Download Jörg Köhl Prof. Dr. med. Jörg Köhl Institute for Systemic Inflammation

Curriculum Vitae – Jörg Köhl
Prof. Dr. med. Jörg Köhl
Institute for Systemic Inflammation Research
University of Lübeck
Ratzeburger Allee 160
23538 Lübeck
Ph:+49 451 500 3067
Expertise:
• Complement, IgG Fc receptors, Innate immunity
Scientific background
from
to
Training and positions
1981
1982
Study of biology at the Universities of Mainz and Bochum.
1982
1988
Study of medicine at the University of Mainz, MD license 1988
1986
1988
Doctoral thesis (Dr. med.) at the Institute for Medical
Microbiology of the University of Mainz (“magna cum laude”)
1988
Assistant
1991 in de Post-doctoral fellow at the Institute for Medical Microbiology ,
Medical School of Hannover (MHH, Head: Prof. BitterSuermann).
1991
1992
Resident, Department of Pulmonary Medicine, MHH
1993
1994
Post-doctoral fellow at the Institute for Medical Microbiology,
MHH
1994
Board certified in Medical Microbiology and Epidemiology of
Infectious Diseases, General Medical Council of Lower Saxony,
Germany
1995
Post-doctoral lecture qualification and university teaching
credentials (Habilitation) in Medical Microbiology
1995
2002
Group leader at the Institute for Medical Microbiology, MHH.
1999
2002
Appointment as apl. Professor and Associate Director,
Institute for Medical Microbiology, MHH
1999
2002
Spokesperson of DFG-funded transfer unit (TFB) 15: The
significance of the complement cleavage product C3a as a
diagnostic early marker in sepsis, MHH
2002
2008
Tenured Professor of Pediatrics, Division of Molecular
Immunology, Cincinnati Children’s Hospital Research
Foundation, Cincinnati, USA
2013
2017
Spokesperson of the DFG-funded International Research
Traning Group (IRTG) 1911: Immunoregulation of
inflammation in allergy and infection
2008
present
W3 Professor and Director of the Institute for Systemic
Inflammation Research (ISEF), University of Lübeck
2008
present
Adjunct Professor of Pediatrics, Division of Molecular
Immunology, Cincinnati Children’s Hospital Research
Foundation, Cincinnati, USA
Administrative duties and memberships:
University of Lübeck
2013-2017
2012-2015
20122010-2014
2009-2012
Director, International Research Training Group 1911 (DFG):
“Immunoregulation of inflammation in allergy and infection”.
Director, Priority Program: “Modulation of allergy and infectionmediated inflammation” (University of Lübeck).
Board member, Steering committee of the Excellence Cluster 306
(DFG): “Inflammation at interfaces”.
Board member, Collaborative Research Center 22 (DFG); The
allergic immune response of the lung.
Elected Member, Research Committee of the University of Lübeck
Cincinnati Children’s Hospital Medical Center
2004-2008
Immunobiology Graduate Training Program
Member, Faculty membership committee
Member, Student admissions committee
Medical School Hannover
2000
Member, Organizing committee, Symposium: inflammatory
mechanisms and new biotherapeutic approaches (Collaborative
Research Center 244)
1999-2002
Spokesperson, Collaborative Research Center / Transfer Unit 15
(DFG): “The role of the C3a anaphylatoxin as an early diagnostic
marker in sepsis”.
1999
Member, Organizing committee, XXX. Annual Meeting of the
German Society of Immunology
1998 –2000
Board Member, Collaborative Research Center 244 (DFG):
Chronic Inflammation.
Honors
2012-
Founding Editorial Board member, American Journal of Clinical and
Experimental Immunology
2012-
Editorial Board member, Faculty 1000 Research
2011-
Councilor, European Complement Network
2010-
Editorial Board Member, Frontiers in Immunology
2010-
Faculty of 1000, Immunology, Allergy & Hypersensitivity
2007-2012
Councilor, International Complement Society
2005-
Scientific Advisory Board, Aegean Conferences
Extramural funding since 2011
Funding
period
2014-2017
2013-2017
2013-2017
2012-2015
2009-2013
2012
2011-2015
2009-2014
2009-2013
Project title
The role of the
anaphylatoxins C3a and
C5a in the pathogenesis of
experimental allergic
asthma
Cluster laboratory XII:
Mouse model systems of
inflammation
Immunoregulation of
inflammation in allergy and
infection
The role of the
anaphylatoxin C5a in
intestinal immune
responses
The impact of sleep on
immunoregulatory
functions of complement
High-End Cell Sorter
Regulation of the
inflammatory response in
Goodpasture-Syndrom
through complement- and
IgG-receptors
The role of the
anaphylatoxins C3a and
C5a in allergic asthma
The impact of sleep on
immunoregulatory
functions of complement
Total
Number of publications: 145
Cumulative IF: 933,64
h-factor: 41
Applicant
Source
Jörg Köhl DFG
Jörg Köhl / DFG
Paul Saftig
Reference
no.
KO 1245/4-1
EXC 306/2
Jörg Köhl DFG
IRTG 1911/1
Jörg Köhl DFG
KO 1245/3-1
Jörg DFG
Köhl/Stella
Autenrieth
Jörg Köhl DFG
SFB/TR 654
TP C7
Jörg Köhl DFG
INST
392/101-1
FUGG
GRK 1727
TP 8
Jörg Köhl DFG
SFB/TR22
TPA21
Jörg Köhl DFG
SFB654 TP
C7
Important publications
1. Strait R.T., Posgai MT, Mahler A., Barasa N., Jacob C.O., Köhl J., Ehlers M, Stringer
K., Shanmukappa SH, Witte D., Hossain M, Khodoun M, Herr AB, Finkelman F.D.
IgG1 protects against renal disease in a mouse model of cryoglobulinemia. Nature
2014 doi:10.1038/nature13868.
2. Le Friec G., Köhl J., Kemper C. A complement a day keeps the Fox(p3) away. Nat.
Immunol. 2013 14:110-112.
3. Schmudde I., Ströver, J.A., Vollbrandt T., König P., Karsten C.M., Laumonnier Y.,
Köhl J. C5a receptor signaling in dendritic cells controls the development of
maladaptive Th2 and Th17 immunity in experimental allergic asthma. 2013 Mucosal
Immunol. 6:807-825.
4. Karsten C.M., Pandey M.K., Figge J., Taylor P.R., Rosas M., McDonald J.U., Berger
M., Petzold D., Blacnhard V., Winkler A., Hess C., Reid D.M., Majoul I.V., Strait R.T.,
Harris N.L., Köhl G., Nimmerjahn F., Finkelman F.D., Brown G.D., Ehlers M., Köhl J.
Galactosylated IgG1 links FcgRIIB and Dectin-1 to block complement-mediated
inflammation. Nat Med 2012; 18:1401-1406
5. LeFriec G, Sheppar D, Whiteman P, Karsten CM, Shamoun S., Laing A., Bugeon L.,
Dallman M.J., Melchionna T., Chillakuri C., Smith R.A., Couzi L., Fremeau-Bacchi V.,
Köhl J., Waddington S.N., McDonnell J.M., Handford P.A., Baker A., Lea S.M.,
Kemper C. Cross-talk between Jagged1 and CD46 ligand in human T lymphocytes is
a critical defense mechanism of adaptive immunity. Nat Immunol 2012; 13:12131221
6. Hashimoto M, Hirota K, Yoshitomi H, Maeda S, Teradaira S, Akizuki S, Prieto-Martin
P, Nomura T, Sakaguchi N, Köhl J, Heyman B, Takahashi M, Fujita T, Mimori T,
Sakaguchi S.. Complement drives Th17 cell differentiation and triggers
autoimmunity. J Exp Med 2010; 207:1135-43
7. Karsten CM, Köhl J. The complement receptor CD46 tips the scales in TH1 selfcontrol. Nat Immunol 2010; 11:775-777*#
8. Köhl J., Bälder R., Lewkowich I., Pandey M.K., Hawlisch H., Wang L., Herman N.,
Sproles A., Best J., Zwirner J., Lambris J.D., Whitsett J.D., and Wills-Karp M.. A
regulatory role for the C5a anaphylatoxin on type 2 immunity in asthma. J. Clin.
Invest. 2006; 116: 783-796.
9. Hawlisch H, Belkaid Y, Bälder R, Hildeman D, Köhl J. C5a negatively regulates Tolllike receptor 4-induced immune responses. Immunity 2005; 22: 415-426. 10. Hillebrandt S, Wasmuth H.E., Weiskirchen R., Hellerbrand C., Keppeler H., Werth A.,
Wilkens G., Geier A., Schirin-Sokhan, Lorenzen J., Köhl J., Gressner A.M., Matern
S., Lammert F. Complement factor 5 is a genetic risk factor that modifies liver
fibrosis in mice and humans. 2005 Nat. Genetics 37:835-43.