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Integrated Course of HUMAN PHYSIOLOGY European Credit Transfer and Accumulation System = 4 Hours of formal lectures 32 Hours of interactive learning activities 16 Scientific field: Human Physiology BIO/09 Coordinator: Prof. ANTONIO COLANTUONI Department of Clinical Medicine and Surgery, ed. 19, 9th floor, phone 0817463212 e-mail: [email protected] Faculty Position Scientific Fields: Phone F.P. HUMAN PHYSIOLOGY 3212 Mon. 14:30–15:30 ed.19, 9th Floor [email protected] F.P. HUMAN PHYSIOLOGY 3225 Wed. 10:30–12:30 ed.19, 11th Floor [email protected] A.P. HUMAN PHYSIOLOGY 3233 Wed. 11.00-1300 ed.19, 11th Floor [email protected] Colantuoni Antonio Mondola Paolo Santillo Mariarosaria Reception (day/time/building) E-mail EDUCATIONAL OBJECTIVES The human physiology course is focused on the study of the organ functions involved in the body system, starting from the knowledge of organ metabolic activity, up to the dynamic integration of several organs to form a system; The study comprises: 1) The control mechanisms of the different organ functions; 2) The regulatory mechanisms of human body integrated functions in physiological conditions; 3) The application of the general laws of physics, biophysics, chemistry, mathematics, statistics and biomedical technology to the functions of the human body CORE CURRICULUM Human Physiology I program covers: 1)The study of the functioning of the heart and cardiovascular system, under physiological conditions and in response to environmental stress; 1) The study of the essential mechanisms of breathing and its control under physiological conditions as well as in different environmental conditions; 2) The study of the functional mechanisms of kidney under physiological condition, and their involvement in the processes of acid-base balance and body fluid volume regulation; 1 3) The study of the mechanisms involved in digestion and absorption of food nutrients; to know the metabolism and secretion of abdominal organs; 4) The study of the content in nutrients of food and their application to the healthy balanced diet under physiological condition; 5) The study of the functions of blood and body fluids. PRELIMINARY KNOWLEDGE A basic knowledge on cell biology and human anatomy PROPAEDEUTIC COURSE EXAMS A test with multiple choice questions on the arguments listed in the core curriculum is preliminary to the oral examination. The test must be passed (almost 18/30) for the access to oral examination. TEXTBOOKS 1)Berne & Levy Physiology, 6th Updated Edition by Bruce M. Koeppen, Bruce A. Stanton Elsevier 2)Medical Physiology, 3rd Edition by Walter F. Boron (Autore), Emile L. Boulpaep Elsevier DIDACTIC ACTIVITY C.I. HUMAN PHYSIOLOGY WEEK TIME LESSONS Cellular membranes and transmembrane transport of solutes and water. Hemorheology and fluidodynamics: the 1° 14:30 fundamental principles. Hemodynamics: Poiseuille’s law and 6-10 March 15:30 blood viscosity. Homeostatic function of blood. Hemostasis and blood coagulation. 2° 13 -17 March 3° 20 -24 March 4° 27 - 31 March 5° 3-7 April 6° 10 - 12 April 14:30 15:30 Electrical activity of the heart. Seno atrial node: pacemaker cells. Ventricular myocytes. Atrial, atrial-ventricular and ventricular conduction. Electrocardiography: standard limb leads 14:30 15:30 The cardiac pump. Cardiac chambers. Cardiac valves. Cardiac cycle. Measurement of cardiac output. Regulation of cardiac output. Frank-Starling’s law of the heart 14:30 15:30 Regulation of the heartbeat: nervous control of heart rate. The arterial system; regulation of arterial blood pressure. 14:30 15:30 The microcirculation and lymphatics. The peripheral circulation and its control. The peripheral circulation and its control 14:30 15:30 Special circulation: coronary blood flow. Cutaneous circulation; skeletal muscle circulation; cerebral circulation PROFESSORS Colantuoni Colantuoni Colantuoni Colantuoni Pohl Colantuoni 2 WEEK TIME 7° 19 -21 April 13:30 14:30 8° 24 - 28 April 9° 2-5 May 10° 8-12 May 11° 15-19 May 12° 22-26 May 13° 29 May-1 June 14:30 15:30 14:30 15:30 14:30 15:30 14:30 15:30 14:30 15:30 13:30 14:30 LESSONS Respiratory system: Structure and function of the respiratory system. Blood supply to the lung. Pulmonary ventilation: muscles of respiratory. Mechanical properties of the lung and chest wall: static and dynamic. Pulmonary interstitial fluid dynamics: edema. Ventilation and perfusion relationships. Oxygen and carbon dioxide transport. Control of respiration: chemical and nervous. High altitude acclimatization. Elements of renal function: structure and functions of the kidneys and urinary tract. Glomerular filtration and autoregulation. Renal clearances. Solute and water transport along the nephron: tubular functions. Henle’s loop. Distal tubule and collecting duct. Control of body fluids, osmolality and volume: concentration and dilution of urine. Control of extracellular fluid volume and regulation of NaCl excretion. Role of the kidney in the regulation of acidbase balance. Gastro-intestinal system: Motility. Salivary secretion; gastric secretion; pancreatic secretion; function of the liver: bile secretion; intestinal secretion. Digestion and absorption of carbohydrates, proteins and lipids. Intestinal absorption of salts and water. Absorption of vitamins. Absorption of bile acids. Regulation of secretion and motility of gastrointestinal system. Principles of human nutrition. The resting energy expenditure. The exercise induced metabolic activation. Nutrition and lifestyle along the different periods of life. Nutrition during pregnancy, delivery and lactation. PROFESSORS Santillo Mondola Mondola Mondola Mondola Mondola Mondola 3