Download Molecules to Medicine

CIRC 5007
Molecules to Medicine
Content Overview
Module Objectives
Week 1 – Building Blocks
•Students will build a knowledge base for understanding human development, wellness and disease starting with
the most basic building blocks: DNA, RNA , proteins and cells.
•Students will apply this knowledge base to clinical cases including gout, growth failure, thalassemia, and
HIV/AIDS.
Week 2 – And So it Begins…
•Students will learn the molecular and genetic basis of transforming cells into tissues, and ultimately organ
systems with a focus the structure and function of normal tissues.
•Students will build on their knowledge of molecular biology towards an understanding of genetics and genetic
disorders with a focus on cytogenetics, patterns of inheritance, and population genetics
•Students will learn about molecular testing techniques and the process of interpreting testing results in clinical
practice
•Students will apply this knowledge to clinical cases including Prader Willi and Down Syndrome
Week 3 – Up & Running Part 1: Membranes & Fluids
•Students will learn about the structure and function of cell membranes and their role in the transport of fluid,
electrolytes and other small molecules
•Students will learn about the electrochemical balance that exists across the cell membrane and how this
potential is used to transmit signals in the nervous system
•Students will apply this knowledge to clinical cases including sensory disorders and dehydration
Week 4 – Up & Running Part 2: Metabolism
•Students will build on their foundation in biochemistry toward understanding of the role of the metabolism of
amino acids, carbohydrates and lipids in human health and disease
•Students will apply knowledge from this week and past weeks to clinical cases including inborn errors of
metabolism, cystic fibrosis, and diabetes mellitus.
Week 5 – Up & Running Part 3: Movement & Maintenance
•Students will build on their knowledge of cells, membranes and signal transmission towards and understanding
of the physiologic basis of skeletal, cardiac and smooth muscle function
•Students will learn about systems of maintaining homeostasis in the body with a focus on the regulation of body
temperature and fluid balance
•Students will apply knowledge from this week to clinical cases including cirrhosis, muscular dystrophy, and
myasthenia gravis
Week 6-7 – Derangement: How Things Go Wrong
•Students will gain a vocabulary for discussing pathologic changes and a framework for evaluating them in the
clinical context
•Students will learn about the adaptive and pathologic responses of cells and tissues to injury and how to
identify these processes in images
•Students will build on their knowledge of genetics and molecular biology toward an understanding of neoplastic
transformation and the therapies that target neoplastic diseases
•Students will apply knowledge from these weeks to clinical cases including cleft-lip and palate, genetic
counseling and head and neck cancer
Week 8 – Prevention & Intervention
•Students will learn the basic principles of pharmacology with a focus on pharmacokinetics, pharmacodynamics,
and autonomic pharmacology
•Students will learn general concepts of doctoring, including disease prevention and the responsible use of
pharmacologic and other interventions
•Students will apply knowledge from this week to clinical cases including health maintenance visits, autonomic
disorders, and end of life care.
Week 1:
Introduction to M2M
Basic Cytology & Cell Function
Instructional Method
Summary
Hemoglobin
HIV and Screening
Mechanism of Mutations
Hemoglobin
HIV Synthesis case
• Reverse transcription
• Principles of screening
Building Blocks to Growth
HIV Interdisciplinary Rounds
Protein Synthesis and
Mutations
Nucleotide Metabolism
RNA Transcription
Molecular Testing in Medicine
Cases
Week 2:
Quiz on Wk 1 Content
Chromosomes & Mendel’s
Laws
Molecular Genetics in
Medicine
Cytogenic and Mendelian
Disorders
Tissue Adaptations
Population Genetics & HardyWeinberg Equilibrium
Basic Tissues
Basic Tissues Lab
Genetics Group Problem Set
Cytogenetics and Pre-natal
testing
Cell Cycle, Meiosis & Fertility
Down Syndrome Synthesis
Case
• Cytogenetics
• Pre-natal testing
• Sensitivity and specficity
Down Syndrome Primary care
and Patient Presentation
Week 3:
Quiz on Wk 2 Content
Membrane Structure and
Function
Mechanisms of Transport
Resting Membrane Potential
Action Potentials
Neural Sensory Mechanisms
Dehydration and fluid
replacement
Resting Membrane Potential
Synaptic Transmission
Neural Sensory Mechanisms
Dehydration and fluid
replacement
Excitable Membranes and
Action Potentials
Transcapillary Exchange
Passive Membrane Properties
Intercompartmental Fluid
Distribution
Dehydration Interdisciplinary
Rounds
Week 4:
One Carbon Metabolism
Week 9 – Final Exam!
DNA Replication and Repair
Protein Biosynthesis
Carbohydrate Metabolism
Inborn Errors of Metabolism
Lipid Metabolism
Diabetes Mellitus
Amino Acid Metabolism
Inborn Errors of Metabolism
Cholesterol Metabolism
Diabetes Mellitus Synthesis
Case
Amino Acid Metabolism
Carbohydrate Metabolism
Electron Transport and
Oxidative Phosphorylation
Living with Diabetes: Patient
Cystic Fibrosis:
Molecular mechanism to novel Presentation
therapeutics
Mechanism of Hormone
Action
Week 5:
HOLIDAY
Quiz on Wk 3 & 4
Introduction to Muscle
Physiology
Homeostatic Control Systems
Skeletal Muscle Physiology
Body Temperature Regulation
Body Fluid Regulation
Myasthenic Syndromes
Cardiac Muscle Physiology
Synthesis Case Myasthenia
Gravis
Muscle Cases / Review
Smooth Muscle Physiology
Muscular Dystrophy Patient
Presentation
Week 6:
Midterm Exam covering
Content from Wk 1-5
Introduction to pathology and
clinical reasoning
Cell Injury
Cell Injury
Ethics of Genetic Testing:
Panel Discussion
Non-Mendelian Genetic
Disorders
Cell-Tissue Injury Lab
Morphology of Cell Injury
Cleft-lip and palate
Cleft-Lip and Palate Synthesis
Case
Cleft-Lip interdisciplinary
rounds
Week 7:
Anatomic Pathology;
Method
Case-Based Learning
Hours
36
Story of Neoplasia
Cancer Genetics and
Therapeutics
• Intro to Chemotherapy
Lymph nodes and cancer
Story of Neoplasia
Epidemiology & Prevention of
Cancer
Lymph nodes and Cancer
Synthesis Case
Notes
Synthesis Cases, PPT guided large group
cases, case-based problem sets
Conference
12
Patient presentations, tumor board,
palliative conference, CPC, Ethics Panel
Independent Learning
12
SoftChalk, Web Based activities
Laboratory
6
3 x 2-hr Laboratory activities
Lecture
55
Approximately 2/3 used interactive
techniques (e.g.. ARS )
Peer Instruction
0*
*Not a formal part of this module but
students likely doing this on their own
Self-Study
0**
*Occasionally included in pre/post
materials but unable to measure
Team-Based Learning
15
5 x 3-hr TBL activities
Inflammation
Neoplasia
Pharmacokinetics / Dynamics
• Pathology
• Cellular Basis
• Molecular Basis
Neoplasia Lab
Oncogenes and Tumor
Suppressor Genes
Tumor Board for Synthesis
Case
Week 8:
Quiz on Wk 6 &7
Medical Pharmacology:
Pharmacodynamics
Preventative Medicine
Pharmacology:
Rational use and application
Preventative Medicine Cases
Medical Pharmacology:
Pharmacokinetics
Autonomic Pharmacology
End of Life Care
Autonomic Pharmacology
End of Life Care Synthesis Case
Clinical Pathological
Conference
Palliative Care Conference
Autonomic Nervous System
Autonomic Pharmacology
Week 9: Exam Week
Weeks 1-8 Content Review
Final Exam
Covers Wk 1-8 Content