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Principal Investigator/Program Director (Last, First, Middle): Morris, Katherine T. BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Katherine T. Morris Assistant Professor, Division of Surgical Oncology, Department of Surgery, University of New Mexico. eRA COMMONS USER NAME KTMorris EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) BS MD 1988-1992 1992-1996 University of Washington, Seattle, Washington Oregon Health and Science University, Portland, Oregon FIELD OF STUDY Mathematics Medicine A. Personal Statement As a Surgical Oncologist with a clinical focus on gastrointestinal tumors, I will use my expertise in the natural history and clinical management of gastric and colorectal cancers to facilitate this project examining pathways of chronic inflammation and their relation to the development of these malignancies. While there is a clear clinical link between conditions causing chronic inflammation and certain cancers (H. pylori infection and gastric adenocarcinoma, inflammatory bowel disease and colorectal cancer), the molecular mechanisms by which this occurs have not been fully elucidated. As an Assistant Professor recently recruited to UNM, I have actively sought collaborations with promising scientists such as Dr. Beswick in an effort to further this type of clinically relevant research which is critically necessary to rapidly translate laboratory based scientific observations into new treatment options for patients. I am particularly interested in this project as findings regarding the mechanisms by which chronic inflammation can influence gastrointestinal tumors such as gastric and colorectal cancer may also have applicability to the development of other inflammation related GI cancers such as gallbladder cancer and cholangiocarcinoma, potentially leading to new screening and treatment options for all these tumors which, combined, represent a significant public health concern. B. Positions and Honors Positions and Employment 2003 - 1996 Resident in General Surgery, Oregon Health and Science University, Portland, OR 2005 –2003 Surgical Oncology Fellow, Memorial Sloan Kettering Cancer Center, New York, NY 2006 –2005 Surgical Oncologist, Oregon Surgical Consultants, Portland, OR 2010 –2005 Medical Director of Cancer Research, Legacy Health System, Portland, OR 2010 –2007 NW Surgical Oncology, PC, Surgical Oncologist, Portland, OR 2010 –2007 Medical Director of Hepatobiliary Program, Legacy Health System, Portland, OR 2010Assistant Professor, Division of Surgical Oncology, Department of Surgery, University of New Mexico, Albuquerque, NM Other Experience and Professional Memberships 2007 Member, American Association for Cancer Research 2006 Member, Society of Surgical Oncology 2005 Member, American Society of Clinical Oncology 2005 Member, American College of Surgeons 2010 – 2006 Member, Human Services Commission, State of Oregon, Genetics Advisory Subcommittee 2009-2010 State Chair, American College of Surgeons Commission on Cancer, Oregon. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 1 Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Morris, Katherine T. Honors 2000 2000 1999, 2000, & 2001 2001 2001 2009 2009 Oregon Health Sciences University Alumni Association Resident Paper Award American Radium Society Young Oncologist Travel Grant Baker-Moseley Award in Surgical Oncology - American College of Surgeons American Association for Endocrine Surgeons Best Basic Science Paper Award Pacific Coast Surgical Society Resident Paper Award Portland Business Journal Forty Under Forty Portland Monthly Magazine Top Doctors, Surgical Oncology C. Selected Peer-reviewed Publications (in chronological order): 1. Thompson, S. J., Ordonez A. N., Ashley, M. D., Jessick, V. J., Murphy, B., Gafken, P., Henshall, D., Morris, K., Simon, R. P., & Meller, R. “Identification of a novel Bim E3 ligase, tri-partite motif containing protein 2, and its role in rapid ischemic tolerance induced neuroprotection.” In Press Journal of Biological Chemistry 2011 2. Morris KT, Gönen M, Schwartz L, Tuorto S, DeMatteo R, D’Angelica M, Jarnagin WR, Fong Y. “A Simple Measurement of Intra-abdominal Fat Predicts Outcome After Upper Abdominal Surgery.” Archives of Surgery, November 2010; 145(11): 1069-1073. 3. Sambasivan C, Deveney K, Morris KT. “Oncologic Outcomes after Resection of Rectal Cancer: Laparoscopic versus Open Approach.” American Journal of Surgery, May 2010; 199: 599-603. 4. McLaughlin SA, Wright MJ, Morris KT, Sampson MR, Brockway JP, Hurley KE, Riedel ER, and Van Zee KJ. “Prevalence of lymphedema in 936 women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: I. Objective measurements.” Journal of Clinical Oncology, November 2008; 26(32): 5213-9. 5. McLaughlin SA, Wright MJ, Morris KT, Sampson MR, Brockway JP, Hurley KE, Riedel ER, and Van Zee KJ. “Prevalence of lymphedema in 936 women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: II. Patient perceptions and precautionary behaviors.” Journal of Clinical Oncology, November 2008; 26(32): 5220-6. 6. Morris KT, Busam KJ, Bero S, Patel A, Brady MS. “Primary cutaneous melanoma with regression does not require a lower threshold for sentinel lymph node biopsy.” Annals of Surgical Oncology, January 2008; 15(1): 316-322. 7. Morris KT, Song TJ, and Fong Y. “Recent advancements in diagnosis and treatment of metastatic colorectal cancer to the liver.” Surgical Oncology, November 2006; 15(3): 129-134. 8. Morris AM, Flowers CR, Morris KT, Schmidt WA, Pommier RF, and Vetto JT. “Comparing the costeffectiveness of the triple test score to traditional methods for evaluating palpable breast masses.” Medical Care, August 2003; 41(8): 962-971. 9. Morris KT, Toth-Fejel S, Schmidt J, Fletcher WS, and Pommier RF. “High DHEA predicts breast cancer cell growth in tissue culture: A renewed role for adrenalectomy.” Surgery, December 2001; 130(6): 947-53. 10. Morris KT, Pommier RF, Morris A, Schmidt WA, Beagle G, Alexander PW, Toth-Fejel S, Schmidt J, Vetto JT. “Usefulness of the triple test score for palpable breast masses.” Archives of Surgery, September, 2001; 136(9): 1008-1013. 11. Morris KT, Stevens J, Fletcher WS, Pommier RF, and Vetto JT. “Usefulness of preoperative lymphoscintigraphy for the identification of SLN location in melanoma.” American Journal of Surgery, May 2001; 181: 423-426. 12. Morris KT, Johnson N, Dorsey P, Krasikov N, and Allen M. “Genetic counseling impacts decision for prophylactic surgery for patients perceived to be at high risk for breast cancer.” American Journal of Surgery, May 2001; 181: 431-433. 13. Morris KT, Marquez C, and Vetto JT. “Prevention of local recurrence after surgical debulking of nodal and subcutaneous melanoma deposits by hypofractionated radiation therapy.” Annals of Surgical Oncology, October 2000; 7(9): 680-4. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 2 Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): Morris, Katherine T. 14. Morris KT, Johnson N, Homer L, and Walts D. “A comparison of complementary therapy use between breast cancer patients and patients with other primary tumor sites.” American Journal of Surgery, May 2000; 179(5): 407-11. 15. Morris KT, Pommier RF, Vetto JT. “Office based wire guided open breast biopsy under local anesthesia is accurate and cost effective.” American Journal of Surgery, May 2000; 179(5): 422-5. D. Research Support Completed Research Support LGSF Morris (PI) Legacy Good Samaritan Foundation Grant 10/01/2005-10/01/2010 Legacy Health System Tumor Bank. The goal of this project was to establish a prospectively maintained collection of tumor tissue with ongoing patient status updates. Confidentiality is assured by a code number linkage which is stored in our secure Cancer Registry. The tissue is used for translational research and all participating patients give informed consent. This project is ongoing under another PI since my departure. Role: PI LGSF Morris (PI) Legacy Good Samaritan Foundation Grant 04/01/2008-03/01/2009 Combined selective internal radiation therapy and radiofrequency ablation for primary and secondary hepatic malignancies with correlative study of treated samples. The goals of this project were: to assess the safety of combined selective internal radiation therapy and radiofrequency ablation for primary and secondary hepatic malignancies, and to perform analysis of markers of angiogenesis and apoptosis in the treated tissues. Role: Co-PI PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 2 Continuation Format Page