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Longevity in the 21st Century Richard Willets Longevity in the 21st Century • • • • • • • Background 20th Century Trends International Experience Medical Advances The Threat From Infectious Diseases Projecting the Future Implications Longevity in the 21st Century • • • • • • • Background 20th Century Trends International Experience Medical Advances The Threat From Infectious Diseases Projecting the Future Implications Background • The UK Actuarial Profession established a Working Party in 2003 to produce a review paper on longevity trends − − − − − − − − − − Richard Willets (chairman) Adrian Gallop Tony Leandro Joseph Lu Angus Macdonald Keith Miller Stephen Richards Neil Robjohns John Ryan Howard Waters Background • The paper “Longevity in the 21st Century” was presented to the Faculty of Actuaries on 15 March 2004 and the Institute of Actuaries on 26 April 2004 • A separate paper “The cohort effect: insights and explanations” (Richard Willets) was presented at the same meetings Background • A Working Party of the Continuous Mortality Investigation Bureau (C.M.I.B.) is considering the issue of future mortality projection • New projections are planned for 2005 to be used with new “00” series tables • This group published Working Paper 3 – “Projecting future mortality – a discussion paper” in March 2004 • A recent seminar at Staple Inn backed the call for “measures of uncertainty” in projections Longevity in the 21st Century • • • • • • • Background 20th Century Trends International Experience Medical Advances The Threat From Infectious Diseases Projecting the Future Implications 20th Century Trends Reduction in the mortality rate for males aged 65-74 in the England & Wales population since 1901 • 20% fall between 1901 & 1969 (68 years) Source: own calculations using O.N.S. data 20th Century Trends Reduction in the mortality rate for males aged 65-74 in the England & Wales population since 1901 • 20% fall between 1901 & 1969 (68 years) • 20% fall between 1969 & 1986 (17 years) Source: own calculations using O.N.S. data 20th Century Trends Reduction in the mortality rate for males aged 65-74 in the England & Wales population since 1901 • 20% fall between 1901 & 1969 (68 years) • 20% fall between 1969 & 1986 (17 years) • 20% fall between 1986 & 1996 (10 years) Source: own calculations using O.N.S. data 20th Century Trends Reduction in the mortality rate for males aged 65-74 in the England & Wales population since 1901 • • • • 20% 20% 20% 20% fall fall fall fall between between between between 1901 1969 1986 1996 & & & & 1969 1986 1996 2002 (68 years) (17 years) (10 years) (6 years) Source: own calculations using O.N.S. data 20th Century Trends At the beginning of the 21st Century we are observing accelerating rates of improvement at older ages Average annual rates of mortality improvement for males in the population of England & Wales Age group 60-69 70-79 80-89 1990 to 1994 3.0% 1.8% 1.1% Note: “mortality improvement” is taken to mean the % reduction in mortality rate 1994 to 1998 3.2% 2.3% 1.2% 1998 to 2002 3.9% 3.7% 2.5% Source: own calculations using O.N.S. data – trend lines fitted using log linear regression 20th Century Trends At the beginning of the 21st Century we are observing accelerating rates of improvement at older ages Average annual rates of mortality improvement for females in the population of England & Wales Age group 60-69 70-79 80-89 1990 to 1994 2.4% 1.0% 0.8% Note: “mortality improvement” is taken to mean the % reduction in mortality rate 1994 to 1998 2.5% 1.0% 0.4% 1998 to 2002 3.1% 3.0% 1.7% Source: own calculations using O.N.S. data – trend lines fitted using log linear regression 20th Century Trends Heart disease mortality is falling sharply Heart disease deaths per 1,000,000 – males aged 60-69 in England & Wales 12,000 Period 1960-1970 1970-1980 1980-1990 1990-2000 10,000 8,000 “Premature death from heart disease in England could be almost unheard of within a decade” 6,000 4,000 2,000 0 1960 1970 1980 1990 2000 Reduction -5% -1% 20% 45% Source: own calculations using O.N.S. data 20th Century Trends Mortality rates are falling in other causes Deaths per 1,000,000 – males aged 60-69 in Eng & Wales 10,000 4,000 Cancer 9,000 3,000 8,000 2,000 7,000 1,000 6,000 1970 1980 1990 2000 0 1970 Stroke Source: own calculations using O.N.S. data 1980 1990 2000 20th Century Trends • Future projections should be grounded in as good an understanding of the past as possible • The paper focuses on “five key forces” currently shaping the pattern of mortality change 20th Century Trends • The paper focuses on “five key forces” currently shaping the pattern of mortality change:− The UK “cohort effect” − The “ageing of mortality improvement” − Past patterns of cigarette smoking − Increased uncertainty at younger ages − Widening social-economic class differentials The UK “cohort effect” Rate of mortality improvement by age group and decade – females in England & Wales 1960s 4.0% 1970s 1980s 3.0% 1990s 2.0% 1.0% 0.0% 25-29 Source: own calculations using O.N.S. figures 35-39 45-49 55-59 age group 65-69 75-79 85+ The UK “cohort effect” Rate of mortality improvement by age group and decade – females in England & Wales the “cohort effect” 4.0% 1960s 1970s 1980s 3.0% 1990s 2.0% 1.0% 0.0% 25-29 Source: own calculations using O.N.S. figures 35-39 45-49 55-59 age group 65-69 75-79 85+ The UK “cohort effect” Rate of mortality improvement by age group and decade – males in England & Wales the “cohort effect” 4.0% 1960s 1970s 1980s 3.0% 1990s 2.0% 1.0% 0.0% 25-29 Source: own calculations using O.N.S. figures 35-39 45-49 55-59 age group 65-69 75-79 85+ The UK “cohort effect” Mortality projections • Faster improvements have been observed for the UK generation born 1925-1945 – centred on 1931 • This feature has been explicitly allowed for in G.A.D. mortality projections since the 1990s • In 2002 the C.M.I.B. published a paper which described a similar effect in insurance and pensioner data – centred on 1926 • The C.M.I.B. published three “interim” projections which allowed for this feature (known as the “short”, “medium” and “long” cohort projections) The UK “cohort effect” Impact of year of birth in a model of mortality change for males in the population of England & Wales 2.0% Addition to average annual 1.5% rate of improvement due to year of birth 1.0% 0.5% 0.0% 1900 1910 1920 1930 -0.5% Source: own calculations using O.N.S. figures -1.0% -1.5% Year of birth 1940 1950 The UK “cohort effect” Impact of year of birth in a model of lung cancer mortality change for males in the population of E&W 3.0% Addition to average annual 2.0% rate of improvement due to year of birth 1.0% 0.0% 1900 1910 1920 1930 -1.0% -2.0% Source: own calculations using O.N.S. figures -3.0% Year of birth 1940 1950 The UK “cohort effect” Female cumulative constant tar cigarette consumption (CCTCC) by age and central year of birth, UK Rate of lung cancer mortality for females in England & Wales by year of birth 0.3% Age group 0.2% 50-54 55-59 60-64 65-69 0.2% 70-74 75-79 80-84 0.1% 0.1% 0.0% 1870 1880 1890 1900 1910 1920 1930 1940 1950 Sources: O.N.S. & Lee et al (1993) The UK “cohort effect” Impact of year of birth in a model of heart disease mortality change for males in the population of E&W 3.0% Addition to average annual 2.0% rate of improvement due to year of birth 1.0% 0.0% 1900 1910 1920 1930 -1.0% -2.0% Source: own calculations using O.N.S. figures -3.0% Year of birth 1940 1950 The UK “cohort effect” Impact of year of birth in a model of mortality change for males in the population of E&W 3.0% lung cancer heart disease Addition to average annual 2.0% rate of improvement due to year of birth 1.0% 0.0% 1900 1910 1920 1930 -1.0% -2.0% Source: own calculations using O.N.S. figures -3.0% Year of birth 1940 1950 The UK “cohort effect” Impact of year of birth in a model of mortality change for males in the population of England & Wales 2.0% Second cohort due to a wider range of factors First cohort largely due to trends in smoking Addition to average annual 1.5% rate of improvement due to year of birth 1.0% 0.5% 0.0% 1900 1910 1920 1930 -0.5% Source: own calculations using O.N.S. figures -1.0% -1.5% Year of birth 1940 1950 The UK “cohort effect” Research in other fields • Researchers in a range of disciplines believe that people born in different generations are likely to experience different health characteristics in later life • In epidemiology a “life course” approach to understanding disease trends has developed “…a degree of anticipation is possible within lifetimes…through those things which make an imprint on life at one point, and which are carried forward on into later life.” Professor Michael Wadsworth (1991) The UK “cohort effect” Possible causes of the UK “cohort effect” • • • • • Patterns of cigarette consumption World War II Birth rates Diet Welfare State The ageing of mortality improvement The ages experiencing the most rapid change have shifted upwards 4.0% 1911-1960 Rate of mortality improvement 3.0% 2.0% 1.0% 0.0% 20-24 Source: own calculations using O.N.S. data for males in England & Wales 30-34 40-44 Age Group 50-54 60-64 70-74 80-84 The ageing of mortality improvement The ages experiencing the most rapid change have shifted upwards 4.0% 1911-1960 Rate of mortality improvement 3.0% 1960-2001 2.0% 1.0% 0.0% 20-24 Source: own calculations using O.N.S. data for males in England & Wales 30-34 40-44 Age Group 50-54 60-64 70-74 80-84 Cigarette smoking Trends in cigarette consumption • Consumption of cigarettes in the UK has been falling since the 1960s • Smoking prevalence rates stabilised in the 1990s • The impact on mortality trends is difficult to quantify because of the enduring nature of the damage caused by cigarette smoking • Smoking patterns have certainly contributed towards the cohort effect • Reduction in cigarette smoking may account for a half to a third of recent improvements at some ages Uncertainty at younger ages Increased uncertainty at younger ages • In the 1980s and 1990s improvements in healthrelated causes were offset by deteriorations in a range of different causes, notably:− AIDS − Drug & alcohol abuse − Liver disease − Violent deaths − Accidental deaths (other than motor vehicle) Uncertainty at younger ages Mortality rates for men aged 20-39 in England & Wales as a % of rate in 1989 450% drug & alcohol abuse 400% 350% 300% liver disease Together these causes now account for 12% of all deaths for this age group 250% 200% 150% 100% 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 Source: own calculations using O.N.S. data for males in England & Wales Uncertainty at younger ages Average annual rate of mortality improvement, males aged 20-39, England & Wales, 7 year rolling averages 11% 20-24 9% 25-29 30-34 7% 35-39 5% 3% 1% -1% -3% 1950 1955 1960 1965 1970 1975 1980 1985 Central year Source: own calculations using O.N.S. data for males in England & Wales 1990 1995 Uncertainty at younger ages Average annual rates of mortality improvement for the population of England & Wales – 1977 to 2002 year of birth 1900-1924 1925-1947 1948-1970 males 1.6% 2.8% -0.4% females 1.1% 2.4% 0.6% Source: own calculations using O.N.S. figures - improvement rates for all ages between 20 and 89 have been used. Widening socio-economic class differentials Differential in life expectancy at age 65 between manual and non-manual classes, England & Wales, 1972-99 Difference between nonmanual and manual (years) 2.4 male 2.2 female 2.0 1.8 1.6 1.4 1.2 1.0 0.8 0.6 1972-76 1977-81 1982-86 1987-91 1992-96 1997-99 Year Source: own calculations using O.N.S. data for males in England & Wales Widening socio-economic class differentials Average annual rate of mortality improvement for males in the population of England & Wales and in the C.M.I. dataset for males with life assurance policies, 1961-1999 England & Wales population 3.0% Rate of improvement (per annum) CMI assured lives (smoothed) 2.5% 2.0% 1.5% 1.0% 0.5% 0.0% 40 45 50 55 60 65 Age Source: own calculations using C.M.I.B. & O.N.S. data 70 75 80 85 Longevity in the 21st Century • • • • • • • Background 20th Century Trends International Experience Medical Advances The Threat From Infectious Diseases Projecting the Future Implications International experience U.K. mortality rates by age relative to an “international average” from 23 developed countries 130% males females 120% 110% 100% 90% 80% 30 35 40 45 50 55 60 65 Age Source: own calculations using W.H.O. data 70 75 80 85 90 95 International experience Expectation of life (years) for males at age 65 for selected countries in 2000 18 17 16 15 14 Source: own calculations using W.H.O. data Ireland Portugal Germany UK Finland Netherlands Denmark Austria Belgium Norway Greece Singapore Canada USA Spain Italy New Zealand Sweden Australia Switzerland France Japan 12 Israel 13 International experience Pace of mortality improvement for Japanese females by age and calendar year – shaded area shows where change is most rapid Age 85 Age 75 Age 65 Age 55 1960 1970 1980 1990 Source: own calculations using data from www.mortality.org International experience Pace of mortality improvement for Japanese females by age and calendar year – shaded area shows where change is most rapid Age 85 Age 75 Age 65 Age 55 1960 3.5% p.a. improvements at age 55 1970 1980 1990 Source: own calculations using data from www.mortality.org International experience Pace of mortality improvement for Japanese females by age and calendar year – shaded area shows where change is most rapid Age 85 Age 75 Age 65 Age 55 1960 4.5% p.a. improvements at age 65 3.5% p.a. improvements at age 55 1970 1980 1990 Source: own calculations using data from www.mortality.org International experience Pace of mortality improvement for Japanese females by age and calendar year – shaded area shows where change is most rapid Age 85 4.25% p.a. improvements at age 75 Age 75 Age 65 Age 55 1960 4.5% p.a. improvements at age 65 3.5% p.a. improvements at age 55 1970 1980 1990 Source: own calculations using data from www.mortality.org International experience 4.0% p.a. improvements at age 85 Age 85 4.25% p.a. improvements at age 75 Age 75 Age 65 Age 55 1960 4.5% p.a. improvements at age 65 3.5% p.a. improvements at age 55 1970 1980 1990 Pace of mortality improvement for Japanese females by age and calendar year – shaded area shows where change is most rapid Source: own calculations using data from www.mortality.org International experience Ratio of average annual rate of improvement over last 10 years vs. previous 30 years – average based on 5 countries (USA, England & Wales, France, Germany & Japan) 200% Male Female 180% 160% 140% 120% 100% 70 75 80 85 Age Source: own calculations using data from www.mortality.org 90 95 100 Longevity in the 21st Century • • • • • • • Background 20th Century Trends International Experience Medical Advances The Threat From Infectious Diseases Projecting the Future Implications Medical advances The pace of scientific development • The pace of scientific development appears to be accelerating • A substantial element of current improvements are being driven by advances in medicine • Improvements in heart disease mortality have been partially caused by:• new medication, e.g. beta-blockers & statins • new surgical interventions, e.g. CABG & angioplasty • Improvements in cancer mortality have been partially caused by:• advances in treatment • improvements in detection Medical advances The pace of scientific development • Will the accelerating pace of medical advancement drive accelerating mortality improvements? • Two case studies are considered:• A ‘polypill’ to treat cardio-vascular disease • Research into the ageing process Medical advances A ‘polypill’ to treat cardiovascular disease • “The most important B.M.J. in 50 years.” (?) • Proposal is for a single pill consisting of low doses of six (off-patent) drugs already used to treat the risk factors of cardiovascular disease • • • • a statin to reduce cholesterol 3 blood-pressure reducing drugs folic acid aspirin • To be given to everyone over the age of 55 • Wald & Law (2003) claim it could reduce cardiovascular disease by 80% • It has been a controversial proposal but – at the very least - shows how the role of preventative medicine could become more important in the future Medical advances The ageing process • It is generally considered that ageing is a “by-product” of the evolutionary process • However, gerontologists have differing views on the potential of medicine to arrest the ageing process • Some believe that human longevity could be extended dramatically in the 21st Century “… the possibilities of lengthening life appear practically unlimited” “… the only practical limit to human life span is the limit of human technology” “… the cure for ageing…is no longer science fiction” Regelson (1996) Rose (1996) de Grey (2003) Medical advances Developments in anti-ageing research • Telomerase − Enzyme used to make human cells replicate indefinitely in vitro • Gerentogenes − Genes linked to longevity have been manipulated in experiments with animals • Hormone Therapies − Hormones such as D.H.E.A. have been linked to ageing • Caloric restriction − Animal experimentation has shown a link between a diet low in calories and increased lifespan. An ingredient of red wine – resveratol – seems to mimic the age-enhancing effects of caloric restriction. Longevity in the 21st Century • • • • • • • Background 20th Century Trends International Experience Medical Advances The Threat From Infectious Diseases Projecting the Future Implications Infectious diseases Infectious diseases are a growing threat • Rapid global transport, especially air travel (e.g. SARS) • Increasing use of antibacterials in medicine & veterinary science • Potential advances in xenotransplantation • Increasing industrialisation of food production • Human behaviour (unprotected sex and drug use) • Potential threat of bioterrorism Infectious diseases Examples of newly-recognised infectious diseases Year Microbe Disease 1977 Ebola virus 1977 1983 Legionella pneumophilia HIV Ebola haemmorrhagic fever Legionnaires disease 1996 TSE causing agent New variant CJD 2003 SARS-CoV SARS AIDS Infectious diseases Newly reported HIV infections and HIV-related deaths in the UK, 1987-2002 6,000 Newly-reported HIV infections 5,000 HIV-related deaths 4,000 3,000 2,000 1,000 0 1987 1990 1993 1996 Year Source: PHLS, HPA 1999 2002 Infectious diseases Reported cases of MRSA in the UK, 1992-2002 6,000 5,000 4,000 3,000 2,000 1,000 0 1992 Source: HPA 1995 1998 Year 2001 Infectious diseases General points • Advances in medicine and international networking will continue to help limit the effects of new diseases (SARS is a good example) • Arguably HIV is the only infectious agent to emerge in recent decades to have a dramatic impact on global mortality. • HIV remains a threat to health and mortality as well as the global economy • The potential threat of infectious diseases cannot be disregarded • As deaths from heart disease and cancer reduce in future decades the relative impact of deaths from infectious diseases may become more significant Longevity in the 21st Century • • • • • • • Background 20th Century Trends International Experience Medical Advances The Threat From Infectious Diseases Projecting the Future Implications Projecting the future In the first few decades of the 21st Century it is likely that mortality rates for elderly people in the UK will improve at faster pace than ever before • • • • • • Projection of the UK cohort effect Past patterns of smoking prevalence A general “ageing” of mortality improvement Accelerating medical advances Rapid improvements in heart disease mortality Potential for improvement at older ages is greatest Projecting the future Methods of mortality projection There will be a much greater focus on quantifying the uncertainty around future projections Projecting the future Significance of mortality assumptions Annuity costs for a male retiring at age 65 in 2004 derived using a 5.0% interest rate Mortality basis PMA92u2004 [the FSA pension projection basis] Cost relative to PMA92u2004 - PMA92mc [the “medium cohort” basis] 8% “Benchmark A” [based on the assumption that 13% improvements continue at their current pace] Projecting the future Significance of mortality assumptions Pension costs for a male retiring at age 65 in 2019 derived using a 2.5% interest rate Mortality basis PA(90)-2 [the Minimum Funding Requirement basis] Cost relative to PA(90)-2 - PMA92c2020 21% PMA92mc [the “medium cohort” basis] 34% “Benchmark A” [based on the assumption that 49% improvements continue at their current pace] Longevity in the 21st Century • • • • • • • Background 20th Century Trends International Experience Medical Advances The Threat From Infectious Diseases Projecting the Future Implications Implications General • Likely future trends in mortality will have a profound impact on all aspects of our society • Inevitably people will remain in work for longer “Ten years ago, global ageing barely registered as a policy issue. Today… it is the focus of growing concern among political and policy leaders worldwide.” Center for Strategic and International Studies (2003) Implications For life assurance companies • Losses being declared on existing annuity books • Increased reserves for GAOs • Increased capital requirements (partially driven by new FSA regulations) • Increased focus on mortality issues from equity analysts and ratings agencies • Development of alternative annuity products and use of additional rating factors Taken together these factors may lead to the continued worsening of annuity rates Implications For final salary pension schemes • Increasing pressure (not least from equity analysts) to disclose mortality assumptions • Pressure to move towards more flexible definitions of retirement age • Increased buyout costs as closed schemes mature and FSA regulations require insurers to consider a greater range of adverse scenarios in setting capital requirements Implications For the Actuarial Profession • Increasing realisation that we have much to learn from demographers, epidemiologists, gerontologists, etc… • Increasing realisation that we need to play our part in the wider debate Longevity in the 21st Century Richard Willets