Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function by Jennifer L. Brogdon, Yongyao Xu, Susanne J. Szabo, Shaojian An, Francis Buxton, Dalia Cohen, and Qian Huang Blood Volume 109(3):1123-1130 February 1, 2007 ©2007 by American Society of Hematology LAQ824 modulates gene expression in resting human monocyte-derived macrophages from 2 donors. Jennifer L. Brogdon et al. Blood 2007;109:1123-1130 ©2007 by American Society of Hematology LAQ824 alters LPS-induced gene expression profiles in human monocyte-derived macrophages. Jennifer L. Brogdon et al. Blood 2007;109:1123-1130 ©2007 by American Society of Hematology Effects of LAQ824 on the expression of LPS-induced proinflammatory genes in human monocyte-derived macrophages and DCs. (A) mRNA levels of proinflammatory genes, lipid mediators, and chemotactic factors in macrophages treated with indicated stimuli. Jennifer L. Brogdon et al. Blood 2007;109:1123-1130 ©2007 by American Society of Hematology LAQ824 inhibits LPS-induced monocyte but not neutrophil chemotaxis. Jennifer L. Brogdon et al. Blood 2007;109:1123-1130 ©2007 by American Society of Hematology LAQ824 modulates the expression of genes involved in CD4+ T-cell activation in human monocyte-derived macrophages and DCs. (A) mRNA levels of genes involved in Th1/Th2 activation and migration in macrophages. Jennifer L. Brogdon et al. Blood 2007;109:1123-1130 ©2007 by American Society of Hematology LAQ824 inhibits DC-mediated IFN-γ secretion from Th1 but not IL-4 production from Th2 cells. Jennifer L. Brogdon et al. Blood 2007;109:1123-1130 ©2007 by American Society of Hematology LAQ824 inhibits LPS-induced Th1 but not Th2 chemotaxis. Jennifer L. Brogdon et al. Blood 2007;109:1123-1130 ©2007 by American Society of Hematology