Download 16-Hypertension Lecture of Prof. Jamal Al Wakeel 24 Ocotber 2015

Case
Source: NCHS and NHLBI. Hypertension is defined as SBP 140 mm Hg or DBP 90 mmHg, taking
antihypertensive medication, or being told twice by a physician or other professional that one has
hypertension.
Men
BMI <25
BMI 25-<27
BMI 27-<30
BMI >30
100
Percent
75
46.2
50
25
24.6
10.4
3.5 7.4
16.3
23.3
51.7 53.6 49.1
30.2
0
20-39
40-59
*Defined as mean systolic blood pressure 140mm Hg, mean diastolic 90
mm Hg, or currently taking antihypertensive medication.
Brown C et al. Body Mass Index and the Prevalence of
Hypertension and Dyslipidemia. Obes Res. 2000; 8:605-619.
60+
61.6

The overall prevalence of hypertension was ( 15.2% and
40.6% of Saudis were hypertensive or borderline hypertensive)






only 44.7% of hypertensives were aware
Risk of hypertension increased among men, with age,
obesity, diabetes, and hypercholesterolemia.
57.8% of hypertensive Saudis were undiagnosed
71.8% of them received pharmacotherapy
only 37.0% were controlled.
. Source: International Journal of Hypertension
Abdalla A. Saeed, Nasser A. Al-Hamdan
Volume 2011 (2011), Article ID 174135, 8 pages
Hypertension
In 90%-95% of cases no cause can be found
primary hypertension (essential)
Secondary hypertension 5-10%
Mechanism of Blood Pressure:
Blood Pressure = Cardiac output
X
Systemic Vascular Resistance
= CO X SVR
= Stroke volume X HR X SVR
Essential HTN
Risk factors
Obesity---metabolic syndrome
Excessive salt intake---low potassium intake
Excessive alcohol intake
Polycythemia
Lack of exercise
Non-steroid anti-inflammatory drugs
Family history of essential HTN
Caffeine and smoking increase the BP acutely but are not
risk factors for the development of chronic essential HTN
Primary renal disease
Oral contraceptives
Sleep apnea syndrome
Primary hyperaldosteronism
Renovascular disease
Cushing’s syndrome
Pheochromocytoma
Other endocrine disorders
Coarctation of the aorta
CHD Rates by SBP, DBP and Age
Hypertension Update
2016
European Society of Nephrology
Classification of Blood Pressure Levels
Category
Optimal blood
pressure
Normal blood pressure
High-normal blood
pressure
Grade 1 hypertension
(mild)
Grade 2 hypertension
(moderate)
Grade 3 hypertension
(severe)
Isolated systolic
hypertension
Systolic blood pressure
(mmHg)
<120
Diastolic blood
pressure (mmHg)
<80
<130
<85
130-139
85-89
140-159
90-99
160-179
100-109
>/= 180
>/= 110
>140
<90
The Seventh Report of the Joint National Committee
Prevention, Detection, Evaluation, and Treatment
of High Blood Pressure (JNC 7 & 8)
U.S. Department of
Health and Human
Services
National Institutes
of Health
National Heart,
Lung, and Blood
Institute
BP
Classification
SBP
mmHg
Normal
120
and
<80
Prehypertension
120-139
or
80-89
Stage 1 HTN
≥140-159
or
≥90-99
Stage 2 HTN
>160
or
>100
DBP mmHg
Category
Systolic BP (mmHg)
Diastolic (mmHg)
Office BP
≥140
and/or ≥90
Daytime (or awake)
≥135
and/or ≥85
Nighttime (or sleep)
≥120
and/or ≥70
24 h
≥ 130
and/or ≥80
Home BP
≥135
and/or ≥85
Ambulatory BP
Out-of-Office BP
2013 ESH and ESC Guidelines
Type of Instrument of Blood Pressure Measurement
Sphygmomanometer
Type of Instrument of Blood Pressure
Measurement
Home Blood Pressure Monitoring
Ambulatory Pressure
Monitoring
Apply to adults on no antihypertensive
medications and who are not acutely ill.
If there is a disparity in category between the
systolic and diastolic pressures, the higher value
determines the severity of the hypertension.
Measure blood pressure to arm the high reading.
To allow the patients to sit for 3–5
minutes before beginning BP
measurements
Back straight and arm supported at
heart level
Take at least two BP measurements,
spaced 1–2 min apart, and additional
measurements if the first two are quite
different.
Consider the average BP if deemed
appropriate.
To use a standard bladder (12–13 cm
wide and 35 cm long)
A larger bladder for larger arm
(circumference >32 cm)
The bladder of the pressure cuff should
encircle at least 80% of the upper arm
Place the cuff at the heart level, whatever
the position of the patient.
Measure BP in both arms at first visit to
detect possible differences. In this instance,
take the arm with the higher value as the
reference.
Measure BP in sitting and standing position
in elderly subjects and diabetic patients
Use phase I and V (disappearance)
Korotkoff sounds to identify systolic and
diastolic BP, respectively.
The diagnosis of mild hypertension should not be
made until the blood pressure has been
measured on at least three to six visits
Average of 10 to 15 mmHg decrease between
visits 1 and three
Approximately 20 to 25% of patients with mild office
hypertension
More common in elderly
Infrequent in patients with office diastolic pressures
≥105 mmHg
Stroke, Ischemia,
Hemorrhage, Alzheimer’s
Disease, Cognitive, retinal
hemorrhage
CAD, ECG,
Arrthymia, Sudden
Death
CHF
LVH
Aortic Dissection
Renal Disease
Peripheral
Vascular Disease
Hypertensive
Emergency
And Increase
Emergency Morbidity
Hypertension
This left ventricle is very thickened (slightly over 2 cm in thickness),
but the rest of the heart is not greatly enlarged. This is typical for
hypertensive heart disease. The hypertension creates a greater
pressure load on the heart to induce the hypertrophy.
The left ventricle is markedly thickened in this patient with severe
hypertension that was untreated for many years. The myocardial fibers
have undergone hypertrophy.
Hypertensive
Emergency
Severe hypertension (diastolic blood pressure above 120
mmHg) in end organ damage (MI,STROKE,AKI,CHF)
Severe hypertension (diastolic blood pressure above
120 mmHg) in asymptomatic patients
There is no proven benefit from rapid reduction in BP
in asymptomatic patients who have no evidence of
acute end-organ and are little short-term risk
Marked hypertension with encephapapathy& retinal
hemorrhages, exudates, or papilledema
Associated with a diastolic pressure above 120
mmHg
HYPERTENSIVE RETINOPATHY
Grade
Description
I
Minimal narrowing of retinal arteries
II
Narrowing of retinal arteries in conjunction with
regions of focal narrowing and arterio-venous
nipping
III
Abnormalities seen in Grade 1 and II, as well as retinal
hemorrhages, hard exudation and cotton wool spots.
IV
Abnormalities encountered in Grades I through III, as
well as swelling of the optic nerve head and macular
star
Hypertensive Retinopathy Grade 1
Generalized
arteriolar
constrictionseen as `silver
wiring` and
Vascular
tortuosities
Arteriovenous nicking
in association with
hypertension Grade
2
(yellow arrow)
Flame-shaped hemorrhage
in association with severe
hypertension Grade 3
(yellow arrow)
Papilledema
from
malignant hypertension.
There is blurring of the
borders of the optic disk
with hemorrhages (yellow
arrows) and exudates
(white arrow)
Clinical Presentations:
Asymptomatic
Headache
Epistaxis
Chest discomfort
Symptom of complications
Screening:
Every two years for persons with systolic and
diastolic pressures below 120 mmHg and 80 mmHg
Yearly for persons with a systolic pressure of 120 to
139 mmHg OR Diastolic pressure of 80-89 mmHg
1. Confirm the diagnosis of hypertension
2. Detect causes of secondary
hypertension
3. Assess CV risk
4. Organ damage
5. Concomitant clinical conditions.
Routine Tests
Electrocardiogram
Urinalysis
Serum sodium, serum potassium, creatinine, or the
corresponding estimated GFR, and calcium
Blood glucose, and hematocrit
Lipid profile, after 9- to 12-hour fast, that includes high
density and low-density lipoprotein cholesterol, and
triglycerides
Optional tests
Measurement of urinary albumin excretion or
albumin/creatinine ratio
More extensive testing for identifiable causes is not
generally indicated unless BP control is not achieved
mmHg
7% reduction in
risk of IHD
mortality
2 mmHg decrease
in mean SBP
10% reduction in
risk of stroke
mortality
Meta-analysis of 61 prospective, observational studies conducted by Lewington et al
involving one million adults with no previous vascular disease at baseline mmHg
|
43
Who should be treated Low risk ?
If the systolic pressure is persistently ≥140 mmHg
and/or the diastolic pressure is persistently ≥90 mmHg
after three to six visits.
Usual Office BP Threshold Values for Initiation of Pharmacological
Treatment
Population
SBP
Hypertension Update
2016
DBP
High Risk (SPRINT population)
>130
NA
Diabetes
>130
>80
Moderate-to-high risk (TOD or CV risk
factors)*
>140
>90
Low risk (no TOD or CV risk factors)
>160
>100
TOD = target organ damage
*AOBP threshold >135/85
In patients with chronic kidney disease, antihypertensive therapy should be started in
those with systolic blood pressures consistently >140/90 mmHg and treated to a target
of <140/90 mmHg
For patients at moderate absolute CVD risk (<10% 5-year risk) with persistent blood
pressure ≥140 mmHg systolic and/or ≥90 mmHg diastolic, antihypertensive therapy
should be started
For patients at low absolute CVD risk (<10% 5-year risk) with persistent blood
pressure ≥160/100 mmHg, antihypertensive therapy should be started.
Average Percent Reduction
Stroke incidence
35–40%
Myocardial
infarction
Heart failure
20–25%
Renal Failure
35-50%
50%
Lifestyle modifications
High normal SBP >130 – 139 mmHg
DBP 85 – 89 mmHg
 in high risk patients
Drug therapy
Lifestyle changes:
Salt restriction to 4-5 gm/day.
Increased consumption of vegetables,
fruits and low-fat dairy products.
7-8 servings/day of grain/grain products, 45 vegetable, 4-5 fruit
Reduction of weight to BMI of 25 kg/m2.
Waist circumference Men < 102 cm Women <
88 cm
Regular exercise (≥30 min of moderate
dynamic exercise on 5-7 days per week)
Smoking cessation
Potassium supplementation
Treatment of Systolic-Diastolic Hypertension
without Other Compelling Indications
A combination of 2 first line drugs may
be considered as initial therapy if the
blood pressure is >20 mmHg SBP or
>10 mmHg DBP above target
Thiazide
Diuretic
CONSIDER
•Non-adherence
•Secondary HTN
•Interfering drugs or
lifestyle
•White coat effect
Dual Combination
Triple or Quadruple
Therapy
Lifestyle Modification
Initial Therapy
ACEI
ARB
Longacting
CCB
Dual Combination
Beta-blocker*
*Not indicated as first
line therapy over 60 y
Triple or Quadruple
Therapy
Hypertension Update
2016
Aged
under
55 years
Aged over 55
years or black
person of
African
Key
Step 1
12 Choose
a low-cost ARB.
A CCB is preferred but consider
a thiazide-like diuretic if a CCB is
not tolerated or the person has
edema, evidence of heart failure
or a high risk of heart failure.
Step 2
C &D
A&B
A(B) + C or A(B)+D
Step 3
A+C+D
B+ C+D
Step 4
Resistant hypertension
Consider a low dose of
spironolactone15 or higher doses
of a thiazide-like diuretic.
14
15
16 Consider
an alpha- or betablocker if further diuretic therapy
is not tolerated, or is
contraindicated or ineffective.
C – Calciumchannel blocker
(CCB)13
D – Thiazide-like
diuretic
13
At the time of publication
(August 2011), spironolactone did
not have a UK marketing
authorization for this indication.
Informed consent should be
obtained and documented.
A – ACE inhibitor
B-angiotensin II
receptor blocker
(ARB)12
A + C + D + consider
further diuretic14, 15 or
alpha- or
beta-blocker16
Consider seeking expert advice
High Risk Group Therapy
Start in pre-hypertension (130 – 139)/(85 – 89) mmHg
Lifestyle change
Drug therapy (If BP is 130/80 mmHg)
CHF – Thiazide, ACE-1, Aldosterone, BB
Post Myocardial Infarction – BB, ACEi
Diabetes Mellitus – ACEi, ARB, Thiazide, CCB
CKD – ACEi, ABB, Thiazide
Stroke – CCB +ACEi
Anti-hypertensive Medications and
Complications
Diuretics → Hypokalemia
β-Adrenergic Blocking Agents → Bradycardia
Angiotensin-Converting Enzyme Inhibitors →
Hyperkalemia + cough
Angiotensin II Receptor Blockers → Hyperkalemia
Calcium Channel Blocking Agents → Edema +
Tachycardia + Bradycardia+constipation
α-Adrenoceptor Antagonists → 1st dose
hypotension
Drugs with Central Sympatholytic Action →
Drowsiness
Arteriolar Dilators → Tachycardia + Edema
A low dose of initial drug should be used, slowly
titrating upward.
Optimal formulation should provide 24-hour
efficacy with once-daily dose.
Combination therapies may provide additional
efficacy with fewer adverse effects.
Patients should return for follow-up after 2- 4 weeks
and adjustment of medications until the BP goal is
reached
More frequent visits for stage 2 HTN or with
complicating co-morbid conditions.
Serum potassium and creatinine monitored 1–2 times
per year.
Recommended Office BP Treatment Targets
Treatment consists of health behaviour ± pharmacological management
Population
SBP
DBP
High Risk
≤120
NA
Diabetes
< 130
< 80
All others*
< 140
< 90
* Target BP with AOBP < 135/85
Hypertension Update
2016
A Controlled Trial of Renal Denervation for Resistant Hypertension. This
blinded trial did not show a significant reduction of systolic blood
pressure in patients with resistant hypertension 6 months after renalartery denervation as compared with a sham control
Source: The New England Journal of Medicine
April 10, 2014
An implantable device designed to
activate baroreceptors to reduce blood
pressure does not appear to reduce blood
pressure