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Document prepared and review by Drug and Poison Information center SIH Dated: Feb, 2021 Ibuprofen (PO) Indication: - PDA closure, Oral DOSING Closure of patent ductus arteriosus: - 10mg/kg orally followed by 5mg/kg/dose at 24 and 48 hours. Route of administration: - PO Contraindicated Asthma , urticarial,. Black box warning NSAIDs may cause an increased risk of serious cardiovascular thrombotic even. Renal impairment Hepatic doseadjustment Adverse effect If anuria or marked oliguria (urinary output <0.6 mL/kg/hour) is evident at the scheduled time of the second or third dose, hold dose until renal function returns to normal. Use is contraindicated in preterm infants with significant renal impairment. No specific dose adjustment required. GI bleeding, acute kidney failure, intestinal perforation, pulmonary hypertension. Monitoring GI bleeding and BP serum transaminase, and renal function. References: up-to-date, Harriet lane, Neofax, BNF, EMC, Micromedex,
