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Experiment-wide type I error rates
Not
rejected
Rejected
Total
True null
hypotheses
U
V
m0
False null
hypotheses
T
S
m1
m–R
R
m0
Total
Family-wise error rate: P(V > 0), the probability of one or more false
positives. For large m0, this is difficult to keep small.
False discovery rate: E[ V / max{R,1} ], the expected fraction of false
positives among all discoveries.
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