cause of coronary injury after catheter ablation of RVOT tachycardia. – M. Murillo, G. Pizarro, E. Gonzalez Caballero, B. Fuertes, S. Bayona, J.A. Cabrera, D. Sanchez Quintana (Badajoz and Madrid, ES) Incidence and predictors of periprocedural cerebrovascular accident in patients undergoing catheter ablation of atrial fibrillation. – D. Scherr, D. Dalal, D. Spragg, K. Chilukuri, A. Cheng, S. Nazarian, C. Henrikson, R. Berger, H. Calkins, J. Marine (Graz, AT; Baltimore, US) Benefit of redo procedures using radiofrequency after failure of a first catheter ablation of atrial fibrillation using cryotherapy. – A. Guiot, A. Savoure, B. Godin, H. Eltchaninoff, F. Anselme (Rouen, FR) Safety of catheter ablation for atrial fibrillation with therapeutic INRs: comparison with transition using low molecular weight heparin. – B. Saad, C. Slater, L.A. Oliveira Jr, R. Elias, D. Moura Neto, P. Maldonado, A. Camiletti, L.E. Camanho (Rio de Janeiro, BR) Ganglionated plexi ablation in patients with paroxysmal atrial fibrillation: data from continuous subcutaneous monitoring. – A. Romanov, E. Pokushalov, S. Artemenko, V. Shabanov, I. Stenin, D. Elesin, D. Losik, A. Turov (Novosibirsk, RU) Impact of irrigation flow rate on tissue temperature profile and lesion geometry in an ovine thigh muscle radio-frequency ablation model. – S. Nayyar, L. Mackenzie, D.H. Lau, D. Kelly, A.G. Brooks, K. Roberts-Thomson, P. Sanders (Adelaide, AU) P4475 P4476 P4477 P4478 P4479 P4480 271 TUESDAY, 30 AUGUST 2011 – LUNCH TIME SESSIONS 12:30-13:50 | Hands-On Tutorial Room 1 - Zone B TECHNICAL PRINCIPLES, CLINICAL INDICATIONS AND ANALYSIS OF CARDIAC COMPUTED TOMOGRAPHY DATASETS Chairperson(s): T. Pflederer (Erlangen, DE) Hands-On Tutorial organised by Siemens AG, Healthcare Sector (on-site registration) Hands-On Tutorial 12:45-13:30 | Vienna - Zone A HIGHLY PURIFIED OMEGA-3 FATTY ACID ETHYL-ESTERS: WHAT DO THE DATA TELL US? Chairperson(s): J.P.J. Halcox (Cardiff, GB); H. Rupp (Marburg, DE) Mini-Satellite Symposium organised by Abbott EPD 12:45 12:50 13:10 Mini-Satellite Symposium Introduction. – J.P.J. Halcox (Cardiff, GB), H. Rupp (Marburg, DE) Implications of trial results for clinical practice. – J.P.J. Halcox (Cardiff, GB) Not all omega-3 formulations are the same. – H. Rupp (Marburg, DE) 4481 4482 4483 12:45-13:45 | Oslo - Zone B MEET THE GUIDELINES TASK FORCE II Chairperson(s): J.J. Bax (Leiden, NL); U. Sechtem (Stuttgart, DE) 12:45 12:45 13:15 13:15 Special Session Peripheral artery diseases: questions and answers to the panellists. – M. Tendera (Katowice, PL), V. Aboyans (Limoges, FR) Panelists. – S. Kownator (Thionville, FR), M. Roffi (Geneva, CH), D.L. Clement (Ghent, BE), V. Riambau (Barcelona, ES), M. De Carlo (Pisa, IT) Dyslipidemias: questions and answers to the panellists. – Z. Reiner (Zagreb, HR), A. Catapano (Milan, IT) Panelists. – I.M. Graham (Dublin, IE), G. De Backer (St. Martens Latem, BE), M.-R. Taskinen (Helsinki, FI), O. Wiklund (Gothenburg, SE) 4484 4485 4486 4487 12:45-13:30 | Berne - Zone E MEET THE TRIALIST V - CRISP AMI Chairperson(s): K. Huber (Vienna, AT) 12:45 Meet the Trialists CRISP AMI: A multi-center, randomized, controlled study of mechanical left ventricular unloading with counterpulsation to reduce infarct size pre-PCI for acute myocardial infarction: rationale and design of the CRISP AMI trial. – M. Patel (Durham, US) 4488 12:45-13:30 | Bucharest - Zone E RANOLAZINE: FROM LATE INa+ TO ISCHEMIA INHIBITION Chairperson(s): A.J. Camm (London, GB) Mini-Satellite Symposium organised by MENARINI 12:45 12:50 Mini-Satellite Symposium Welcome & Introduction. – A.J. Camm (London, GB) Ranolazine: from late INa+ to ischemia inhibition. – E. Braunwald (Boston, US) 4489 4490 12:45-13:30 | Cairo - Zone E ULTRASOUND IN PRIVATE PRACTICE – UPDATE 2011 Chairperson(s): F.J. Sonntag (Henstedt-Ulzburg, DE); P.A. Sirnes (Moss, NO) Mini-Satellite Symposium organised by GE Healthcare 12:45 13:05 13:20 272 Mini-Satellite Symposium Echocardiography update 2011 - Digital workflow - Image acquisition, review and quantification. – W. Fehske (Niederkassel, DE) Vascular ultrasound update 2011 - Assessing the grade of carotid stenosis. – M. Dauzat (Nimes, FR) Vascular ultrasound update 2011 - Ultrasound assessment of vertebral arteries. – I. Schuster-Beck (Nimes, FR) 4491 4492 4493 TUESDAY, 30 AUGUST 2011 – LUNCH TIME SESSIONS 12:45-13:30 | Athens - Zone F DEVICE THERAPY IN 2011: WHAT’S NEW? Chairperson(s): M. Taborsky (Olomouc, CZ); H. Heidbuchel (Leuven, BE) Mini-Satellite Symposium organised by Medtronic 12:45 12:50 13:05 13:20 Mini-Satellite Symposium Introduction. – M. Taborsky (Olomouc, CZ) Cardiac resynchronization therapy: from guidelines to clinical practice. – S.H. Hohnloser (Frankfurt, DE) Modern implantable cardioverter-defibrillator therapy: saving lives. – M. Sopher (Bournemouth, GB) Discussion. – H. Heidbuchel (Leuven, BE) 4494 4495 4496 4497 12:45-13:30 | Belgrade - Zone F PHOSPHODIESTERASE TYPE-5 INHIBITION IN PULMONARY ARTERIAL HYPERTENSION: WHEN SCIENCE MEETS REAL LIFE Chairperson(s): O. Sitbon (Clamart, FR) Mini-Satellite Symposium organised by Pfizer Ltd 12:45 12:50 13:05 13:25 Mini-Satellite Symposium Welcome and introductory remarks. – O. Sitbon (Clamart, FR) Latest news in phosphodiesterase type-5 inhibition. – J.L. Vachiery (Brussels, BE) Pulmonary arterial hypertension in an adolescent with congenital heart disease: a case-based discussion. – M.A. Gatzoulis (London, GB) Concluding remarks. – O. Sitbon (Clamart, FR) 4498 4499 4500 4501 12:45-13:30 | Tunis - Zone F CONTRACTILITY MODULATION (CCM): CURRENT AND FUTURE CLINICAL APPLICATIONS Chairperson(s): M. Borggrefe (Mannheim, DE); A. Auricchio (Lugano, CH) Mini-Satellite Symposium organised by Impulse Dynamics Germany GmbH 12:45 12:55 13:10 13:25 Mini-Satellite Symposium CCM: addressing unmet clinical needs in heart failure. – G. Hasenfuss (Göttingen, DE) Direct and indirect molecular effects of CCM: how is myocardial function improved? – C. Butter (Bernau bei Berlin, DE) Assessing the clinical impact of CCM: past and ongoing clinical studies. – K.-H. Kuck (Hamburg, DE) Concluding remarks. – A. Auricchio (Lugano, CH) 4502 4503 4504 4505 TUESDAY – LUNCH TIME 12:45-13:30 | Zagreb - Zone F RIGHT HEART FAILURE AND PULMONARY ARTERIAL HYPERTENSION Mini-Satellite Symposium Chairperson(s): M.A. Gomez Sanchez (Pozuelo de Alarcon, ES); G. Simonneau (Clamart, FR) Mini-Satellite Symposium organised by GSK 12:45 12:48 13:01 13:14 13:27 Introduction. – M.A. Gomez Sanchez (Pozuelo de Alarcon, ES) Uses and limitations of echocardiography in pulmonary arterial hypertension. – S. Rosenkranz (Cologne, DE) Magnetic resonance imaging in pulmonary arterial hypertension: is it the future? – A. Vonk Noordegraaf (Amsterdam, NL) Is there specific treatment for right heart failure in pulmonary hypertension? – N. Galie (Bologna, IT) Concluding comments. – G. Simonneau (Clamart, FR) 4506 4507 4508 4509 4510 273 TUESDAY, 30 AUGUST 2011 – AFTERNOON 14:00-15:30 | London & The Hague - Zone A A STEP FURTHER IN HEART FAILURE MANAGEMENT EBAC Accredited Educational Programme EBAC Accredited Educational Programme organised by the Universitätsklinikum Des Saarlandes Course Director: Prof. Michael Böhm (Homburg/Saar, DE) Chairperson(s): J.S. Borer (New York, US); K. Swedberg (Gothenburg, SE) 14:00 14:05 14:25 14:45 15:05 15:25 Introduction. – K. Swedberg (Gothenburg, SE) The systolic heart failure treatment with the If inhibitor ivabradine (SHIFT) study: most recent analysis. – J.S. Borer (New York, US) Heart rate slowing: the key to effective heart failure management. – M. Böhm (Homburg/Saar, DE) A new hope for heart failure patients. – M.R. Cowie (London, GB) Panel discussion: targeting heart rate in the management of heart failure. – K. Swedberg (Gothenburg, SE), J.S. Borer (New York, US), M. Böhm (Homburg/Saar, DE), M.R. Cowie (London, GB), J.-C. Tardif (Montreal, CA) Conclusion. – J.S. Borer (New York, US) 4511 4512 4513 4514 4515 4516 “This educational programme is accredited by the European Board for Accreditation in Cardiology (EBAC) for one hour of External CME credits. Each participant should claim only those hours of credit that have actually been spent in the educational activity. EBAC works in cooperation with the European Accreditation Council for Continuing Medical Education (EACCME), which is an institution of the European Union of Medical Specialists (UEMS).” Programme supported by an unrestricted educational grant from SERVIER 14:00-15:30 | Stockholm - Zone A TRANSCATHETER MITRAL VALVE REPAIR THERAPY: WHAT HAVE WE LEARNED SO FAR? Chairperson(s): A. Vahanian (Paris, FR); N.M. Moat (London, GB) Satellite Symposium organised by Crossroads, the Abbott Vascular education network 14:00 14:05 14:20 14:40 15:00 15:15 Satellite Symposium Introduction. – A. Vahanian (Paris, FR) Surgical approaches to mitral regurgitation. – N.M. Moat (London, GB) Non-surgical techniques for imitral valve regurgitation. – O.W. Franzen (Copenhagen, DK) Latest clinical data with transcatheter mitral valve repair therapy. – A. Vahanian (Paris, FR) Proposed criteria for patient selection for transcatheter mitral valve repair. – F. Maisano (Segrate, IT) Discussion and take-home message. – A. Vahanian (Paris, FR), N.M. Moat (London, GB) 4517 4518 4519 4520 4521 4522 14:00-15:30 | Warsaw - Zone A TRANSCATHETER AORTIC VALVE IMPLANTATION (TAVI) FOR HIGH RISK PATIENTS WITH SEVERE AORTIC STENOSIS Chairperson(s): E.M. Tuzcu (Cleveland, US); C.W. Hamm (Bad Nauheim, DE) Satellite Symposium organised by Edwards Lifesciences 14:00 14:05 14:20 14:35 14:50 15:05 274 Satellite Symposium Introduction. – E.M. Tuzcu (Cleveland, US), C.W. Hamm (Bad Nauheim, DE) The forgotten epidemic: severe aortic stenosis and undertreatment. – B. Iung (Paris, FR) What is TAVI? Expanding treatment options. – O. Wendler (London, GB) What is the current evidence for TAVI? The PARTNER trial results. – A. Pichard (Washington, US) TAVI case overviews and patient selection/screening criteria. – H. Eltchaninoff (Rouen, FR) Panel: Q and A. – H. Eltchaninoff (Rouen, FR), C.W. Hamm (Bad Nauheim, DE), B. Iung (Paris, FR), A. Pichard (Washington, US), E.M. Tuzcu (Cleveland, US), O. Wendler (London, GB) 4523 4524 4525 4526 4527 4528 TUESDAY, 30 AUGUST 2011 – AFTERNOON 14:00-15:30 | Hands-On Tutorial Room 3 - Zone B SPECKLE TRACKING BASED DEFORMATION IMAGING IN VENTRICULAR FUNCTION ASSESSMENT Chairperson(s): I. Salgo (Andover, US) Hands-On Tutorial organised by Philips Healthcare (on-site registration) Hands-On Tutorial 14:00-15:30 | Moscow - Zone B THE UNENDING STORY – NEW MECHANISTIC AND CLINICAL INSIGHTS INTO ASPIRIN Chairperson(s): C. Patrono (Rome, IT); M.A. Hull (Leeds, GB) Satellite Symposium organised by Bayer HealthCare Pharmaceuticals 14:00 14:02 14:30 15:00 Satellite Symposium Welcome and introduction. – M.A. Hull (Leeds, GB) COX- and beyond COX-inhibition - A new mechanistic approach to disease prevention? – P. Patrignani (Chieti, IT) Determinants of the interindividual variability in response to low-dose aspirin in different clinical settings. – C. Patrono (Rome, IT) Does aspirin have gastrointestinal benefits? – M.A. Hull (Leeds, GB) 4529 4530 4531 4532 14:00-17:30 | Riga - Zone B CASE-BASED APPROACH TO ISCHEMIC HEART DISEASE MANAGEMENT Satellite Symposium Chairperson(s): V. Mathew (Rochester, US); D. Holmes (Rochester, US); C. Di Mario (London, GB) Satellite Symposium organised by Mayo Clinic 14:00 Introduction. – V. Mathew (Rochester, US) 4533 14:06 Appropriateness of coronary revascularization in stable disease. – V. Mathew (Rochester, US) Is stable coronary disease really stable? – B.J. Gersh (Rochester, US) Panel discussion. – D. Holmes (Rochester, US), C. Di Mario (London, GB), V. Mathew (Rochester, US), B.J. Gersh (Rochester, US), M. Farkouh (New York, US) Illustrative case: ST Elevation Myocardial Infarction (STEMI). – H. Ting (Rochester, US) Systems based approaches to reperfusion therapy in the 21st century. – H. Ting (Rochester, US) 21st century acute reperfusion therapy and STEMI networks: a European perspective. – K. Huber (Vienna, AT) Panel discussion. – D. Holmes (Rochester, US), C. Di Mario (London, GB), H. Ting (Rochester, US), K. Huber (Vienna, AT), B.J. Gersh (Rochester, US) “Ischemic heart disease: chronic to acute” 14:30 14:45 14:48 15:00 15:12 15:30 Coffee break. 16:00 Introduction. – C. Di Mario (London, GB) Illustrative case: ischemic heart failure. – N. Pereira (Rochester, US) Delivering optimal heart failure management and identifying patients at risk for advanced heart failure. – N. Pereira (Rochester, US) Advanced heart failure: selecting patients for transplantation, ventricular assist devices and total artificial heart. – R. Daly (Rochester, US) Opportunities and challenges of delivering advanced heart failure therapy: a European perspective. – M.G. Crespo-Leiro (La Coruña, ES) Panel discussion. – C. Di Mario (London, GB), N. Pereira (Rochester, US), R. Daly (Rochester, US), T. Munger (Rochester, US), R. Frantz (Rochester, US), M.G. Crespo-Leiro (La Coruña, ES) Balancing clinical need and resource utilization in ischemic heart disease: appropriateness criteria for selecting diagnostic tools and treatment options. – D. Holmes (Rochester, US) Summary remarks. – V. Mathew (Rochester, US) 4535 4536 4537 4538 4539 4540 TUESDAY – AFTERNOON 14:18 4534 “Sequelae of ischemic heart disease: ischemic heart failure” 16:05 16:07 16:22 16:37 16:52 17:07 17:27 4541 4542 4543 4544 4545 4546 4547 4548 275 TUESDAY, 30 AUGUST 2011 – AFTERNOON 14:00-15:30 | Rome - Zone B ADDRESSING GAPS IN PATIENT CARE: THE IMPORTANCE OF ANTICOAGULATION IN SECONDARY PREVENTION Chairperson(s): D.L. Bhatt (Newton, US); P.G. Steg (Paris, FR) Satellite Symposium organised by theheart.org / Medscape Education 14:00 14:05 14:30 14:55 15:20 Satellite Symposium Introduction. – D.L. Bhatt (Newton, US) Addressing the residual risk post ACS: can we reduce the gap. – P.G. Steg (Paris, FR) Combination therapy or triple antiplatelet therapy: the Importance of anticoagulation in secondary prevention. – C. Bode (Freiburg, DE) The overlap of the cardiovascular syndromes of AF-related stroke and atherothrombosis: managing the complex patient. – K.A.A. Fox (Edinburgh, GB) Conclusion remarks. – D.L. Bhatt (Newton, US) 4549 4550 4551 4552 4553 14:00-15:30 | Sofia - Zone B BAROREFLEX ACTIVATION THERAPY FOR THE TREATMENT OF RESISTANT HYPERTENSION AND HEART FAILURE Chairperson(s): E. Braunwald (Boston, US); A. Zanchetti (Milan, IT) Satellite Symposium organised by CVRx Inc. 14:00 14:10 14:25 14:50 15:05 15:15 15:27 Satellite Symposium Brief Introduction and history of the baroreflex as a therapeutic target for cardiovascular disease. – E. Braunwald (Boston, US) Carotid baroreflex physiology and baroreflex activation therapy mechanism of action. – A. Zanchetti (Milan, IT) Results of baroreflex activation therapy for hypertension. – P.W. De Leeuw (Maastricht, NL) Result of baroreflex activation therapy for heart failure. – H.N. Sabbah (Detroit, US) 2nd generation baroreflex activation therapy and ongoing clinical trials. – G. Hasenfuss (Göttingen, DE) Questions & answers. – E. Braunwald (Boston, US) Final remarks. – A. Zanchetti (Milan, IT) 4554 4555 4556 4557 4558 4559 4560 14:00-15:30 | Berne - Zone E PITAVASTATIN: NEW EFFECTIVE OPTION FOR CARDIOVASCULAR RISK REDUCTION Chairperson(s): J. Chapman (Paris, FR); J.J.P. Kastelein (Amsterdam, NL) Satellite Symposium organised by Recordati 14:00 14:05 14:25 14:45 15:05 15:25 276 Welcome. – J.J.P. Kastelein (Amsterdam, NL) Pitavastatin: a different pharmacology. – A. Catapano (Milan, IT) Which is the ideal statin for polymedicated patients. – C. Borghi (Bologna, IT) Pitavastatin and high-density lipoprotein: an added value. – J. Chapman (Paris, FR) Pitavastatin LIVES study. – J.J.P. Kastelein (Amsterdam, NL) Closing remarks. – J. Chapman (Paris, FR) Satellite Symposium 4561 4562 4563 4564 4565 4566 TUESDAY, 30 AUGUST 2011 – AFTERNOON 14:00-15:30 | Budapest - Zone E GUIDELINES IN CLINICAL PRACTICE – THE REALITY OF CARDIOVASCULAR RISK MANAGEMENT TODAY EBAC Accredited Educational Programme EBAC Accredited Educational Programme organised by the Sahlgrenska Academy - Gothenburg University Course Director: Prof. K. Swedberg (Gothenburg, SE) Chairperson(s): P.J. Barter (Sydney, AU); C.J. Packard (Glasgow, GB) 14:00 14:05 14:30 14:55 15:20 Introduction. – P.J. Barter (Sydney, AU) Counting the cost of poor adherence to cardiovascular disease prevention guidelines. – E. Bruckert (Paris, FR) Optimising cardiovascular disease risk management - Tailoring treatment to the patient. – L. Tokgozoglu (Ankara, TR) Future opportunities for cardiovascular disease prevention. – S.J. Nicholls (Cleveland, US) Summary. – C.J. Packard (Glasgow, GB) 4567 4568 4569 4570 4571 “This educational programme is accredited by the European Board for Accreditation in Cardiology (EBAC) for one hour of External CME credits. Each participant should claim only those hours of credit that have actually been spent in the educational activity. EBAC works in cooperation with the European Accreditation Council for Continuing Medical Education (EACCME), which is an institution of the European Union of Medical Specialists (UEMS).” Programme supported by an unrestricted educational grant from AstraZeneca 14:00-15:30 | Athens - Zone F 14:00 14:10 14:25 14:40 14:55 15:10 15:25 Satellite Symposium Welcome and introduction. – J.L. Zamorano Gomez (Madrid, ES) Oral anticoagulation in atrial fibrillation - Recent changes and open questions. – A.J. Camm (London, GB) Target or dose: are all the novel oral anticoagulants the same? – J. Weitz (Ontario, CA) From dose finding to ENGAGE AF - TIMI 48 - Why study two dosages of edoxaban in atrial fibrillation. – R.P. Giugliano (Boston, US) Future perspectives in oral anticoagulation for patients and physicians. – R. De Caterina (Chieti, IT) Panel discussion. – A.J. Camm (London, GB), R. De Caterina (Chieti, IT), R.P. Giugliano (Boston, US), J. Weitz (Ontario, CA), J.L. Zamorano Gomez (Madrid, ES) Closing. – A.J. Camm (London, GB) 4572 4573 4574 4575 4576 4577 4578 TUESDAY – AFTERNOON ORAL ANTICOAGULATION – NEW STRATEGIES TOWARD OPTIMIZED THERAPY Chairperson(s): A.J. Camm (London, GB); J.L. Zamorano Gomez (Madrid, ES) Satellite Symposium organised by Daiichi Sankyo Europe GmbH 14:00-15:30 | Belgrade - Zone F THERAPEUTIC OPTIONS FOR PULMONARY ARTERIAL HYPERTENSION IN 2011, THE START OF A NEW DECADE Chairperson(s): G. Simonneau (Clamart, FR); N. Galie (Bologna, IT) Satellite Symposium organised by Eli Lilly and Company 14:00 14:05 14:20 14:35 14:50 15:05 15:20 Satellite Symposium Introduction. – G. Simonneau (Clamart, FR) Appropriate diagnostic approach for pulmonary arterial hypertension. – A. Torbicki (Warsaw, PL) Learning from registries. – J.S.R. Gibbs (London, GB) Combination therapy for pulmonary arterial hypertension. – N. Galie (Bologna, IT) Long term efficacy of drugs approved for pulmonary arterial hypertension. – M.A. Gomez Sanchez (Pozuelo de Alarcon, ES) Future perspectives in pulmonary arterial hypertension therapy. – J.L. Vachiery (Brussels, BE) Q&A and closing remarks. – N. Galie (Bologna, IT), G. Simonneau (Clamart, FR), A. Torbicki (Warsaw, PL), J.S.R. Gibbs (London, GB), J.L. Vachiery (Brussels, BE), M.A. Gomez Sanchez (Pozuelo de Alarcon, ES) 4579 4580 4581 4582 4583 4584 4585 277 TUESDAY, 30 AUGUST 2011 – AFTERNOON 14:00-15:30 | Berlin - Zone F NEW ADVANCES FOR THE CARDIOVERSION OF RECENT ONSET ATRIAL FIBRILLATION Chairperson(s): J.-Y. Le Heuzey (Paris, FR); A. Capucci (Bologna, IT) Satellite Symposium organised by MSD 14:00 14:05 14:30 14:50 15:15 15:25 Satellite Symposium Welcome and opening remarks. – J.-Y. Le Heuzey (Paris, FR) RHYTHM-AF: a “real world” look at treatment patterns for recent onset atrial fibrillation. – H.J.G.M. Crijns (Maastricht, NL) Unmet needs for the management of recent onset atrial fibrillation and new perspectives on the guidelines for cardioversion of atrial fibrillation. – D. Atar (Oslo, NO) A new treatment option for the cardioversion of patients. – P. Kirchhof (Münster, DE) Panel discussion and questions and answers. – J.-Y. Le Heuzey (Paris, FR) Closing remarks. – A. Capucci (Bologna, IT) 4586 4587 4588 4589 4590 4591 14:00-15:30 | Paris - Zone F INNOVATIONS IN STROKE PREVENTION FOR ATRIAL FIBRILLATION: CLINICAL EVIDENCE AND INTERACTIVE CASE SCENARIOS Chairperson(s): F. Andreotti (Rome, IT); C.B. Granger (Durham, US) Satellite Symposium organised by BMS/Pfizer 14:00 14:05 14:25 14:40 15:00 15:25 Satellite Symposium Welcome and introduction. – F. Andreotti (Rome, IT) Risk assessment and therapeutic gaps in the practice of stroke prevention in atrial fibrillation (SPAF). – G.Y.H. Lip (Birmingham, GB) What have we learned from SPAF trials using antiplatelet agents? – J. Eikelboom (Hamilton, CA) What have we learned from SPAF trials using oral anticoagulants? – C.B. Granger (Durham, US) Audience interaction: challenges in clinical practice. – L.C. Wallentin (Uppsala, SE) Closing remarks. – C.B. Granger (Durham, US) 4592 4593 4594 4595 4596 4597 14:00-15:30 | Tunis - Zone F TARGETING THE EVIDENCE FOR TRIPLE ANTIPLATELET THERAPY IN HIGH-RISK ACUTE CORONARY SYNDROMES (ACS) PERCUTANEOUS CORONARY INTERVENTION (PCI): DEPLOYING BASIC SCIENCE IN CLINICAL PRACTICE Chairperson(s): J.-P. Collet (Paris, FR); H. Schuehlen (Berlin, DE) Satellite Symposium organised by Eli Lilly and Company 14:00 14:05 14:25 14:45 15:05 15:25 Satellite Symposium Introduction and welcome. – J.-P. Collet (Paris, FR) Know your enemy: understanding the science of thrombus formation. – J. Silvain (Paris, FR) Analysing the clinical intelligence: choosing the right antiplatelet combination for the right patient. – G. De Luca (Novara, IT) Strategies for treating high-risk ACS patients: decisions from the front line. – D. Fraser (Manchester, GB) Discussion. Closing remarks. – H. Schuehlen (Berlin, DE) 4598 4599 4600 4601 4602 14:15-15:35 | Hands-On Tutorial Room 1 - Zone B 3D GUIDED INTERVENTIONS FOR STRUCTURAL AND CORONARY HEART DISEASE Chairperson(s): G. Brockmann (Munich, DE); H. Rittger (Coburg, DE) Hands-On Tutorial organised by Siemens AG, Healthcare Sector (on-site registration) 278 Hands-On Tutorial TUESDAY, 30 AUGUST 2011 – AFTERNOON 15:30-16:30 | Moderated Posters - Poster Zone C (QR 361*) GLOBAL CARDIO-VASCULAR RISK AND BURDEN Chairperson(s): M.K. Mathew (Chennai, IN); K. Kotseva (London, GB) Moderated Posters Posters must be set up between 13:30 and 14:00, removed between 18:00 and 18:30 and be on display from 14:00 to 18:00.The following abstracts were chosen for their outstanding quality and will be discussed in a special area in the Poster hall during the Moderated Poster Session chaired by the two above-mentioned chairpersons between 15:30 and 16:30. 15:30 15:37 15:45 15:52 16:00 16:07 16:15 P4603 P4604 P4605 P4606 P4607 P4608 P4609 P4610 TUESDAY – AFTERNOON 16:22 Longitudinal trends in cardiovascular mortality and major cardiovascular risk factors in the Czech population between 1985 and 2007/8. Czech MONICA and Czech post-MONICA. – J. Bruthans, R. Cifkova, Z. Skodova, V. Adamkova, M. Jozifova, M. Galovcova, P. Wohlfart, J. Holub, V. Lanska (Prague, CZ) Twenty year trends in cardiovascular risk factors in India. – R. Gupta, S. Guptha, A. Agrawal, V.P. Gupta (Jaipur, IN) Clinical utility of standard lipids and apolipoproteins in relation to coronary heart disease events in the elderly. The three city study. – C. Straczek, H. Marti-Soler, C. Helmer, K. Ritchie, C. Tzourio, J.P. Empana (Paris, Villejuif, Bordeaux and Montpellier, FR) Ambulatory heart rate predicts cardiovascular and noncardiovascular outcome: Dublin outcome study. – L. Van Der Poel, E. Dolan, E.T. O’Brien (Dublin, IE) Economic burden of cardiovascular diseases in Russian Federation. – A. Kontsevaya, A. Kalinina (Moscow, RU) Galectin-3, cardiovascular risk factors, and outcome in the general population. – R.A. De Boer, D.J. Van Veldhuisen, R.T. Gansevoort, A. Muller Kobold, H.H.W. Sillje, W.H. Van Gilst, H.L. Hillege, S.J.L. Bakker, P. Van Der Harst (Groningen, NL) Adiponectin and long term mortality in coronary heart disease patients according to the severity of the disease. – S. Hascoet, M. Elbaz, V. Bongard, F. Bouisset, B. Perret, M. Galinier, D. Carrie, J. Ferrieres, J.B. Ruidavets (Toulouse, FR) The effects of air pollution on cardiovascular system: a systematic review of evidence. – B. Parapid, N. Milic, S. Jankovic, L.J. Markovic-Denic, V. Spiric-Tomic, Z. Gledovic, J. Marinkovic (Belgrade, RS) *Abstracts can be accessed at: QR 361 279 TUESDAY, 30 AUGUST 2011 – AFTERNOON 15:30-16:30 | Moderated Posters - Poster Zone C (QR 362*) LEFT ATRIAL MECHANICS BY ECHOCARDIOGRAPHY Chairperson(s): P. Colonna (Bari, IT); R.E. Ronderos (La Plata, AR) Moderated Posters Posters must be set up between 13:30 and 14:00, removed between 18:00 and 18:30 and be on display from 14:00 to 18:00.The following abstracts were chosen for their outstanding quality and will be discussed in a special area in the Poster hall during the Moderated Poster Session chaired by the two above-mentioned chairpersons between 15:30 and 16:30. 15:30 15:37 15:45 15:52 16:00 16:07 16:15 16:22 A comprehensive characterization of the normal murine left atrium: high frame rate echocardiographic study of morphology and function. – P. Barbier, U. Guerrini, M. Franzosi, L. Castiglioni, E. Nobili, F. Colazzo, T.M. Li Causi, L. Sironi, E. Tremoli (Milan, IT) Evaluation of the left atrial appendage with real-time three-dimensional transesophageal echocardiography: implications for catheter-based left atrial appendage closure. – G. Nucifora, F. Faletra, F. Regoli, E. Pasotti, G. Pedrazzini, T. Moccetti, A. Auricchio (Lugano, CH) Strain and strain rate evaluation of atrial phasic function in normal aging. – A. Boyd, D.A.B. Richards, T. Marwick, L. Thomas (Sydney, AU; Cleveland, US) Left ventricular longitudinal systolic function and arterial stiffness are the main determinants of left atrial function in patients with risk factors. – R. Dulgheru, A. Ciobanu, S. Magda, R.C. Rimbas, A.D. Margulescu, S. Mihaila, M. Cinteza, D. Vinereanu (Bucharest, RO) Prediction of left atrial booster pump function by tissue Doppler late diastolic myocardial velocity from septal mitral annulus. – M. Masuda, K. Iwakura, A. Okamura, Y. Koyama, K. Inoue, M. Date, Y. Higucgu, K. Fujii (Osaka, JP) Atrial mechanical function as a predictor of recurrent attack in patient with paroxysmal atrial fibrillation. – J. Yoon, J. Moon, J.Y. Kim, P.K. Min, B.K. Lee, B.K. Hong, S.J. Rim, H.M. Kwon (Seoul, KR) The left atrial filling 2D speckle strain rate is biphasic: implications for a correct interpretation of atrial physiology. – P. Barbier, C. Cefalu’, G. Berna (Milan, IT) Atrial mechanical function than LA size, as a predictor of recurrence in patient with paroxysmal atrial fibrillation. – J. Yoon, J. Moon, J.Y. Kim, P.K. Min, Y.W. Yoon, B.K. Lee, B.K. Hong, S.J. Rim, H.M. Kwon (Seoul, KR) P4611 P4612 P4613 P4614 P4615 P4616 (W) P4617 P4618 16:00-17:20 | Hands-On Tutorial Room 1 - Zone B CARDIAC MAGNETIC RESONANCE IMAGING IN CARDIOMYOPATHIES Chairperson(s): G. von der Recke (Bonn, DE) Hands-On Tutorial organised by Siemens AG, Healthcare Sector (on-site registration) Hands-On Tutorial 16:00-17:30 | Hands-On Tutorial Room 3 - Zone B IMPROVING CARDIAC CARE BY PATIENT-SPECIFIC MODELING – FOCUS ON CARDIAC Hands-On Tutorial RESYNCHRONIZATION THERAPY Chairperson(s): R. Razavi (London, GB); J. Weese (Hamburg, DE); M. Sermesant (Sophia Antipolis, FR) Hands-On Tutorial organised by Philips Healthcare (on-site registration) 16:00-17:30 | Berlin - Zone F NEW ADVANCES IN CARDIOVASCULAR RISK REDUCTION IN HIGH-RISK PATIENTS Chairperson(s): J.J.P. Kastelein (Amsterdam, NL); C. Baigent (Oxford, GB) Satellite Symposium organised by MSD 16:00 16:05 16:20 16:40 17:00 17:15 17:25 Welcome and opening remarks. – J.J.P. Kastelein (Amsterdam, NL) Unmet medical need in the treatment of high-risk patient populations. – J.J.P. Kastelein (Amsterdam, NL) Insights from the SHARP study results. – C. Baigent (Oxford, GB) Effective treatment options with add-on or combination therapy. – M. Davidson (Chicago, US) Patient case studies discussion: therapeutic choices in high-risk patients. – D. Mueller-Wieland (Dusseldorf, DE) Panel discussion an Q&A. – J.J.P. Kastelein (Amsterdam, NL) Closing remarks. – J.J.P. Kastelein (Amsterdam, NL) *Abstracts can be accessed at: 280 QR 362 Satellite Symposium 4619 4620 4621 4622 4623 4624 4625 TUESDAY, 30 AUGUST 2011 – AFTERNOON 16:30-18:00 | Belgrade - Zone F 16:30 16:35 17:00 17:25 17:50 Satellite Symposium Welcome & introduction. – A.J. Camm (London, GB) Chronic stable angina: a well-treated condition or one requiring new therapeutic strategies? – J.L. Lopez-Sendon (Madrid, ES) The role of the late sodium current as a new target in ischaemic heart disease. – A. Zaza (Milan, IT) European management of ischaemic heart disease - Evolving targets for personalised treatment. – A.J. Camm (London, GB) Conclusions & summary. – J.L. Lopez-Sendon (Madrid, ES) 4626 4627 4628 4629 4630 TUESDAY – AFTERNOON A NEW PARADIGM IN THE TREATMENT OF ISCHAEMIC HEART DISEASE Chairperson(s): A.J. Camm (London, GB); J.L. Lopez-Sendon (Madrid, ES) Satellite Symposium organised by MENARINI 281 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS 14:00-18:00 | Posters - Poster Zone C POSTER SESSION 6 Poster Session Posters must be set up between 13:30 and 14:00, removed between 18:00 and 18:30 and be on display from 14:00 to 18:00.The presenter should be present throughout the coffee break (15:30 to 16:30) in order to discuss the Poster. THE CHANGING STRUCTURE OF THE GROWING HEART (QR 30601*) Creating mouse embryonic stem cell-derived cardiomyocyte sheet using three-dimensional bioreactor cultivation system. – K. Matsuura, T. Shimizu, J.K. Yakashita, N. Hagiwara, T. Okano (Tokyo and Kyoto, JP) Interaction of TGF-beta-receptor 1 kinase and mechanical stress determine cardiac fibroblast differentiation and myofibroblast dedifferentiation. – R.B. Driesen, J. Abi-Char, R. Fagard, K.R. Sipido, V.V. Petrov (Leuven, BE) The cardiac beta-catenin interaction partner four-and-a-half LIM protein 2 (FHL2) promotes cardiac differentiation in vitro. – A. Renger, C. Noack, M.P. Zafiriou, R. Dietz, M.W. Bergmann, L. Zelarayan (Göttingen, Berlin and Hamburg, DE) Electrical stimulation for cardiac bioengineering with subcutaneous and cardiac adipose-tissue derived progenitor cells (ATDPCs). – A. Llucia-Valldeperas, B. Sanchez, C. Soler-Botija, S. Roura, C. Prat-Vidal, C. Galvez-Monton, R. Bragos, A. Bayes-Genis (Badalona and Barcelona, ES) Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation. – A. Bondue, S. Tannler, G. Chiapparo, S. Chabab, M. Ramialison, C. Paulissen, B. Beck, R. Harvey, C. Blanpain (Brussels, BE; Darlinghurst, AU) Specifically designed, bioactive nanofiber-matrix supports cell-based therapy in ischemic tissue repair. – J. Tongers, M.J. Webber, M.-A. Renault, J.G. Roncalli, E. Klyachko, T. Thorne, J. Bauersachs, S.I. Stupp, D.W. Losordo (Hannover, DE; Evanston and Chicago, US) Ion channel and cardiac ontogeny of human cardiomyocytes derived from vector-free induced pluripotent stem cells. – W. Shim, A. Mehta, Y.Y. Chung, A. Ng, H.M. Wei, G. Dusting, W. Sun, P. Wong (Singapore, SG; Melbourne, AU) Molecular patterning of the arterial pole of the mouse heart. – P. Parisot, M. Theveniau-Ruissy, R. Kelly (Marseille, FR) Cardiac-specific RNAi knockdown of Abra disrupts heart function and decreased lifespan in Drosophila melanogaster. – K.L. Beaumont, E. Rosato, N.W. Chong (Leicester, GB) Murine alternatively spliced tissue factor is not sufficient for embryonic development and does not trigger coagulation. – S.H.M. Sluka, A. Akhmedov, J. Vogel, T.F. Luscher, F.C. Tanner (Zurich, CH) Notch 1 mutations in patients with aortic aneurysm and bicuspidal valve. – O. Freylikhman, A. Malashicheva, T. Tatarinova, N. Tsoy, O. Irtyuga, O. Moiseeva, A. Kostareva, E. Shlyakhto (Saint-Patersburg, RU) Heterogeneity of global gene expression profiles between endocardial and epicardial normal myocardium diminishes in canine failing hearts. – K.D. Min, M. Asakura, H. Asanuma, S. Ito, A. Takahashi, H. Sasaki, H. Takahama, S. Yamazaki, N. Mochizuki, M. Kitakaze (Osaka and Kyoto, JP; Baltimore, US) Vasculogenic recruitment switch is activated in idiopathic dilated cardiomyopathy. – S. Roura Ferrer, C. Galvez-Monton, J.M. Pujal Reyes, C. Prat-Vidal, C. Soler-Botija, A. Llucia-Valldeperas, A. Bayes-Genis (Badalona, ES) A comprehensive characterization of the normal murine left atrium: anatomy and histology. – L. Castiglioni, E. Nobili, F. Colazzo, M. Franzosi, T.M. Li Causi, U. Guerrini, L. Sironi, E. Tremoli, P. Barbier (Milan, IT) Novel cardiovascular quantitative trait loci in a rat intercross. – R. Ahmed, P. Muckett, S. Cook (London, GB) P4631 P4632 P4633 (W) P4634 P4635 P4636 P4637 P4638 P4639 P4640 P4641 P4642 P4643 P4644 P4645 THE MANY FACETS OF REGENERATION (QR 30602*) Increasing the efficacy of myocardial gene therapy with an intra-aortic balloon pump in a large animal model of heart failure. – D. Ladage, L. Tilemann, K. Ishikawa, C. Kho, A. Lee, R.J. Hajjar, Y. Kawase (New York, US) Influence of non-cardiomyocytes on persistence and survival of rat neonatal cardiomyocytes after injection into infarcted syngeneic hearts. – B. Krausgrill, S. Oeckenpoehler, M. Maass, M. Raths, M. Halbach, K. Schenk, J. Hescheler, J. Mueller-Ehmsen (Cologne, DE) *Abstracts can be accessed at: 282 QR 30601 QR 30602 P4646 P4647 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Atorvastatin improves effects of transplanted mesenchymal stem cells through AMP-activated protein kinase in post-infarcted porcine hearts. – Q.-T. Dong, Y.-J. Yang, L. Song, H.-Y. Qian (Beijing, CN) Connexin 43 expression is essential for functional cardiomyogenic differentiation of human fetal mesenchymal stem cells. – A.A. Ramkisoensing, D.A. Pijnappels, J. Swildens, M.J. Schalij, A.A.F. De Vries, D.E. Atsma (Leiden, NL) Mesenchymal stem cells modulate the immune response and ameliorate cardiac dysfunction in a mouse model of acute coxsackie virus B3-induced myocarditis. – K. Savvatis, S. Van Linthout, D. Westermann, J. Schefold, A. Weithaeuser, P.M. Becher, H.P. Schultheiss, C. Tschoepe (Berlin, DE) Intracoronary delivery of allogeneic mesenchymal precursor cells directly after acute myocardial infarction decreases infarct size and improves cardiac function in sheep. – H.J. Houtgraaf, R. De Jong, D. De Groot, I. Hoeffer, G. Pasterkamp, H.J. Duckers (Rotterdam and Utrecht, NL) Cardiopoietic mesenchymal stem cells for treatment of ischemic cardiomyopathy: first-in-man phase II multicentre clinical trial. – J. Bartunek, D. Dolatabadi, M. Vanderheyden, J. Dens, M. Ostojic, A. Behfar, S. Henry, M. Tendera, S. Waldman, A. Terzic (Aalst, Charleroi, Genk and Mont-Saint-Guibert, BE; Belgrade, RS; Rochester and Philadelphia, US; Katowice, PL) Therapeutic lymphangiogenesis with implantation of adipose-derived regenerative cells. – Y. Shimizu, S. Shintani, R. Shibata, Y. Izumi, Y. Ogura, M. Ishii, T. Murohara (Nagoya, JP) Selected CD133+ endothelial progenitor cells to create angiogenesis in no-option patients. The design of the PROGENITOR randomized trial. – P. Jimenez-Quevedo, J. Gonzalez Ferrer, L. Llorente, M. Sabate, X. Garcia Moll, R. Hernandez-Antolin, N. Gonzalo, C. Banuelos, M. Del Trigo, C. Macaya (Madrid and Barcelona, ES) MicroRNA126 is secreted in microvesicles from CD34 stem or progenitor cells and is critical for their proangiogenic capacity - down-regulation in patients with type-2 diabetes. – P. Mocharla, S. Briand, G. Giannotti, C. Doerries, T.F. Luescher, U. Landmesser (Zurich, CH; Pisa, IT) Mobilization of Oct4+ very small embryonic-like cells induced by physical exercise in patients with coronary artery disease. – W. Wojakowski, B. Machalinski, M. Kotowski, E.K. Zuba-Surma, M. Kazmierski, M. Kucia, E. Nabialek, S. Dworowy, M.Z. Ratajczak, M. Tendera (Katowice, Szczecin and Krakow, PL; Louisville, US) Targeted positioning of endothelial progenitor cells to the injured mouse carotid artery using magnetic nanoparticles. – M.U. Becher, K. Zimmermann, D. Wenzel, B.K. Fleischmann, G. Nickenig, N. Werner, A. Pfeifer (Bonn, DE) Ex vivo priming of late outgrowth endothelial progenitor cells with erythropoietin before transplantation enhances their angiogenic potential and requires the CD131 receptor subunit. – G. Sarlon, Y. Bennis, F. Sabatier, M. Clot-Chabot, F. Dignat-George, B. Guillet, P. Pisano (Marseille, FR) Dynamics of active and passive contribution of stem cell scaffolding in cardiomyoplasty for post myocardial infarction. – W. Shim, L. Qian, Y.C. Gu, M.S. Atan, K.P. Lim, L.P. Tan, C.H. Lim, Y.K. Sin, P. Wong (Singapore, SG) P4648 P4649 P4650 P4651 P4652 P4653 P4654 P4655 P4656 P4657 P4658 P4659 STEM CELLS – DO ALL ROADS LOAD TO REGENERATION? (QR 30603*) *Abstracts can be accessed at: P4660 P4661 P4662 TUESDAY – AFTERNOON LQTS2 modelling with patient-specific induced pluripotent stem cell -derived cardiomyocytes. – V.J. Kujala, A.L. Lahti, K. Aalto-Setala (Tampere, FI) The role of microRNA-145 in the differentiation of human embryonic stem cells into smooth muscle cells. – K. Yamahara, S. Yamaguchi, K. Homma, H. Itoh (Osaka and Tokyo, JP) Central role of cardiomyocytes in cell therapy: transplantation of cardiac tissue sheets with defined cell populations from pluripotent stem cells. – H. Masumoto, T. Shimizu, T. Ikeda, T. Okano, R. Sakata, J.K. Yamashita (Kyoto and Tokyo, JP) Excitation propagation in cardiac cell monolayer derived from human pluripotent stem cells. – S. Kadota, I. Minami, K. Agladze, N. Nakatsuji (Kyoto, JP) Induced pluripotent stem cell derived cardiomyocytes integrate electrically after transplantation in murine hearts. – G. Peinkofer, M. Halbach, S. Baumgartner, B. Krausgrill, A. Fatima, T. Saric, J. Hescheler, J. Mueller-Ehmsen (Cologne, DE) Transendocardial cell injection is not superior compared with intracoronary infusion in a porcine model of chronic ischemic heart disease: a randomized study imaging labelled cells. – T. Van Der Spoel, K.V. Vrijsen, F. Nijsen, J.P.G. Sluijter, J. Bemelmans, M.J.M. Cramer, I. Hoefer, P.A.F.M. Doevendans, E. Van Belle, S.A.J. Chamuleau (Utrecht, NL) Effect of intracoronary injection of mononuclear bone marrow cells on electrocardiographic parameters in patients after acute myocardial infarction: two year follow-up study. – E. Trzos, J.D.K. Kasprzak, T.R. Rechcinski, M.K.-P. Krzeminska-Pakula, K.W.-D. Wierzbowska-Drabik, B.U. Uznanska, U.C.-G. Cieslik-Guerra, M.K. Kurpesa (Lodz, PL) Exercise capacity, arrhythmic risk profile and pulmonary function is not influenced by bone marrow stem cells i.c. infusion in patients with acute myocardial infarction. – M. Popiel, E. Straburzynska-Migaj, P. Breborowicz, S. Grajek, A. Katarzynska-Szymanska, M. Lesiak, L. Gil, A. Czyz, K. Sawinski, M. Kozlowska-Skrzypczak (Poznan, PL) P4663 P4664 P4665 P4666 P4667 QR 30603 283 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Effect of autologous 5-azacytidine-cultured bone-marrow stem cells on perfusion and left ventricular function in patients with heart failure. – T.M. Belyavskaya, E.A. Scridlevskaya, A.G. Konoplyannikov, L.E. Samoilenko, V.B. Sergienko, R.S. Akchurin (Moscow and Obninsk, RU) Subpopulations of c-kit+ HSC display differences in proliferation potential and gene expression pattern after CFU assay. – P. Mark, A. Toelk, C.A. Lux, A. Skorska, E. Pittermann, D. Scharfenberg, W. Li, N. Ma, G. Steinhoff (Rostock, DE) Perivascular administration of mesenchymal stem cells from bone marrow inhibits neointimal formation in a paracine fashion in rat carotid arteries. – Y. Iso, S. Yamaya, J. Spees, Y. Takeyama, H. Suzuki (Yokohama, JP; Vermont, US) Intramyocardial bone marrow cell injection in patients with chronic myocardial ischemia: results long term follow-up. – S.F. Rodrigo, J. Van Ramshorst, S.L. Beeres, P. Dibbets-Schneider, M.P.M. Stokkel, J.J. Zwaginga, E.E. Van Der Wall, M.J. Schalij, J.J. Bax, D.E. Atsma (Leiden, NL) Essential, but not differential role of CXCR7 and CXCR4 on platelet-derived SDF-1-mediated adhesion of human CD34+ cells in vitro and after vascular injury in vivo. – V. Panagiota, K. Sopova, A. Perk, A. Paul, M. Gawaz, K. Stellos (Tübingen, DE) Functional restoration of hyperglycemia-exposed bone marrow stem cells by oxytocin. – Y.S. Kim, Y. Ahn, S.M. Kwon, S.H. Lee, J.H. Kim, M.H. Jeong, J.G. Cho, J.C. Park, J.C. Kang (Gwangju and Pusan, KR) Intracoronary bone marrow derived CD34+ cells improve left ventricular function in patients with severe dilated cardiopathy. – J. Bartolucci, F. Figueroa, F. Carrion, R. Lamich, P. Pedreros, C. Carvallo, P. Sanhueza, E. Abarzua, C. Goset, C. Nazzal (Santiago, CL) Cardiomyocyte damage-released extracellular S100A1 protein promotes regeneration of infarcted myocardium by enhanced egress of bone marrow-derived progenitor cells. – D. Rohde, G. Qiu, N. Herzog, H.A. Katus, K. Peppel, P. Most (Heidelberg, DE; Philadelphia, US) Bone marrow stem-cell therapy for idiopathic dilated cardiomyopathy. – J. Suarez De Lezo, M. Romero, M. Pan, M.D. Carmona, J. Segura, S. Nogueras, J. Suarez De Lezo Jr, F. Mazuelos, D. Mesa, I. Herrera (Córdoba, ES) Identification of BMSP-1 by bioinformatic secretome analysis as a novel cardioprotective protein produced by human CXCR4+ bone marrow cells. – M. Korf-Klingebiel, T. Brod, C. Willenbockel, K.C. Wollert (Hannover, DE) Human relevance of pre-clinical studies in stem cell therapy; overview and meta-analysis of large animal models of ischemic heart disease. – T. Van Der Spoel, S.J. Jansen Of Lorkeers, P. Agostoni, E. Van Belle, M. Gyongyosi, J.P.G. Sluijter, M.J.M. Cramer, P.A.F.M. Doevendans, S.A.J. Chamuleau (Utrecht, NL; Vienna, AT) Matrix metalloproteinases and transforming growth factor beta gene expression - an interaction of proand antiatherosclerotic factors in acute coronary syndromes. – A. Kulach, J. Dabek, Z. Gasior (Katowice, PL) P4668 P4669 P4670 P4671 P4672 P4673 P4674 P4675 P4676 P4677 P4678 P4679 NOVEL IMAGING APPROACHES TO MYOCARDIAL FUNCTION (QR 30604*) Endothelin and N-terminal pro-B type natriuretic peptide reflect impaired right ventricular function and decreased exercise capacity in patients with systemic sclerosis. – M. Ciurzynski, P. Bienias, K. Irzyk, Z. Rymarczyk, M. Kostrubiec, A. Szewczyk, M. Siwicka, Z. Bartoszewicz, U. Demkow, P. Pruszczyk (Warsaw, PL) Effect of multiple pacing sites on left ventricular function. experimental study. – S. Toumanidis, A. Kaladaridis, D. Bramos, E. Skaltsiotes, G. Kottis, A. Antoniou, I. Agrios, D. Takos, I. Mathew, N. Vasiladiotis (Athens, GR) Effects of continuous positive airway pressure on cardiac remodeling in obstructive sleep apnea as assessed by cardiac biomarkers, echocardiography and cardiac MRI. – D. Jassal, J. Colish, J.R. Walker, N. Elmayergi, M. Lytwyn, A. Francis, S. Bohonis, M. Zeglinski, I.D. Kirkpatrick, S. Sharma (Winnipeg, CA) Correlations between left atrial volume index and echocardiographic parameters of increased filling pressure after acute myocardial infarction in hypertensive patients. – R. Musetescu, D. Toader, E.A. Belu, A.E. Musetescu, M. Popescu, D.D. Ionescu (Craiova, RO) Reduced segmental left ventricular systolic strain after anthracycline chemotherapy. – P.W. Stoodley, D. Richards, A. Boyd, R. Hui, P. Harnett, S. Meikle, J. Clarke, L. Thomas (Sydney, AU) Quantitative assessment of left ventricular function by 2D-speckle tracking during exercise: a feasibility study. – C. Szymanski, M. Campana, J. Magne, M. Rosca, L. Pierard, P. Lancellotti (Liège, BE; Brescia, IT) Longitudinal global strain: a new surrogate of systolic function in myocardial infarction. – S. Pires, N. Cortez-Dias, L. Santos, S. Ribeiro, D. Silva, C. Jorge, P. Carrilho, J. Silva Marques, M.G. Lopes, F.J. Pinto (Lisbon, PT) Assessment of left ventricular function by real-time three-dimensional speckle tracking echocardiography compared to magnetic resonance imaging. – C. Bremont, L. Macron, D. Hayat, J. Nahum, A. Bensaid, J.L. Dubois-Rande, P. Gueret, P. Lim (Créteil, FR) *Abstracts can be accessed at: 284 QR 30604 P4680 P4681 P4682 P4683 P4684 P4685 P4686 P4687 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Analysis of right ventricular dimensions and function after tricuspid valvuloplasty concomitant with complex left-sided heart surgery. – G. Koppers, R. Reyskens, W. Mullens, P.M. Vandervoort, J. Dens, H. Gutermann, C. Van Kerrebroeck, R. Dion, D. Verhaert (Hasselt and Genk, BE) Deterioration of right ventricular myocardial systolic function in monocrotaline-induced pulmonary arterial hypertension canine model: echocardiographic evaluation by 2D speckle tracking. – S. Nishio, H. Yamada, R. Tamai, K. Endo, S. Hayashi, K. Kusunose, T. Soeki, T. Wakatsuki, Y. Sakai, M. Sata (Tokushima and Osaka, JP) Advanced echocardiographic imaging for the evaluation of right ventricular function in pulmonary hypertension. – S. Pica, S. Ghio, G. Tonti, L. Scelsi, C. Raineri, R. Camporotondo, A. Pazzano, L. Oltrona Visconti (Pavia and L’Aquila, IT) Assessment of right ventricular longitudinal peak systolic strain measurement in the subcostal view: feasibility and validation in patients with suspected pulmonary hypertension. – M.L.A. Haeck, R.W.C. Scherptong, M.L. Antoni, N. Ajmone Marsan, H.W. Vliegen, E.R. Holman, M.J. Schalij, J.J. Bax, V. Delgado (Leiden, NL) Right ventricular dysfunction in patients with end-stage renal disease. – D. Benzarouel, M. El Hattaoui (Marrakech, MA) Acute effect of passive smoking on pulmonary stiffness and right ventricular function in young healthy volunteers. – M.G. Kaya, M. Yarlioglues, N. Kalay, I. Gul, I. Ozdogru (Kayseri, TR) Early and medium-term evolution of right ventricular function in patients with severe aortic valve stenosis after transcatheter aortic valve implantation. – M. Delgado Ortega, M.D. Mesa Rubio, M. Ruiz Ortiz, M.L. Pena Pena, M. Santisteban Sanchez De Puerta, J. Suarez De Lezo Cruz-Conde, M. Pan Alvarez-Osorio, S. Ojeda Pineda, J. Suarez De Lezo Herrero De Tejada, F. Mazuelos Bellido (Córdoba, ES) Left ventricular function in hypertension: new insight by speckle tracking echocardiography. – C. Zito, E. Imbalzano, A. Saitta, G. Oreto, M. Cusma-Piccione, G. Di Bella, R. Nava, M. Ferro, E. Alati, S. Carerj (Messina, IT) Difference in right ventricular adaptation to afterload between patients with pulmonary hypertension in mild stage and patients with left-sided heart failure. – S. Fuke, K.F. Kusano, M. Tanaka, A. Ogawa, S. Nagase, K. Nakamura, T. Sato, T. Ujihira, H. Ito (Okayama, JP) Effect of age, gender and ethnicity on LV rotation and torsion in healthy individuals. – J.P. Sun, R. Guo, X.S. Yang, F. Fang, Y.Y. Lam, P.W. Lee, C.M. Yu (Hong Kong, HK) Noninvasive assessment of myocardial fiber orientation using echocardiography-based shear wave imaging. – W.-N. Lee, M. Pernot, M. Couade, A. Bel, P. Bruneval, A.A. Hagege, M. Fink, M. Tanter, E. Messas (Paris, FR) Quantitative assessment of myocardial stiffness using shear wave imaging in normal and hypertrophic isolated rat hearts. – M. Pernot, M. Couade, P. Mateo, B. Crozatier, R. Fischmeister, M. Tanter (Paris and Chatenay-Malabry, FR) P4688 P4689 P4690 P4691 P4692 P4693 P4694 P4695 P4696 P4697 P4698 P4699 APPROPRIATENESS OF IMAGING (QR 30605*) *Abstracts can be accessed at: P4700 P4701 TUESDAY – AFTERNOON Cardiovascular screening by pocket-sized ultrasound among patients admitted to cardiac department at a Norwegian non-university hospital. – K. Skjetne, T. Graven, J.O. Kleinau, B.O. Haugen, H. Dalen (Levanger and Trondheim, NO) Pocket sized echo: effectiveness for ward based transthoracic studies. – S. Gianstefani, N. Catibog, A. Whittaker, A. Douiri, J.A. Reiken, M.J. Monaghan (London, GB) Value of computed tomography coronary angiography in the triage of acute chest pain in the emergency department. – G. Pires De Morais, N. Bettencourt, G. Silva, N. Ferreira, M. Carvalho, D. Leite, J. Rocha, C. Fonseca, V. Gama Ribeiro (Vila Nova de Gaia, PT) CT coronary angiography in asymptomatic high risk patients. – L.A. Neefjes, G.J.R. Ten Kate, A. Rossi, K. Nieman, J.M.H. Galema-Boers, E.J.G. Sijbrands, G.P. Krestin, N.R. Mollet, P.J. De Feyter (Rotterdam, NL) The use of CT coronary angiography in a community rapid access chest pain clinic. – G. Koulaouzidis, A. Powell, K. Wong, T. McArthur, C. Metcalf, J. Hill, K. Manis, P.J. Jenkins, D. Brennand-Roper (London, GB) How accurate are stress tests in predicting specific areas of ischemia? – A. Rajamanickam, S. Kapadia, T. Catacutan, A. Chadi, A. Satra, M. Nasif, S. Butler, S. Ellis, J.B. Young, M. Cerqueira (Newark and Cleveland, US) Incremental value of non-invasive stress testing on the diagnostic yield of invasive coronary angiography. – R. Buechel, M.J. Zellweger (Basel, CH) Appropriateness of echocardiography requests in the hospital setting: results from a multicenter evaluation in the Florence area, Italy. – P. Ballo, F. Bandini, L. Chiodi, A. Fortini, R. Laureano, M. Milli, G. Nenci, G.M. Santoro, P. Vannelli, A. Zuppiroli (Florence, Borgo San Lorenzo and Figline Valdarno, IT) P4702 P4703 P4704 P4705 P4706 P4707 (W) QR 30605 285 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS CORONARY AND CAROTID ATHEROSCLEROSIS (QR 30606*) Coronary risk factors and myocardial blood flow in patients evaluated for coronary artery disease: a quantitative [15O]H2O PET/CT study. – I. Danad, P.G. Raijmakers, Y.E. Appelman, H.J. Harms, S. De Haan, C. Van Kuijk, O.S. Hoekstra, A.A. Lammertsma, A.C. Van Rossum, P. Knaapen (Amsterdam, NL) Quantitative evaluation of coronary in-stent restenoses with emstone high-definition CT in comparison with quantitative coronary angiography and Intra-vascular ultrasound: preliminary results. – D. Andreini, G. Pontone, S. Mushtaq, A. Bartorelli, D. Trabattoni, E. Bertella, E. Conte, G. Ballerini, M. Pepi (Milan, IT) Anatomical versus functional severity of coronary artery stenoses using coronary computed tomography angiography and myocardial perfusion imaging. – H. Fukuda, M. Moroi, H. Masai, T. Kunimasa, R. Nakazato, T. Furuhashi, K. Sugi (Tokyo, JP) Impact of microalbuminuria on the characteristics of coronary plaques using computed tomography angiography in diabetic patients. – A. Sato, Y. Kakefuda, T. Adachi, E. Ojima, H. Watabe, A. Atsumi, T. Kimura, T. Hoshi, K. Aonuma (Tsukuba, JP) Efficacy on cardiac function in percutaneous coronary intervention for chronic total occlusions analyzed by echocardiography. – H. Takimura, T. Muramatsu, R. Tsukahara, Y. Ito, T. Sakai, H. Ishimori, K. Hirano, M. Nakano, M. Yamawaki, M. Araki (Yokohama, JP) Transthoracic coronary flow reserve stratifies outcomes in patients with intermediate or equivocal left main coronary artery disease. – A. Djordjevic-Dikic, M. Tesic, J. Stepanovic, V. Giga, M. Dobric, B. Beleslin, I. Paunovic, I. Jovanovic, D. Zamaklar-Trifunovic, M. Ostojic (Belgrade, RS) Neointimal hyperplasia is enhanced at fracture site in sirolimus-eluting stents as assessed by optical coherence tomography. – M. Kashiwagi, A. Tanaka, H. Kitabata, K. Komukai, T. Tanimoto, Y. Ino, K. Hirata, M. Mizukoshi, T. Imanishi, T. Akasaka (Wakayama, JP) High pressure post-dilatation procedure may induce neointimal coverage on sirolimus-eluting stent struts. – M. Taniike, M. Nishino, T. Yoshimura, D. Nakamura, N. Makino, H. Kato, Y. Egami, R. Shutta, J. Tanouchi, Y. Yamada (Sakai, JP) Optical coherence tomography in combination with intracoronary thermography for the detection of functional and morphological characteristics of culprit lesions in patients with ACS. – M. Riga, K. Toutouzas, A. Karanasos, E. Tsiamis, A. Synetos, A. Michelongona, M. Drakopoulou, C. Stefanadis (Athens, GR) Calculation the translesional pressure gradients on coronary stenosis by combining three-dimensional coronary angiography parameters with frame count data. – B. Tar, P. Lugosi, S. Ember, M. Svab, J. Santa, Z. Beres, S. Bakk, R. Kolozsvari, P. Polgar, Z. Koszegi (Nyíregyháza and Debrecen, HU) Value of intravascular ultrasound in borderline left main stenosis. Analysis of 159 consecutive lesions. – D.H. Koschyk, F. Markworth, Y. Von Kodolitsch, R. Koester, B. Goldmann, S. Willems, J. Kaehler, H. Reichenspurner, T. Meinertz, S. Baldus (Hamburg, DE) Tissue characterization of in-stent neointima using integrated backscatter intravascular ultrasound;Comparison with optical coherence tomography. – K. Sato, H. Takebayashi, K. Goto, S. Kodama, M. Taniguchi, Y. Kikuta, Y. Fujiwara, S. Hiramatsu, S. Haruta (Fukuyama, JP) Clinical presentations of acute coronary syndrome related to the lesion pathophysiology assessed by intravascular ultrasound and optical coherence tomography. – M. Kato, K. Dote, S. Sasaki, E. Kagawa, Y. Nakano, M. Kajikawa, A. Higashi, K. Itakura (Hiroshima, JP) Diagnosis of subtle type A aortic dissection using transesophageal echocardiography. – J. Albers, L.O. Conzelmann, C.-F. Vahl (Mainz, DE) Integrated ultrasound study as a gatekeeper for coronary and carotid atherosclerosis. – F. Rigo, N. Gaibazzi, P.C. Ballo, A. Moreo, C. Giannattasio, E. Grolla, C. Palombo (Mestre-Venice, Parma, Florence, Milan and Pisa, IT) Subclinical arteriosclerotic change in patients with diabetes or hypertension who have normal intima-media thickness on carotid ultrasound. – S.A. Kim, S.H. Jo, H.S. Kim, S.J. Han, W.J. Park, C.Y. Rhim, J.-W. Ha (Anyang-Si, Gyeonggi-Do and Seoul, KR) Potential role of low kV ex vivo micro-CT for 3D morphometry of paraffin embedded coronary vessels before histology. – D. Panetta, C. Kusmic, G. Pelosi, F. Viglione, A. Del Guerra, A. L’Abbate, P.A. Salvadori (Pisa, IT) Uptake of aluminium phtalocyanine in endarterectomy carotid plaques in human: study in vitro. – Y.U.E. Efremova, G.N. Soboleva, E.R. Andreeva, N.V. Radukhina, E.M. Tararak, Y.U.A. Karpov (Moscow, RU) *Abstracts can be accessed at: 286 QR 30606 P4708 P4709 P4710 P4711 P4712 P4713 P4714 P4715 P4716 P4717 P4718 P4719 P4720 P4721 P4722 P4723 P4724 P4725 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Trends in baseline carotid intima-media thickness (cIMT) and LDL-C levels in statin LDL-C lowering studies during 1988-2008. – M.H. Davidson, Q. Dong, J.E. Tomassini, D. Neff, A.B. Polis, A.M. Tershakovec (Chicago and Whitehouse Station, US) Noninvasive assessment of carotid plaque inflammation: first clinical application of microwave radiometry. – A. Synetos, M. Drakopoulou, K. Toutouzas, H. Nikolaou, K. Stathogiannis, A. Michelongona, E. Tsiamis, C. Grassos, E. Siores, C. Stefanadis (Athens, GR; Bolton, GB) P4726 P4727 DETECTION AND QUANTIFICATION OF ATHEROSCLEROTIC BURDEN (QR 30607*) *Abstracts can be accessed at: P4728 P4729 P4730 P4731 P4732 P4733 P4734 P4735 P4736 P4737 P4738 P4739 TUESDAY – AFTERNOON Carotid plaque score versus coronary artery calcium score in the prediction of cardiovascular event in patients with diabetes mellitus. – N. Yokoyama, R. Iino, K. Konno, T. Isshiki (Tokyo, JP) Family history of early cardiovascular disease is associated with carotid atherosclerosis in patients with familial hypercholesterolemia. – C. Masoura, C. Pitsavos, K. Aznaouridis, I. Skoumas, C. Vlachopoulos, K. Psarros, V. Metaxa, K. Liontou, C. Stefanadis (Athens, GR) Prevalence and predictors of asymptomatic carotid atherosclerosis in climacteric women. – I. Lucena, L. Costa, A.P. Tavares-Souza, D. Fantato, B. Bezerra, N. Morais, P. Veras, M. Novaes, J.C. Nicolau (São Paulo and Recife, BR) Functional arterial stiffness predicts a thickening of carotid intima-media one year later in patients with lifestyle-related disease. – M. Ogura N, D. Kamekawa, K. Kamiya, A. Mastunaga, M. Kimura, R. Shimizu, T. Ogura, C. Noda, M. Yamaoka-Tojo, T. Masuda (Sagamihara and Yamanashi, Japan, JP) Radiofrequency-based estimates of local common carotid stiffness and intima-media thickness: implications for detecting early vascular involvement in hypertension and diabetes. – C. Palombo, M. Kozakova, G. Bini, C. Morizzo, R. Miccoli, G. Dell’Omo, R. Pedrinelli, V. Di Bello, N. Guraschi, A. Balbarini (Pisa and Genoa, IT) The grading of a carotid bruit and its relationship to carotid artery peak systolic velocities. – M. Matangi, A. Dillon, A. Johri, D. Armstrong, U. Jurt, R. Pal, D. Brouillard (Kingston, CA) Arterial stiffness in families with premature coronary artery disease. – T.A. Mulders, B. Van Den Boogaard, A. Bakker, M.D. Trip, E.S.G. Stroes, B.J.H. Van Den Born, S.J. Pinto-Sietsma (Amsterdam, NL) Familial AAA: high prevalence and decreased cardiac risk factors. – K.M. Van De Luijtgaarden, S.E. Hoeks, M.T. Voute, E.J. Bakker, T.M. Valentijn, N.J. Ravensbergen, F. Bastos Goncalves, H.J. Verhagen, D. Majoor Krakauer, D. Poldermans (Rotterdam, NL) Brachial-ankle pulse wave velocity as a predictor of cardiovascular events: a meta-analysis of longitudinal studies. – K. Aznaouridis, C. Vlachopoulos, C. Stefanadis (Athens, GR) Addition of claudication to the Framingham risk score improves mortality prediction. – A.G. Kieback, M. Dorr, T. Ittermann, R. Lorbeer, H. Wallaschofski, H. Voelzke, S.B. Felix (Greifswald, DE) The ankle brachial index is an independent predictor of mortality in anticoagulated patients with atrial fibrillation. – V. Roldan, F. Marin, P. Gallego, J.M. Torregrosa, B. Muina, E. Jover, S. Montoro-Garcia, M. Valdes, V. Vicente, G.Y.H. Lip (Murcia, ES; Birmingham, GB) Arterial structure and function in patients with familial combined hyperlipidemia. – C. Masoura, C. Pitsavos, I. Skoumas, K. Aznaouridis, C. Vlachopoulos, K. Psarros, V. Metaxa, K. Liontou, C. Stefanadis (Athens, GR) Lipoprotein (a) levels independently predict elevated coronary calcium score in those at intermediate or high risk of a cardiovascular event- implications for screening algorithms. – M.E. Legget, C.J. Ellis, C. Edwards, N. Van Pelt, J.A. Ormiston, J. Christiansen, H. Winch, G. Gamble, R. Young (Auckland, NZ) Living in a city centre increases the risk of CT verified coronary artery calcification. – A. Diederichsen, O. Gerke, J. Lambrecthsen (Odense and Svendborg, DK) Impact of left ventricular hypertrophy on the presence of coronary artery disease using multislice computed tomography in asymptomatic patients without coronary artery calcification. – K. Harada, N. Terada, A. Okada, M. Shigekiyo, H. Yoshikawa, A. Hirono, T. Yamamoto, H. Yamamoto, K. Tamura, H. Fujinaga (Tokushima, JP) Prediction of cardiovascular risk from nocturnal pulse wave signal using the autonomic state indicator (ASI) technology. – B. Sanner, D. Sommermeyer, D. Zou, D.N. Eder, J. Hedner, J. Ficker, W. Randerath, T. Penzel, L. Grote (Wuppertal, Karlsruhe, Nuremberg, Solingen and Berlin, DE; Gothenburg, SE) Clinical application of carotid intima and media thickness for coronary artery disease using inverse probability-weighted estimators. – G. Kim, H.J. Youn, Y.S. Choi, H.O. Jung, S.Y. Jung, S.H. Ann, T.S. Kim, J.E. Yi (Seoul, KR) Relationship between the carotid atherosclerotic burden and severe coronary artery disease. – D. Lowenstein Haber, M. Perea, M. Villanueva, M. Pipkin, R. Danielo, C. Rodriguez Correa, E. Guevara, G. Guinta, M. Cors, E. Bozovich (Buenos Aires, AR) P4740 P4741 P4742 P4743 P4744 P4745 QR 30607 287 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Early vascular ageing in coronary artery disease and diabetes mellitus. – Z. Lenkey, B. Gaszner, M. Illyes, R. Bocskei, L. Priegl, Z.S. Sarszegi, F.T. Molnar, I.G. Horvath, A. Cziraki (Pécs and Budapest, HU) Association between UKPDS risk score and coronary artery disease severity, ankle-brachial index, cardiovascular autonomic neuropathy and diastolic dysfunction in type 2 diabetes mellitus. – C.J. Magri, A. Cassar, S. Fava, H. Felice, A. Fenech (Msida, MT) P4746 P4747 CARDIOVASCULAR RISK; MARKERS AND TECHNIQUES (QR 30608*) Incremental value of using NT pro-BNP and cystatin C as predictors of adverse events in low and intermediate risk patients presenting to Emergency Department with chest pain. – S. Mathewkutty, K. Shah, R. Iyengar, L. Hermann, L. Razzouk, R. Esquitin, R. Vedanthan, L. Ramanathan, A. Aneja, M. Farkouh (New York and Cleveland, US) Presentation and management of acute coronary syndromes in the elderly: the Myocardial Ischaemia National Audit Project (MINAP) 2003-2010. – C.P. Gale, B.A. Cattle, A. Woolston, T.H. West, A.D. Simms, K.A.A. Fox, R.M. West (Leeds and Edinburgh, GB) Age and in-patient mortality after presentation to hospital with acute coronary syndrome: the Myocardial Ischaemia National Audit Project (MINAP) 2003-2010. – C.P. Gale, B.A. Cattle, A. Woolston, T.H. West, A.D. Simms, K.A.A. Fox, R.M. West (Leeds and Edinburgh, GB) Cancer mortality in a population hospitalized for cardiovascular disease. – C. Carpeggiani, C. Michelassi, P. Landi, P. Marraccini, E. Picano (Pisa, IT) Need for cardiac valvular surgery in 2011: preliminary results from a community screening of an Italian unselected population. – L.E. Pastormerlo, A. Dushpanova, F. Pali, D. Della Latta, A. Nardelli, D. Chiappino, M. Emdin, S. Maffei (Pisa and Massa, IT) Biomarkers and clinical factors associated with atrial fibrillation in Russian population. – P.G. Platonov, M.A. Shkolnikova, J.G. Smith, Y.V. Shubik, D. Jdanov, V.M. Shkolnikov (Lund, SE; Moscow and Saint Petersburg, RU; Rostock, DE) Regional comparison of selected cardiovascular risk factors of Croatian hospitalized coronary heart disease patients in the period of 6 years (2003-2009). – H. Vrazic, J. Sikic, T. Lucijanic, K. Matic, T. Bozin, I. Subjak, M. Udovicic, S. Sokol, I. Sakic, M. Bergovec (Zagreb, HR) Appropriate cutoff values for serum uric acid levels in relation to multiple cardiometabolic risk factors among Japanese junior high school students. – M. Hongo, H. Hidaka, S. Sakaguchi, K. Nakanishi, A. Izawa, U. Ikeda, Y. Yazaki (Matsumoto, JP) Clinical applicability of the 30-year Framingham risk score. Usefulness in cardiovascular risk stratification and diagnosis of subclinical carotid atherosclerosis. – D.A. Siniawski, W.M. Masson, J. Krauss, A.M. Cagide (Buenos Aires, AR) Long term effects of nutraceuticals (Berberine, Red Yeast Rice, Policosanol) in elderly hypercholesterolemic patients. – G. Marazzi, L. Cacciotti, F. Pelliccia, M. Volterrani, G. Caminiti, L. Iaia, B. Sposato, A. Carluccio, G. Rosano (Rome, IT) Do risk scores for silent atherosclerosis underestimate disease risk? – F. Moscoso Costa, J. Ferreira, S. Carvalho, G. Cardoso, R. Cale, P.G. Santos, M. Santos, C. Aguiar, M. Trabulo, M. Mendes (Lisbon, PT) Metabolic profile and control by treatment and relationships with blood pressure values in patients from central and eastern European countries: the BP-CARE metabolic study. – G. Seravalle, G. Brambilla, R. Cifkova, S. Laurent, K. Narkiewicz, J. Redon, C. Farsang, F. Quarti Trevano, G. Mancia, G. Grassi (Milan and Monza, IT; Prague, CZ; Paris, FR; Gdansk, PL; Valencia, ES; Budapest, HU) First and fifth day BNP and long-term mortality in ST-elevation myocardial infarction patients. – A. Tycinska, R. Sawicki, B. Sobkowicz, A. Lisowska, B. Mroczko, W.J. Musial, S. Dobrzycki, A. Kozieradzka, M. Szmitkowski (Bialystok, PL) Evaluation of risk factors for cardiovascular events among patients on the cadaveric renal transplant list. – N.Y. Wong, C.T. Chin, S.M. Zaini, P.S. Tee, L.W. Khin, S.M. Koh, T. Kee, W.C. Tan (Singapore, SG) Prevalence of left ventricular hypertrophy in patients with chronic obstructive pulmonary disease. – S. Rekhraj, J. George, A. Nadir, B. Szwejkowski, A.D. Struthers (Dundee, GB) Ambulatory blood pressure monitoring is associated with subclinical atherosclerosis in normotensive spinal cord injury subjects. – J.D. Garcez-Seabra, J.R. Matos-Souza, D. Goulart, E. Abib, K.R. Pithon, A. Cliquet Junior, W. Nadruz Junior (Campinas, BR) Difference in efficiency of lipid lowering pharmacotherapy in ambulatory patients between primary and specialist care - 3ST-POL. – D. Sliz, M. Naruszewicz, K.J. Filipiak, J. Siebert, A. Mamcarz (Warsaw and Gdansk, PL) Correlations between various obesity parameters and coronary artery disease severity. – A. Farrag, A. El Hag, A. Hassan, B. Zarief (Cairo, EG) A cardiovascular risk profile derived from administrative data. – H. De Vries (Amsterdam, NL) *Abstracts can be accessed at: 288 QR 30608 P4748 P4749 P4750 P4751 P4752 P4753 P4754 P4755 P4756 P4757 P4758 P4759 P4760 P4761 P4762 P4763 P4764 P4765 P4766 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS P4767 P4768 P4769 P4770 P4771 (W) P4772 P4773 P4774 P4775 P4776 P4777 P4778 P4779 P4780 P4781 P4782 (W) TUESDAY – AFTERNOON High cardiovascular risk increases cost and length of sick leave from non-cardiovascular cause. – L.M. Ruilope, E. Calvo-Bonacho, M.A. Sanchez-Chaparro, J.C. Sainz, M. Ruiz-Moraga, L. Quevedo-Aguado, C. Fernandez-Labandera, A. Zanchetti (Madrid and Malaga, ES; Milan, IT) Hypertension, the strongest risk factor for CVD events and mortality in an Iranian population: Isfahan cohort study. – M. Talaei Pashiri, M. Sadeghi, S. Oveisgharan, N. Sarrafzadegan (Isfahan, IR) Cardiovascular autonomic neuropathy and subclinical cardiovascular disease in asymptomatic normoalbuminuric type 1 diabetes patients. – U.M. Mogensen, T. Jensen, L. Kober, H. Kelbaek, U. Dixen, J. Hilsted, K.F. Kofoed (Copenhagen, DK) Diabetes mellitus and its influence in cardiac rehabilitation program for coronary patients. – M. Paiva, A. Rocha, A. Lebreiro, A. Correia, A. Sousa, C. Sousa, I. Rangel, V. Araujo, F. Parada, M. Maciel (Porto, PT) Significant differential metabolic effects of rosuvastatin and pravastatin in hypercholesterolemic patients. – K. Koh, M. Quon (Incheon, KR; Bethesda, US) Type 2 diabetes and the progression of visualized atherosclerosis to clinical cardiovascular events. – C. Saely, P. Rein, A. Vonbank, K. Huber, H. Drexel (Feldkirch and Vienna, AT; Triesen, LI) Impact of previous metabolic control in the post acute coronary syndrome outcome in diabetics. – S. Monteiro, R. Teixeira, R. Batista, E. Jorge, F. Saraiva, P. Mendes, H. Martins, P. Monteiro, M. Freitas, L. Providencia (Coimbra, PT) Alpha hydroxybutyric acid as a novel biomarker for coronary heart disease. – K. Ikewaki, H. Nagase, K. Shimizu, H. Matsuzawa, S. Yagi, M. Nishizawa, T. Ohno, Y. Nakada, M. Shimizu, S. Mochizuki (Tokorozawa, Osaka and Tokyo, JP) Circulating leukocyte telomere length and oxidative stress: a new target for statin therapy. – S. Saliques, J.R. Teyssier, C. Vergely, J. Lorin, M. Farnier, A. Donzel, S. Ragot, Y. Cottin, L. Rochette, M. Zeller (Dijon, FR) Serum cathepsin S predicts the risk for mortality in elderly men and woman. – E. Jobs, E. Ingelsson, U. Riserus, E. Nerpin, M. Jobs, J. Sundstrom, S. Basu, A. Larsson, L. Lind, J. Arnlov (Uppsala, Stockholm and Falun, SE) sRAGE (soluble receptor of advanced glycation end-products): a new biomarker of arterial thrombosis during systemic lupus erythematosus. – H. Maillard-Lefebvre, N. Costedoat-Chalumeau, N. Grossin, J. Salleron, S. Dubucquoi, E. Hachulla, P.-Y. Hatron, E. Boulanger, Z. Amoura, M. Lambert (Lille and Paris, FR) Are the traditional cardiovascular disease risk factors enough for assessing the cardiovascular risk in inflammatory joint diseases? – T. Korotaeva, E. Loginova, D. Novikova, N. Klimova, L. Denisov (Moscow, RU) Plasma concentration of matrix metalloproteinase-2 is related to thrombotic events in patients in patients with stable coronary disease. – A. Komarov, A. Dobrovolsky, E. Titaeva, O. Shakmatova, T. Ilyushchenko, G. Dzhalilova, A. Deev, E. Panchenko (Moscow, RU) Estrone, coronary artery disease, and death in postmenopausal women. – A.P. Mansur, T.C.B.F. Silva, N.H. Lopes, J.Y. Takada, S.D. Avakian, J.A.F. Ramires (São Paulo, BR) Is uric acid a novel risk factor? Its interplay with arterial stiffness, peripheral and central pressures in healthy, normotensive individuals. – P. Xaplanteris, C. Vlachopoulos, P. Pietri, I. Dima, D. Terentes-Printzios, E. Christoforatou, A. Samentzas, C. Stefanadis (Athens, GR) Erythrocyte anisocytosis is associated with cholesterol content of erythrocyte membrane. Preliminary atomic-force microscopy data. – D.N. Tziakas, D. Stamopoulos, G. Chalikias, D. Stakos, S. Apostolakis, A. Thomaidi, A. Lantzouraki, H. Boudoulas, S.V. Konstantinides (Alexandroupolis and Athens, GR) AB0 blood type is not associated with outcome after vascular surgery. – E.J. Bakker, S.E. Hoeks, M.T. Voute, K.M. Van De Luijtgaarden, Y.R.B.M. Van Gestel, H.J.M. Verhagen, D. Poldermans (Rotterdam, NL) Vitamin D deficiency is associated with increased 30-day cardiovascular events after vascular surgery. – K.M. Van De Luijtgaarden, M.T. Voute, S.E. Hoeks, N.J. Ravensbergen, T.M. Valentijn, E.J. Bakker, F. Bastos Goncalves, D. Goei, H.J. Verhagen, D. Poldermans (Rotterdam, NL) Predictors of perioperative renal failure after noncardiac, nonvascular surgery in patients with previously normal renal function. – M. Biteker, F. Biteker, D. Duman, A. Dayan (Istanbul, TR) Risk factors and hospital mortality in STEMI: multicenter study. – I. Santos Rodriguez, G. Perez Ojeda, N. Alonso Orcajo, S. Estrada Gomez, M.J. Ruiz Olgado, J.M. Duran, P. Pabon Osuna, M.A. Cruz Banuelos, C. Hernandez, F. De Castro (Salamanca, Burgos, León, Zamora and Castilla y León, ES) HDL-cholesterol predicts survival after heart transplantation. – C.M. Tavares Aguiar, M.J. Rebocho, M. Abecasis, M. Marques, J.P. Neves (Carnaxide, PT) Long term prognosis value of heart rate in coronary artery disease. – F. Bouisset, V. Bongard, J.B. Ruidavets, D. Taraszkiewicz, M. Galinier, D. Carrie, M. Elbaz, J. Ferrieres (Toulouse, FR) Women with established coronary heart disease have worse control of hypertension than men. Data from Euroaspire III survey -Poland. – S. Surowiec, P. Jankowski, R. Wolfshaut-Wolak, M. Loster, T. Grodzicki, A. Pajak, K. Kawecka-Jaszcz (Krakow, PL) P4783 P4784 P4785 P4786 P4787 P4788 P4789 289 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Cardiovascular risk factors in a Roma community. – E. Apetrei, C. Matei, M. Creteanu, M. Creteanu Jr, D. Iliescu, C. Jianu (Bucharest, Suceava, Radauti and Drobeta Turnu Severin, RO) Does risk factors for cardiovascular disease have a similar prevalence in rural and urban Polish primary care patients? Insights from IDEA study. – M. Chrostowska, A. Szyndler, M. Hoffmann, K. Polonis, K. Narkiewicz (Gdansk, PL) P4790 P4791 OPTICAL COHERENCE TOMOGRAPHY (QR 30609*) Spatial distribution of culprit lesion thin-cap fibroatheromas in acute coronary syndromes. An optical coherence tomography study. – M. Riga, K. Toutouzas, A. Karanasos, E. Tsiamis, A. Synetos, A. Papanikolaou, K. Stathogiannis, E. Stefanadi, G. Triantafyllou, C. Stefanadis (Athens, GR) Association of intimal thickening of non-atheromatic coronary segments with culprit plaque morphology. – A. Karanasos, K. Toutouzas, E. Tsiamis, M. Riga, A. Synetos, M. Drakopoulou, G. Triantafyllou, C. Tsioufis, D. Tousoulis, C. Stefanadis (Athens, GR) Comparative assessment of vascular healing following implantation of drug eluting stents in animal models and man. – K. Steigerwald, C. Malle, J. Jehle, A. Kastrati, A. Schoemig, M. Joner (Munich, DE) Insights on the substrate of coronary stent thrombosis obtained with optical coherence tomography. – N. Gonzalo Lopez, F. Alfonso Manterola, J. Escaned Barbosa, C. Banuelos De Lucas, P. Jimenez Quevedo, C. Nolte, A. Fernandez Ortiz, E. Garcia, R. Hernandez Antolin, C. Macaya Miguel (Madrid, ES) Incidence, predictors and long term prognosis of stent edge dissections detected by optical coherence tomography. – K. Bouki, E. Sakkali, D. Chatzopoulos, S. Psychari, J. Makrygiannis, D. Barmperis, E. Kapsali, T. Apostolou (Piraeus, GR) Neointimal coverage on second generation drug-eluting stent struts crossing side-branch vessels compared with paclitaxel-eluting stent: an optical coherence tomography analysis. – K. Nasu, M. Habara, T. Kurita, T. Ito, E. Ko, D. Yokota, Y. Kinoshita, M. Terashima, T. Suzuki (Toyohashi, JP) New insights into the coronary bifurcation with the use of off-line 3-dimensional terumo OFDI imaging. – V. Farooq, J.H. Heo, B.D. Gogas, T. Okamura, J. Gomez-Lara, S. Brugaletta, M. Radu, H.M. Garcia-Garcia, P.W. Serruys (Rotterdam, NL) Optical coherence tomography tissue characterization predicts plaque progression of nonculprit lesion after acute coronary syndrome. – K. Komukai, A. Tanaka, T. Tanimoto, H. Kitabata, Y. Ino, K. Kimura, K. Hirata, M. Mizukoshi, T. Imanishi, T. Akasaka (Wakayama, JP) Clinical impact of small-sized stent mal-apposition after stent implantation as detected by optical coherence tomography. – K. Ishibashi, H. Kitabata, K. Komukai, T. Tanimoto, Y. Ino, K. Kimura, K. Hirata, M. Mizukoshi, T. Imanishi, T. Akasaka (Wakayama, JP) Favorable effects of lipid-soluble statin on neointimal growth after sirolimus-eluting stents implantation as compared to water -soluble statin. – R. Shutta, M. Nishino, M. Taniike, N. Makino, H. Kato, Y. Egami, J. Tanouchi, Y. Yamada (Sakai, JP) Differences of optical coherence tomographic findings and clinical outcomes between excimer laser and cutting balloon angioplasty for focal in-stent lesion. – M. Nishino, M. Taniike, N. Makino, H. Kato, Y. Egami, R. Shutta, H. Morita, J. Tanouchi, Y. Yamada (Sakai, JP) Natural consequence of stent malapposition tissue prolapse, thrombus and stent edge dissection assessed by optical coherence tomography. – H. Kawamori, J. Shite, T. Shinke, H. Otake, D. Matumoto, M. Nakagawa, Y. Nagoshi, A. Kozuki, H. Hariki, T. Inoue (Kobe, JP) In vivo optical coherence tomography assessment of very late drug-eluting stent thrombosis compared with late restenosis and no-event patients. – S. Miyazaki, Y. Hiasa, T. Takahashi, P. Chen, R. Ogura, S. Hosokawa, K. Kishi, R. Ohtani (Komatsushima, JP) Uneven distribution of the factors of plaque vulnerability in atherosclerotic plaques in the left anterior descending coronary arteries detected by optical coherence tomography color-coded mapping. – Y. Ishihara, M. Kawasaki, A. Hattori, T. Aoyama, S. Ojio, M. Arai, K. Nishigaki, G. Takemura, S. Minatoguchi (Gifu City, JP) Comparison of contrast media and low molecular dextran for frequency-domain optical coherence tomography imaging. – Y. Ozaki, H. Kitabata, K. Ishibashi, K. Komukai, T. Tanimoto, Y. Ino, K. Kimura, M. Mizukoshi, T. Imanishi, T. Akasaka (Wakayama, JP) Interstudy reproducibility of the second generation, Fourier domain OCT in patients with coronary artery disease. – Z. Jamil, G. Tearney, N. Bruining, K. Sihan, G. Van Soest, J. Ligthart, B. Bouma, E. Regar (Rotterdam, NL; Boston, US) *Abstracts can be accessed at: 290 QR 30609 P4792 P4793 P4794 P4795 P4796 P4797 P4798 P4799 P4800 P4801 P4802 P4803 P4804 P4805 P4806 P4807 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Safety and feasibility of the second generation, Fourier domain optical coherence tomography: comparison to a historic cohort - a single center experience. – T. Okamura, N. Gonzalo, J.L. Gutierrez-Chico, G. Van Soest, N. Bruining, G. Tearney, B. Bouma, P.W. Serruys, F. Zijlstra, E. Regar (Rotterdam, NL; Boston, US) Detection of macrophage accumulation within atherosclerotic coronary plaque with use of attenuation curve in optical coherence tomography. – H. Haruta, T. Takayama, T. Hiro, A. Hirayama (Tokyo, JP) Angioscopic findings of arterial repair following everolimus-eluting stent implantation: 8-month follow-up study in patients. – M. Awata, F. Sera, T. Ishihara, T. Watanabe, M. Fujita, O. Iida, Y. Ishida, S. Nanto, M. Uematsu, S. Nagata (Amagasaki and Suita, JP) Clinical predictors of fibrous cap thickness and macrophage accumulation in coronary plaques. – T. Sato, T. Kameyama, T. Noto, H. Inoue (Toyama, JP) P4808 P4809 P4810 P4811 FRACTIONAL FLOW RESERVE (QR 30610*) *Abstracts can be accessed at: P4812 P4813 P4814 P4815 P4816 P4817 P4818 P4819 P4820 P4821 TUESDAY – AFTERNOON Percent stenosis is a weak predictor of Fractional Flow Reserve (FFR) in intermediate coronary lesions: insights from a large french multicenter registry. – E. Van Belle, T. Cuisset, G. Rioufol, C. Pouillot, E. Teiger, D. Barreau, M. Hanssen, L. Belle, C. Bretelle, P. Dupouy (Lille, Marseille, Lyon, St. Denis de la Réunion, Créteil, Toulon, Hagenau, Annecy, Valence and Antony, FR) Nitroprusside: an excellent alternative for fractional flow reserve assessment. – D. Lindefjeld, J. Diaz, R. Cardenal, A. Gomez, C. Sanchez, J. Roa, J. Landero, P. Gomez, M. Gracia, E. Bobo (Huelva, ES) Adenosine versus nitroprusside to induce maximal hyperaemia for fractional flow reserve assessment. – A.M. Leone, A.R. De Caterina, A. Aurelio, E. Basile, D. Russo, A. Iaconelli, G. Niccoli, I. Porto, A.G. Rebuzzi, F. Crea (Rome, IT) Influence of percutaneous coronary intervention on true microvascular resistance in patients with non-ST elevation acute coronary syndrome. – C. Akdeniz, Y. Nisanci, S. Umman, B. Umman, E. Golcuk, M. Sezer (Istanbul, TR) Impact of predilatation on periprocedural microvascular injury in patients with non-ST elevation acute coronary syndrome undergoing stenting. – C. Akdeniz, S. Umman, Y. Nisanci, B. Umman, A. Kaplan, E. Aslanger, O. Kiraslan, A. Yilmaz, A. Atakan, M. Sezer (Istanbul, TR) Effects of cardiovascular risk factors on macrovascular endothelial function and microvascular reactivity assessed with near-infra red spectroscopy in adults with different cardiovascular status. – M. Gayda, M. Juneau, J.C. Tardif, J. Lambert, A. Nigam (Montreal, CA) Determinants of coronary flow velocity reserve in patients with moderate or severe aortic stenosis and nonobstructive coronary arteries. – M. Banovic, T. Vujisic-Tesic, M. Callahan, I. Nedeljkovic, D. Trifunovic, M. Petrovic, O. Petrovic, C. Offord, M. Ostojic (Belgrade, RS; Rochester, US) Safety of deferring revascularization in lesions with FFR ≥0.75 but a small IVUS-derived lumen area. – S. Junagade, M.-Y. Chan, A.-F. Low, S.-G. Teo, A.-M. Richards, T.-C. Yeo, H.-C. Tan, C.-H. Lee (Singapore, SG) The value of fractional flow reserve in predicting myocardial protective effect in patients with previous myocardial infarction undergoing percutaneous coronary intervention. – Y. Ishibashi, M. Yamauchi, M. Uematsu, R. Kamijima, A. Hayashi, Y. Akashi, H. Musha, Y. Miyake (Yokohama and Kawasaki, JP) Which reaction in coronary arteries induced by acetylcholine at low or moderate doses, is clinically useful? – H. Teragawa, N. Mitsuba, K. Nishioka, S. Kurisu, Y. Kihara (Hiroshima, JP) Usefulness of a trans-stent fractional flow reserve gradient for assessing the immediate results of drug-eluting stent implantation. – H.S. Lim, S.J. Tahk, H.M. Yang, D.Y. Joe, M.H. Yoon, B.J. Choi, S.Y. Choi, J.S. Park, G.S. Hwang, J.H. Shin (Suwon, KR) Superior diagnostic accuracy of combined intracoronary hemodynamic information in assessment of functional lesion severity. – T.P. Van De Hoef, M. Siebes, S.A.J. Chamuleau, J. Baan Jr, J.P.S. Henriques, M. Voskuil, M. Bax, J.A.E. Spaan, J.J. Piek, M. Meuwissen (Amsterdam, Utrecht and Breda, NL) Effect of venous pressure on fractional flow reserve and index of microcirculatory resistance in patients with stable chest pain syndromes. – A. Alfiadh, M. Mok, T. Lancefield, D. Clark, O. Farouque (Melbourne, AU) Coronary endothelial function by the index of microcirculatory resistance can be estimated by evaluating left ventricular contractile reserve at low dose dobutamine echocardiography. – M. Leung, S. Lo, C. Juergens, D. Leung (Sydney, AU) Feasibility of transradial approach without radial artery spasm prophylaxis for intracoronary spasm provocation test. – A. Karagianni, T. Schaeufele, A. Athanasiadis, A. Yilmaz, U. Sechtem (Stuttgart, DE) P4822 P4823 P4824 P4825 P4826 QR 30610 291 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Prognostic value of TIMI flow grade II in the era of GP IIb/IIIa antagonists in patients undergoing direct PCI for acute myocardial infarction. – D. Rzepka, H. Bonnemeier, T. Demming, J. Heckmann, B. Weidtmann, N. Frey (Kiel, DE) Changes in left ventricular ejection fraction and coronary flow reserve after coronary microembolization. – J. Ma, J. Qian, J. Ge (Shanghai, CN) High asymmetric dimethylarginine and C-reactive protein levels in conjunction with low testosterone concentration have an additive unfavourable effect on penile vasculature and carotid wall thickness. – D. Terentes-Printzios, C. Vlachopoulos, N. Ioakeimidis, K. Rokkas, P. Xaplanteris, I. Dima, A. Aggelis, K. Aznaouridis, C. Aggeli, C. Stefanadis (Athens, GR) Effects of n-3 polyunsaturated fatty acids on left ventricular function and coronary flow in children with type 1 diabetes mellitus. – E. Aburawi, P. Liuba, M. Odermarsky, S. Sjoblad, E. Pesonen (Lund and Al-Ain, AE; Lund, SE) Impact of a “fractional flow reserve (FFR)-guided” coronary revascularization strategy on individual decision making: insights from a large french multicenter registry. – E. Van Belle, T. Cuisset, G. Rioufol, C. Pouillot, E. Teiger, D. Barreau, M. Hanssen, L. Belle, C. Besnard, P. Dupouy (Lille, Marseille, Lyon, La Réunion, Créteil, Toulon, Hagenau, Annecy and Antony, FR) P4827 P4828 P4829 P4830 P4831 NON INVASIVE AND INVASIVE CORONARY IMAGING (QR 30611*) Intravascular ultrasound findings at in-stent restenosis segment of overlapped drug-eluting stent. – Y. Sakamoto, T. Muramatsu, R. Tsukahara, Y. Ito, H. Ishimori, K. Hirano, M. Nakano, M. Yamawaki, M. Araki, H. Takimura (Yokohama, JP) Reproducibility of intravascular ultrasound iMAP for radiofrequency data analysis: implications for design of longitudinal studies. – J.H. Heo, S. Brugaletta, H.M. Garcia-Garcia, J. Gomez-Lara, J.M.R. Lighthart, R. Diletti, P.W. Serruys (Rotterdam, NL) Association of elevated blood glucose levels on admission with tissue characterization in non-diabetic patients with acute coronary syndrome with ST segment elevation. – K. Trusinskis, D. Juhnevica, K. Strenge, D. Sondore, I. Narbute, G. Latkovskis, S. Jegere, I. Kumsars, J. Dijkstra, A. Erglis (Riga, LV; Leiden, NL) Longitudinal distribution of the necrotic rich plaques in non-culprit vessels of patients presenting with acute coronary syndromes. Substudy of the PROSPECT trial. – J.J. Wykrzykowska, H.M. Garcia-Garcia, A. Maehara, M. Fahy, A. Lansky, B. De Bruyne, G. Mintz, G. Weisz, G. Stone, P.W. Serruys (Amsterdam and Rotterdam, NL; New York, US; Aalst, BE) European multicenter study on the between-center reproducibility of volumetric radiofrequency-based intravascular ultrasound analyses in coronary lesions prior to stenting. – J. Huisman, R. Egede, A. Rdzanek, D. Boese, R. Erbel, J. Kochman, L.O. Jensen, M. Hartmann, G.S. Mintz, C. Von Birgelen (Enschede, NL; Odense, DK; Warsaw, PL; Essen, DE; New York, US) Detection of thin-cap fibroatheroma by plaque composition analysis using iMap-intravascular ultrasound in patients with stable angina pectoris. – S. Koga, S. Ikeda, T. Nakata, T. Yoshida, M. Takeno, Y. Koide, K. Maemura (Nagasaki, JP) Combined use of intravascular ultrasound and optical coherence tomography in patients suffering from stent thrombosis. – F. Alfonso Manterola, J. Dutary, N. Gonzalo, P. Jimenez-Quevedo, M. Paulo, C. Banuelos, J. Escaned, M.J. Perez-Vizcayno, R. Hernandez, C. Macaya (Madrid, ES) Distribution of coronary atherosclerosis in relation to peripheral vascular changes in patients with erectile dysfunction. – N. Ioakeimidis, C. Vlachopoulos, A. Aggelis, D. Terentes-Printzios, K. Aznaouridis, A. Samentzas, K. Rokkas, E. Christoforatou, E. Tsiamis, C. Stefanadis (Athens, GR) Expansive coronary remodeling is associated with low endothelial shear stress, high plaque volume and increased elasticity. – A. Antoniadis, Y. Chatzizisis, S. Katranas, V. Giannoglou, K. Koskinas, G. Giannoglou (Thessaloniki, GR) Dual-source CT angiography and intravascular ultrasound assessment of restenosis in patients after coronary stenting for bifurcation left main stenosis. – J. Veselka, D. Zemanek, P. Cadova, P. Hajek, P. Tomasov, M. Maly, T. Adla (Prague, CZ) Benefits of pancreas transplantation on coronary atherosclerosis and microvascular dysfunction: a serial IVUS study. – M. De Carlo, F. Donati, L. Misuraca, P. Marchetti, B. Papini, M. Barsotti, F. Vistoli, S. Del Prato, U. Boggi, A.S. Petronio (Pisa, IT) The impact of plaque characterization assessed by intravascular ultrasound on myocardial perfusion after primary angioplasty in patients with ST-segment elevation myocardial infarction. – T. Nakata, K. Fujii, M. Fukunaga, D. Kawasaki, M. Kawabata, M. Masutani, M. Ohyanagi, T. Masuyama (Nishinomiya, JP) The relationship between lipid volume in coronary plaque and slow flow phenomenon in percutaneous coronary intervention. – T. Nihei, S. Namiuchi, T. Kawaguchi, T. Takii, C. Takahashi, T. Sugie, A. Kato (Sendai, JP) Prevalence of angioscopic in-stent thrombosis after drug-eluting stent implantation (cypher vs TAXUS). a serial observation with coronary angioscopy. – D. Kitano, T. Takayama, T. Hiro, A. Hirayama (Tokyo, JP) *Abstracts can be accessed at: 292 QR 30611 P4832 P4833 P4834 P4835 P4836 P4837 P4838 P4839 P4840 P4841 P4842 P4843 P4844 P4845 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Angioscopic prevalence in the patients with diabetes mellitus after drug-eluting stent implantation (everolimus- versus paclitaxel-eluting stent). A serial observation with coronary angioscopy. – D. Kitano, T. Takayama, T. Kanai, M. Akabane, T. Kawano, M. Ichikawa, H. Haruta, Y. Hayashida, T. Hiro, A. Hirayama (Tokyo, JP) Appearance of thrombus formation and yellow plaque in proximal and distal stent segment after paclitaxel-eluting stent implantation. – Y. Kakefuda, A. Sato, T. Adachi, H. Watabe, E. Ojima, Y. Naruse, T. Hoshi, N. Murakoshi, K. Aonuma (Tsukuba, JP) 3D quantitative coronary angiography (QCA) confers additional advantage over 2D QCA for the assessment of intermediate left main stenosis: a comparison with intravascular ultrasound. – I. Porto, I. Dato, D. Todaro, M. Calabrese, S. Rigattieri, A.M. Leone, G. Niccoli, F. Burzotta, C. Trani, F. Crea (Rome, IT) Coronary artery angiographic changes in veterans intoxicated by mustard gas. – M. Shabestari, F. Jabari, B. Gohari, N. Moazen, H. Azizi, T. Moghiman, S. Ibrahimzadeh, A. Amirabadi (Mashhad, IR) Should dual axis rotational coronary angiography be the preferred mode of coronary angiography? – C.P. Lim, L.L.H. Chua, S.T. Lim (Singapore, SG) Culprit lesion characteristics in acute coronary syndrome and stable angina assessed by optical coherence tomography, angioscopy, intravascular ultrasound and multidetector computed tomography. – Y. Ozaki, M. Okumura, T.F. Ismail, S. Motoyama, H. Naruse, K. Hattori, H. Kawai, M. Sarai, J. Ishii, J. Narula (Toyoake, JP; London, GB; Irvine, US) Evaluation of the spatial relationship between the site of most severe narrowing and plaque vulnerability, as assessed by virtual histology intravascular ultrasound. – M.A. De Graaf, J.E. Van Velzen, F.R. De Graaf, C.E. Veltman, M.J. Schalij, E.E. Van Der Wall, J.D. Schuijf, J.J. Bax, J.W. Jukema (Leiden, NL) VH-IVUS-Identified vulnerable plaques are associated with increased MACE. The VIVA (VH-IVUS in Vulnerable Atherosclerosis) study. – P. Calvert, D.R. Obaid, M. O’Sullivan, L.M. Shapiro, D.C. McNab, C.G. Densem, P.M. Schofield, K.K. Ray, N.E.J. West, M.R. Bennett (Cambridge and London, GB) The association between necrotic core distribution at the coronary bifurcation and side branch bifurcation angle: a virtual histology intravascular ultrasound study. – H. Amano, K. Wagatsuma, M. Toda, H. Nii, Y. Uchida, Y. Fujii, J. Yamazaki (Tokyo, JP) Insulin resistance is associated with VH-IVUS derived amount of necrotic core in plaque components in patients with coronary artery disease. – Y.M. Park, S.H. Han, K. Shin, M.G. Kim, W.C. Kang, K.K. Koh, K. Lee, T. Ahn, I.S. Choi, E.K. Shin (Incheon, KR) P4846 P4847 P4848 P4849 P4850 P4851 P4852 P4853 P4854 P4855 STEMI: MANAGEMENT AND OUTCOME (QR 30612*) *Abstracts can be accessed at: P4856 (W) P4857 P4858 TUESDAY – AFTERNOON Impact of thrombus burden in ST-elevation myocardial infarction patients treated with or without thrombus aspiration. – M.A. Kampinga, Y.L. Gu, W.G. Wieringa, A.F.M. Van Den Heuvel, E.S. Tan, G. Pundziute, H.W. Van Der Werf, I.C.C. Van Der Horst, F. Zijlstra, B.J.G.L. De Smet (Groningen and Rotterdam, NL) Treatment of multivessel coronary artery disease in primary PCI for ST elevation myocardial infarction: culprit only revascularisation is associated with higher MACE rates. – T.E. Pain, D.A. Jones, K. Rathod, R. Weerackody, S. Gallagher, A. Jain, C. Knight, A. Mathur, A. Wragg (London, GB) Treatment of no-reflow during acute myocardial infarction: head to head dipyridamole versus verapamil. – A. Arrivi, G. Tanzilli, N. Cocco, K. Mukred, F. Pelliccia, V. Pasceri, E. Mangieri (Rome, IT) Outcome of primary PCI using prasugrel, bivalirudin and preferred radial access. – A. Baumbach, T. Johnson, V. Oriolo, D. Smith, J. Usher, A. Davies, J. Strange (Bristol, GB) Patients with acute ST segment elevation myocardial infarction treated with percutaneous coronary intervention discharged before or at fourth days of hospitalization have worse long term outcome. – M. Hawranek, M. Gierlotka, M. Gasior, D. Pres, A. Kurek, P. Buchta, T. Osadnik, M. Wrobel, A. Lekston, L. Polonski (Zabrze, PL) Ivabradine improves short-term outcomes after primary percutaneous coronary intervention in patients presenting with acute ST-segment elevation myocardial infarction. – S. Cay, G. Cagirci, N. Sen, R. Atak, A.D. Demir, A.R. Erbay (Istanbul, Antalya, Ankara, Eskisehir and Yozgat, TR) Compared long-term survival of reperfused STEMI, non-reperfused STEMI and NSTEMI with or without PCI: 3-year results from the FAST-MI registry. – E. Puymirat, N. Aissaoui, G. Lemesle, L. Lorgis, M. Hanssen, E. Drouet, G. Mulak, J. Ferrieres, T. Simon, N. Danchin (Paris, Lille, Dijon, Haguenau and Toulouse, FR) Ventricular fibrillation is a major determinant of in-hospital mortality but does not impact long-term mortality after myocardial infarction: the FAST-MI registry. – E. Marijon, E. Puymirat, N. Aissaoui, G. Lemesle, L. Lorgis, L. Belle, V. Bataille, E. Drouet, T. Simon, N. Danchin (Paris, Lille, Dijon, Annecy and Toulouse, FR) P4859 P4860 P4861 P4862 P4863 QR 30612 293 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS A well organized regional network is a major determinant of improvement of acute myocardial infarction management. – C. El Khoury, P. Serre, E. Flocard, O. Capel, X. Jacob, L. Banaei, A. Desplanques, E. Bonnefoy-Cudraz (Vienne, Bourg en Bresse, Lyon and Saint Denis, FR) A randomized comparison of systematic vs. angiography-guided thrombus aspiration prior to coronary stenting in patients with less than 12h ST-elevation MI. A pilot study. – A. Moynagh, D. O H-Ici, J. Uribe, T. Hovasse, T. Unterseeh, Y. Louvard, T. Lefevre, J. Garot, M.C. Morice, P. Garot (Massy and Quincy, FR) Long-term clinical outcomes of infarct-related artery versus multivessel revascularization in acute ST-segment elevation myocardial infarction with multivessel disease: an analysis from KAMIR. – H.W. Lee, T.J. Hong, S.K. Ahn, M.J. Yang, J.H. Choi, B.W. Kim, H.C. Lee, K.S. Cha (Busan, KR) Early ambulance initiation versus cath-lab initiation of high dose clopidogrel in STEMI patients undergoing primary PCI. – S. Postma, J.H.E. Dambrink, M.J. De Boer, A.T.M. Gosselink, J.P. Ottervanger, J.C.A. Hoorntje, A.J. Wienke, H. Suryapranata, A.W.J. Van ’T Hof (Zwolle and Nijmegen, NL) Mortality of patients with ST-segment elevation myocardial infarction (STEMI) and cardiogenic shock treated by PCI is correlated to the infarct related artery - results from the PL-ACS Registry. – P. Trzeciak, M. Gierlotka, M. Gasior, M. Zembala, Z. Kalarus, K. Wilczek, L. Polonski (Zabrze, PL) Door to balloon time in primary angioplasty via the radial versus femoral approach and direct culprit vessel PCI versus initial diagnostic angiography. – M. Egred, A. Bagnall, J. Ahmed, A. Zaman, I. Purcell, R. Edwards, B. Keavney, I. Spyridopoulos (Newcastle-upon-Tyne, GB) False activation for primary percutaneous coronary intervention is not a benign phenomenon. – U. Chaudhry, C. Mavroudis, R.D. Rakhit (London, GB) Long-term outcomes of patients with acute myocardial infarction undergoing primary PCI excluded from the HORIZONS-AMI trial: results from a high volume recruiting center. – L. Fiocca, R. Rossini, H. Parise, G. Musumeci, A. Vassileva, N. Lortkipanidze, O. Valsecchi, R. Mehran, G.W. Stone, G. Guagliumi (Bergamo, IT; New York, US) A multimedia campaign in a Dutch region reduces patient delay in ST-elevation acute myocardial infarction treatment. – M. Bax, T.C.M. Heemskerk, T. Eckhardt, G.A.M. Ariens, P.J.M. Uitewaal, S. Imami, J.W. Bech, P. Oemrawsingh, L. Savalle, C.E. Schotborgh (The Hague and Delft, NL) PCI in STEMI: wire reperfusion, determinants and prognostic implications. – J. Szarfer, M.A. Riccitelli, A. Garcia Escudero, J. Gagliardi, G. Gigena, F. Blanco, R. Blanco, A. Alonso, A. Rodriguez, R. Sarmiento (Buenos Aires, AR) Primary PCI with DES implantation in patients with STEMI/LBBB. Euro Heart Survey ACS III registry (2006-2008). – W. Wojakowski, M. Tendera, M. Tubaro, M. Gierlotka, H. Bueno, M. Hochadel, Y. Hasin, J.-P. Bassand, A.K. Gitt (Katowice and Zabrze, PL; Rome, IT; Madrid, ES; Ludwigshafen am Rhein, DE; Tiberias, IL; Besançon, FR) Variations in practice and outcomes in patients undergoing primary percutaneous coronary intervention in the United States and Canada: insights from the APEX-AMI trial. – R.H. Mehta, P. Kaul, R.D. Lopes, M.R. Patel, K.S. Pieper, P.W. Armstrong, C.B. Granger (Durham, US; Edmonton, CA) Clinical outcomes in unselected patients presenting with acute STEMI complicated by cardiogenic shock in the primary PCI era - Early percutaneous haemodynamic support is indicated but underutilised. – R.P. Weerackody, K. Qureshi, A. Kapur, A. Wragg, E. Smith, R.A. Archbold (London, GB) Myocardial salvage is reduced in primary PCI-treated STEMI patients with microvascular obstruction, demonstrated by early and late CMR. – S. Limalanathan, J. Eritsland, G.O. Andersen, N.E. Klow, M. Abdelnoor, P. Hoffmann (Oslo, NO) Multivessel coronary disease determines 5-year mortality of patients with cardiogenic shock treated with percutaneous coronary intervention for ST-segment elevation myocardial infarction. – M. Hawranek, D. Pres, M. Gasior, M. Gierlotka, M. Tajstra, J. Piegza, T. Osadnik, A. Lekston, L. Polonski (Zabrze, PL) Reperfusion strategies in greater paris area and associated mortality in a 6-year registry. – N. Karam, M. Tafflet, S. Bataille, J.M. Juliard, J.Y. Letarnec, G.A. Capitani, F. Templier, P. Garot, Y. Lambert, X. Jouven (Paris, Melun, Corbeil-Essonnes, Garches, Massy and Le Chesnay, France, FR) Factors predicting mortality after primary percutaneous coronary intervention: impact of transradial access. – I. Hizoh, G. Szabo, A. Kecskes, N. Kiss, L. Major, Z. Gulyas, K. Hering, Z. Majoros, I. Zatroch, R.G. Kiss (Budapest, HU) Temporal trends in treatment and outcomes of patients with ST-segment elevation myocardial infarction (STEMI) in clinical practice - analysis from the PL-ACS registry. – L. Polonski, M. Gasior, M. Gierlotka, P. Buszman, W. Ruzyllo, J. Dubiel, W. Banasiak, Z. Kalarus, M. Zembala, G. Opolski (Zabrze, Katowice, Warsaw, Krakow and Wroclaw, PL) Assessment of the management of acute myocardial infarction in emergency room, compared to prehospital management. – P. Serre, C. El Khoury, E. Flocard, O. Capel, K. Echahed, S. Cieslak, F. Pajot, E. Bonnefoy-Cudraz (Bourg en Bresse, Vienne, Lyon, Valence, Bourgoin Jallieu and montelimar, FR) Impact of guidelines on the evolution of reperfusion strategies in acute STEMI. – N. Karam, M. Tafflet, S. Bataille, C. Lapandry, H. Auger, A. Greffet, S. Dubourdieu, F. Dupas, X. Jouven, Y. Lambert (Paris, FR) 294 P4864 P4865 P4866 P4867 P4868 P4869 P4870 P4871 P4872 P4873 P4874 P4875 P4876 P4877 P4878 P4879 P4880 P4881 P4882 P4883 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS P4884 P4885 P4886 P4887 P4888 P4889 P4890 P4891 P4892 P4893 P4894 P4895 P4896 P4897 TUESDAY – AFTERNOON The impact of symptom-to-door time and door-to-balloon time on 12-month mortality in patients undergoing primary percutaneous coronary interventions for ST-segment elevation myocardial infarction. – J.H. Lee, W.S. Choi, S.H. Park, D.H. Yang, H.S. Park, Y. Cho, S.C. Chae, J.E. Jun, M.H. Jeong, Y.J. Kim (Daegu and Gwangju, KR) Does field-triage of STEMI patients by paramedics improve door-to-balloon times and clinical outcomes in infarct PCI? Insights from the Melbourne Interventional Group (MIG) registry. – W.Y. Childs, N. Andrianopoulos, S. Sidharta, L. Roberts, S.J. Duffy, A. Ajani, J. Lefkovits, D. Clark, O. Farouque, G. New (Melbourne, AU) A higher baseline hemoglobin concentration is associated with a higher in-hospital mortality in patients with ST-segment elevation myocardial infarction. – O. Zouaghi, B.B. De Breyne, F.S. Sibellas, W.S. Sijilmassi, G.K. Kirkorian, E.B.C. Bonnefoy-Cudraz (Lyon, FR) ADAMTS1 is a novel acute biphasic marker for ischemia and reperfusion in myocardial infarction. – S. Hirohata, M. Obika, H. Ogawa, T. Miyoshi, R. Shinohata, S. Usui, S. Kusachi, Y. Ninomiya, H. Ito (Okayama, JP) National efforts to improve door-to-balloon time in ST-elevation myocardial infarction: results from 15 primary percutaneous coronary intervention centers in taiwan. – S.K. Chua, J.J. Cheng, S.H.H. Liao (Taipei, TW) The influence of Killip-Kimball classification on 5-year mortality in patients with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention. – D. Pres, M. Gasior, M. Gierlotka, M. Hawranek, M. Tajstra, K. Wilczek, P. Buchta, A. Lekston, L. Polonski (Zabrze, PL) Gender disparities in the management in ST and non ST segment elevation myocardial infarction. Insights from the Euro Heart Survey ACS III Registry. – F. Schiele, H. Bueno, M. Tubaro, M. Hochadel, N. Meneveau, W. Wojakowski, M. Gierlotka, K.A.A. Fox, A.K. Gitt, J.-P. Bassand (Besançon, FR; Madrid, ES; Rome, IT; Ludwigshafen am Rhein, DE; Katowice and Zabrze, PL; Edinburgh, GB) Is it possible to simplify risk stratification scores for patients with ST-segment elevation acute myocardial infarction submitted to primary angioplasty? – A.T. Timoteo, J.P. Lopes, L. Cardona, J.A. Oliveira, M.L. Ferreira, R.C. Ferreira (Lisbon, PT) Major bleeding is a predictor of mid-term mortality in STEMI patients treated with primary PCI. The ANIN myocardial infarction registry. – M. Polanska-Skrzypczyk, M. Karcz, P. Bekta, C. Kepka, W. Ruzyllo, A. Ciszewski, A. Witkowski (Warsaw, PL) Triple versus dual antiplatelet therapy in acute myocardial infarction in relation to renal function: data from the korean acute myocardial infarction registry: data from the korean acute myocardial. – S.J. Ha, S.H. Woo, W. Kim, S.R. Lee, S.K. Oh, S.W. Rha, Y.S. Jang, M.H. Jeong, C.J. Kim, H.S. Kim (Seoul, Jeonju, Iksan and Gwangju, KR) Contrast induced nephropathy after primary PCI for STEMI: usefulness of a new definition. – J. Silvain, V. Spagnoli, O. Barthelemy, A. Bellemain-Appaix, F. Beygui, N. Vignolles, G. Cayla, S. O’Connor, J.-P. Collet, G. Montalescot (Paris, FR) Evaluation of right ventricular function by 2D speckle tracking strain and strain rate imaging in acute myocardial infarction due to right coronary artery occlusion. – R.B. Bakal, K. Teber, B. Dindar, O. Omaygenc, C. Dogan, O. Candan, A. Demirkiran, S. Akpinar, G. Sahin, N. Ozdemir (Istanbul, TR) Clinical and angiographic predictors and implications of successful thrombus aspiration in STEMI. – A. Blasco, F.J. Goicolea, A. Muniz, B. Perez, M. Hernandez, L. Goicolea, A. Peinado, J.A. Fernandez, A. Garcia-Touchard, J.F. Oteo (Madrid, ES) The controlled reperfusion with bivalirudin and intra coronary abciximab in the porcine myocardial infarction/reperfusion model. – P.P. Buszman, W. Wojakowski, M. Debinski, K. Milewski, W. Jackiewicz, J. Pajak, B. Orlik, B. Trela, M. Kawka, P.E. Buszman (Katowice, PL) The off hours paradigm in primary percutaneous coronary intervention can be overcome by network structures. – R.G. Birkemeyer, T. Miljak, U. Meyerfeldt, M. Neuhaus, D. Hildebrand, H. Kohler, W. Jung (Villingen-Schwenningen, DE) Associations between symptom-to-door time and biomarkers on 12-month mortality in patients with acute myocardial infarction. – J.H. Lee, K.H. Kim, W.S. Choi, S.H. Park, M.H. Bae, D.H. Yang, H.S. Park, Y. Cho, S.C. Chae, J.E. Jun (Daegu, KR) Impact of target treatment delays according to current STEMI guidelines on myocardial salvage. – L. Sanchis, X. Bosch, S. Goncalves, A. Regueiro, A. Betriu, M. Masotti, V. Martin, M. Sabate, J. Ortiz (Barcelona, ES) Multi-vessel disease identified at PPCI: prevalence, associations and outcome. – D. Austin, Z. Adam, M. Awan, A.G.C. Sutton, J.A. Hall, R.A. Wright, D.F. Muir, N.M. Swanson, J. Carter, M.A. De Belder (Middlesbrough, GB) Intravenous aldosterone blockade at presentation improves myocardial perfusion after primary PCI for STEMI. – F. Beygui, J.P. Labbe, N. Vignolles, B. Bertin, A. Bellemain-Appaix, J. Silvain, G. Cayla, O. Barthelemy, J.-P. Collet, G. Montalescot (Paris, FR) May G-CSF after large anterior acute STEMI influence LV systolic and diastolic function? Results of Stem Cells Mobilization in Acute Myocardial Infarction (STEM-AMI) trial. – F. Gentile, V. Dadone, L. Lenatti, C. Malafronte, G. Pompilio, L. Squadroni, F. Di Gennaro, S. Maggiolini, G. Colombo, F. Achilli (Cinisello Balsamo, Lecco, Milan, Monza and Merate, IT) P4898 P4899 P4900 P4901 P4902 P4903 295 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Characteristics, mortality and prognosis factors of acute right ventricular myocardial infarction in the modern era. – C. Meune, N. Aissaoui, K. Wahbi, O. Merceron, S. Weber (Paris, FR) Evaluating the potential effect of N-acetylcysteine on early remodeling biomarkers of ST-segment elevation myocardial infarction: A double blind placebo controlled study. – A.H. Talasaz, H. Khalili, F. Fahimi (Tehran, IR) Acute myocardial infarction: pre-hospital epidemiology profile in the city of Moscow. – N. Plavunov, V. Baratashvili, Y.U. Ovasapian (Moscow, RU) Ventricular fibrillation during first 48 hours of ST-elevation myocardial infarction treated with primary angioplasty does not affect one-year survival. – M. Demidova, C.-J. Hoijer, D. Erlinge, P.G. Platonov (Lund, SE) Efficacy of a new accelerated streptokinase regime in acute myocardial infarction (a double blind randomized clinical trial). – S. Ghaffari, B. Kazemiarbat, I. Ghorbani Golzari, L. Pourafkari (Tabriz, IR) Age related mortality of primary PCI patients at a high volume UK cardiac centre. – N. Malik, G.G. Babu, R.K. Aggarwal, P.A. Kelly, J.R. Davies, N.M. Robinson (Basildon, GB) Impact of diverting off-hours calls to emergency medical dispatch centers on time delays and acute revascularization procedures for patients with acute myocardial infarction. Data from RICO survey. – F. Dumont, L. Lorgis, J.M. Yeguiayan, M. Zeller, A. Avondo, G. Dentan, J.N. Beis, Y. Cottin, M. Freysz, G. Morel (Dijon and Fontaine les Dijon, FR) Mid-term outcomes of iodixanol versus iomeprol contrast medium after primary angioplasty for st elevation myocardial infarction. – L. Bertelli, F.A. Sgura, M. Manicardi, A. Campioli, G. Spadafora, C. Leuzzi, R. Rossi, G. Biondi Zoccai, G.M. Sangiorgi, M.G. Modena (Modena, IT) Survival in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary angioplasty is not dependent on socio-economic status in the UK. – S.S. Kalra, A.M. Shah, J.A. Byrne, J.M. Hill, R. Dworakowski, A. Qasim, P.A. MacCarthy, N. Melikian (London, GB) Myocardial infarction complicated by cardiogenic shock in patients with multivessel coronary artery disease treated with percutaneous coronary intervention - 3-year outcomes. – A. Lekston, B. Hudzik, M. Gasior, J. Szkodzinski, G. Slonka, M. Gierlotka, M. Hawranek, L. Polonski (Zabrze, PL) Use of statins at hospital discharge influence 5-year mortality of patients with acute ST segment elevation myocardial infarction treated with percutaneous coronary intervention. – M. Hawranek, M. Gierlotka, M. Gasior, U. Nowak, A.M. Frycz-Kurek, M. Tajstra, T. Osadnik, B. Hudzik, A. Lekston, L. Polonski (Zabrze, PL) Stringent glycemic control on the first day post admission improves outcome in patients with acute ST-segment elevation myocardial infarction. – Y. Yazeed, Y. Sharaf, H. Kandil, S.H. El Tobgi (Cairo, EG) Sex-specific coronary heart disease mortality trends in Brazil from 1980 to 2008. – A.S. Cordeiro Da Rocha, B.R. Tura, A.R. De Lorenzo, F.J.M. Pittella, M.A. Mattos (Rio de Janeiro, BR) How different is the management? Results from the brazilian acute coronary syndrome registry. – L. Piegas, A. Avezum, H.P. Guimaraes, H.J.L. Reis, A.J. Muniz, E.S. Santos, P. Smith, J.R.Z. Mendes, R. De Souza (São Paulo, Belém do Pará and Juiz de Fora, BR) Clinical predictors of ten-year event-free survival after myocardial infarction. – G. Berton, R. Cordiano, R. Palmieri, G.L. Guarnieri, C. Cavuto, A. Cati, F. Gidoni Guarnieri, G. Preti, R. De Toni, P. Palatini (Conegliano, Adria, Bassano and Padua, IT) Long-term outcomes and glucometabolic status in non-diabetic patients with acute myocardial infarction. – L. David, A. Grosu (Chisinau, MD) P4904 P4905 P4906 P4907 P4908 P4909 P4910 P4911 P4912 P4913 P4914 P4915 P4916 P4917 P4918 P4919 TREATMENT OF HYPERTENSION (QR 30613*) Long-term effects of music therapy on patients with hypertension and acute myocardial infarction after previous revascularization; 9-year experience. – P.M. Mitrovic, Z. Vasiljevic, B. Stefanovic, A. Paladin, M. Radovanovic, N. Radovanovic, D. Rajic, G. Matic, T. Jozic, A. Novakovic (Belgrade, RS) The combination of drug and CPAP - therapy of the patients with II - III stage arterial hypertension and a high degree of cardiovascular risk. – Y.E.A. Pavlyuk, Y.U.N. Sirenko, Y.U.N. Pogoretskiy, O.L. Recovets (Kiev, UA) Antihypertensive and metabolic effects of perindopril/amlodipine in hypertensives with coronary artery disease: results of the perindopril/amlodipine reducing blood pressure level study (PEARL study). – V.L. Nagy, E. Lantos, N. Habony (Budapest, HU) Long term effect of continuous positive airway pressure on hypertension control in patients with obstructive sleep apnea: A 3 year follow-up study. – A. Kasiakogias, C. Tsioufis, C. Thomopoulos, L. Lioni, D. Aragiannis, K. Kintis, M. Almyroudi, M. Alchanatis, I. Kallikazaros, C. Stefanadis (Athens, GR) Prognosticators of left ventricular mass regression in hypertensive patients: a prospective study. – E. Andrikou, C. Tsioufis, C. Thomopoulos, I. Andrikou, N. Alexopoulos, I. Bafakis, M. Poulakis, D. Aragiannis, D. Syrseloudis, C. Stefanadis (Athens, GR) *Abstracts can be accessed at: 296 QR 30613 P4920 P4921 P4922 P4923 P4924 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS P4925 P4926 P4927 P4928 P4929 P4930 P4931 P4932 P4933 P4934 P4935 P4936 P4937 P4938 P4939 P4940 TUESDAY – AFTERNOON Renal sympathetic denervation using an irrigated radiofrequency ablation catheter for the management of drug-resistant hypertension. – H. Ahmed, P. Neuzil, J. Skoda, J. Petru, L. Sediva, S. Kralovec, V.Y. Reddy (New York, US; Prague, CZ) Gene Expressions of Angiotensin II Receptor Type 1A and Angiotensin Converting Enzyme in Spontaneously Hypertensive Rats after Losartan Treatment. – K.C. Kim, M.S. Cho, Y.M. Hong (Seoul, KR) Treatment by ACE inhibitors of an arterial hypertension at patients with hepatic pathologies. – I. Komissarenko, I.A. Komissarenko, O.M. Mikheyeva, L.B. Lazebnik (Moscow, RU) Short-term effects of percutaneous renal denervation on central hemodynamics and aortic stiffness: a prospective evaluation. – M. Reppel, K.F. Franzen, F. Himmel, S. Gisch, T. Graf, F. Bode, H. Schunkert, J. Weil, K. Mortensen (Lübeck, DE) Pre-clinical experience with a next-generation system for prolonged baroreflex activation. – T.E. Lohmeier, K. Ludwig, R.S. Kieval (Jackson and Minneapolis, US) Treatment of hypertension in the elderly - data from an international cohort of hypertensives treated by cardiologists. – F. Mahfoud, M. Thoenes, M. Böhm, B.V. Khan, W. Kirch, L. Thevasthasan, P. Bramlage (Homburg, Dresden and Mahlow, DE; Atlanta and New York, US) The influence of antihypertensive treatment on arterial stiffness and arterial wall shear stress. – M. Rajzer, W. Wojciechowska, M. Klocek, K. Kawecka-Jaszcz (Krakow, PL) Cancer risk not increased by RAAS blockade - real world population study in Taiwan. – P. Pai, C.H. Muo, P.C. Chen, Y.T. Lee (Taichung, TW) Preventive effects of valsartan on stroke are emphasized in patients without treatment of calcium channel blockers: sub-analysis of KYOTO HEART study. – H. Yamada, T. Sawada, M. Koide, J. Shiraishi, H. Matsubara (Kyoto, JP) Effect of spironolactone treatment on microalbuminuria and proteinuria in patients with resistant arterial hypertension: insights from the ASPIRANT trial. – E. Kocianova, J. Vaclavik, R. Sedlak, M. Plachy, K. Navratil, J. Plasek, J. Jarkovsky, T. Vaclavik, R. Husar, M. Taborsky (Olomouc, Prostejov, Brno, Ostrava, Prague and Hranice na Morave, CZ) Effects of azelnidipine on single cardiomyocyte mechanics. – G. Iribe, K. Kaihara, H. Ito, K. Naruse (Okayama, JP) Daily physical activity and blood pressure control in hypertensive patients followed in primary care centers in Chile. – M. Bravo, C.X. Romero, T. Romero, E. Koch, D. Sandoval, M. Cano, I. Ahlers, O. Henriquez, A.I.J. Gajardo (Santiago, CL; San Diego, US) Blood pressure reduction in diabetic patients with cardio-renal complications. Results from the 3A registry. – M.V. Lehmann, R. Dechend, E. Kaiser, E. Deeg, J. Senges, U. Zeymer, R.E. Schmieder (Erlangen, Berlin, Nuremberg and Ludwigshafen, DE) Favorable effect of angiotensin receptor blockers compared to calcium blockers on exercise-induced inflammatory and coagulative response. – C. Liakos, G. Vyssoulis, A. Michaelides, E. Chatzistamatiou, G. Theodosiades, M. Toutouza, C. Tsioufis, A. Miliou, M. Markou, C. Stefanadis (Athens, GR) Trends in hypertension prevalence, control and guidelines implementation in Spain through last decade. – A. Cordero, V. Bertomeu-Martinez, P. Mazon, L. Facila, J. Cosin, V. Bertomeu-Gonzalez, M. Rodriguez, E. Galve, I. Lekuona, J.R. Gonzalez-Juanatey (Alicante, Santiago de Compostela, Castellón, Valencia, Pamplona, Barcelona and Bilbao, ES) Pharmacological instrument for the genetically determined arterial hypertension treatment. – O. Zabela, V. Shylau, E. Fedulova, O. Kardash, N. Nadina, T. Krasnenkova, E. Shafranovskaya (Minsk, BY) Ace2 enzyme, that breaks down angiotensin I and angiotensin II, shows increased activity in patients with treated hypertension. – M. Fagyas, K. Uri, I. Manyine Siket, I. Edes, Z. Papp, A. Toth (Debrecen, HU) P4941 TRANSCATHETER AORTIC VALVE IMPLANTATION – IMAGING (QR 30614*) Implications of aortic valve calcification for paravalvular aortic regurgitation post-transcatheter aortic valve implantation. – S.H. Ewe, A.C.T. Ng, J.D. Schuijf, F. Van Der Kley, A. Colli, A. De Weger, N.A. Marsan, M.J. Schalij, J.J. Bax, V. Delgado (Leiden, NL; Badalona, ES) Transfemoral aortic valve implantation: new criteria to predict vascular complications. – K. Hayashida, T. Lefevre, B. Chevalier, T. Hovasse, M. Romano, P. Garot, D. Mylotte, J. Uribe, B. Cormier, M.C. Morice (Massy and Quincy, FR) Clinical and echocardiographic predictors of paravalvular aortic regurgitation after implantation of CoreValve aortic valve prosthesis. – M. Crespin-Crespin, D. Mesa Rubio, M. Ruiz Ortiz, M. Delgado Ortega, M.C. Leon Del Pino, J. Suarez De Lezo Cruz-Conde, M. Pan Alvarez-Ossorio, D. Garcia Fuertes, J. Suarez De Lezo Herreros De Tejada, F. Mazuelos Bellido (Córdoba, ES) *Abstracts can be accessed at: P4942 P4943 P4944 QR 30614 297 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS The Doppler-based renal resistive index predicts acute kidney injury in patients after transcatheter aortic valve implantation. – J.-M. Sinning, V. Adenauer, H. Steinhaeuser, A. Ghanem, C. Hammerstingl, E. Grube, G. Nickenig, N. Werner (Bonn, DE) Incidence of peri-procedural ischemic brain lesions in cerebral MRI: comparison of transcatheter aortic valve implantation and conventional aortic valve replacement. – M.B. Arnold, S. Ensminger, S. Ott, S. Achenbach, 0. Roerick, R. Feyrer, A. Doerfler, W.G. Daniel, M. Weyand, J. Ludwig (Erlangen, DE) Prediction of aortic annulus plane angulation and C-arm positioning by 3D analysis of pre-procedural multislice computed tomography: benefit on safety outcome in patients referred for TAVI. – M. Samim, P.R. Stella, J. Kluin, F. Ramjankhan, R.P.J. Budde, P. Agostoni, G. Sieswerda, L. Van Herwerden, P.A.F.M. Doevendans, E. Van Belle (Utrecht, NL; Lille, FR) TAVI operator radiation dose compared to PCI and ICD operators: do we need additional radiation protection for trans-catheter structural heart interventions. – M. Drury-Smith, A. Maher, C. Douglas-Hill, R. Singh, M. Bhabra, J. Cotton, S. Khogali (Wolverhampton, GB) Intracardiac echocardiography: a new guiding tool for transcatheter aortic valve implantation. – T. Bartel, N. Bonaros, G. Friedrich, L. Mueller, S. Mueller (Innsbruck, AT) Validation and characterization of Doppler-echocardiographic measures of prosthetic valve effective area following transcatheter aortic implantation. – M.-A. Clavel, J. Rodes-Cabau, S. Bergeron, E. Dumont, R. Bagur, R. De Larochelliere, D. Doyle, J. Lemieux, J.G. Dumesnil, P. Pibarot (Quebec, CA) Predictive factors of aortic regurgitation after transcatheter aortic valve implantation: a 2D- and 3D-transoesophageal echocardiographic study in 135 patients. – P. Gripari, M. Muratori, N. Ajmone Marsan, S. Hooi Ewe, C.T. Arnold, F. Van Der Kley, M. Fusari, J.J. Bax, G. Tamborini, M. Pepi (Milan, IT; Leiden, NL) Choice of CoreValve prosthesis size in case of disagreement between echocardiography and computed tomography: impact on procedural and 1-year results. – M. De Carlo, G. Benedetti, M. Schlueter, C. Giannini, C. Nardi, M. Coceani, F. Guarracino, P. Marraccini, A.S. Petronio (Pisa, IT) Multimodality imaging in transcatheter aortic valve implantation and post-procedural outcome: comparison between cardiovascular magnetic resonance, cardiac computed tomography and echocardiography. – A. Jabbour, T. Ismail, A. Gulati, I. Roussin, F. Alpendurada, S. Davies, M. Mullen, M. Rubens, N. Moat, R. Mohiaddin (London, GB) 3-mensio software for the measurement of the aortic annulus before TAVI: agreement with multi-slice tomography and with echocardiography. – M. De Carlo, G. Benedetti, M. Schlueter, C. Giannini, M. Coceani, M.G. Delle Donne, F. Guarracino, P. Marraccini, A.S. Petronio (Pisa, IT) Right ventricular function deteriorates after surgical aortic valve replacement but not after transcatheter aortic valve implantation. – A. Kempny, G.-P. Diller, S. Orwat, G. Kaleschke, G. Kerckhoff, R. Schmidt, J. Mascherbauer, H. Reinecke, H. Baumgartner (Münster, DE) Longitudinal left ventricular 2D strain is a strong predictor of myocardial recovery and symptomatic improvement after transcatheter aortic valve implantation. – A. Kempny, G.-P. Diller, S. Orwat, G. Kaleschke, G. Kerckhoff, S. Schmidt, J. Mascherbauer, H. Reinecke, H. Baumgartner (Münster, DE) Value of 3d-echocardiography in patient selection prior to implantation of a corevalve-prosthesis. – R. Schueler, M. Weber, D. Momcilovic, A. Ghanem, J.M. Sinning, N. Werner, G. Nickenig, C. Hammerstingl (Bonn, DE) Impact of severe left ventricular systolic dysfunction on clinical and echocardiographic outcomes following transcatheter aortic valve implantation for severe aortic stenosis. – C. Fiorina, M. De Carlo, G.P. Ussia, A. Ramondo, F. Maisano, S. Klugmann, F. Bedogni, C. Tamburino, A.S. Petronio, F. Ettori (Brescia, Pisa, Catania, Padua and Milan, IT) Aortic leaflet calcification and annulus dimensions on contrast MSCT predict the need for balloon post-dilatation during TAVI. – C.J. Schultz, A. Rossi, N. Van Mieghem, L. Papodopoulou, R. Van Domburg, A. Moelker, R. Van Geuns, K. Nieman, P.W. Serruys, P.P.T. De Jaegere (Rotterdam, NL) Impact of three dimensional transesophageal echocardiography on prosthesis sizing for transcatheter aortic valve implantation. – O. Husser, S. Rauch, M. Resch, J. Nunez, V. Bodi, M. Hilker, C. Schmid, G.A.J. Riegger, A. Luchner, C. Hengstenberg (Regensburg, DE; Valencia, ES) Anatomical constraints in transcatheter aortic valve implantation: really a limitation in patient treatment? – O. Sousa, D. Caeiro, M. Carvalho, J. Rocha, D. Leite, N. Bettencourt, J. Ribeiro, A. Albuquerque, L. Simoes, V. Gama (Vila Nova de Gaia, PT) Valvulo-arterial impedance (Zva): a new index of global hemodynamic load in the evaluation of severe aortic stenosis treated by transcutaneous aortic valve prosthetic implantation (Corevalve). – C. Giannini, C. Cucco, A.I. Corciu, M.G. Delle Donne, V. Barletta, M. De Carlo, F.L. Dini, M. Marzilli, A.S. Petronio, V. Di Bello (Pisa, IT) 298 P4945 P4946 P4947 P4948 P4949 P4950 P4951 P4952 P4953 P4954 P4955 P4956 P4957 P4958 P4959 P4960 P4961 P4962 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS TRANSCATHETER AORTIC VALVE IMPLANTATION – CLINICAL (QR 30615*) *Abstracts can be accessed at: P4963 P4964 P4965 P4966 P4967 P4968 P4969 P4970 P4971 P4972 P4973 P4974 P4975 P4976 TUESDAY – AFTERNOON Transcatheter aortic valve implantation: impaired kidney function is an important predictor for survival and quality of life. Results from the German aortic valve interventions registry. – S. Sack, G.C. Schuler, H. Sievert, R. Hambrecht, K.E. Hauptmann, C. Naber, U. Gerckens, R. Zahn, E. Grube, J. Senges (Munich, Leipzig, Frankfurt, Bremen, Schweinfurt, Essen, Siegburg, Ludwigshafen am Rhein and Ludwigshafen, DE) Role of inflammation and reactive oxygen species in Acute Kidney Injury (AKI) after Transcatheter Aortic Valve Implantation (TAVI). – R. Dworakowski, O. Wendler, A.M. Bhan, E. Alcock, J. Byrne, B. Brickham, T. Dew, A.M. Shah, P. MacCarthy (London, GB) Incidence and outcome of Paravalvular Aortic Regurgitation (PAR) after transfemoral aortic valve implantation (TAVI). – P.C. Patsalis, F. Al-Rashid, M. Riebisch, B. Plicht, D. Wendt, M. Thielmann, H. Jakob, H. Eggebrecht, R. Erbel, P.H. Kahlert (Essen and Frankfurt, DE) Transcatheter aortic valve implantation via direct aortic approach: initial clinical experience with this novel approach. – M. Chan, C. Di Mario, S.W. Davies, F. Azeem, R. Trimlett, N. Moat (London, GB) Frequency and predictors of acute kidney injury, and its impact on outcome after transcatheter aortic valve implantation. – K. Gebauer, M. Meyborg, N. Malyar, G. Kerkhoff, G. Kaleschke, H. Baumgartner, H. Reinecke (Münster, DE) The burden of not treating patients with severe aortic stenosis: comparison of secondary care resource consumption in TAVI versus medical management cohort of 30 patients in a UK NHS setting. – M. Cook, P. Brasseur, R. Busca (Watford, GB; Tolochenaz, CH) Previous heart surgery does not influence the outcome of Transcatheter Aortic Valve Implantation (TAVI) patients: results of the German registry on TAVI. – M. Kasel, M. Horack, G.C. Schuler, K.-H. Kuck, U. Sechtem, H.G. Richardt, S. Sack, R. Zahn, J. Senges, E. Hoffmann (Munich, Ludwigshafen, Leipzig, Hamburg, Stuttgart and Bad Segeberg, DE) Quality of life dynamics after transcatheter aortic valve implantation. – M. Krane, M.A. Deutsch, N. Piazza, T. Muhtarova, E. Yacine, D. Mazzitelli, B. Voss, H. Ruge, S. Bleiziffer, R. Lange (Munich, DE) Non-responding to transcatheter aortic valve implantation: impact of mitral valve regurgitation and left atrial enlargement on symptomatic benefit. – M. Gotzmann, W. Bojara, M. Lindstaedt, A. Ewers, A. Germing, A. Muegge (Bochum, DE) Transcatheter aortic valve implantation versus surgical aortic valve replacement in patients with severe aortic stenosis. – M. Barbanti, G.P. Ussia, D. Capodanno, P. Aruta, A.M. Pistritto, V. Cammalleri, M. Scarabelli, G. Del Campo, C. Mignosa, C. Tamburino (Catania, IT) Hemodynamic results after TAVI: up to 3 years follow-up of 338 patients after corevalve implantation. – A. Opitz, I. Hettich, A. Hutter, S. Bleiziffer, H. Ruge, N. Piazza, D. Mazzitelli, R. Lange (Munich, DE) Transcatheter aortic valve implantation: economic evaluation of the FRANCE (FRench Aortic National Corevalve and Edwards) registry. – K. Chevreul, M. Brunn, B. Cadier, I. Durand-Zaleski, A. Pavie, P. Gueret (Paris and Créteil, FR) Acute results and late outcomes of transcatheter aortic valve implantation according to the valve academic research consortium classification: results of the prospective single centre Rouen registry. – B. Borz, E. Durand, M. Godin, C. Tron, C. Sanchez Giron, P.Y. Litzler, J.P. Bessou, A. Cribier, H. Eltchaninoff (Rouen, FR) Acute kidney injury following transcatheter aortic valve implantation: incidence, predictors and 1-year clinical outcome. – F. Saia, C. Ciuca, C. Marrozzini, N. Taglieri, C. Moretti, C. Savini, E. Pilato, F. Petridis, R. Di Bartolomeo, A. Marzocchi (Bologna, IT) One-year outcome of patients eligible to transcatheter aortic valve implantation according to actual treatment. – F. Saia, C. Ciuca, C. Marrozzini, T. Palmerini, N. Taglieri, C. Moretti, B. Bordoni, G. Dall’ara, A. Branzi, A. Marzocchi (Bologna, IT) Transcatheter aortic valve implantation: 1 year follow-up and predictors of mortality. Data from a multi-centre real world registry. – R. Zahn, G.C. Schuler, H. Sievert, R. Erbel, R. Hambrecht, G. Nickenig, K.E. Hauptmann, S. Sack, J. Senges, U. Gerckens (Ludwigshafen am Rhein, Leipzig, Frankfurt, Essen, Bremen, Bonn, Trier, Munich, Ludwigshafen and Siegburg, DE) Transcatheter aortic valve implantation: a new therapeutic option in patients with degenerated aortic bioprostheses? Results from the German aortic valve interventions registry. – R. Zahn, T. Bauer, G.C. Schuler, H. Sievert, P. Kahlert, R. Hambrecht, G. Nickenig, K.E. Hauptmann, C.H. Naber, U. Gerckens (Ludwigshafen am Rhein, Leipzig, Frankfurt am Main, Essen, Bremen, Bonn, Trier and Siegburg, DE) Transcatheter aortic valve implantation versus balloon valvuloplasty - periprocedural outcome data from the German-TAVI Registry. – R. Hein, R. Zahn, M. Horack, U. Gerckens, H. Sievert, K.-H. Kuck, R. Hambrecht, H. Ince, J. Senges, H. Mudra (Munich, Ludwigshafen, Bonn, Frankfurt am Main, Hamburg, Bremen and Rostock, DE) P4977 P4978 P4979 P4980 QR 30615 299 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Transcatheter aortic valve implantation in low-gradient aortic stenosis: results from the german transcatheter aortic interventions-registry. – A. Lauten, M. Ferrari, C. Jung, R. Zahn, H. Sievert, A. Linke, E. Grube, S. Sack, J. Senges, H.R. Figulla (Jena, Ludwigshafen am Rhein, Frankfurt, Leipzig, Siegburg and Munich, DE) Transcatheter aortic valve implantation for severe symptomatic aortic stenosis: results in patients with porcelain aorta. – R. Zahn, G.C. Schuler, H. Sievert, R. Erbel, R. Hambrecht, G. Nickenig, K.E. Hauptmann, C.H. Naber, S. Sack, U. Gerckens (Ludwigshafen am Rhein, Leipzig, Frankfurt am Main, Essen, Bremen, Bonn, Trier, Munich and Siegburg, DE) Antithrombotic therapy after transfemoral aortic valve implantation (TAVI). Potential hazard of triple-therapy. – U. Zeymer, R. Zahn, U. Gerckens, G. Richard, H.R. Figulla, J. Senges (Ludwigshafen am Rhein, Siegburg, Bad Segeberg and Jena, DE) Incidence of corevalve dislocation - a single-center experience. – F. Al-Rashid, P. Patsalis, H. Eggebrecht, B. Plicht, T. Konorza, D. Wendt, M. Thielmann, H. Jakob, R. Erbel, P.H. Kahlert (Essen, DE) Patient prosthesis mismatch after transfemoral TAVI: survival in 12 month follow up. – H. Westhoelter, P. Kahlert, F. Al-Rashid, T.F.M. Konorza, R. Erbel, B. Plicht (Essen, DE) Learning curve of transcatheter aortic valve implantation: trends in mortality over the years. – P. Salinas, R. Moreno, L. Calvo, D. Dobarro, G. Galeote, S. Jimenez-Valero, A. Sanchez-Recalde, A. Alvarez, I. Plaza, J. Lopez-Sendon (Madrid, ES) Prosthesis performance and outcome of transcatheter aortic valve implantation: a single center experience. – V. Gasparetto, M. Napodano, A. D’onofrio, C. Fraccaro, G. Tarantini, D. Pittarello, R. Bianco, G. Gerosa, S. Iliceto, G. Isabella (Padua, IT) Bleeding risk factors in transcatheter aortic valve implantation (TAVI) patients. – J. Stepinska, K. Czerwinska, A. Witkowski, M. Dabrowski, M. Banaszewski, P. Michalek, Z. Chmielak, K. Kusmierski, T. Hryniewiecki, M. Demkow (Warsaw, PL) Periprocedural bleeding predicts outcome after transcatheter aortic valve implantation (TAVI). – B.P. Halliday, R. Dworakowski, B. Brickham, O. Wendler, P. MacCarthy (London, GB) Conduction abnormalities after balloon valvuloplasty predict permanent pacemaker requirement in transcatheter aortic valve implantation. – D. John, S. Hausen, G. Latsios, S. Yuecel, H.-C. Eberle, M. Farazandeh, U. Gerckens, E. Grube, O. Bruder, C.K. Naber (Essen, Bonn and Siegburg, DE) Invasive assessment of atrioventricular conduction changes following transcatheter aortic valve implantation with self-expandable or balloon-expandable prosthesis. – A. Rollin-Garderes, N. Dumonteil, P. Mondoly, B. Marcheix, A. Duparc, N. Boudou, D. Tchetche, P.H. Maury, M. Delay, D. Carrie (Toulouse, FR) Gender differences in clinical presentation and outcome of transcatheter aortic valve implantation for severe aortic stenosis. – K. Hayashida, M.C. Morice, B. Chevalier, T. Hovasse, M. Romano, P. Garot, B. Cormier, T. Lefevre (Massy and Quincy, FR) Success of transcatheter aortic valve implantation (TAVI) according to standardized outcome definitions by the valve academic research consortium (VARC). – B.E. Stahli, R. Bunzli, J. Grunenfelder, D. Bettex, D.L. Nguyen-Kim, V. Falk, T.F. Luscher, R. Corti, W. Maier, L. Altwegg (Zurich, CH) Transcatheter aortic valve implantation with the Edwards valve prosthesis in patients with low (<20%) logistic euroscore: results of a prospective single center registry. – M. Godin, B. Borz, C. Tron, E. Durand, F. Doguet, P.-Y. Litzler, J.-P. Bessou, A. Cribier, H. Eltchaninoff (Rouen, FR) Impact of mitral regurgitation on outcome of transcatheter aortic valve implantation. – A. D’onofrio, V. Gasparetto, M. Napodano, C. Fraccaro, V. Renier, G. Tarantini, D. Pittarello, S. Iliceto, G. Isabella, G. Gerosa (Padua, IT) Impact of prosthesis-patient mismatch on hemodynamic and clinical outcomes after transcatheter aortic valve implantation with balloon-expandable valves. – S.H. Ewe, V. Delgado, G. Tamborini, M. Muratori, M. Pepi, F. Van Der Kley, M. Fusari, P. Biglioli, J.J. Bax, N.A. Marsan (Leiden, NL; Milan, IT) Numerous patients fail the aortic annulus criteria in transcatheter aortic valve implantation - comparison of current devices. – D. John, S. Hausen, G. Latsios, S. Yuecel, H.-C. Eberle, M. Farazandeh, U. Gerckens, E. Grube, C.K. Naber, O. Bruder (Essen, Bonn and Siegburg, DE) P4981 P4982 P4983 P4984 P4985 P4986 P4987 P4988 P4989 P4990 P4991 P4992 P4993 P4994 P4995 P4996 P4997 HEART FAILURE – LEFT VENTRICULAR FUNCTION (QR 30616*) Matrix metalloproteinase-1 is differently regulated in patients with heart failure and normal EF compared to reduced EF: a trigger for cardiac dilation. – D. Westermann, D. Lindner, C. Tschoepe, H.-P. Schultheiss (Berlin, DE) *Abstracts can be accessed at: 300 QR 30616 P4998 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS P4999 P5000 P5001 P5002 P5003 P5004 P5005 P5006 P5007 P5008 P5009 P5010 P5011 P5012 P5013 P5014 P5015 TUESDAY – AFTERNOON High diastolic stiffness modifies sarcomeric structure in failing human cardiomyocytes. – D. Czuriga, R.J.P. Musters, A. Borbely, I. Falcao-Pires, S.J.P. Bogaards, A.F. Leite-Moreira, Z. Papp, J. Van Der Velden, G.J.M. Stienen, W.J. Paulus (Amsterdam, NL; Porto, PT; Debrecen, HU) Left atrial reservoir function is reduced in diastolic heart failure in a compensated state. – M. Obokata, S. Tange, H. Arima, N. Kobayashi, Y. Ono, J. Kuribara, G. Ui, M. Kurabayashi (Maebashi, JP) Genetic predisposition in hypertension with normal ejection fraction to oxidative stress is greater than that of controls and increases with the degree of left ventricular diastolic dysfunction. – A. Fazakas, Z.S. Szelenyi, P. M Szabo, A. Patocs, M. Doleschall, I. Karadi, A. Vereckei (Budapest, HU) Left ventricular diastolic dysfunction and cardiovascular autonomic neuropathy in type 2 diabetes mellitus. – C.J. Magri, A. Cassar, S. Fava, A. Fenech (Msida, MT) Left atrial diastolic dysfunction: an unrecognized cause of pulmonary venous hypertension. – H. Kadakia, S. Channah, J.T. Heywood, A. Johnson, M. Smith, T. Khan (San Diego, US) Efficacy and safety of ivabradine in hemodialysed patients with diastolic heart failure. – G. Cice, S. D’isa, A. D’Andrea, G. Rosano, M.G. Russo, R. Calabro (Naples and Rome, IT) Serum cystatin C is associated with diastolic dysfunction and altered collagen metabolism in hypertensive patients with heart failure. – A. Gonzalez Miqueo, A. Huerta, B. Lopez Salazar, O. Beloqui, J. Diez (Pamplona, ES) Coordinated changes in titin phosphorylation increase myofilament stiffness in failing hearts. – M. Krueger, L. Gout, M. Von Frieling-Salewsky, S. Koetter, W.A. Linke (Bochum, DE) In patients with heart failure and normal ejection fraction, integrated backscatters are markers of diastolic function. – B. D’here, D. Stepowski, C. Vallet, B. Kurtz, J. Caudron, J.N. Dacher, V. Richard, M. Vasse, H. Eltchaninoff, F. Bauer (Rouen, FR) Association between neurohormonal activation and submaximal exercise capacity in patients with diastolic dysfunction and diastolic heart failure. – A. Duvinage, R. Stahrenberg, G. Gelbrich, G. Hasenfuss, R. Wachter, B. Pieske, F. Edelmann (Göttingen and Leipzig, DE; Graz, AT) Prolonged diastolic vortex duration in heart failure with preserved ejection fraction. – T.T. Le, F. Huang, R.S. Tan (Singapore, SG) Left atrial volume index has more accuracy than left atrial diameter index for the diagnosis of heart failure with normal ejection fraction in outpatients. – A.J. Lagoeiro Jorge, M.L. Ribeiro, M.L.G. Rosa, F.V. Licio, L.C.M. Fernandes, P.G. Lanzieri, B.A.L. Jorge, E.T. Mesquita (Niterói and Rio de Janeiro, BR) Elevated mid-region pro-adrenomedullin is associated with increased mortality in stable outpatients with diastolic dysfunction. – Y. Xue, P. Taub, A. Fard, N.M. Iqbal, H. Nguyen, P. Clopton, A.S. Maisel (San Diego, US) The effect of Losartan plus Hydrochlorothiazide combination therapy on left ventricular diastolic function in patient with hypertension: EDEN Multicenter Trial. – K. Ishii, H. Ito, H. Kihara, H. Watanabe, K. Shimada, K. Iwakura, J. Yoshikawa (Osaka, Okayama, Asahikawa, Tokyo and Nishinomiya, JP) Anemia and mortality in patients with heart failure associated with preserved LV ejection fraction in Korean acute heart failure registry. – J.E. Kim, S.M. Kim, S.Y. Lee, J.W. Bae, K.K. Hwang, D.W. Kim, M.C. Cho (Cheongju, KR) What distinguishes restrictive cardiomyopathy from heart failure with preserved ejection fraction? – S. Schwartzenberg, A. From, R.A. Nishimura, P. Sorajja, M. Redfield, B. Borlaug (Rehovot, IL; Rochester, US) Regional strain imaging diastolic index changes differently in patients with CAD or hypertension. – K.G. Adamyan, A.L. Chilingaryan (Yerevan, AM) Relationship of left ventricular diastolic function and sympathetic innervation in patients with dilated cardiomyopathy. – A. Patrianakos, C. Goudis, E. Nyktari, G. Solidakis, S. Koukouraki, N. Karkavitsas, P.E. Vardas (Heraklion, GR) Arterial properties for the diagnosis of diastolic heart failure. – T. Weber, A. Haiden, M. Ammer, M. Rammer, V. Riegelnik, R. Zweiker, B. Eber (Wels and Graz, AT) Epicardial fat is a determinant of diastolic dysfunction. – J.L. Cavalcante, B.K. Tamarappoo, D.H. Kwon, C. Alraies, S. Halliburton, D. Dey, D.S. Berman, T.H. Marwick (Cleveland and Los Angeles, US) Left atrial mechanical function at rest and during dobutamine stress in healthy young and elderly subjects as evaluated by cardiac magnetic resonance - a study of left ventricular compliance. – K.A. Ahtarovski, N.G. Vejlstrup, K.K. Iversen, J.T. Loenborg, T. Engstroem (Copenhagen, DK) Analysis of circulating glycosylated N-terminal-proBNP and nonglycosylated N-terminal proBNP in patients with heart failure (HF) and chronic renal failure (CRF) on hemodialysis. – T. Nishikimi, M. Ikeda, Y. Takeda, T. Ishimitsu, N. Minamino, K. Kuwahara, Y. Nakagawa, H. Kinoshita, K. Nakao (Kyoto, Tochigi and Osaka, JP) Relationship between amino-terminal pro-B-type natriuretic peptide (NT-proBNP) and left atrial volume index in older subjects at risk of heart failure. – J.M. Coller, M. McGrady, C. Reid, B. Boffa, D. Liew, S. Stewart, R. Wolfe, H. Krum, D.J. Campbell, D.L. Prior (Melbourne, AU) Left atrial longitudinal strain by speckle tracking echocardiography correlates well with NT-proBNP levels in patients admitted to the cardiac intensive care unit. – M. Cameli, E. Palmerini, M. Lisi, E. Bennati, R. De Vito, R. Favilli, S. Mondillo (Siena, IT) P5016 P5017 P5018 P5019 P5020 P5021 P5022 301 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Sitagliptin, a dipeptidyl peptidase-4 inhibitor, increases bioactive BNP level with the improvement of left ventricular mass index in patients with chronic heart failure. – T. Tsutamoto, H. Sakai, C. Kawahara, M. Fujii, M. Yamaji, M. Ohnishi, T. Matsumoto, A. Wada, T. Yamamoto, M. Horie (Inugami, Otsu and Kusatsu, JP) Reference intervals for C-type natriuretic peptide plasma levels in healthy newborns and infants. – M. Cabiati, M. Cantinotti, C. Caselli, S. Storti, N. Assanta, T. Prescimone, B. Murzi, D. Giannessi, S. Del Ry (Pisa, IT) Adiponectin and brain natriuretic peptide relationship in newborns, infants and children. – C. Caselli, M. Cantinotti, M. Cabiati, S. Storti, T. Prescimone, N. Assanta, B. Murzi, S. Del Ry, D. Giannessi (Pisa and Siena, IT) Chronic hypoxemia and acute exercise-induced changes in oxygenation do not have a clinically relevant impact on circulating concentrations of B-type natriuretic peptides. – M. Zurek, M.T. Maeder, M. Brutsche, C.H. Mueller (Zurich, St. Gallen and Basel, CH) The impact of n terminal pro natriuretic peptide (NT pro BNP) on number needed to screen for heart failure by echocardiography. Prospective observational comparative study. – M. Al Barjas, R. Morris, D. Nair, J. Davar (London, GB) Relationship between ACE-2 activity, infarct size and left ventricular systolic function following STEMI. – J. Ortiz, M. Riera, X. Bosch, T. De Caralt, R.J. Perea, J. Pascual, M.J. Soler (Barcelona, ES) The effect of renal function on brain natriuretic peptide and N-terminal pro brain natriuretic peptide levels, and their correlation. – H. Takase, Y. Dohi, T. Toriyama, T. Okado, H. Sonoda, A. Hagikura, G. Kimura (Hamamatsu and Nagoya, JP) Comparative study on the severity of heart failure based on NYHA heart failure classification and the levels of NT-proBNP, BNP and (NT-proBNP/BNP in pmol/L). – T. Shimada, T. Sumiyoshi, S. Sasaki, M. Nagayama, T. Tobaru, O. Doi, H. Kambara (Shizuoka and Tokyo, JP) Simultaneous determination of plasma levels and cardiac expression of CNP in end-stage heart failure patients undergoing left ventricular assist devices. – M. Cabiati, R. Caruso, C. Caselli, C. Baroni, T. Prescimone, M. Frigerio, D. Giannessi, S. Del Ry, O. Parodi (Pisa and Milan, IT) Short term effects of cardiac resynchronization therapy on inflammatory and neurohormonal markers. – A. Kusiak, J. Wilinski, D. Czarnecka, W. Wojciechowska, B. Bacior, M. Jastrzebski, T. Sondej, A. Przybyla, M. Kocowska, K. Kawecka-Jaszcz (Krakow, PL) Six minute walk test reflects neurohormonal activation in systemic sclerosis patients. – K. Irzyk, M. Ciurzynski, P. Bienias, Z. Rymarczyk, M. Kostrubiec, A. Szewczyk, M. Siwicka, B. Bartoszewicz, U. Demkow, P. Pruszczyk (Warsaw, PL) Increased levels of fibroblast growth actor 23 (FGF23) in chronic heart failure patients. – D. Gruson, S. Goletti, S. Ahn, M.F. Rousseau (Brussels, BE) Sympathetic overactivation in dilated phase of hypertrophic cardiomyopathy. – R. Ushijima, S. Joho, Y. Oda, D. Harada, T. Hirai, H. Asanoi, H. Inoue (Toyama and Imizu, JP) Brain natriuretic peptide and renal dysfunction: cardio-renal interactions in patients with acute heart failure. – A.-G. Fruntelata, O.F. Tautu, M. Merisor, G. Calcaianu, S. Andrei, G. Stefan, M.C. Greavu, M. Dorobantu (Bucharest, RO) Clinical, echocardiographic and neurohormonal response to cardiac resynchronization therapy: are they interchangeable? – G.E. Hoogslag, U. Hoke, H.F. Verwey, J. Thijssen, D. Auger, N. Ajmone Marsan, E.E. Van Der Wall, M.J. Schalij, J.J. Bax, V. Delgado (Leiden, NL) Statin treatment reduces early cardiac inflammatory infiltration and apoptosis and prevents progression in the long term. – T.J. Fang, C.C. Fang, K.S. Lin (Taipei, TW) Prognostic value of exercise-induced left ventricular systolic dysfunction in hypertensive patients with no angiographic evidence of coronary artery disease. – O. Prada-Delgado, E. Barge-Caballero, J. Peteiro, A. Bouzas-Mosquera, E. Mendez-Eirin, A. Lopez-Sainz, G. Barge-Caballero, R. Estevez-Loureiro, M. Crespo-Leiro, A. Castro-Beiras (A Coruña, ES) Desmin expression and mitochondrial changes in heart muscle from patient with idiopathic dilated cardiomyopathy. – A. Pawlak, A. Nasierowska-Guttmajer, A. Karkucinska-Wieckowska, E. Czarnowska, R.J. Gil (Warsaw, PL) Increased end diastolic wall stress precedes left ventricular hypertrophy in dilative heart failure introduction and use of the volume-based wall stress index. – P. Alter, H. Rupp, F. Stoll, P. Adams, M.B. Rominger, B. Maisch (Marburg, DE) Diagnosis of heart failure in a primary health care center: usefulness of Framingham clinical criteria, ECG and NT-proBNP. – J.M. Verdu, J. Comin-Colet, M. Domingo, J. Lupon, S. Fuentes, A. Mena, J.M. Baena, M.A. Munoz, J.M. Casacuberta, J. Bruguera (Barcelona, Badalona and Santa Coloma de Gramanet, ES) Pathophysiology of asymptomatic left ventricular dysfunction in systemic sclerosis. – C. Carmona-Henryon, F. Thuny, F. Schnell, L. Potton, C. Bergerot, L. Ernande, H. Rafi, M. Ovize, P. Croisille, G.A. Derumeaux (Lyon, Rennes and Clichy, FR) Diagnostic value of rigid body rotation in noncompaction cardiomyopathy: a new objective and quantitative functional diagnostic criterion. – B.M. Van Dalen, K. Caliskan, O.I. Soliman, F. Kauer, H.B. Van Der Zwaan, W.B. Vletter, F.J. Ten Cate, M.L. Geleijnse (Rotterdam, NL) 302 P5023 P5024 P5025 P5026 P5027 P5028 P5029 P5030 P5031 P5032 P5033 P5034 P5035 P5036 P5037 P5038 P5039 P5040 P5041 P5042 P5043 P5044 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Clinical characteristics and prognosis of patients with post-capillary reactive pulmonary hypertension caused by left heart disease. – S. Tatebe, Y. Fukumoto, K. Sugimura, K. Satoh, Y. Miura, K. Nochioka, S. Yamamoto, H. Shimokawa (Sendai, JP) Novel insights into the pathogenesis of cardiac fibrosis in the failing heart. – D.M. Kaye, X.M. Gao, O. Khammy, Y. Zhang, J. Mariani, X.J. Du, M.T. Maeder (Melbourne, AU) Novel biomarkers enhance diagnostic differentiation between acute heart failure and pulmonary disease exacerbation in patients presenting with dyspnea. – G.S. Filippatos, D. Farmakis, O. Hartmann, C. Mueller, W.F. Peacock, J. Parissis, N. Morgenthaler, P. Ponikowski, S.A. Anker, A. Maisel (Athens, GR; Hennigsdorf and Berlin, DE; Basel, CH; Cleveland and San Diego, US; Wroclaw, PL) An easily applicable in everyday clinical practice diagnostic algorithm for the detection of iron deficiency in heart failure. – J. Terrovitis, E. Kaldara, A. Ntalianis, C. Kapelios, S. Sventzouri, S. Vakrou, N. Michelinakis, G. Sainis, C. Matsouka, J. Nanas (Athens, GR) Decreased circulating T regulatory cells are associated with chronic heart failure and secondary pulmonary hypertension. – L. Koller, S. Blum, M. Korpak, A. Hermann, G. Zorn, G. Maurer, J. Wojta, R. Pacher, M. Huelsmann, A. Niessner (Vienna, AT) Two-dimensional speckle tracking imaging detects early subendocardial fibrosis reflecting elevated wall stress in Dahl salt-sensitive rat. – T. Ishizu, Y. Seo, R. Koshizuka, Y. Kameda, T. Kimura, D. Xu, N. Murakoshi, S. Sakai, K. Aonuma (Tsukuba, JP) CD34+ and endothelial progenitor cells in patients with chronic heart failure. – K.A. Khmelnitskaya, E.V. Shlyakhto (Saint Petersburg, RU) Management of patients with systolic heart failure by cardiologists versus general practitioners in Poland: do we implement ESC guidelines efficiently? – E.A. Jankowska, B. Kurian, C. Zajaczkowski, W. Banasiak, P. Ponikowski (Wroclaw and Warsaw, PL) Circulating levels of n-3 polyunsaturated fatty acids in patients with chronic heart failure. Data from the GISSI-HF trial. – R. Latini, S. Masson, M. Tacconi, R. Bernasconi, L. Dragani, V. Milani, M.G. Franzosi, R. Marchioli, L. Tavazzi, G. Tognoni (Milan, Santa Maria Imbaro and Cotignola, IT) P5045 P5046 P5047 P5048 P5049 P5050 P5051 P5052 P5053 ELECTROCARDIOGRAM: OLD FEATURES AND NEW TOOLS (QR 30617*) *Abstracts can be accessed at: P5054 P5055 P5056 P5057 P5058 TUESDAY – AFTERNOON Pacemaker-related endocarditis: clinical features and prognosis. Results of a large single center series over a 24-year period (1987-2010). – J.C. Castillo Dominguez, M. Anguita, M. Ruiz, D. Mesa, M. Delgado, E. Romo, A. Lopez-Granados, J. Arizon, J. Suarez De Lezo (Córdoba, ES) The contribution of paced QRS morphology to assessment of right ventricular pacing site. – L. Kamenik, T. Hnatek, P. Sedlon, J. Skvaril, M. Cernohous, E. Krcova, M. Zavoral (Prague, CZ) Apical pacing versus septal pacing in patients with atrial fibrillation and ejection fraction above 39%. We still believe that apical pacing is the right choice? – G. Vanerio, D. Banina, P. Fernandez Banizzi, L. Vidal (Montevideo, UY) Permanent pacemaker implantation via the femoral vein: a safe alternative when pectoral approach is contraindicated. – J. Elduayen-Gragera, F. Diaz-Cortegana, A. Martinez-Naharro, S. Sanchez-Giralt, J.J. Garcia-Guerrero, J. Fernandez De La Concha, A. Redondo, R. Alonso Gonzalez (Badajoz, ES) AAI mode pacing in patients with sick sinus syndrome. 20 years follow-up data from a single Norwegian non-university hospital. – J.O. Kleinau, T. Graven, H. Dalen (Levanger and Trondheim, NO) Efficacy of antitachycardia pacing in hypertrophic cardiomyopathy with implantable cardioverter-defibrillators. – C.H. Lee, S. Kim, H.O. Choi, K.H. Kim, G. Nam, K. Choi, Y. Kim (Seoul, KR) Long term evolution of atrio-ventricular conduction in sinus dysfunction patients. Is AV block the only clinical outcome? – P. Mabo, A. Solnon, A. Tassin, R.P. Martins, L. Graindorge, J.P. Cebron (Rennes, Nantes, Angers and Clamart, FR) Use of a wearable cardioverter defibrillator among pre-partum pregnant women: an analysis of safety, characteristics and outcomes. – M. Saltzberg, S. Szymkiewicz, N. Bianco (Newark and Pittsburgh, US) Increased risk of sudden death in patients with Medtronic sprint fidelis ICD lead. – P. Palmisano, L. Nuzzi, M. Zaccaria, P. Guida, F. Nacci, M. Anaclerio, G. Luzzi, S. Favale (Bari, IT) Use of implantable cardioverter defibrillator and cardiac resynchronization therapy in high-risk patients: an Italian survey study on 220 cardiology departments. – G. Inama, C. Pedrinazzi, M. Landolina, F. Oliva, M. Senni, A. Proclemer, M. Zoni Berisso (Crema, Pavia, Milan, Bergamo, Udine and Genoa, IT) P5059 P5060 P5061 (W) P5062 P5063 QR 30617 303 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Minimizing ICD therapies: the ADVANCE III trial. – M. Gasparini, A. Proclemer, A. Arenal, B. Lemke, M. Wijffels, J. De Sousa, M. Lunati, A. Okreglicki, J.O. Schwab, E. Santi (Rozzano, Udine, Milan and Rome, IT; Madrid, ES; Ludenscheid and Bonn, DE; Nieuwegein, NL; Lisbon, PT; Cape Town, ZA) The long-term clinical outcomes of radiofrequency catheter ablation for inducible ventricular tachycardia prior to implantation of cardioverter-defibrillator. – H. Suenaga, S. Saito (Kamakura City, JP) Tachycardia zone setting to avoid inappropriate shock in Brugada syndrome patients with implantable cardioverter defibrillator. – N. Nishii, H. Morita, M. Kubo, K. Nakagawa, M. Tanaka, M. Murakami, S. Nagase, K. Kusano, H. Itoh (Okayama, JP) Follow up of patients with automatic implantable cardioverter defibrillator without testing the defibrillation threshold. – M.E. Trucco, M. Arce, J. Palazzolo, F. Femenia (Mendoza, AR) Shock waveform optimization improves defibrillation success in patients with single coil defibrillation system. – J. Gabriels, A.S. Budzikowski, C. Mitre, O. Esan, T. Bustros, J. Kassotis (New York, US) The noninvasive assessment of the effect of defibrillation on cardiac index in patients with heart failure and implanted cardioverter-defibrillator. – P. Krzesinski, D. Michalkiewicz, Z. Orski, K. Krzyzanowski, K. Makowski, G.G. Gielerak (Warsaw, PL) Subcutaneous ICD - initial experience. – P. Galvao Santos, D. Cavaco, P.P. Adragao, F. Morgado, K. Reis Santos, P. Carmo, F. Costa, M. Mendes (Lisbon, PT) DC cardioversion of atrial fibrillation for patients over 75 years: is it worth the energy? – N. Child, G. Hunter, P. O’Kane, J. Paisey, R. Balasubramaniam, T. Levy (Southampton and Bournemouth, GB) Distinct role of electrocardiographic criteria in echocardiographic diagnosis of left ventricular hypertrophy according to age in the general population. – D. Tsiachris, C. Chrysohoou, E. Oikonomou, G. Lazaros, K. Dimitriadis, D. Maragiannis, D. Roussos, E. Christoforatou, C. Pitsavos, C. Stefanadis (Athens, GR) Redefining the african 12-lead ECG: electrocardiographic findings in heart disease-free urban africans. – K. Sliwa, G. Lee, M.J. Carrington, I.W.P. Obel, S. Pretorius, S. Stewart (Cape Town and Johannesburg, ZA; Melbourne, AU) Association of nocturnal dipping of heart rate, heart rate variability and cardiovascular mortality in patients on chronic hemodialysis. – T. Aoyama, H. Ishii, H. Takahashi, Y. Kumada, M. Tanaka, D. Kamoi, Y. Kawamura, K. Kawashima, T. Murohara (Nagoya, JP) Variations of J point elevation in the electrocardiogram of an apparently healthy caucasian population. – S. Heng, E. Clark, P.W. Macfarlane (Glasgow, GB) Configuration of P-wave morphology of lead V3-V6 in lower right atrial tachycardia. – Y. Huo, S. Richter, B. Andrea, A. Arya, R. Schoenbauer, T. Gaspar, P. Sommer, U. Wetzel, G. Hindricks, A. Bollmann (Leipzig, DE) Electrocardiographic abnormalities and risk of development of severe cardiac involvement. – S. Nagao, H. Watanabe, M. Kodama, J. Tanaka, E. Suzuki, I. Narita, Y. Aizawa (Niigata, JP) The prevalence and significance of electrocardiographic abnormalities in a dilated cardiomyopathy cohort characterised by cardiovascular magnetic resonance. – A. Gulati, T. Ismail, N. Ismail, A. Jabbour, S. Raza, K. Morarji, A. Ali, F. Alpendurada, D. Pennell, S. Prasad (London, GB) T-wave alternans in apparently healthy subjects and in different subsets of patients with ischemic heart disease. – R. Mollo, I. Coviello, A. Spinelli, G. Pinnacchio, G. Careri, I. Battipaglia, A. Cosenza, F. Infusino, G.A. Lanza, F. Crea (Rome, IT) Validation of the clinical value of ECG algorithm in preablation location of arrhythmogenic foci in patients with RVOT arrhythmias. – M. Pytkowski, A. Maciag, A. Jankowska, I. Kowalik, A. Kraska, D. Luczak, M. Farkowski, H. Szwed (Warsaw, PL) Wide QRS tachycardias: comparison among two electrocardiographic algorithms. Is there a better accuracy? – F. Darrieux, E. Kaiser, S. Barbosa, J.C. Sousa, A.A. Carmo, R. Grinberg, S. Lara, D. Hachul, M. Scanavacca, E. Sosa (São Paulo, BR) Effect of primary percutaneous coronary intervention for acute myocardial infarction on deceleration capacity of heart rate. – A. Bauer, K. Rizas, C. Eick, C. Zuern, M. Gawaz (Tübingen, DE) Spatial QRS-T angle is significantly increased in asymptomatic sarcoid patients with ventricular arrhythmias. – E. Gialafos, V. Kouranos, K. Aggeli, T. Papaioannou, A. Kalianos, S. Stampola, J. Arapis, A. Rapti, J. Gialafos, C. Stefanadis (Athens, GR) A study of QTc interval in healthy subjects with and without early repolarization. – G.K. Panicker, D. Manohar, D.R. Karnad, V. Salvi, S.N. Kothari, Y.Y. Lokhandwala (Mumbai, IN) Patients who increase troponin levels after transcatheter aortic valve implantation manifest distinct electrocardiographic findings. – M. Vavuranakis, C. Moldovan, T. Papaioannou, D. Brachatis, M. Kariori, C. Chrysochoou, G. Lazaros, V. Voudris, S. Thomopoulou, C. Stefanadis (Athens, GR) 304 P5064 P5065 P5066 P5067 P5068 P5069 P5070 P5071 P5072 P5073 P5074 P5075 P5076 P5077 P5078 P5079 P5080 P5081 P5082 P5083 P5084 P5085 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS NEW INSIGHTS IN DRUGS AND MECHANISMS (QR 30618*) *Abstracts can be accessed at: P5086 P5087 P5088 P5089 P5090 P5091 P5092 P5093 P5094 P5095 P5096 P5097 P5098 P5099 P5100 TUESDAY – AFTERNOON Are dietary omega-3 fatty acids antiarrhythmic, proarrhythmic, both or neither? – G.E. Billman, I.M. Bonilla, C.A. Carnes, W.S. Harris, E. Vanoli, P.B. Adamson, P.J. Schwartz (Columbus, Sioux Falls and Oklahoma City, US; Pavia, IT) Interest of hydroquinidine in asymptomatic Brugada patients with inducible VF. – A. Bouzeman, S. Traulle, A. Messali, F. Extramiana, E. Marijon, J.S. Hermida, A. Leenhardt (Paris and Amiens, FR) Inhibition of sodium-calcium-exchanger by SEA0400 does not prevent irregular activity in an isolated rabbit heart model of atrial fibrillation. – G. Frommeyer, C. Pott, S. Ghezelbash, T. Uphaus, D. Kaiser, L. Eckardt, P. Milberg (Münster, DE) Dronedarone exerts anti-thrombotic properties - a novel pleiotropic effect? – A. Breitenstein, S. Sluka, A. Akhmedov, G.G. Camici, J. Steffel, F. Duru, T.F. Luscher, F.C. Tanner (Zurich, CH) Carvedilol targets human atrial-selective K2P3.1 (TASK1) potassium leak channels. – D. Thomas, K. Staudacher, I. Staudacher, E. Ficker, C. Seyler, J. Gierten, J. Kisselbach, P.A. Schweizer, H.A. Katus, R. Becker (Heidelberg, DE; Cleveland, US) Evaluation of propafenone effectiveness and safety for the management of atrial fibrillation in patients with chronic heart failure with preserved left ventricle ejection fraction. – O. Miller, A. Tarasov, U. Pozdnyakov, S. Luchinsky, V. Doschitsyn, O. Reynbakh (Novosibirsk, Zhukovsky and Moscow, RU) Dronedarone in clinical routine use in patients with atrial arrhythmias. – J. Salmas, S. John, J. Kornej, U. Wetzel, D. Husser, G. Hindricks, A. Bollmann (Leipzig, DE) Effects of ranolazine on torsades de pointes in an isolated rabbit heart model. – M. Zabel, J. Seegers, N. Wallisch (Göttingen, DE) High levels of n-3 polyunsaturated fatty acids in cell membranes may increase risk of postoperative atrial fibrillation - a potential proarrhythmic effect? – L. Bjorgvinsdottir, D.O. Arnar, O.S. Indridason, R. Heidarsdottir, B. Torfason, R. Palsson, G.V. Skuladottir (Reykjavik, IS) Anti-arrhythmic effects of very low density lipoproteins. – Y. Shao, A. Miljanovic, S. Gizurarson, T. Ramunddal, J. Boren, E. Omerovic (Gothenburg, SE) Does the combination of therapeutic hypothermia and acute coronary angiography improve outcome. – J. Bro-Jeppesen, J. Kjaergaard, F. Pedersen, M. Wanscher, S. Nielsen, J. Moller, C. Hassager (Copenhagen, DK) Differences in baseline electrophysiologic properties and electrical remodeling among pacemaker patients who develop atrial tachyarrhythmias: results of the ASSERT mechanisms of atrial fibrillation St. – J. Healey, C.W. Israel, S.J. Connolly, S.H. Hohnloser, G.M. Nair, A. Capucci, M.R. Gold, I.C. Van Gelder, C.P. Lau, C.A. Morillo (Hamilton, CA; Frankfurt am Main, DE; Ancona, IT; Charleston, US; Groningen, NL; Hong Kong, HK) Targeting of heterocellular coupling in fibrotic neonatal rat myocardial cultures by lentiviral connexin43 knockdown is anti-arrhythmic. – S.F. Askar, B.O. Bingen, J. Swildens, D.L. Ypey, A. Van Der Laarse, D.E. Atsma, A.A.F. De Vries, M.J. Schalij, D.A. Pijnappels (Leiden, NL) The hyperglycemia causes electrical and structural remodeling of ventricular myocardium in heart/muscle-specific manganese superoxide dismutase -deficient mice model. – S. Ishikawa, S. Niwano, H. Niwano, M. Murakami, Y. Masaki, T. Kosukegawa, S. Kurokawa, Y. Noda, T. Shimizu, T. Izumi (Kanagawa and Tokyo, JP) Effect of antiarrhythmic peptide on ventricular arrhythmia inducing by lysophosphatidic acid. – T.J. Wang, Q. Zhou, C.T. Zhang, Y.J. Yang, R.D. Xu, L. Ruan (Beijing, Xiangfan and Wuhan, CN) Predictors of regional atrial myocardial fibrosis: implications for obesity atrial fibrillation. – H. Abed, A.J. Nelson, A. Carbone, M. Alasady, D.P. Leong, D. Kelly, S.G. Worthley, W.P. Abhayaratna, G.A. Wittert, P. Sanders (Adelaide and Melbourne, AU) A prospective study evaluating the efficacy of catheter ablation of atrial fibrillation in patients with obstructive sleep apnoea syndrome. – T. Neumann, D. Pajitnev, S. Zaltsberg, J. Schmitt, H. Greiss, A. Berkowitsch, C.W. Hamm, H.F. Pitschner, M. Kuniss (Bad Nauheim, DE) Dietary omega-3 fatty acids promote disturbances in intracellular calcium cycling in ventricular myocytes isolated from post myocardial infarction hearts. – G.E. Billman, A.E. Belevych, H.-T. Ho, D. Terentyev, I.M. Bonilla, W.S. Harris, C.A. Carnes, S. Gyorke (Columbus and Sioux Falls, US) Alterations in connexin and ion channel gene expression induced by autonomic stimulation: a potential modulation factor of atrial remodeling? – M.M. Oliveira, G. Postolache, V. Geraldes, J.P. Gomes, C. Tavares, S. Laranjo, R. Ferreira, I. Rocha (Lisbon, PT) Obesity-induced regional and global conduction disturbances predispose to atrial fibrillation, independent of hemodynamic changes. – H. Abed, P. Kuklik, A. Nelson, M. Alasady, D.H. Lau, D. Kelly, S.G. Worthley, W.P. Abhayaratna, G.A. Wittert, P. Sanders (Adelaide and Melbourne, AU) P5101 P5102 P5103 P5104 P5105 QR 30618 305 TUESDAY, 30 AUGUST 2011 – AFTERNOON POSTERS Dynamic weight gain and atrial electrical remodelling: implications for atrial fibrillation. – H. Abed, P. Kuklik, A. Brooks, D. Kelly, D. Lau, M. Alasady, W.P. Abhayaratna, G.A. Wittert, P. Sanders (Adelaide, Melbourne and Canberra, AU) The impact of hypertension on the electroanatomical characteristics of patients with atrial fibrillation. – T. Wang, Y.L. Xia, Z.Z. Xie, S.L. Zhang, L.J. Gao, Y.Z. Yang (Dalian, CN) LDL-cholesterol destabilizes calcium handling in cultured atrial myocytes by reducing connexin-40 expression and slowing the conduction velocity of the calcium signal. – M. Barriga, R. Cal, A. Llach, L. Badimon, J. Cinca, V. Llorente-Cortes, L. Hove-Madsen (Barcelona, ES) Blockade of the Na+/Ca2+ exchange system with KB-R7943 and of the beta-adrenergic receptor with propranolol decreases myocardial electrophysiological heterogeneity produced by acute local stretching. – L. Such-Miquel, F.J. Chorro-Gasco, I. Trapero, M. Zarzoso, G. Parra, L. Brines, J. Canoves, F. Pelechano, A. Alberola, L. Such (Valencia, ES) 306 P5106 P5107 P5108 P5109