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SGUL/LSHTM MRC London Intercollegiate Doctoral Training Partnership – 2017/18 Potential PhD Projects Title of PhD project Risk of sexual transmission of Zika virus infection: a study among sex workers and their clients in an endemic area of coastal Ecuador Supervisor Prof Phil Cooper SGUL Co-Supervisor Dr Tariq Sadiq SGUL Brief description of project Zika virus (ZV), an RNA virus that has spread rapidly throughout tropical regions of Latin America has been detected in seminal fluid and vulvovinal fluids for several months after acute infection with documented cases of sexual transmission of ZV. The project will involve laboratory and epidemiological field work in a coastal area of Ecuador where Zika virus transmission has become epidemic and where we are currently studying sexually transmitted infections among sex workers and their clients. The study will examine viral persistence post-infection and potential risks of sexual transmission of infection a well as the genetic evolution of viral strains. Particular prior educational requirements for a student undertaking this project Familiarity with or training in epidemiology and biostatistics; laboratory experience of molecular biological techniques including PCR; knowledge of or willingness to learn Spanish. Skills we expect a student to develop/acquire whilst pursuing this project Field methods in epidemiology including administration of questionnaires; biostatistics; sample processing and analysis for real-time PCR and sequencing; phylogenetics; training in good clinical practice. 1