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 Program of Mentors for Selected Trainees HIV-­‐TB Epidemiology/Clinical Research Mentors Dr. Kelly Dooley Dr. Dooley is an Assistant Professor at the Johns Hopkins School of Medicine. In addition to her MD and Clinical Fellowships in both Infectious Diseases and Clinical Pharmacology, Dr. Dooley has a Ph.D in Clinical Investigation. Her research has focused on evaluation of new TB treatment regimens, with particular interest in the pharmacology of TB and HIV drug interactions. She is a recognized leader in HIVTB research, having served on the TBTC Pharmacokinetic and Pharmacodynamic Studies Working Group, the AIDS Clinical Trials Group (ACTG) Tuberculosis Transformative Science Group (TB TSG), the IMPAACT TB Scientific Group and Chaired the Drug Evaluation Subcommittee of RESIST-­‐TB Working Group. Dr. Dooley is a faculty mentor for the Hopkins Clinical Pharmacology T32 Training Grant and has mentored 6 research trainees over the past 3 years. Dr. Dooley is available to mentor BJGMC trainees with research interest in the pharmacology of drugs used to treat TB among those co-­‐infected with HIV. Dr. David Dowdy Dr. Dowdy is Assistant Professor in the Department of Epidemiology of the Johns Hopkins Bloomberg School of Public Health. He has conducted evaluations of TB diagnostic tests in the United States and Brazil. Using traditional epidemiological and statistical techniques, he has conducted cohort studies of people living with HIV/AIDS in the United States and South Africa, ICU survivors, and TB suspects in Brazil and Uganda. As a health economist, he has evaluated the costs and cost-­‐effectiveness of numerous TB diagnostic tests (sputum smear microscopy, culture, serology, hypothetical point-­‐of-­‐care tests, and nucleic acid amplification) in seven countries (the United States, Brazil, India, China, South Africa, Uganda, and Kenya). Dr. Dowdy is best known as a mathematical modeler. He has evaluated the medium-­‐term epidemiological and economic impact of improved TB diagnostic tests: both locally and globally, in hypothetical and real populations. As noted in his letter of support, Dr. Dowdy has recently been funded to conduct both economic analyses and mathematical modeling efforts of the TB treatment and prevention programs in India. He has also generously offered to include BJGMC trainees in the TB modeling workshops which he will be conducting in India over the coming two years. Dr. Dowdy has also been a consultant for WHO and the Center for Global Development and Population Services International. Dr. Dowdy is one of the best educators at Johns Hopkins, having received multiple teaching awards. Dr. Dowdy will be available to mentor trainees from BJGMC who are interested in research related to HIV/TB coinfection, mathematical modeling, health economics, or translational epidemiology. Dr. Jonathan Golub Dr. Golub is Associate Professor of Medicine at Johns Hopkins and a leading investigator in the Hopkins Center for TB Research, where his research focuses on the epidemiology, detection and prevention of TB in developing countries. Of particular interest to the current proposal, he developed a Johns Hopkins based ICOHRTA training program for Brazilian researchers and over the past 7 years, over 70 trainees have attended the program and continue to be mentored. For 3 years, this program was extended through a Fogarty supplement to include trainees researching HIV-­‐related malignancies from Brazil and South Africa. In addition, he has led three large cluster randomized trials in Rio de Janeiro, Brazil investigating preventive treatment and case finding strategies for TB in Brazil and currently is PI of an R01 clinical trial assessing smoking cessation among HIV-­‐infected patients in South Africa. Also, in Brazil, South Africa and other Program of Mentors for Selected Trainees countries, he is leading several studies investigating the impact of social determinants on TB disease, including diabetes and tobacco exposure. Currently, Dr. Golub is collaborating with Dr. Bollinger, Dr. Dowdy, Dr. Gupta and scientists at BJGMC on preparation of two NIH grants to investigate the impact of HIV, diabetes, smoking and biomass fuel smoke exposure on TB outcomes in India. Dr. Golub leads a Fogarty training program for Brazil and South Africa and participates in other training grants as faculty mentor. He has personally mentored 28 trainees. Dr. Golub will be available to mentor BJGMC trainees with research interest in HIV-­‐TB epidemiology. Dr. Amita Gupta Dr. Gupta is an Associate Professor in the Johns Hopkins School of Medicine. She is also Principal Investigator for the NIH funded BJMC Clinical Trials Unit, which is conducting multiple clinical trials for the ACTG and IMPAACT networks. She has also been a leader of the Hopkins team working with BJMC HIV research collaboration for the past 10 years. As PI of the BJGMC CTU, a leader of a number of IMPAACT and ACTG protocols, as well as a member of the ACTG and Vice Chair of the IMPAACT TB Research Committees, she will be particularly helpful in identifying opportunities for new HIV-­‐TB research, as well as identifying the specific research competencies and capacities that will position BJMC to contribute to new HIV-­‐TB research. Dr. Gupta has mentored 26 research trainees at Hopkins and will be available to mentor BJGMC trainees with interest in HIV-­‐TB epidemiology and clinical research. Dr. Nikhil Gupte Dr. Gupte is a Research Associate faculty member in the Johns Hopkins School of Medicine. He is based full-­‐time in India and is the Data Management Director and Deputy Director of the BJGMC CTU. Through the support of the Hopkins Fogarty AITRP, Dr. Gupte received his PhD in Biostatistics from the Johns Hopkins Bloomberg School of Public Health, under the guidance of Dr. Ron Brookmeyer. After receiving his PhD, he returned to India as a leader of the BJGMC-­‐JHU research partnership. He has over 10 years of experience in public health research in developing countries. His research is focused on clinical, behavioral and lab research related to HIV/AIDS and TB prevention in India. He is also the lead statistician on a phase II randomized, open-­‐label trial of rifapentine in place of rifampicin for intensive phase treatment of smear-­‐positive pulmonary TB currently ongoing in South Africa. In addition, Dr. Gupte is a recognized leader in Biostatistics education in India. He has developed and taught biostatistics courses at MIMER Medical College Talegaon and the Department of Statistics, University of Pune. He has also developed and taught a number of NIH-­‐supported Biostatistics training courses in India, including the first on-­‐line course in Biostatistics in India. He received the 2003 Helen Abbey Award for excellence in teaching from the Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health. He also received the 2002 Louis I. and Thomas D. Dublin Award for advancement of research in Biostatistics and Epidemiology and was a 2011 Inductee in the Johns Hopkins Bloomberg School of Public Health Delta-­‐Omega Alpha Society. We are very fortunate to have this outstanding Fogarty AITRP Alumnus take a leadership role in this new Fogarty HIV-­‐TB Research Training Program. Dr. Gupte will establish a Data Management and Biostatistical Core Faciltiy at BJMC for the trainees, where he will teach courses for the Core Research Competencies I and II Seminar Series, as well as provide data management and statistical support for the trainees. Dr. Gupte will be available to mentor BJGMC trainees with research interest in related to bio-­‐statistical methods in TB research. Program of Mentors for Selected Trainees Dr. Vidya Mave Dr. Mave is Site Coordinator for the BJGMC CTU in Pune, where she coordinates all of the clinical research activities for the BJGMC-­‐JHU partnership, including the ACTG and IMPAACT trials. She is also on the faculty of the Johns Hopkins Department of Medicine. Prior to returning to India, she was an Assistant Professor of Infectious Diseases at Tulane University. Her research interests include the epidemiology of latent TB infection among pregnant women, the role of vitamin D levels in pediatric TB infection and studies of the patterns of TB drug resistance in Pune. Over the past 2 years, she has mentored 8 pre-­‐doctoral and postdoctoral trainees from Hopkins, who have come to Pune for research training and experience. Dr. Mave will be available to mentor BJGMC trainees with interest in HIV-­‐TB epidemiology and clinical research. Dr. Yuka Manabe Dr. Manabe is an Associate Professor of Medicine at Johns Hopkins where she began her faculty career studying the molecular and immunopathogenis of TB. Her interest in immune reconstitution inflammatory syndrome brought her to the Infectious Diseases Institute at Makerere University in Uganda in 2007 where she began clinical research in TB-­‐HIV co-­‐infection and more recently have begun some translational research in TB immunopathogenesis. From 2008-­‐2012, she was also Head of Research at IDI and mentored many young PhD and Masters students. Dr. Manabe will be available to mentor BJGMC trainees with interest in TB epidemiology, TB clinical trials, and implementation science in the area of TB-­‐HIV integration of care. HIV-­‐TB Laboratory Research Mentors Dr. Bill Bishai Dr. Bishai is Professor of Medicine at Johns Hopkins with extensive research experience in several areas of mycobacterial research, including drug and drug target discovery, animal models, molecular pathogenesis, host-­‐pathogen interactions, and molecular genetics. For 18 years his work has focused on TB. In particular, he has worked on the roles of Mycobacterium tuberculosis (M.tb.) sigma factors, the generation of transposon mutants, knock-­‐in and knock-­‐
down strategies, and the use of mutants in understanding the mechanism of action of existing and novel anti-­‐TB compounds and drug regimens. Dr. Bishai served as Co-­‐Chair of the World Health Organization’s Stop TB Partnership Working Group for New Drugs. Dr. Bishai will be available to mentor BJGMC trainees interested in research related to TB pathogenesis and disease diagnosis and chemotherapy. Dr. Shyam Biswal Dr. Biswal is a Professor in the Johns Hopkins Bloomberg School of Public Health where his research has focused on the pathogenesis of respiratory diseases. His laboratory has done the seminal translational research that provided the link between defect in Nrf2 with progression of COPD lungs and cigarette smoke induced emphysema in mouse models. His laboratory was first in reporting the overarching induction of multitudes of antioxidant genes and detoxification pathways by nrf2 activation and its ability to activate antibacterial defenses and phagocytosis in macrophages from COPD patients and mouse models. Dr. Biswal is also PI of a Fogarty Training Grant supporting research capacity strengthening with multiple institutions in and near Pune, India, focused on the relationship between respiratory diseases and indoor air pollution. Dr. Biswal’s area of research is of great interest to BJGMC, since up to 70% of HIV-­‐TB patients in Pune have exposure to indoor air pollution through use of biomass fuel cooking. Dr. Biswal has Program of Mentors for Selected Trainees mentored more than 25 fellows in last 10 years as a mentor for individual NRSA and also the NIEHS and the NHLBI institutional training grant. Dr. Biswal is available to mentor BJGMC trainees with who are interested in research related to innate immune response, exposure to indoor air pollution or cigarette smoke and TB. Dr. Sanjay Jain Dr. Jain is an Associate Professor in the Johns Hopkins School of Medicine, with a joint appointment in the Department of International Health. He is Director of the Hopkins Center for Infection and Inflammation Imaging Research. His primary research interests have been TB pathogenesis with a focus on translational research on molecular imaging, diagnostics and CNS TB. He has a dedicated and fully equipped biosafety level 2 and 3 spaces, small animal imaging equipment (CT, PET, SPECT/CT), biosafety cells. He is a recipient of the NIH Directors New Innovator Award and has been a faculty mentor for 4 training grants (Pediatric ID Post-­‐Doctoral Fellowship NIH T32, Pediatric Departmental NIH T32, Department of Pediatrics K-­‐12 program and the Adult ID Post-­‐Doctoral Fellowship NIH T32). He has personally mentored 24 trainees in his laboratory since 2005. Dr. Jain will be available to mentor BJGMC trainees interested in laboratory-­‐related translational research in HIV-­‐TB co-­‐infection. Dr. Petros Karakousis Dr. Karakousis is Associate Professor at the Johns Hopkins School of Medicine and a lead investigator in the Hopkins Center for TB Research, where his research has focused on the development of several in vitro and in vivo models of TB latency and studies of the regulatory and metabolic networks required for Mtb growth restriction and antibiotic tolerance. Recently, he has developed novel assays to determine drug resistance from archived isolates of patients with MDR-­‐TB. He has collaborated in the past on several studies with Dr. Bollinger, leading to scientific publications. He is faculty mentor for a number of other training grants, including the Division of ID T32 Postdoctoral program and has been an excellent mentor to 16 trainees over the past 10 years at Hopkins. Dr. Karakousis will be available to mentor BJGMC trainees who are interested in research related to the molecular mechanisms of TB latency and the development of rapid molecular diagnostic methods for detection of TB and drug resistance. Dr. Gyanu Lamichhane Dr. Lamichhane is an Assistant Professor in the Johns Hopkins School of Medicine and an investigator in the Hopkins Center for TB Reseaerch. His primary research interest has been focused on the identification of genes/proteins required for growth of Mtb. Dr. Lamichhane has received numerous research awards, including the Paul Ehrlich Research Award and the W. Leigh Thompson Excellence in Research Award. Dr. Lamichhane is a faculty mentor on the Hopkins Post-­‐doctoral Infectious Diseases Fellowship T32 grant and has personally mentored 10 trainees. Dr. Lamichhane will be available to mentor BJGMC trainees with interest in research related to basic growth assays and fundamental basis of drug resistance of Mtb. Dr. Eric Nuermberger Dr. Nuermberger is Associate Professor of Medicine and International Health at Johns Hopkins, where he has been engaged in the development of new drugs and the repurposing of existing agents for the treatment of TB for over a decade. His laboratory’s work in in vitro and animal models has informed the clinical development of virtually all drugs currently in clinical trials for TB (e.g., moxifloxacin, rifapentine, PA-­‐824, OPC-­‐67683, TMC207 and PNU-­‐100480). He has been a leader of the TB Transformative Science Group of the ACTG and Program of Mentors for Selected Trainees the Core Science Group of the TBTC. He has mentored more than 10 graduate students and post-­‐doctoral fellows who have worked on projects related to the development of improved in vitro and animal models for TB drug development applications, the evaluation of new drug candidates in pre-­‐clinical models, pharmacodynamically based optimization of drug dosing and the kinetics of the emergence of drug resistance. Dr. Nuermberger will be available to mentor trainees from BJGMC who are interested in research related to the chemotherapy of TB. Dr. Nikki Parrish Dr. Parrish is Assistant Professor in the Department of Pathology and Director of Medical Mycobacteriology, at the Johns Hopkins School of Medicine. Her research focus has been on the biochemistry and genetics of Mycobacterium and she has more than 18 years of experience in the field of tuberculosis drug research and clinical diagnostic development. She also has been involved in numerous clinical studies including evaluation of new technologies, clinical trials with subsequent FDA approval of new diagnostic tests, and development of novel methods for routine clinical use. Over the years, she has trained many graduate students, laboratorians, medical technologists, research fellows and residents. Dr. Parrish has also been a technical consultant for the BJGMC CTU in Pune, to assist in the expansion of laboratory capacity for the isolation and characterization of TB. Dr. Parrish will be available to mentor trainees from BJGMC trainees with interest in laboratory research of TB.