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Acute lymphoblastic leukemia with TEL-AML1 fusion has
lower expression of genes involved in purine metabolism
and lower de novo purine synthesis
by Gianluigi Zaza, Wenjian Yang, Leo Kager, Meyling Cheok, James Downing,
Ching-Hon Pui, Cheng Cheng, Mary V. Relling, and William E. Evans
Blood
Volume 104(5):1435-1441
September 1, 2004
©2004 by American Society of Hematology
Rate of de novo purine synthesis (DNPS) in ALL cells of different genetic and lineage subtypes.
Gianluigi Zaza et al. Blood 2004;104:1435-1441
©2004 by American Society of Hematology
“Supervised” hierarchical clustering and principal components analysis (PCA) using purine
pathway genes discriminating TEL-AML1 and non–TEL-AML1 B-lineage ALL. (A) Each patient's
ALL cells are depicted as vertical columns, with green symbols indicating ALL ...
Gianluigi Zaza et al. Blood 2004;104:1435-1441
©2004 by American Society of Hematology
Gene expression versus rate of DNPS after adjusting for TEL-AML1 in 2 discriminating genes.
Gianluigi Zaza et al. Blood 2004;104:1435-1441
©2004 by American Society of Hematology
Concordance of protein levels and gene expression for 2 purine genes discriminating TELAML1–positive and TEL-AML1–negative ALL cells.
Gianluigi Zaza et al. Blood 2004;104:1435-1441
©2004 by American Society of Hematology
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