Download 1123-1130 February 1, 2007

Histone deacetylase activities are required for innate
immune cell control of Th1 but not Th2 effector cell
function
by Jennifer L. Brogdon, Yongyao Xu, Susanne J. Szabo, Shaojian An, Francis
Buxton, Dalia Cohen, and Qian Huang
Blood
Volume 109(3):1123-1130
February 1, 2007
©2007 by American Society of Hematology
LAQ824 modulates gene expression in resting human monocyte-derived macrophages from 2
donors.
Jennifer L. Brogdon et al. Blood 2007;109:1123-1130
©2007 by American Society of Hematology
LAQ824 alters LPS-induced gene expression profiles in human monocyte-derived macrophages.
Jennifer L. Brogdon et al. Blood 2007;109:1123-1130
©2007 by American Society of Hematology
Effects of LAQ824 on the expression of LPS-induced proinflammatory genes in human
monocyte-derived macrophages and DCs. (A) mRNA levels of proinflammatory genes, lipid
mediators, and chemotactic factors in macrophages treated with indicated stimuli.
Jennifer L. Brogdon et al. Blood 2007;109:1123-1130
©2007 by American Society of Hematology
LAQ824 inhibits LPS-induced monocyte but not neutrophil chemotaxis.
Jennifer L. Brogdon et al. Blood 2007;109:1123-1130
©2007 by American Society of Hematology
LAQ824 modulates the expression of genes involved in CD4+ T-cell activation in human
monocyte-derived macrophages and DCs. (A) mRNA levels of genes involved in Th1/Th2
activation and migration in macrophages.
Jennifer L. Brogdon et al. Blood 2007;109:1123-1130
©2007 by American Society of Hematology
LAQ824 inhibits DC-mediated IFN-γ secretion from Th1 but not IL-4 production from Th2 cells.
Jennifer L. Brogdon et al. Blood 2007;109:1123-1130
©2007 by American Society of Hematology
LAQ824 inhibits LPS-induced Th1 but not Th2 chemotaxis.
Jennifer L. Brogdon et al. Blood 2007;109:1123-1130
©2007 by American Society of Hematology