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Table A Clinical symptoms Onset date Days after symptoms onset * Days after rash onset * Rash duration Rash type Low grade fever (duration) Headache Retro-orbital pain Photophobia Fatigue/ malaise Myalgia Arthralgia (region) Patient 1 01/11/16 2 01/24/16 3 01/22/16 4 01/31/16 3 2 5 1 <1** 1 1 1 5 days 6 days Macular and maculopapular + (2 days) + + 2 days 2 days Maculopapular Maculopapular Macular + (wrist and elbows) - - + (4 days) + + NI + + + (large and small joints) - Arthritis Anorexia + Nausea/ vomiting + Diarrhea Abdominal pain Dysuria Bleeding/ petechia Dizziness/ light headedness Pruritus + + + Paresthesias + Conjunctivitis Edema + (local/site) (hands) Lymphadenopathy (local/ site) Enanthem NI NI Respiratory symptoms Jaundice Seizures * Regarding the date of sample collection; **the collection date was in the first day of rash manifestation Table B Clinical symptoms Onset date Days after sypmtons onset * Days after rash onset * Rash duration Patient 5 01/26/16 6 01/26/16 7 01/31/16 8 01/31/16 9 01/28/16 2 3 1 2 5 2 <1 1 2 2 20 days 4 days 5 days 6 days 3 days Rash type Macular Low grade fever (duration) Headache Retro-orbital pain Photophobia Fatigue/ malaise Myalgia Arthralgia (region) + + + + + - Arthritis Anorexia Nausea/ vomiting Diarrhea Abdominal pain Dysuria Bleeding/ petechia Dizziness/ light headedness Pruritus Paresthesias Conjunctivitis Edema Lymphadenopathy (local/ site) Enanthem + + + - Maculopapular + (1 day) + + + (wrists, ankles, knees, hands) + + - Maculopapular - Macular and maculopapular + (2 days) + + + - Maculopapular + + + + - + (large and small joints) - - - - + - - - - + + + + (feet and hands) + + + + - + - + + + (hands) - + - - - - + (cervical) - - - - + (Cervical and auricular) - Respiratory + + symptoms Jaundice Seizures * Regarding the date of sample collection; **the collection date was in the first day of rash manifestation Table C Socialdemographic data Patient 1 2 Gender female female Age 36 30 Gestational age 18 33 (weeks) Family members illness Partner illness Repellent spray + + use Previous DENV + infection Domicile in Rio Duque de Nova Iguaçu de Janeiro Caxias State NA – not applicable; NI- not informed 3 4 male 24 female 42 NA 21 + - NI NI + NI - Rio de Janeiro Duque de Caxias Table D Social demographic data Gender Age Gestational age (weeks) Family members illness Partner illness Repellent spray use Previous DENV infection Domicile in Rio de Janeiro State Patient 5 6 7 8 9 female 30 male 68 female 20 female 27 female 22 NA NA 17 21 20 - + - - - - - - - - + - + + + + + - + - Rio de Janeiro Rio de Janeiro Rio de Janeiro Duque de Caxias Rio de Janeiro NA – not applicable; NI- not informed