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Plasma of Preeclamptic Women Stimulates and Then
Inhibits Endothelial Prostacyclin
by Philip N. Baker, Sandra T. Davidge, Jerzy Barankiewicz, and James M. Roberts
Hypertension
Volume 27(1):56-61
January 1, 1996
Copyright © American Heart Association, Inc. All rights reserved.
Plot shows endothelial cell prostaglandin I2 (PGI2) production (displayed on a log scale),
measured as the stable metabolite 6-keto-PGF1α, after exposure to plasma from preeclamptic (•)
and healthy pregnant (○) women.
Philip N. Baker et al. Hypertension. 1996;27:56-61
Copyright © American Heart Association, Inc. All rights reserved.
Plot shows endothelial cell prostaglandin E2 (PGE2) production (displayed on a log scale) after
exposure to plasma from preeclamptic (•) and healthy pregnant (○) women.
Philip N. Baker et al. Hypertension. 1996;27:56-61
Copyright © American Heart Association, Inc. All rights reserved.
Bar graph shows endothelial cell prostaglandin (PG) production in the first 15 minutes after
exposure to 100 mmol/L arachidonic acid (AA) by cells that had previously been exposed for 72
hours to pooled plasma from either preeclamptic or healthy pregnant women.
Philip N. Baker et al. Hypertension. 1996;27:56-61
Copyright © American Heart Association, Inc. All rights reserved.
Bar graphs show endothelial cell prostaglandin I2 (PGI2) production after exposure to untreated
and heat-, acid-, and protease-treated pooled plasma from preeclamptic and healthy pregnant
women in the first 24 hours of incubation (top) and between 24 and 72 hours of incubation
(bottom).
Philip N. Baker et al. Hypertension. 1996;27:56-61
Copyright © American Heart Association, Inc. All rights reserved.