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Synthetic Biology for Programmers Joshua D. Bruning Examples Photographic film Water that changes pH when exposed to arsenic Salmonella that secretes spider silk proteins instead of toxins Toggle switch Science + Engineering Convergence of biology and engineering Representation Base = bit Wetware Software that Builds Hardware Reading (Sequencing) Partial analysis (~1 million bp) 2008: ~$1,000 2009: ~$300-$500 Full human genome (~3 billion bp) 2008: ~$350,000 2009: ~$99,000 Writing (Synthesizing) $1/bp phiX-174: $5,386 Smallpox: $186,102 Human: ~$3,000,000,000 Abstraction Systems Devices Parts DNA BioBricks Open-source genetic parts http://partsregistry.org Long-term goal: to build a synthetic living organism that is completely understood Refactoring Genetic programming vs. Structural programming Bacteriophage T7 Emulation Graph theory Boolean networks Ordinary differential equations Stochastic differential equations Master equations Social Issues Risk/Security What’s wrong with the DNA God gave us? Economics/Patents Organization