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Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis by Gianluigi Zaza, Wenjian Yang, Leo Kager, Meyling Cheok, James Downing, Ching-Hon Pui, Cheng Cheng, Mary V. Relling, and William E. Evans Blood Volume 104(5):1435-1441 September 1, 2004 ©2004 by American Society of Hematology Rate of de novo purine synthesis (DNPS) in ALL cells of different genetic and lineage subtypes. Gianluigi Zaza et al. Blood 2004;104:1435-1441 ©2004 by American Society of Hematology “Supervised” hierarchical clustering and principal components analysis (PCA) using purine pathway genes discriminating TEL-AML1 and non–TEL-AML1 B-lineage ALL. (A) Each patient's ALL cells are depicted as vertical columns, with green symbols indicating ALL ... Gianluigi Zaza et al. Blood 2004;104:1435-1441 ©2004 by American Society of Hematology Gene expression versus rate of DNPS after adjusting for TEL-AML1 in 2 discriminating genes. Gianluigi Zaza et al. Blood 2004;104:1435-1441 ©2004 by American Society of Hematology Concordance of protein levels and gene expression for 2 purine genes discriminating TELAML1–positive and TEL-AML1–negative ALL cells. Gianluigi Zaza et al. Blood 2004;104:1435-1441 ©2004 by American Society of Hematology