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"By what route, and under circumstances, does the virus pass from its reservoir into other animals?" Conclusions: Ebola Virus Disease is particularly devastating to the human population because there is no current vaccine available for clinical use. There is also no specific treatment for EVD, only oral rehydration for patients suffering from dehydration, which is why the fatality rate in humans is 90%. What is Ebola? ▸ ▸ Ebola is an infectious, fatal disease marked by fever and severe internal bleeding, spread through contact with infected body fluids by a filovirus. Ebola outbreaks have been observed in chimpanzees and gorillas. It first appeared in 1976 in 2 simultaneous outbreaks, in Nzara, Sudan, and in Yambuku, Republic of Congo. The latter was in a village situated near the Ebola River . The CNS or central nervous system is affected by headaches, agitation, confusion, depression, fatigue, and seizures, and sometimes a coma can occur. When the infection attacks, it causes damage to the skin. Small white blisters will develop in the skin, along with red spots referred to as "maculopapular rash", usually around needle injection sites. ▸ Cause and Effects: ▸ Ebola is introduced into the human population through contact with the blood, secretions, organs or other bodily fluids of infected animals and iis then passed on as humans come more and more in contact with each other. Symptoms of the Ebola virus show up 2 to 21 days after someone is infected. As the virus spreads through the body's cells, it damages the immune system and organs. Ultimately, Ebola causes levels of blood-clotting cells, called platelets, to fall, which can lead to severe bleeding. Many of the early symptoms of Ebola look like the flu or other mild illnesses. They such as fever ,headache ,muscle aches ,sore throat , weakness and ,diarrhea. As the disease gets worse, people who are infected may develop things such as bleeding inside and outside of the body, rash , and may have trouble breathing. Also Ebola may be caused by any of four out of five ebola viruses. These viruses are the following: Bundibugyo virus, ebola virus, sudan virus, and tai forest virus. Transmission of the virus is not limited to direct contact with blood or bodily fluids from an infected person it can get transmitted through dead people, or by contact with contaminated medical equipment ▸ Currently, the best treatment for Ebola involves providing fluid to the patient to replace the bleeding that occurs from all orifices as the hemorrhagic fever destroys the body from within. Ebola is common in third world countries, especially Africa,because it is introduced to the human population through close contact with blood or other bodily fluids of infected animals, such as handling of infected chimpanzees, gorillas, fruit bats, monkeys, forest antelope and porcupines found ill or dead or in the rainforest. Ebola also spreads from human to human through the same means, contact of infected bodily fluids. Ebola Virus Disease is a severe acute viral illness causing low white blood cell and platelet counts and elevated liver enzymes, which leads impaired kidney and liver function, and internal and external bleeding, usually the cause of death in Ebola patients. The skin becomes very weak that it easily tears and bleeds with any movement made. The surface of the tongue will begin to take on a red color. The virus can even attack the connective tissues that are rapidly multiplying in collagen (collagen is responsible for keeping the organs in place). Ebola virus also causes blood clots in the bloodstream. Death may be caused by shock, renal failure, or loss of blood. : Rationale Ebola is a virus that greatly effects not only the human population in various parts of the world, but also in animals such as chimpanzees and gorillas, that can be affected by the disease, and bats, that carry the disease. The spread of the Ebola virus from infected animals to humans classifies it as a zoonotic virus, and the fact that there is no known cure for the Ebola virus makes it especially devastating to infected patients, human and animal. Further questions: ▸ If the virus changes at all from the infection of animals to that of humans, how does it change to be so deadly? ▸ Could there possibly be the development of a vaccine for animals and not humans, or vice versa? ▸ What are some of the possible cures or vaccines being developed for the Ebola virus? ▸ Who is most at risk for ebola virus? ▸ When should someone seek medical care? ▸ How is Ebola virus diagnosed in the laboratory?