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Our ref: MMT/AdvisoryNote/Spiriva Handihaler Date October 2016 To: Practice Prescribing Leads Practice Managers Re: Unit 1 St James Business Park Grimbald Crag Court Knaresborough HG5 8QB Spiriva Handihaler Dear Colleague, For the October “Hints and Tips on Prescribing”, the Medicines Management Team would like to encourage practices to review patients who have been prescribed a Spiriva Handihaler for the treatment of COPD. This is because there are now alternative inhalers available which patients may find easier to use. The Handihaler requires patients to load a capsule into the device, whereas Spiriva Respimat and the newer options such as Incruse Ellipta and Eklira Genuair are ready to use and do not require pre-loading and so are particularly beneficial for elderly patients and those with reduced manual dexterity. Spiriva Handihaler contains tiotropium and the alternative devices also contain long acting muscarinic agonists (LAMAs). In addition, the newer devices are also lower in price and by switching over to one of these products, over £60k could be saved per annum in HaRD CCG. Incruse Ellipta, Eklira Genuair and Spiriva Respimat are included in the new guidelines for the diagnosis and management of COPD from HDFT and the Respiratory Team at HDFT are also encouraging the use of these new devices. Brand name Spiriva Handihaler Manufacturer Boehringer Ingleheim LAMA Tiotropium Manufacturer’s licensed dose Strength 18 microgram capsule 18micrograms (one capsule) once a day Price Device plus 30 caps £34.87 30 capsules only £33.50 Spiriva Respimat Incruse Ellipta Eklira Genuair Boehringer Ingleheim Tiotropium GSK Umeclidinium bromide Astra Zeneca Aclidinium bromide 2.5 microgram per dose 5 micrograms (two puffs) once daily 60 dose inhaler 65 micrograms per dose (equiv. to 55micrograms of umeclidinium) 55 micrograms of umeclidinium once a day 30 dose dry powder inhaler 375 micrograms per dose (equiv. to 322 micrograms of aclidinium) 322 micrograms of aclidinium twice a day 60 dose dry powder inhaler £23 £27.50 £28.60 Action points Please review all patients who are currently prescribed a Spiriva Handihaler and consider changing to Spiriva Respimat, Incruse Ellipta, Eklira Genuair. We suggest that each practice obtains some placebo devices from the local company reps in order to allow all staff involved in the treatment of COPD to become familiar with these new devices. Contact details of company reps: Spiriva Handihaler Monthly briefing/letter – Oct 16 GSK: Maria Lancaster 07771 810661 Page 1 of 2 HaRD Medicines Management Team Astra Zeneca: Yvonne Webster 07810 528683 Boehringer: Donna Dabell 07770 334904 Ensure that patients are shown how to use their new inhaler. If patients are switched to Spiriva Respimat, Incruse Ellipta or Eklira Genuair, please prescribe by the brand name. Please be aware there have been two recent prescribing errors involving Spiriva Respimat inhaler, which contains only tiotropium and Spiolto Respimat inhaler, which is a LAMA / LABA combination inhaler and contains tiotropium and olodaterol. Please share this information with all members of staff in the practice who are involved in the treatment of patients with COPD. Prescriptions for Spiriva Handihaler in HaRD practices - 3 months to June 2016 Prescriber Name BEECH HOUSE SURGERY CHURCH AVENUE MEDICAL GROUP CHURCH LANE SURGERY DR AKESTER & PARTNERS DR INGRAM & PTRS EAST PARADE SURGERY EASTGATE MEDICAL GROUP KINGSWOOD SURGERY NIDDERDALE GROUP PRACTICE NORTH HOUSE SURGERY PARK PARADE SURGERY RIPON SPA SURGERY SPRINGBANK SURGERY STOCKWELL ROAD SURGERY THE LEEDS ROAD PRACTICE THE MOSS PRACTICE THE SPA SURGERY TOTALS Total Items (3m) Total Costs (3m) Est. annual savings if switch 137 £4,254.66 £2794 179 £7,640.41 £5018 348 £11,434.45 £7509 111 £3,538.36 £2324 48 £1,533.30 £1007 78 £4,325.86 £2841 262 £8,827.30 £5797 108 £3,878.87 £2547 139 £4,326.10 £2841 226 £7,095.62 £4660 65 £2,646.40 £1738 244 £7,736.41 £5081 72 £2,273.65 £1493 98 £3,888.58 £2554 226 £7,095.47 £4660 373 £13,478.72 £8852 179 £7,093.49 £4658 2,893 £101,067.65 £66374 Our Prescribing Support Team is available to help practices with this work if required. HaRD versions of OptimiseRx and SystmOne and EMIS formularies will be amended to incorporate these recommendations. Local community pharmacies have been e-mailed to inform them that practices will be undertaking this switch. As the timings of the switch will vary between practices it is advisable that each practice notifies its local pharmacies in advance of the switch to enable effective management of stock. Yours sincerely, The Medicines Management Team, HaRD CCG. References 1. eBNF accessed 8.9.16 2. Guidelines for the diagnosis and management of HDFT: http://www.harrogateformulary.nhs.uk/chaptersSubDetails.asp?FormularySectionID=3&SubSectionRef=03&SubSectionID=A100 Spiriva Handihaler Monthly briefing/letter – Oct 16 Page 2 of 2 HaRD Medicines Management Team